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Protein

Unconventional myosin-Ib

Gene

MYO1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.By similarity

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi108 – 115ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ib
Alternative name(s):
MYH-1c
Myosin I alpha
Short name:
MMI-alpha
Short name:
MMIa
Gene namesi
Name:MYO1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000128641.18
HGNCiHGNC:7596 MYO1B
MIMi606537 gene
neXtProtiNX_O43795

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4430
OpenTargetsiENSG00000128641
PharmGKBiPA31398

Polymorphism and mutation databases

BioMutaiMYO1B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234421 – 1136Unconventional myosin-IbAdd BLAST1136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43795
MaxQBiO43795
PaxDbiO43795
PeptideAtlasiO43795
PRIDEiO43795
ProteomicsDBi49172
49173 [O43795-2]

PTM databases

iPTMnetiO43795
PhosphoSitePlusiO43795
SwissPalmiO43795

Expressioni

Gene expression databases

BgeeiENSG00000128641 Expressed in 219 organ(s), highest expression level in visceral pleura
CleanExiHS_MYO1B
ExpressionAtlasiO43795 baseline and differential
GenevisibleiO43795 HS

Organism-specific databases

HPAiHPA013607
HPA060144

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110567, 67 interactors
IntActiO43795, 60 interactors
MINTiO43795
STRINGi9606.ENSP00000306382

Structurei

3D structure databases

ProteinModelPortaliO43795
SMRiO43795
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 701Myosin motorPROSITE-ProRule annotationAdd BLAST687
Domaini704 – 733IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini728 – 748IQ 2PROSITE-ProRule annotationAdd BLAST21
Domaini750 – 779IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini779 – 808IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini808 – 837IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini837 – 866IQ 6PROSITE-ProRule annotationAdd BLAST30
Domaini952 – 1136TH1PROSITE-ProRule annotationAdd BLAST185

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni578 – 600Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00920000148963
HOGENOMiHOG000260264
HOVERGENiHBG062373
InParanoidiO43795
KOiK10356
OMAiAMWKAGH
OrthoDBiEOG091G0136
PhylomeDBiO43795
TreeFamiTF312960

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 6 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 5 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43795-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKMEVKTSL LDNMIGVGDM VLLEPLNEET FINNLKKRFD HSEIYTYIGS
60 70 80 90 100
VVISVNPYRS LPIYSPEKVE EYRNRNFYEL SPHIFALSDE AYRSLRDQDK
110 120 130 140 150
DQCILITGES GAGKTEASKL VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE
160 170 180 190 200
AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP LGGVISNYLL EKSRVVKQPR
210 220 230 240 250
GERNFHVFYQ LLSGASEELL NKLKLERDFS RYNYLSLDSA KVNGVDDAAN
260 270 280 290 300
FRTVRNAMQI VGFMDHEAES VLAVVAAVLK LGNIEFKPES RVNGLDESKI
310 320 330 340 350
KDKNELKEIC ELTGIDQSVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD
360 370 380 390 400
ALAKNLYSRL FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE
410 420 430 440 450
QFIINYCNEK LQQIFIELTL KEEQEEYIRE DIEWTHIDYF NNAIICDLIE
460 470 480 490 500
NNTNGILAML DEECLRPGTV TDETFLEKLN QVCATHQHFE SRMSKCSRFL
510 520 530 540 550
NDTSLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ AMWKASHALI
560 570 580 590 600
KSLFPEGNPA KINLKRPPTA GSQFKASVAT LMKNLQTKNP NYIRCIKPND
610 620 630 640 650
KKAAHIFNEA LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK
660 670 680 690 700
QTWPHWKGPA RSGVEVLFNE LEIPVEEYSF GRSKIFIRNP RTLFKLEDLR
710 720 730 740 750
KQRLEDLATL IQKIYRGWKC RTHFLLMKKS QIVIAAWYRR YAQQKRYQQT
760 770 780 790 800
KSSALVIQSY IRGWKARKIL RELKHQKRCK EAVTTIAAYW HGTQARRELR
810 820 830 840 850
RLKEEARNKH AIAVIWAYWL GSKARRELKR LKEEARRKHA VAVIWAYWLG
860 870 880 890 900
LKVRREYRKF FRANAGKKIY EFTLQRIVQK YFLEMKNKMP SLSPIDKNWP
910 920 930 940 950
SRPYLFLDST HKELKRIFHL WRCKKYRDQF TDQQKLIYEE KLEASELFKD
960 970 980 990 1000
KKALYPSSVG QPFQGAYLEI NKNPKYKKLK DAIEEKIIIA EVVNKINRAN
1010 1020 1030 1040 1050
GKSTSRIFLL TNNNLLLADQ KSGQIKSEVP LVDVTKVSMS SQNDGFFAVH
1060 1070 1080 1090 1100
LKEGSEAASK GDFLFSSDHL IEMATKLYRT TLSQTKQKLN IEISDEFLVQ
1110 1120 1130
FRQDKVCVKF IQGNQKNGSV PTCKRKNNRL LEVAVP
Length:1,136
Mass (Da):131,985
Last modified:February 1, 2005 - v3
Checksum:i98B7F2357928218D
GO
Isoform 2 (identifier: O43795-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     795-852: Missing.

Show »
Length:1,078
Mass (Da):124,951
Checksum:iD77952776D3EFDE5
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDF6E9PDF6_HUMAN
Unconventional myosin-Ib
MYO1B
1,107Annotation score:
C9JUP5C9JUP5_HUMAN
Unconventional myosin-Ib
MYO1B
149Annotation score:
C9JYW1C9JYW1_HUMAN
Unconventional myosin-Ib
MYO1B
163Annotation score:
E7EQD9E7EQD9_HUMAN
Unconventional myosin-Ib
MYO1B
303Annotation score:
C9K0I9C9K0I9_HUMAN
Unconventional myosin-Ib
MYO1B
83Annotation score:
A0A0U1RRI3A0A0U1RRI3_HUMAN
Unconventional myosin-Ib
MYO1B
189Annotation score:
H7C2Y7H7C2Y7_HUMAN
Unconventional myosin-Ib
MYO1B
192Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036007385V → G in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036008385V → I in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_014113969E → K in a melanoma patient. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012759795 – 852Missing in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053558 mRNA Translation: AAH53558.1
AJ001381 mRNA Translation: CAA04712.1
AJ001382 mRNA Translation: CAA04713.1
CCDSiCCDS2311.1 [O43795-2]
CCDS46477.1 [O43795-1]
RefSeqiNP_001123630.1, NM_001130158.2 [O43795-1]
NP_001155291.1, NM_001161819.2 [O43795-1]
NP_036355.2, NM_012223.4 [O43795-2]
XP_005246629.1, XM_005246572.1 [O43795-1]
UniGeneiHs.439620

Genome annotation databases

EnsembliENST00000304164; ENSP00000306382; ENSG00000128641 [O43795-1]
ENST00000339514; ENSP00000341903; ENSG00000128641 [O43795-2]
ENST00000392318; ENSP00000376132; ENSG00000128641 [O43795-1]
GeneIDi4430
KEGGihsa:4430
UCSCiuc002usq.3 human [O43795-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053558 mRNA Translation: AAH53558.1
AJ001381 mRNA Translation: CAA04712.1
AJ001382 mRNA Translation: CAA04713.1
CCDSiCCDS2311.1 [O43795-2]
CCDS46477.1 [O43795-1]
RefSeqiNP_001123630.1, NM_001130158.2 [O43795-1]
NP_001155291.1, NM_001161819.2 [O43795-1]
NP_036355.2, NM_012223.4 [O43795-2]
XP_005246629.1, XM_005246572.1 [O43795-1]
UniGeneiHs.439620

3D structure databases

ProteinModelPortaliO43795
SMRiO43795
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110567, 67 interactors
IntActiO43795, 60 interactors
MINTiO43795
STRINGi9606.ENSP00000306382

PTM databases

iPTMnetiO43795
PhosphoSitePlusiO43795
SwissPalmiO43795

Polymorphism and mutation databases

BioMutaiMYO1B

Proteomic databases

EPDiO43795
MaxQBiO43795
PaxDbiO43795
PeptideAtlasiO43795
PRIDEiO43795
ProteomicsDBi49172
49173 [O43795-2]

Protocols and materials databases

DNASUi4430
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304164; ENSP00000306382; ENSG00000128641 [O43795-1]
ENST00000339514; ENSP00000341903; ENSG00000128641 [O43795-2]
ENST00000392318; ENSP00000376132; ENSG00000128641 [O43795-1]
GeneIDi4430
KEGGihsa:4430
UCSCiuc002usq.3 human [O43795-1]

Organism-specific databases

CTDi4430
DisGeNETi4430
EuPathDBiHostDB:ENSG00000128641.18
GeneCardsiMYO1B
HGNCiHGNC:7596 MYO1B
HPAiHPA013607
HPA060144
MIMi606537 gene
neXtProtiNX_O43795
OpenTargetsiENSG00000128641
PharmGKBiPA31398
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00920000148963
HOGENOMiHOG000260264
HOVERGENiHBG062373
InParanoidiO43795
KOiK10356
OMAiAMWKAGH
OrthoDBiEOG091G0136
PhylomeDBiO43795
TreeFamiTF312960

Miscellaneous databases

ChiTaRSiMYO1B human
GeneWikiiMYO1B
GenomeRNAii4430
PROiPR:O43795
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128641 Expressed in 219 organ(s), highest expression level in visceral pleura
CleanExiHS_MYO1B
ExpressionAtlasiO43795 baseline and differential
GenevisibleiO43795 HS

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 6 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 5 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1B_HUMAN
AccessioniPrimary (citable) accession number: O43795
Secondary accession number(s): O43794, Q7Z6L5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 2005
Last modified: October 10, 2018
This is version 171 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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