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Protein

LanC-like protein 1

Gene

LANCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in EPS8 signaling. Binds glutathione.1 Publication

Caution

Was originally thought to be a G-protein coupled receptor.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi276Zinc1
Binding sitei317Glutathione1 Publication1
Metal bindingi322Zinc1
Metal bindingi323Zinc1

GO - Molecular functioni

  • catalytic activity Source: InterPro
  • glutathione binding Source: UniProtKB
  • G protein-coupled receptor activity Source: ProtInc
  • low-density lipoprotein particle receptor binding Source: MGI
  • SH3 domain binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LanC-like protein 1
Alternative name(s):
40 kDa erythrocyte membrane protein
Short name:
p40
Gene namesi
Name:LANCL1
Synonyms:GPR69A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115365.11
HGNCiHGNC:6508 LANCL1
MIMi604155 gene
neXtProtiNX_O43813

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi4R → A: Loss of glutathione binding. 1 Publication1
Mutagenesisi317K → A: Loss of glutathione binding. 1 Publication1
Mutagenesisi322C → A: Loss of glutathione binding. 1 Publication1
Mutagenesisi364R → A or E: Loss of glutathione binding. 1 Publication1

Organism-specific databases

DisGeNETi10314
OpenTargetsiENSG00000115365
PharmGKBiPA30293

Polymorphism and mutation databases

BioMutaiLANCL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001912682 – 399LanC-like protein 1Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei142N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO43813
PaxDbiO43813
PeptideAtlasiO43813
PRIDEiO43813
ProteomicsDBi49178

PTM databases

iPTMnetiO43813
PhosphoSitePlusiO43813
SwissPalmiO43813

Expressioni

Tissue specificityi

Detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta and spleen (at protein level). Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and testis.3 Publications

Gene expression databases

BgeeiENSG00000115365 Expressed in 236 organ(s), highest expression level in Brodmann (1909) area 46
CleanExiHS_LANCL1
ExpressionAtlasiO43813 baseline and differential
GenevisibleiO43813 HS

Organism-specific databases

HPAiHPA034994

Interactioni

Subunit structurei

Interacts with the C-terminal of STOM. Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding. Interacts with P.falciparum SBP1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Eps8Q085092EBI-3046631,EBI-375596From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115599, 22 interactors
IntActiO43813, 18 interactors
MINTiO43813
STRINGi9606.ENSP00000233714

Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43813
SMRiO43813
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43813

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni364 – 367Glutathione binding4

Sequence similaritiesi

Belongs to the LanC-like protein family.Curated

Phylogenomic databases

eggNOGiKOG2787 Eukaryota
ENOG410XQIA LUCA
GeneTreeiENSGT00530000063186
HOGENOMiHOG000240926
HOVERGENiHBG065387
InParanoidiO43813
OMAiYGRMGYL
OrthoDBiEOG091G02TS
PhylomeDBiO43813
TreeFamiTF300068

Family and domain databases

CDDicd04794 euk_LANCL, 1 hit
Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR007822 LANC-like
IPR020464 LanC-like_prot_euk
PfamiView protein in Pfam
PF05147 LANC_like, 1 hit
PRINTSiPR01951 LANCEUKARYTE
PR01950 LANCSUPER
SMARTiView protein in SMART
SM01260 LANC_like, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O43813-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQRAFPNPY ADYNKSLAEG YFDAAGRLTP EFSQRLTNKI RELLQQMERG
60 70 80 90 100
LKSADPRDGT GYTGWAGIAV LYLHLYDVFG DPAYLQLAHG YVKQSLNCLT
110 120 130 140 150
KRSITFLCGD AGPLAVAAVL YHKMNNEKQA EDCITRLIHL NKIDPHAPNE
160 170 180 190 200
MLYGRIGYIY ALLFVNKNFG VEKIPQSHIQ QICETILTSG ENLARKRNFT
210 220 230 240 250
AKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLQVSQGKL HSLVKPSVDY
260 270 280 290 300
VCQLKFPSGN YPPCIGDNRD LLVHWCHGAP GVIYMLIQAY KVFREEKYLC
310 320 330 340 350
DAYQCADVIW QYGLLKKGYG LCHGSAGNAY AFLTLYNLTQ DMKYLYRACK
360 370 380 390
FAEWCLEYGE HGCRTPDTPF SLFEGMAGTI YFLADLLVPT KARFPAFEL
Length:399
Mass (Da):45,283
Last modified:June 1, 1998 - v1
Checksum:i2664F275F9281AF2
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHS0E9PHS0_HUMAN
LanC-like protein 1
LANCL1
196Annotation score:
H7C2E3H7C2E3_HUMAN
LanC-like protein 1
LANCL1
147Annotation score:
F8WDS9F8WDS9_HUMAN
LanC-like protein 1
LANCL1
82Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11395 mRNA Translation: CAA72205.1
AJ289236
, AJ289237, AJ289238, AJ289239 Genomic DNA Translation: CAC21950.1
BC028685 mRNA Translation: AAH28685.1
CCDSiCCDS2392.1
RefSeqiNP_001130046.1, NM_001136574.1
NP_001130047.1, NM_001136575.1
NP_006046.1, NM_006055.2
UniGeneiHs.13351

Genome annotation databases

EnsembliENST00000233714; ENSP00000233714; ENSG00000115365
ENST00000431941; ENSP00000397646; ENSG00000115365
ENST00000441020; ENSP00000393323; ENSG00000115365
ENST00000443314; ENSP00000388713; ENSG00000115365
ENST00000450366; ENSP00000393597; ENSG00000115365
GeneIDi10314
KEGGihsa:10314

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11395 mRNA Translation: CAA72205.1
AJ289236
, AJ289237, AJ289238, AJ289239 Genomic DNA Translation: CAC21950.1
BC028685 mRNA Translation: AAH28685.1
CCDSiCCDS2392.1
RefSeqiNP_001130046.1, NM_001136574.1
NP_001130047.1, NM_001136575.1
NP_006046.1, NM_006055.2
UniGeneiHs.13351

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E6UX-ray2.60A/B/C/D1-399[»]
3E73X-ray2.80A/B1-399[»]
ProteinModelPortaliO43813
SMRiO43813
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115599, 22 interactors
IntActiO43813, 18 interactors
MINTiO43813
STRINGi9606.ENSP00000233714

PTM databases

iPTMnetiO43813
PhosphoSitePlusiO43813
SwissPalmiO43813

Polymorphism and mutation databases

BioMutaiLANCL1

Proteomic databases

EPDiO43813
PaxDbiO43813
PeptideAtlasiO43813
PRIDEiO43813
ProteomicsDBi49178

Protocols and materials databases

DNASUi10314
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233714; ENSP00000233714; ENSG00000115365
ENST00000431941; ENSP00000397646; ENSG00000115365
ENST00000441020; ENSP00000393323; ENSG00000115365
ENST00000443314; ENSP00000388713; ENSG00000115365
ENST00000450366; ENSP00000393597; ENSG00000115365
GeneIDi10314
KEGGihsa:10314

Organism-specific databases

CTDi10314
DisGeNETi10314
EuPathDBiHostDB:ENSG00000115365.11
GeneCardsiLANCL1
HGNCiHGNC:6508 LANCL1
HPAiHPA034994
MIMi604155 gene
neXtProtiNX_O43813
OpenTargetsiENSG00000115365
PharmGKBiPA30293
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2787 Eukaryota
ENOG410XQIA LUCA
GeneTreeiENSGT00530000063186
HOGENOMiHOG000240926
HOVERGENiHBG065387
InParanoidiO43813
OMAiYGRMGYL
OrthoDBiEOG091G02TS
PhylomeDBiO43813
TreeFamiTF300068

Miscellaneous databases

ChiTaRSiLANCL1 human
EvolutionaryTraceiO43813
GenomeRNAii10314
PROiPR:O43813
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115365 Expressed in 236 organ(s), highest expression level in Brodmann (1909) area 46
CleanExiHS_LANCL1
ExpressionAtlasiO43813 baseline and differential
GenevisibleiO43813 HS

Family and domain databases

CDDicd04794 euk_LANCL, 1 hit
Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR007822 LANC-like
IPR020464 LanC-like_prot_euk
PfamiView protein in Pfam
PF05147 LANC_like, 1 hit
PRINTSiPR01951 LANCEUKARYTE
PR01950 LANCSUPER
SMARTiView protein in SMART
SM01260 LANC_like, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLANC1_HUMAN
AccessioniPrimary (citable) accession number: O43813
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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