UniProtKB - O43805 (SSNA1_HUMAN)
Protein
Sjoegren syndrome nuclear autoantigen 1
Gene
SSNA1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- ciliary basal body-plasma membrane docking Source: Reactome
- ciliary receptor clustering involved in smoothened signaling pathway Source: Ensembl
- G2/M transition of mitotic cell cycle Source: Reactome
- intraciliary transport Source: Ensembl
- regulation of G2/M transition of mitotic cell cycle Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | O43805 |
Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-8854518, AURKA Activation by TPX2 |
Names & Taxonomyi
Protein namesi | Recommended name: Sjoegren syndrome nuclear autoantigen 1Alternative name(s): Nuclear autoantigen of 14 kDa |
Gene namesi | Name:SSNA1 Synonyms:NA14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11321, SSNA1 |
MIMi | 610882, gene |
neXtProti | NX_O43805 |
VEuPathDBi | HostDB:ENSG00000176101.11 |
Subcellular locationi
Cytoskeleton
- centrosome 1 Publication
Nucleus
Cytoskeleton
- centrosome Source: UniProtKB
- ciliary basal body Source: GO_Central
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: ProtInc
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 8636 |
OpenTargetsi | ENSG00000176101 |
PharmGKBi | PA36145 |
Miscellaneous databases
Pharosi | O43805, Tbio |
Genetic variation databases
BioMutai | SSNA1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000114483 | 2 – 119 | Sjoegren syndrome nuclear autoantigen 1Add BLAST | 118 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylthreonineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O43805 |
jPOSTi | O43805 |
MassIVEi | O43805 |
MaxQBi | O43805 |
PaxDbi | O43805 |
PeptideAtlasi | O43805 |
PRIDEi | O43805 |
ProteomicsDBi | 49174 |
PTM databases
iPTMneti | O43805 |
PhosphoSitePlusi | O43805 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000176101, Expressed in right testis and 241 other tissues |
ExpressionAtlasi | O43805, baseline and differential |
Genevisiblei | O43805, HS |
Organism-specific databases
HPAi | ENSG00000176101, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsO43805
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 114189, 34 interactors |
IntActi | O43805, 21 interactors |
MINTi | O43805 |
STRINGi | 9606.ENSP00000313752 |
Miscellaneous databases
RNActi | O43805, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 13 – 70 | Sequence analysisAdd BLAST | 58 |
Sequence similaritiesi
Belongs to the SSNA1 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502S16M, Eukaryota |
GeneTreei | ENSGT00390000012318 |
HOGENOMi | CLU_153440_0_0_1 |
InParanoidi | O43805 |
OMAi | QHDIRIL |
OrthoDBi | 1513306at2759 |
PhylomeDBi | O43805 |
TreeFami | TF328451 |
Family and domain databases
InterProi | View protein in InterPro IPR033362, SSNA1_fam |
PANTHERi | PTHR28661, PTHR28661, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O43805-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTQQGAALQN YNNELVKCIE ELCQKREELC RQIQEEEDEK QRLQNEVRQL
60 70 80 90 100
TEKLARVNEN LARKIASRNE FDRTIAETEA AYLKILESSQ TLLSVLKREA
110
GNLTKATAPD QKSSGGRDS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WV26 | A0A087WV26_HUMAN | Sjoegren syndrome nuclear autoantig... | SSNA1 | 81 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 | V → A in CAG47034 (Ref. 3) Curated | 1 | |
Sequence conflicti | 89 | S → F in CAB09660 (PubMed:9430706).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036343 | 17 | K → N in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1289962028Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z96932 mRNA Translation: CAB09660.1 BT006766 mRNA Translation: AAP35412.1 CR542238 mRNA Translation: CAG47034.1 AL929554 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88362.1 BC000864 mRNA Translation: AAH00864.1 |
CCDSi | CCDS7034.1 |
RefSeqi | NP_003722.2, NM_003731.2 |
Genome annotation databases
Ensembli | ENST00000322310; ENSP00000313752; ENSG00000176101 |
GeneIDi | 8636 |
KEGGi | hsa:8636 |
UCSCi | uc004cls.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z96932 mRNA Translation: CAB09660.1 BT006766 mRNA Translation: AAP35412.1 CR542238 mRNA Translation: CAG47034.1 AL929554 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88362.1 BC000864 mRNA Translation: AAH00864.1 |
CCDSi | CCDS7034.1 |
RefSeqi | NP_003722.2, NM_003731.2 |
3D structure databases
SMRi | O43805 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114189, 34 interactors |
IntActi | O43805, 21 interactors |
MINTi | O43805 |
STRINGi | 9606.ENSP00000313752 |
PTM databases
iPTMneti | O43805 |
PhosphoSitePlusi | O43805 |
Genetic variation databases
BioMutai | SSNA1 |
Proteomic databases
EPDi | O43805 |
jPOSTi | O43805 |
MassIVEi | O43805 |
MaxQBi | O43805 |
PaxDbi | O43805 |
PeptideAtlasi | O43805 |
PRIDEi | O43805 |
ProteomicsDBi | 49174 |
Protocols and materials databases
Antibodypediai | 32398, 104 antibodies |
DNASUi | 8636 |
Genome annotation databases
Ensembli | ENST00000322310; ENSP00000313752; ENSG00000176101 |
GeneIDi | 8636 |
KEGGi | hsa:8636 |
UCSCi | uc004cls.3, human |
Organism-specific databases
CTDi | 8636 |
DisGeNETi | 8636 |
GeneCardsi | SSNA1 |
HGNCi | HGNC:11321, SSNA1 |
HPAi | ENSG00000176101, Low tissue specificity |
MIMi | 610882, gene |
neXtProti | NX_O43805 |
OpenTargetsi | ENSG00000176101 |
PharmGKBi | PA36145 |
VEuPathDBi | HostDB:ENSG00000176101.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S16M, Eukaryota |
GeneTreei | ENSGT00390000012318 |
HOGENOMi | CLU_153440_0_0_1 |
InParanoidi | O43805 |
OMAi | QHDIRIL |
OrthoDBi | 1513306at2759 |
PhylomeDBi | O43805 |
TreeFami | TF328451 |
Enzyme and pathway databases
PathwayCommonsi | O43805 |
Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-8854518, AURKA Activation by TPX2 |
Miscellaneous databases
BioGRID-ORCSi | 8636, 6 hits in 997 CRISPR screens |
ChiTaRSi | SSNA1, human |
GenomeRNAii | 8636 |
Pharosi | O43805, Tbio |
PROi | PR:O43805 |
RNActi | O43805, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000176101, Expressed in right testis and 241 other tissues |
ExpressionAtlasi | O43805, baseline and differential |
Genevisiblei | O43805, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033362, SSNA1_fam |
PANTHERi | PTHR28661, PTHR28661, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SSNA1_HUMAN | |
Accessioni | O43805Primary (citable) accession number: O43805 Secondary accession number(s): Q5VSG0, Q6FG70, Q9BVW8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | September 13, 2004 | |
Last modified: | April 7, 2021 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families