UniProtKB - O43808 (PM34_HUMAN)
Protein
Peroxisomal membrane protein PMP34
Gene
SLC25A17
Organism
Homo sapiens (Human)
Status
Functioni
Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD+), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD+ from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro.2 Publications
Caution
Was first identified as a peroxisomal ATP transporter (PubMed:12445829). However, later experiments showed that it acts as a peroxisomal transporter for multiple cofactors (PubMed:22185573).2 Publications
GO - Molecular functioni
- adenine nucleotide transmembrane transporter activity Source: Reactome
- ADP transmembrane transporter activity Source: UniProtKB
- AMP transmembrane transporter activity Source: UniProtKB
- ATP transmembrane transporter activity Source: BHF-UCL
- chaperone binding Source: BHF-UCL
- coenzyme A transmembrane transporter activity Source: UniProtKB
- FAD transmembrane transporter activity Source: UniProtKB
- FMN transmembrane transporter activity Source: UniProtKB
- NAD transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- ATP transport Source: BHF-UCL
- fatty acid alpha-oxidation Source: Reactome
- fatty acid beta-oxidation Source: BHF-UCL
- fatty acid transport Source: BHF-UCL
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | O43808 |
Reactomei | R-HSA-389599, Alpha-oxidation of phytanate R-HSA-9603798, Class I peroxisomal membrane protein import |
Protein family/group databases
TCDBi | 2.A.29.20.1, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisomal membrane protein PMP34Alternative name(s): 34 kDa peroxisomal membrane protein Solute carrier family 25 member 17 |
Gene namesi | Name:SLC25A17 Synonyms:PMP34 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100372.14 |
HGNCi | HGNC:10987, SLC25A17 |
MIMi | 606795, gene |
neXtProti | NX_O43808 |
Subcellular locationi
Peroxisome
Other locations
Peroxisome
- integral component of peroxisomal membrane Source: UniProtKB
- peroxisomal membrane Source: UniProtKB
- peroxisome Source: BHF-UCL
Other locations
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | Cytoplasmic | 9 | |
Transmembranei | 10 – 30 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 31 – 66 | LumenalSequence analysisAdd BLAST | 36 | |
Transmembranei | 67 – 87 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 88 – 104 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 105 – 125 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 126 – 160 | LumenalSequence analysisAdd BLAST | 35 | |
Transmembranei | 161 – 181 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 182 – 202 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 203 – 223 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 224 – 280 | LumenalSequence analysisAdd BLAST | 57 | |
Transmembranei | 281 – 301 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 302 – 307 | Cytoplasmic | 6 |
Keywords - Cellular componenti
Cytoplasm, Membrane, PeroxisomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 190 – 199 | KRQLLKKRMK → AAQLLAAAMA: Localizes in the cytoplasm. 1 Publication | 10 | |
Mutagenesisi | 283 – 285 | LMF → KKK: Impairs interaction with PEX19. 1 Publication | 3 | |
Mutagenesisi | 289 – 290 | EK → LL: Impairs interaction with PEX19. 1 Publication | 2 | |
Mutagenesisi | 302 – 303 | KR → EE: No effect on interaction with PEX19. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 10478 |
OpenTargetsi | ENSG00000100372 |
PharmGKBi | PA35863 |
Miscellaneous databases
Pharosi | O43808, Tbio |
Polymorphism and mutation databases
BioMutai | SLC25A17 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090705 | 1 – 307 | Peroxisomal membrane protein PMP34Add BLAST | 307 |
Proteomic databases
EPDi | O43808 |
jPOSTi | O43808 |
MassIVEi | O43808 |
MaxQBi | O43808 |
PaxDbi | O43808 |
PeptideAtlasi | O43808 |
PRIDEi | O43808 |
ProteomicsDBi | 49175 |
PTM databases
iPTMneti | O43808 |
PhosphoSitePlusi | O43808 |
Expressioni
Tissue specificityi
Ubiquitous. Expressed in liver.1 Publication
Gene expression databases
Bgeei | ENSG00000100372, Expressed in left ovary and 229 other tissues |
ExpressionAtlasi | O43808, baseline and differential |
Genevisiblei | O43808, HS |
Organism-specific databases
HPAi | ENSG00000100372, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the newly synthesized SLC25A17 in the cytosol.
3 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- chaperone binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 115741, 34 interactors |
IntActi | O43808, 14 interactors |
STRINGi | 9606.ENSP00000390722 |
Miscellaneous databases
RNActi | O43808, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 7 – 92 | Solcar 1Add BLAST | 86 | |
Repeati | 99 – 192 | Solcar 2Add BLAST | 94 | |
Repeati | 200 – 294 | Solcar 3Add BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 147 | Necessary for targeting to peroxisomes and interaction with PEX19Add BLAST | 147 | |
Regioni | 244 – 307 | Necessary for targeting to peroxisomes and interaction with PEX19Add BLAST | 64 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 190 – 199 | Peroxisome localization signal | 10 |
Domaini
The N- and C-terminal portions are exposed to the cytoplasm. Lacks a typical peroxisomal sorting signal. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity.
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0769, Eukaryota |
GeneTreei | ENSGT00920000149129 |
InParanoidi | O43808 |
OMAi | LQYTVFE |
OrthoDBi | 1186395at2759 |
PhylomeDBi | O43808 |
TreeFami | TF324772 |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
O43808-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASVLSYESL VHAVAGAVGS VTAMTVFFPL DTARLRLQVD EKRKSKTTHM
60 70 80 90 100
VLLEIIKEEG LLAPYRGWFP VISSLCCSNF VYFYTFNSLK ALWVKGQHST
110 120 130 140 150
TGKDLVVGFV AGVVNVLLTT PLWVVNTRLK LQGAKFRNED IVPTNYKGII
160 170 180 190 200
DAFHQIIRDE GISALWNGTF PSLLLVFNPA IQFMFYEGLK RQLLKKRMKL
210 220 230 240 250
SSLDVFIIGA VAKAIATTVT YPLQTVQSIL RFGRHRLNPE NRTLGSLRNI
260 270 280 290 300
LYLLHQRVRR FGIMGLYKGL EAKLLQTVLT AALMFLVYEK LTAATFTVMG
LKRAHQH
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB0QYW5 | B0QYW5_HUMAN | Peroxisomal membrane protein PMP34 | SLC25A17 | 225 | Annotation score: | ||
F6RTR7 | F6RTR7_HUMAN | Peroxisomal membrane protein PMP34 | SLC25A17 | 234 | Annotation score: | ||
F8WE74 | F8WE74_HUMAN | Peroxisomal membrane protein PMP34 | SLC25A17 | 239 | Annotation score: | ||
F8WEC6 | F8WEC6_HUMAN | Peroxisomal membrane protein PMP34 | SLC25A17 | 148 | Annotation score: | ||
F8WA85 | F8WA85_HUMAN | Peroxisomal membrane protein PMP34 | SLC25A17 | 63 | Annotation score: | ||
B1AHN4 | B1AHN4_HUMAN | Peroxisomal membrane protein PMP34 | SLC25A17 | 92 | Annotation score: | ||
F8WCH6 | F8WCH6_HUMAN | Peroxisomal membrane protein PMP34 | SLC25A17 | 48 | Annotation score: | ||
F2Z2I9 | F2Z2I9_HUMAN | Peroxisomal membrane protein PMP34 | SLC25A17 | 45 | Annotation score: | ||
F8WCN9 | F8WCN9_HUMAN | Peroxisomal membrane protein PMP34 | SLC25A17 | 56 | Annotation score: | ||
F8WF87 | F8WF87_HUMAN | Peroxisomal membrane protein PMP34 | SLC25A17 | 49 | Annotation score: | ||
There is more potential isoformShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050139 | 98 | H → R. Corresponds to variant dbSNP:rs12159334Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y12860 mRNA Translation: CAA73367.1 CR456577 mRNA Translation: CAG30463.1 AK292924 mRNA Translation: BAF85613.1 AL049764 Genomic DNA No translation available. Z98048 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60390.1 BC005957 mRNA Translation: AAH05957.1 BC012998 mRNA Translation: AAH12998.1 |
CCDSi | CCDS14005.1 |
RefSeqi | NP_001269656.1, NM_001282727.1 NP_006349.1, NM_006358.3 |
Genome annotation databases
Ensembli | ENST00000435456; ENSP00000390722; ENSG00000100372 |
GeneIDi | 10478 |
KEGGi | hsa:10478 |
UCSCi | uc003azc.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y12860 mRNA Translation: CAA73367.1 CR456577 mRNA Translation: CAG30463.1 AK292924 mRNA Translation: BAF85613.1 AL049764 Genomic DNA No translation available. Z98048 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60390.1 BC005957 mRNA Translation: AAH05957.1 BC012998 mRNA Translation: AAH12998.1 |
CCDSi | CCDS14005.1 |
RefSeqi | NP_001269656.1, NM_001282727.1 NP_006349.1, NM_006358.3 |
3D structure databases
SMRi | O43808 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115741, 34 interactors |
IntActi | O43808, 14 interactors |
STRINGi | 9606.ENSP00000390722 |
Protein family/group databases
TCDBi | 2.A.29.20.1, the mitochondrial carrier (mc) family |
PTM databases
iPTMneti | O43808 |
PhosphoSitePlusi | O43808 |
Polymorphism and mutation databases
BioMutai | SLC25A17 |
Proteomic databases
EPDi | O43808 |
jPOSTi | O43808 |
MassIVEi | O43808 |
MaxQBi | O43808 |
PaxDbi | O43808 |
PeptideAtlasi | O43808 |
PRIDEi | O43808 |
ProteomicsDBi | 49175 |
Protocols and materials databases
Antibodypediai | 26801, 98 antibodies |
DNASUi | 10478 |
Genome annotation databases
Ensembli | ENST00000435456; ENSP00000390722; ENSG00000100372 |
GeneIDi | 10478 |
KEGGi | hsa:10478 |
UCSCi | uc003azc.5, human |
Organism-specific databases
CTDi | 10478 |
DisGeNETi | 10478 |
EuPathDBi | HostDB:ENSG00000100372.14 |
GeneCardsi | SLC25A17 |
HGNCi | HGNC:10987, SLC25A17 |
HPAi | ENSG00000100372, Low tissue specificity |
MIMi | 606795, gene |
neXtProti | NX_O43808 |
OpenTargetsi | ENSG00000100372 |
PharmGKBi | PA35863 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0769, Eukaryota |
GeneTreei | ENSGT00920000149129 |
InParanoidi | O43808 |
OMAi | LQYTVFE |
OrthoDBi | 1186395at2759 |
PhylomeDBi | O43808 |
TreeFami | TF324772 |
Enzyme and pathway databases
PathwayCommonsi | O43808 |
Reactomei | R-HSA-389599, Alpha-oxidation of phytanate R-HSA-9603798, Class I peroxisomal membrane protein import |
Miscellaneous databases
BioGRID-ORCSi | 10478, 1 hit in 842 CRISPR screens |
ChiTaRSi | SLC25A17, human |
GeneWikii | SLC25A17 |
GenomeRNAii | 10478 |
Pharosi | O43808, Tbio |
PROi | PR:O43808 |
RNActi | O43808, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100372, Expressed in left ovary and 229 other tissues |
ExpressionAtlasi | O43808, baseline and differential |
Genevisiblei | O43808, HS |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PM34_HUMAN | |
Accessioni | O43808Primary (citable) accession number: O43808 Secondary accession number(s): A8KA59 Q9UGY7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | June 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations