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UniProtKB - O43820 (HYAL3_HUMAN)

Protein

Hyaluronidase-3

Gene

HYAL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.1 Publication EC:3.2.1.35

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei129Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processFertilization

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:ENSG00000114366-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.2.1.35 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2024101 CS/DS degradation
R-HSA-2160916 Hyaluronan uptake and degradation

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GH56 Glycoside Hydrolase Family 56

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hyaluronidase-3 (EC:3.2.1.351 Publication)
Short name:
Hyal-3
Alternative name(s):
Hyaluronoglucosaminidase-3
Lung carcinoma protein 3
Short name:
LuCa-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HYAL3
Synonyms:LUCA3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000186792.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:5322 HYAL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604038 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43820

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8372

Open Targets

More...OpenTargetsi		ENSG00000186792

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29573

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HYAL3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024820021 – 417Hyaluronidase-3Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi42 ↔ 331By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi205 ↔ 220By similarity
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi356 ↔ 367By similarity
Disulfide bondi361 ↔ 395By similarity
Disulfide bondi397 ↔ 406By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43820

PeptideAtlas

More...PeptideAtlasi		O43820

PRoteomics IDEntifications database

More...PRIDEi		O43820

ProteomicsDB human proteome resource

More...ProteomicsDBi		49183
49184 [O43820-2]
49185 [O43820-3]
49186 [O43820-4]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in sperm (PubMed:20586096). Highly expressed in epidermis of the skin, where it is expressed intracellularily in the deep horny layer (at protein level) (PubMed:21699545). Bone marrow, testis and kidney (PubMed:10493834).3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is not significantly up- or down-regulated by ultraviolet irradiation B (UV-B) in epidermis (PubMed:21699545).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186792 Expressed in 89 organ(s), highest expression level in caudate nucleus

CleanEx database of gene expression profiles

More...CleanExi		HS_HYAL3

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43820 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43820 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA049402

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
DAB1O755533EBI-3913399,EBI-7875264

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		113967, 4 interactors

Protein interaction database and analysis system

More...IntActi		O43820, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000337425

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O43820

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43820

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini352 – 407EGF-likeAdd BLAST56

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IH0U Eukaryota
ENOG410XPZT LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154357

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG052053

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43820

KEGG Orthology (KO)

More...KOi		K01197

Identification of Orthologs from Complete Genome Data

More...OMAi		FPACGNG

Database of Orthologous Groups

More...OrthoDBi		1096692at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43820

TreeFam database of animal gene trees

More...TreeFami		TF321598

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013785 Aldolase_TIM
IPR017853 Glycoside_hydrolase_SF
IPR018155 Hyaluronidase
IPR027260 Hyaluronidase-3

The PANTHER Classification System

More...PANTHERi		PTHR11769 PTHR11769, 1 hit
PTHR11769:SF19 PTHR11769:SF19, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01630 Glyco_hydro_56, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038193 Hyaluronidase, 1 hit
PIRSF500776 Hyaluronidase_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00846 GLHYDRLASE56

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51445 SSF51445, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O43820-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTQLGPALV LGVALCLGCG QPLPQVPERP FSVLWNVPSA HCEARFGVHL 
        60         70         80         90        100
PLNALGIIAN RGQHFHGQNM TIFYKNQLGL YPYFGPRGTA HNGGIPQALP 
       110        120        130        140        150
LDRHLALAAY QIHHSLRPGF AGPAVLDWEE WCPLWAGNWG RRRAYQAASW 
       160        170        180        190        200
AWAQQVFPDL DPQEQLYKAY TGFEQAARAL MEDTLRVAQA LRPHGLWGFY 
       210        220        230        240        250
HYPACGNGWH SMASNYTGRC HAATLARNTQ LHWLWAASSA LFPSIYLPPR 
       260        270        280        290        300
LPPAHHQAFV RHRLEEAFRV ALVGHRHPLP VLAYVRLTHR RSGRFLSQDD 
       310        320        330        340        350
LVQSIGVSAA LGAAGVVLWG DLSLSSSEEE CWHLHDYLVD TLGPYVINVT 
       360        370        380        390        400
RAAMACSHQR CHGHGRCARR DPGQMEAFLH LWPDGSLGDW KSFSCHCYWG 
       410 
WAGPTCQEPR PGPKEAV
Length:417
Mass (Da):46,501
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6E7DE5369EF2BB8
GO
Isoform 2 (identifier: O43820-2) [UniParc]FASTAAdd to basket
Also known as: HYAL3v1

The sequence of this isoform differs from the canonical sequence as follows:
     299-328: Missing.

Note: Enzymatically inactive.
Show »
Length:387
Mass (Da):43,602
Checksum:i32FE18A2329307A6
GO
Isoform 3 (identifier: O43820-3) [UniParc]FASTAAdd to basket
Also known as: HYAL3v2

The sequence of this isoform differs from the canonical sequence as follows:
     1-249: Missing.
     250-250: R → M

Note: Enzymatically inactive.
Show »
Length:168
Mass (Da):18,764
Checksum:iC29CE942F2F784F8
GO
Isoform 4 (identifier: O43820-4) [UniParc]FASTAAdd to basket
Also known as: HYAL3v3

The sequence of this isoform differs from the canonical sequence as follows:
     1-249: Missing.
     250-250: R → M
     299-328: Missing.

Note: Enzymatically inactive.
Show »
Length:138
Mass (Da):15,865
Checksum:i8E94BC56A7606001
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JB51C9JB51_HUMAN
Hyaluronidase
HYAL3
159Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC70915 differs from that shown. Reason: Frameshift at position 410.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54A → S in AAH05896 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027263113H → Y1 PublicationCorresponds to variant dbSNP:rs13100173Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0201921 – 249Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_020193250R → M in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_020194299 – 328Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF036035 mRNA Translation: AAD04257.1
AF502909 mRNA Translation: AAM60775.1
AF502910 mRNA Translation: AAM60776.1
AF502911 mRNA Translation: AAM60777.1
AF502912 mRNA Translation: AAM60778.1
AF040710 mRNA Translation: AAC70915.1 Frameshift.
U73167 Genomic DNA Translation: AAC02729.1
BC005896 mRNA Translation: AAH05896.1
BC012892 mRNA Translation: AAH12892.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2815.1 [O43820-1]
CCDS56257.1 [O43820-2]
CCDS56259.1 [O43820-4]
CCDS56260.1 [O43820-3]

NCBI Reference Sequences

More...RefSeqi		NP_001186958.1, NM_001200029.1 [O43820-1]
NP_001186959.1, NM_001200030.1 [O43820-2]
NP_001186960.1, NM_001200031.1 [O43820-3]
NP_001186961.1, NM_001200032.1 [O43820-4]
NP_003540.2, NM_003549.3 [O43820-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.129910
Hs.729310

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000336307; ENSP00000337425; ENSG00000186792 [O43820-1]
ENST00000359051; ENSP00000351946; ENSG00000186792 [O43820-2]
ENST00000415204; ENSP00000401092; ENSG00000186792 [O43820-3]
ENST00000450982; ENSP00000391922; ENSG00000186792 [O43820-2]
ENST00000513170; ENSP00000424633; ENSG00000186792 [O43820-4]
ENST00000621157; ENSP00000479935; ENSG00000186792 [O43820-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8372

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8372

UCSC genome browser

More...UCSCi		uc003czd.3 human [O43820-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036035 mRNA Translation: AAD04257.1
AF502909 mRNA Translation: AAM60775.1
AF502910 mRNA Translation: AAM60776.1
AF502911 mRNA Translation: AAM60777.1
AF502912 mRNA Translation: AAM60778.1
AF040710 mRNA Translation: AAC70915.1 Frameshift.
U73167 Genomic DNA Translation: AAC02729.1
BC005896 mRNA Translation: AAH05896.1
BC012892 mRNA Translation: AAH12892.1
CCDSiCCDS2815.1 [O43820-1]
CCDS56257.1 [O43820-2]
CCDS56259.1 [O43820-4]
CCDS56260.1 [O43820-3]
RefSeqiNP_001186958.1, NM_001200029.1 [O43820-1]
NP_001186959.1, NM_001200030.1 [O43820-2]
NP_001186960.1, NM_001200031.1 [O43820-3]
NP_001186961.1, NM_001200032.1 [O43820-4]
NP_003540.2, NM_003549.3 [O43820-1]
UniGeneiHs.129910
Hs.729310

3D structure databases

ProteinModelPortaliO43820
SMRiO43820
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113967, 4 interactors
IntActiO43820, 4 interactors
STRINGi9606.ENSP00000337425

Protein family/group databases

CAZyiGH56 Glycoside Hydrolase Family 56

Polymorphism and mutation databases

BioMutaiHYAL3

Proteomic databases

PaxDbiO43820
PeptideAtlasiO43820
PRIDEiO43820
ProteomicsDBi49183
49184 [O43820-2]
49185 [O43820-3]
49186 [O43820-4]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		8372
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336307; ENSP00000337425; ENSG00000186792 [O43820-1]
ENST00000359051; ENSP00000351946; ENSG00000186792 [O43820-2]
ENST00000415204; ENSP00000401092; ENSG00000186792 [O43820-3]
ENST00000450982; ENSP00000391922; ENSG00000186792 [O43820-2]
ENST00000513170; ENSP00000424633; ENSG00000186792 [O43820-4]
ENST00000621157; ENSP00000479935; ENSG00000186792 [O43820-1]
GeneIDi8372
KEGGihsa:8372
UCSCiuc003czd.3 human [O43820-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8372
DisGeNETi8372
EuPathDBiHostDB:ENSG00000186792.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		HYAL3
HGNCiHGNC:5322 HYAL3
HPAiHPA049402
MIMi604038 gene
neXtProtiNX_O43820
OpenTargetsiENSG00000186792
PharmGKBiPA29573

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IH0U Eukaryota
ENOG410XPZT LUCA
GeneTreeiENSGT00940000154357
HOVERGENiHBG052053
InParanoidiO43820
KOiK01197
OMAiFPACGNG
OrthoDBi1096692at2759
PhylomeDBiO43820
TreeFamiTF321598

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000114366-MONOMER
BRENDAi3.2.1.35 2681
ReactomeiR-HSA-2024101 CS/DS degradation
R-HSA-2160916 Hyaluronan uptake and degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HYAL3 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HYAL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8372

Protein Ontology

More...PROi		PR:O43820

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186792 Expressed in 89 organ(s), highest expression level in caudate nucleus
CleanExiHS_HYAL3
ExpressionAtlasiO43820 baseline and differential
GenevisibleiO43820 HS

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR017853 Glycoside_hydrolase_SF
IPR018155 Hyaluronidase
IPR027260 Hyaluronidase-3
PANTHERiPTHR11769 PTHR11769, 1 hit
PTHR11769:SF19 PTHR11769:SF19, 1 hit
PfamiView protein in Pfam
PF01630 Glyco_hydro_56, 1 hit
PIRSFiPIRSF038193 Hyaluronidase, 1 hit
PIRSF500776 Hyaluronidase_3, 1 hit
PRINTSiPR00846 GLHYDRLASE56
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHYAL3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43820
Secondary accession number(s): O60540
, Q8NFK2, Q8NFK3, Q8NFK4, Q96E56, Q9BRW9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 1998
Last modified: January 16, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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