UniProtKB - O43813 (LANC1_HUMAN)
Protein
Glutathione S-transferase LANCL1
Gene
LANCL1
Organism
Homo sapiens (Human)
Status
Functioni
Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316).By similarity1 Publication
Miscellaneous
Was originally thought to be a G-protein coupled receptor.1 Publication
Catalytic activityi
- EC:2.5.1.18By similarity
- 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H+By similarityEC:2.5.1.18By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 276 | Zinc1 Publication | 1 | |
Binding sitei | 317 | Glutathione1 Publication | 1 | |
Metal bindingi | 322 | Zinc1 Publication | 1 | |
Metal bindingi | 323 | Zinc1 Publication | 1 |
GO - Molecular functioni
- glutathione binding Source: UniProtKB
- glutathione transferase activity Source: UniProtKB
- G protein-coupled receptor activity Source: ProtInc
- low-density lipoprotein particle receptor binding Source: MGI
- SH3 domain binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- G protein-coupled receptor signaling pathway Source: ProtInc
- regulation of neuron apoptotic process Source: UniProtKB
- regulation of oxidative stress-induced neuron death Source: UniProtKB
Keywordsi
Molecular function | Transferase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O43813 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione S-transferase LANCL1By similarity (EC:2.5.1.18By similarity)Alternative name(s): 40 kDa erythrocyte membrane protein Short name: p40By similarity LanC-like protein 11 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000115365.11 |
HGNCi | HGNC:6508, LANCL1 |
MIMi | 604155, gene |
neXtProti | NX_O43813 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Peripheral membrane protein 1 Publication
Other locations
- Cytoplasm 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 4 | R → A: Loss of glutathione binding. 1 Publication | 1 | |
Mutagenesisi | 317 | K → A: Loss of glutathione binding. 1 Publication | 1 | |
Mutagenesisi | 322 | C → A: Loss of glutathione binding. 1 Publication | 1 | |
Mutagenesisi | 364 | R → A or E: Loss of glutathione binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 10314 |
OpenTargetsi | ENSG00000115365 |
PharmGKBi | PA30293 |
Miscellaneous databases
Pharosi | O43813, Tbio |
Polymorphism and mutation databases
BioMutai | LANCL1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000191268 | 2 – 399 | Glutathione S-transferase LANCL1Add BLAST | 398 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 142 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O43813 |
jPOSTi | O43813 |
MassIVEi | O43813 |
PaxDbi | O43813 |
PeptideAtlasi | O43813 |
PRIDEi | O43813 |
ProteomicsDBi | 49178 |
PTM databases
iPTMneti | O43813 |
PhosphoSitePlusi | O43813 |
SwissPalmi | O43813 |
Expressioni
Tissue specificityi
Detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta and spleen (at protein level). Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and testis.3 Publications
Gene expression databases
Bgeei | ENSG00000115365, Expressed in Brodmann (1909) area 46 and 250 other tissues |
ExpressionAtlasi | O43813, baseline and differential |
Genevisiblei | O43813, HS |
Organism-specific databases
HPAi | ENSG00000115365, Tissue enhanced (brain) |
Interactioni
Subunit structurei
(Microbial infection) Interacts with P.falciparum SBP1.
1 PublicationBinary interactionsi
Hide detailsO43813
With | #Exp. | IntAct |
---|---|---|
BAIAP2L1 [Q9UHR4] | 3 | EBI-3046631,EBI-2483278 |
Eps8 [Q08509] from Mus musculus. | 2 | EBI-3046631,EBI-375596 |
GO - Molecular functioni
- low-density lipoprotein particle receptor binding Source: MGI
- SH3 domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115599, 49 interactors |
IntActi | O43813, 31 interactors |
MINTi | O43813 |
STRINGi | 9606.ENSP00000388713 |
Miscellaneous databases
RNActi | O43813, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O43813 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O43813 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 364 – 367 | Glutathione binding1 Publication | 4 |
Sequence similaritiesi
Belongs to the LanC-like protein family.Curated
Phylogenomic databases
eggNOGi | KOG2787, Eukaryota |
GeneTreei | ENSGT00530000063186 |
HOGENOMi | CLU_036244_0_0_1 |
InParanoidi | O43813 |
OMAi | ACMFADW |
PhylomeDBi | O43813 |
TreeFami | TF300068 |
Family and domain databases
CDDi | cd04794, euk_LANCL, 1 hit |
Gene3Di | 1.50.10.10, 1 hit |
InterProi | View protein in InterPro IPR012341, 6hp_glycosidase-like_sf IPR007822, LANC-like IPR020464, LanC-like_prot_euk |
Pfami | View protein in Pfam PF05147, LANC_like, 1 hit |
PRINTSi | PR01951, LANCEUKARYTE PR01950, LANCSUPER |
SMARTi | View protein in SMART SM01260, LANC_like, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
O43813-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQRAFPNPY ADYNKSLAEG YFDAAGRLTP EFSQRLTNKI RELLQQMERG
60 70 80 90 100
LKSADPRDGT GYTGWAGIAV LYLHLYDVFG DPAYLQLAHG YVKQSLNCLT
110 120 130 140 150
KRSITFLCGD AGPLAVAAVL YHKMNNEKQA EDCITRLIHL NKIDPHAPNE
160 170 180 190 200
MLYGRIGYIY ALLFVNKNFG VEKIPQSHIQ QICETILTSG ENLARKRNFT
210 220 230 240 250
AKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLQVSQGKL HSLVKPSVDY
260 270 280 290 300
VCQLKFPSGN YPPCIGDNRD LLVHWCHGAP GVIYMLIQAY KVFREEKYLC
310 320 330 340 350
DAYQCADVIW QYGLLKKGYG LCHGSAGNAY AFLTLYNLTQ DMKYLYRACK
360 370 380 390
FAEWCLEYGE HGCRTPDTPF SLFEGMAGTI YFLADLLVPT KARFPAFEL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PHS0 | E9PHS0_HUMAN | Glutathione S-transferase LANCL1 | LANCL1 | 196 | Annotation score: | ||
H7C2E3 | H7C2E3_HUMAN | Glutathione S-transferase LANCL1 | LANCL1 | 147 | Annotation score: | ||
F8WDS9 | F8WDS9_HUMAN | Glutathione S-transferase LANCL1 | LANCL1 | 82 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11395 mRNA Translation: CAA72205.1 AJ289236 , AJ289237, AJ289238, AJ289239 Genomic DNA Translation: CAC21950.1 BC028685 mRNA Translation: AAH28685.1 |
CCDSi | CCDS2392.1 |
RefSeqi | NP_001130046.1, NM_001136574.1 NP_001130047.1, NM_001136575.1 NP_006046.1, NM_006055.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11395 mRNA Translation: CAA72205.1 AJ289236 , AJ289237, AJ289238, AJ289239 Genomic DNA Translation: CAC21950.1 BC028685 mRNA Translation: AAH28685.1 |
CCDSi | CCDS2392.1 |
RefSeqi | NP_001130046.1, NM_001136574.1 NP_001130047.1, NM_001136575.1 NP_006046.1, NM_006055.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3E6U | X-ray | 2.60 | A/B/C/D | 1-399 | [»] | |
3E73 | X-ray | 2.80 | A/B | 1-399 | [»] | |
SMRi | O43813 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115599, 49 interactors |
IntActi | O43813, 31 interactors |
MINTi | O43813 |
STRINGi | 9606.ENSP00000388713 |
PTM databases
iPTMneti | O43813 |
PhosphoSitePlusi | O43813 |
SwissPalmi | O43813 |
Polymorphism and mutation databases
BioMutai | LANCL1 |
Proteomic databases
EPDi | O43813 |
jPOSTi | O43813 |
MassIVEi | O43813 |
PaxDbi | O43813 |
PeptideAtlasi | O43813 |
PRIDEi | O43813 |
ProteomicsDBi | 49178 |
Protocols and materials databases
Antibodypediai | 34207, 104 antibodies |
DNASUi | 10314 |
Genome annotation databases
Organism-specific databases
CTDi | 10314 |
DisGeNETi | 10314 |
EuPathDBi | HostDB:ENSG00000115365.11 |
GeneCardsi | LANCL1 |
HGNCi | HGNC:6508, LANCL1 |
HPAi | ENSG00000115365, Tissue enhanced (brain) |
MIMi | 604155, gene |
neXtProti | NX_O43813 |
OpenTargetsi | ENSG00000115365 |
PharmGKBi | PA30293 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2787, Eukaryota |
GeneTreei | ENSGT00530000063186 |
HOGENOMi | CLU_036244_0_0_1 |
InParanoidi | O43813 |
OMAi | ACMFADW |
PhylomeDBi | O43813 |
TreeFami | TF300068 |
Enzyme and pathway databases
PathwayCommonsi | O43813 |
Miscellaneous databases
BioGRID-ORCSi | 10314, 2 hits in 847 CRISPR screens |
ChiTaRSi | LANCL1, human |
EvolutionaryTracei | O43813 |
GenomeRNAii | 10314 |
Pharosi | O43813, Tbio |
PROi | PR:O43813 |
RNActi | O43813, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115365, Expressed in Brodmann (1909) area 46 and 250 other tissues |
ExpressionAtlasi | O43813, baseline and differential |
Genevisiblei | O43813, HS |
Family and domain databases
CDDi | cd04794, euk_LANCL, 1 hit |
Gene3Di | 1.50.10.10, 1 hit |
InterProi | View protein in InterPro IPR012341, 6hp_glycosidase-like_sf IPR007822, LANC-like IPR020464, LanC-like_prot_euk |
Pfami | View protein in Pfam PF05147, LANC_like, 1 hit |
PRINTSi | PR01951, LANCEUKARYTE PR01950, LANCSUPER |
SMARTi | View protein in SMART SM01260, LANC_like, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LANC1_HUMAN | |
Accessioni | O43813Primary (citable) accession number: O43813 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | June 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM