Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O43820 (HYAL3_HUMAN)

Entry version 163 (02 Jun 2021)
Sequence version 1 (01 Jun 1998)
Previous versions | rss
Add a publicationFeedback
Protein

Hyaluronidase-3

Gene

HYAL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.1 Publication EC:3.2.1.35

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei129Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processFertilization

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:ENSG00000114366-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.2.1.35, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43820

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2024101, CS/DS degradation
R-HSA-2160916, Hyaluronan uptake and degradation

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GH56, Glycoside Hydrolase Family 56

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hyaluronidase-3 (EC:3.2.1.351 Publication)
Short name:
Hyal-3
Alternative name(s):
Hyaluronoglucosaminidase-3
Lung carcinoma protein 3
Short name:
LuCa-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HYAL3
Synonyms:LUCA3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5322, HYAL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604038, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43820

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000186792.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8372

Open Targets

More...OpenTargetsi		ENSG00000186792

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29573

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43820, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HYAL3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024820021 – 417Hyaluronidase-3Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi42 ↔ 331By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi205 ↔ 220By similarity
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi356 ↔ 367By similarity
Disulfide bondi361 ↔ 395By similarity
Disulfide bondi397 ↔ 406By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43820

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43820

PeptideAtlas

More...PeptideAtlasi		O43820

PRoteomics IDEntifications database

More...PRIDEi		O43820

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49183 [O43820-1]
49184 [O43820-2]
49185 [O43820-3]
49186 [O43820-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O43820, 2 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in sperm (PubMed:20586096). Highly expressed in epidermis of the skin, where it is expressed intracellularily in the deep horny layer (at protein level) (PubMed:21699545). Bone marrow, testis and kidney (PubMed:10493834).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is not significantly up- or down-regulated by ultraviolet irradiation B (UV-B) in epidermis (PubMed:21699545).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186792, Expressed in bone marrow and 116 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43820, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43820, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186792, Group enriched (blood, bone marrow, brain, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113967, 6 interactors

Protein interaction database and analysis system

More...IntActi		O43820, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000337425

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43820, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43820

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini352 – 407EGF-likeAdd BLAST56

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTXP, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01020000230364

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_036366_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43820

Identification of Orthologs from Complete Genome Data

More...OMAi		FYRFPAC

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43820

TreeFam database of animal gene trees

More...TreeFami		TF321598

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013785, Aldolase_TIM
IPR017853, Glycoside_hydrolase_SF
IPR018155, Hyaluronidase
IPR027260, Hyaluronidase-3

The PANTHER Classification System

More...PANTHERi		PTHR11769, PTHR11769, 1 hit
PTHR11769:SF19, PTHR11769:SF19, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01630, Glyco_hydro_56, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038193, Hyaluronidase, 1 hit
PIRSF500776, Hyaluronidase_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00846, GLHYDRLASE56

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51445, SSF51445, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O43820-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTQLGPALV LGVALCLGCG QPLPQVPERP FSVLWNVPSA HCEARFGVHL 
        60         70         80         90        100
PLNALGIIAN RGQHFHGQNM TIFYKNQLGL YPYFGPRGTA HNGGIPQALP 
       110        120        130        140        150
LDRHLALAAY QIHHSLRPGF AGPAVLDWEE WCPLWAGNWG RRRAYQAASW 
       160        170        180        190        200
AWAQQVFPDL DPQEQLYKAY TGFEQAARAL MEDTLRVAQA LRPHGLWGFY 
       210        220        230        240        250
HYPACGNGWH SMASNYTGRC HAATLARNTQ LHWLWAASSA LFPSIYLPPR 
       260        270        280        290        300
LPPAHHQAFV RHRLEEAFRV ALVGHRHPLP VLAYVRLTHR RSGRFLSQDD 
       310        320        330        340        350
LVQSIGVSAA LGAAGVVLWG DLSLSSSEEE CWHLHDYLVD TLGPYVINVT 
       360        370        380        390        400
RAAMACSHQR CHGHGRCARR DPGQMEAFLH LWPDGSLGDW KSFSCHCYWG 
       410 
WAGPTCQEPR PGPKEAV
Length:417
Mass (Da):46,501
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6E7DE5369EF2BB8
GO
Isoform 2 (identifier: O43820-2) [UniParc]FASTAAdd to basket
Also known as: HYAL3v1

The sequence of this isoform differs from the canonical sequence as follows:
     299-328: Missing.

Note: Enzymatically inactive.Curated
Show »
Length:387
Mass (Da):43,602
Checksum:i32FE18A2329307A6
GO
Isoform 3 (identifier: O43820-3) [UniParc]FASTAAdd to basket
Also known as: HYAL3v2

The sequence of this isoform differs from the canonical sequence as follows:
     1-249: Missing.
     250-250: R → M

Note: Enzymatically inactive.Curated
Show »
Length:168
Mass (Da):18,764
Checksum:iC29CE942F2F784F8
GO
Isoform 4 (identifier: O43820-4) [UniParc]FASTAAdd to basket
Also known as: HYAL3v3

The sequence of this isoform differs from the canonical sequence as follows:
     1-249: Missing.
     250-250: R → M
     299-328: Missing.

Note: Enzymatically inactive.Curated
Show »
Length:138
Mass (Da):15,865
Checksum:i8E94BC56A7606001
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JB51C9JB51_HUMAN
Hyaluronidase
HYAL3
159Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC70915 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54A → S in AAH05896 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027263113H → Y1 PublicationCorresponds to variant dbSNP:rs13100173Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0201921 – 249Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_020193250R → M in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_020194299 – 328Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF036035 mRNA Translation: AAD04257.1
AF502909 mRNA Translation: AAM60775.1
AF502910 mRNA Translation: AAM60776.1
AF502911 mRNA Translation: AAM60777.1
AF502912 mRNA Translation: AAM60778.1
AF040710 mRNA Translation: AAC70915.1 Frameshift.
U73167 Genomic DNA Translation: AAC02729.1
BC005896 mRNA Translation: AAH05896.1
BC012892 mRNA Translation: AAH12892.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2815.1 [O43820-1]
CCDS56257.1 [O43820-2]
CCDS56259.1 [O43820-4]
CCDS56260.1 [O43820-3]

NCBI Reference Sequences

More...RefSeqi		NP_001186958.1, NM_001200029.1 [O43820-1]
NP_001186959.1, NM_001200030.1 [O43820-2]
NP_001186960.1, NM_001200031.1 [O43820-3]
NP_001186961.1, NM_001200032.1 [O43820-4]
NP_003540.2, NM_003549.3 [O43820-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000336307; ENSP00000337425; ENSG00000186792 [O43820-1]
ENST00000359051; ENSP00000351946; ENSG00000186792 [O43820-2]
ENST00000415204; ENSP00000401092; ENSG00000186792 [O43820-3]
ENST00000450982; ENSP00000391922; ENSG00000186792 [O43820-2]
ENST00000513170; ENSP00000424633; ENSG00000186792 [O43820-4]
ENST00000621157; ENSP00000479935; ENSG00000186792 [O43820-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8372

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8372

UCSC genome browser

More...UCSCi		uc003czd.3, human [O43820-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036035 mRNA Translation: AAD04257.1
AF502909 mRNA Translation: AAM60775.1
AF502910 mRNA Translation: AAM60776.1
AF502911 mRNA Translation: AAM60777.1
AF502912 mRNA Translation: AAM60778.1
AF040710 mRNA Translation: AAC70915.1 Frameshift.
U73167 Genomic DNA Translation: AAC02729.1
BC005896 mRNA Translation: AAH05896.1
BC012892 mRNA Translation: AAH12892.1
CCDSiCCDS2815.1 [O43820-1]
CCDS56257.1 [O43820-2]
CCDS56259.1 [O43820-4]
CCDS56260.1 [O43820-3]
RefSeqiNP_001186958.1, NM_001200029.1 [O43820-1]
NP_001186959.1, NM_001200030.1 [O43820-2]
NP_001186960.1, NM_001200031.1 [O43820-3]
NP_001186961.1, NM_001200032.1 [O43820-4]
NP_003540.2, NM_003549.3 [O43820-1]

3D structure databases

SMRiO43820
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113967, 6 interactors
IntActiO43820, 6 interactors
STRINGi9606.ENSP00000337425

Protein family/group databases

CAZyiGH56, Glycoside Hydrolase Family 56

PTM databases

GlyGeniO43820, 2 sites

Genetic variation databases

BioMutaiHYAL3

Proteomic databases

MassIVEiO43820
PaxDbiO43820
PeptideAtlasiO43820
PRIDEiO43820
ProteomicsDBi49183 [O43820-1]
49184 [O43820-2]
49185 [O43820-3]
49186 [O43820-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34877, 188 antibodies

The DNASU plasmid repository

More...DNASUi		8372

Genome annotation databases

EnsembliENST00000336307; ENSP00000337425; ENSG00000186792 [O43820-1]
ENST00000359051; ENSP00000351946; ENSG00000186792 [O43820-2]
ENST00000415204; ENSP00000401092; ENSG00000186792 [O43820-3]
ENST00000450982; ENSP00000391922; ENSG00000186792 [O43820-2]
ENST00000513170; ENSP00000424633; ENSG00000186792 [O43820-4]
ENST00000621157; ENSP00000479935; ENSG00000186792 [O43820-1]
GeneIDi8372
KEGGihsa:8372
UCSCiuc003czd.3, human [O43820-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8372
DisGeNETi8372

GeneCards: human genes, protein and diseases

More...GeneCardsi		HYAL3
HGNCiHGNC:5322, HYAL3
HPAiENSG00000186792, Group enriched (blood, bone marrow, brain, testis)
MIMi604038, gene
neXtProtiNX_O43820
OpenTargetsiENSG00000186792
PharmGKBiPA29573
VEuPathDBiHostDB:ENSG00000186792.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTXP, Eukaryota
GeneTreeiENSGT01020000230364
HOGENOMiCLU_036366_0_0_1
InParanoidiO43820
OMAiFYRFPAC
PhylomeDBiO43820
TreeFamiTF321598

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000114366-MONOMER
BRENDAi3.2.1.35, 2681
PathwayCommonsiO43820
ReactomeiR-HSA-2024101, CS/DS degradation
R-HSA-2160916, Hyaluronan uptake and degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8372, 11 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HYAL3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HYAL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8372
PharosiO43820, Tbio

Protein Ontology

More...PROi		PR:O43820
RNActiO43820, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186792, Expressed in bone marrow and 116 other tissues
ExpressionAtlasiO43820, baseline and differential
GenevisibleiO43820, HS

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785, Aldolase_TIM
IPR017853, Glycoside_hydrolase_SF
IPR018155, Hyaluronidase
IPR027260, Hyaluronidase-3
PANTHERiPTHR11769, PTHR11769, 1 hit
PTHR11769:SF19, PTHR11769:SF19, 1 hit
PfamiView protein in Pfam
PF01630, Glyco_hydro_56, 1 hit
PIRSFiPIRSF038193, Hyaluronidase, 1 hit
PIRSF500776, Hyaluronidase_3, 1 hit
PRINTSiPR00846, GLHYDRLASE56
SUPFAMiSSF51445, SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHYAL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43820
Secondary accession number(s): O60540
, Q8NFK2, Q8NFK3, Q8NFK4, Q96E56, Q9BRW9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 1998
Last modified: June 2, 2021
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again