SPOP

Functionⁱ

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL.6 Publications

Miscellaneous

Antigen recognized by serum from scleroderma patient.

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279055

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

proteasome-mediated ubiquitin-dependent protein catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22085717
protein ubiquitination Source: UniProtKB-UniPathway
regulation of proteolysis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin-dependent protein catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ubl conjugation pathway

Biological process

Ubl conjugation pathway

Enzyme and pathway databases

BRENDAⁱ	6.3.2.19 2681
Reactomeⁱ	R-HSA-5632684 Hedgehog 'on' state
SignaLinkⁱ	O43791
SIGNORⁱ	O43791
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Speckle-type POZ protein Alternative name(s): HIB homolog 1 Roadkill homolog 1
Gene namesⁱ	Name:SPOP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000121067.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11254 SPOP
MIMⁱ	602650 gene
neXtProtⁱ	NX_O43791

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	87	Y → A: Strongly reduced affinity for substrate proteins. 1 Publication	1
Mutagenesisⁱ	123	Y → A: Strongly reduced affinity for substrate proteins. 1 Publication	1
Mutagenesisⁱ	130	D → A: Strongly reduced affinity for substrate proteins. 1 Publication	1
Mutagenesisⁱ	131	W → A: Strongly reduced affinity for substrate proteins. 1 Publication	1
Mutagenesisⁱ	133	F → A: Strongly reduced affinity for substrate proteins. 1 Publication	1
Mutagenesisⁱ	186	L → D: Strongly reduced homodimerization. Reduces the activity of the cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. 1 Publication	1
Mutagenesisⁱ	190	L → D: Strongly reduced homodimerization. Reduces the activity of the cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. 1 Publication	1
Mutagenesisⁱ	193	L → D: Strongly reduced homodimerization. Reduces the activity of the cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. 1 Publication	1
Mutagenesisⁱ	217	I → K: Strongly reduced homodimerization. Reduces the activity of the cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8405
Open Targets More...OpenTargetsⁱ	ENSG00000121067
PharmGKBⁱ	PA36084

Polymorphism and mutation databases

BioMutaⁱ	SPOP

BioMutaⁱ

SPOP

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191621	1 – 374	Speckle-type POZ proteinAdd BLAST		374

Proteomic databases

EPDⁱ	O43791
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43791
PaxDbⁱ	O43791
PeptideAtlas More...PeptideAtlasⁱ	O43791
PRIDEⁱ	O43791
ProteomicsDBⁱ	49171

PTM databases

iPTMnetⁱ	O43791
PhosphoSitePlusⁱ	O43791

Expressionⁱ

Tissue specificityⁱ

Widely expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000121067 Expressed in 244 organ(s), highest expression level in vagina
CleanExⁱ	HS_SPOP
ExpressionAtlasⁱ	O43791 baseline and differential
Genevisibleⁱ	O43791 HS

Interactionⁱ

Subunit structureⁱ

Interacts with GLI2 and GLI3 (By similarity). Homodimer and homooligomer. Heterodimer with SPOPL. Each dimer interacts with two CUL3 molecules. Part of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain CUL3 and homodimeric SPOP, or the heterodimer formed by SPOP and SPOPL, plus a target protein, such as H2AFY, PDX1/IPF1, BMI1, BRMS1 and DAXX.By similarity7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CUL3	Q13618	2	EBI-743549,EBI-456129
DAXX	Q9UER7	5	EBI-743549,EBI-77321
DUSP7	Q16829	5	EBI-743549,EBI-1265847
MYD88	Q99836	6	EBI-743549,EBI-447677
NCOA3	Q9Y6Q9	6	EBI-743549,EBI-81196
PTEN	P60484	4	EBI-743549,EBI-696162

GO - Molecular functionⁱ

ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279055

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113993, 57 interactors
CORUMⁱ	O43791
Database of interacting proteins More...DIPⁱ	DIP-50517N
ELMⁱ	O43791
IntActⁱ	O43791, 30 interactors
Molecular INTeraction database More...MINTⁱ	O43791
STRINGⁱ	9606.ENSP00000240327

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	31 – 40	Combined sources	10
Helixⁱ	41 – 43	Combined sources	3
Helixⁱ	45 – 48	Combined sources	4
Beta strandⁱ	57 – 60	Combined sources	4
Helixⁱ	61 – 63	Combined sources	3
Beta strandⁱ	65 – 72	Combined sources	8
Helixⁱ	78 – 80	Combined sources	3
Beta strandⁱ	83 – 92	Combined sources	10
Beta strandⁱ	94 – 107	Combined sources	14
Beta strandⁱ	113 – 118	Combined sources	6
Beta strandⁱ	123 – 126	Combined sources	4
Beta strandⁱ	130 – 138	Combined sources	9
Helixⁱ	139 – 143	Combined sources	5
Helixⁱ	145 – 147	Combined sources	3
Beta strandⁱ	148 – 150	Combined sources	3
Helixⁱ	151 – 153	Combined sources	3
Beta strandⁱ	155 – 163	Combined sources	9
Helixⁱ	186 – 196	Combined sources	11
Beta strandⁱ	202 – 206	Combined sources	5
Beta strandⁱ	209 – 213	Combined sources	5
Helixⁱ	215 – 221	Combined sources	7
Helixⁱ	223 – 230	Combined sources	8
Beta strandⁱ	231 – 233	Combined sources	3
Helixⁱ	234 – 238	Combined sources	5
Beta strandⁱ	240 – 243	Combined sources	4
Helixⁱ	248 – 260	Combined sources	13
Helixⁱ	266 – 268	Combined sources	3
Helixⁱ	270 – 279	Combined sources	10
Helixⁱ	283 – 290	Combined sources	8
Turnⁱ	299 – 301	Combined sources	3
Helixⁱ	302 – 311	Combined sources	10
Helixⁱ	315 – 327	Combined sources	13
Helixⁱ	329 – 332	Combined sources	4
Helixⁱ	336 – 344	Combined sources	9
Helixⁱ	346 – 357	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	O43791
SMRⁱ	O43791
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O43791

EvolutionaryTraceⁱ

O43791

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	31 – 161	MATHPROSITE-ProRule annotationAdd BLAST		131
Domainⁱ	173 – 297	BTBPROSITE-ProRule annotationAdd BLAST		125

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	71 – 191	Required for nuclear localizationAdd BLAST	121
Regionⁱ	123 – 133	Important for binding substrate proteinsAdd BLAST	11
Regionⁱ	186 – 217	Important for homodimerizationAdd BLAST	32
Regionⁱ	297 – 355	Important for homodimerizationAdd BLAST	59

Domainⁱ

The BTB (POZ) domain mediates dimerization and interaction with CUL3.1 Publication

The MATH domain mediates interaction with protein-ubiquitin ligase substrates, such as H2AFY and BMI1.1 Publication

Sequence similaritiesⁱ

Belongs to the Tdpoz family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1987 Eukaryota ENOG410XQV8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000361
HOGENOMⁱ	HOG000231621
HOVERGENⁱ	HBG001393
InParanoidⁱ	O43791
KEGG Orthology (KO) More...KOⁱ	K10523
OMAⁱ	FNYMWTI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07ZM
PhylomeDBⁱ	O43791
TreeFamⁱ	TF313419

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14734 SPOP_C, 1 hit
Gene3Dⁱ	2.60.210.10, 1 hit
InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR002083 MATH/TRAF_dom IPR011333 SKP1/BTB/POZ_sf IPR034089 SPOP_C IPR008974 TRAF-like
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00917 MATH, 1 hit
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00061 MATH, 1 hit
SUPFAMⁱ	SSF49599 SSF49599, 1 hit SSF54695 SSF54695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS50144 MATH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show all Align All

O43791-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRVPSPPPP AEMSSGPVAE SWCYTQIKVV KFSYMWTINN FSFCREEMGE 
        60         70         80         90        100
VIKSSTFSSG ANDKLKWCLR VNPKGLDEES KDYLSLYLLL VSCPKSEVRA 
       110        120        130        140        150
KFKFSILNAK GEETKAMESQ RAYRFVQGKD WGFKKFIRRD FLLDEANGLL 
       160        170        180        190        200
PDDKLTLFCE VSVVQDSVNI SGQNTMNMVK VPECRLADEL GGLWENSRFT 
       210        220        230        240        250
DCCLCVAGQE FQAHKAILAA RSPVFSAMFE HEMEESKKNR VEINDVEPEV 
       260        270        280        290        300
FKEMMCFIYT GKAPNLDKMA DDLLAAADKY ALERLKVMCE DALCSNLSVE 
       310        320        330        340        350
NAAEILILAD LHSADQLKTQ AVDFINYHAS DVLETSGWKS MVVSHPHLVA 
       360        370 
EAYRSLASAQ CPFLGPPRKR LKQS

Length:374

Mass (Da):42,132

Last modified:June 1, 1998 - v1

Checksum:ⁱEE5F4C5CF6FD09DC

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RDG8	D6RDG8_HUMAN	Speckle-type POZ protein Speckle-type POZ protein	SPOP	238	Annotation score:
D6RDV6	D6RDV6_HUMAN	Speckle-type POZ protein Speckle-type POZ protein	SPOP	262	Annotation score:
D6RBH6	D6RBH6_HUMAN	Speckle-type POZ protein Speckle-type POZ protein	SPOP	138	Annotation score:
D6RGZ4	D6RGZ4_HUMAN	Speckle-type POZ protein Speckle-type POZ protein	SPOP	185	Annotation score:
H0Y977	H0Y977_HUMAN	Speckle-type POZ protein Speckle-type POZ protein	SPOP	72	Annotation score:
D6RFL7	D6RFL7_HUMAN	Speckle-type POZ protein Speckle-type POZ protein	SPOP	117	Annotation score:
D6RD94	D6RD94_HUMAN	Speckle-type POZ protein Speckle-type POZ protein	SPOP	66	Annotation score:
D6RIS7	D6RIS7_HUMAN	Speckle-type POZ protein Speckle-type POZ protein	SPOP	40	Annotation score:
D6RA79	D6RA79_HUMAN	Speckle-type POZ protein Speckle-type POZ protein	SPOP	32	Annotation score:
D6RBR3	D6RBR3_HUMAN	Speckle-type POZ protein Speckle-type POZ protein	SPOP	44	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	239	N → S in BAD96309 (Ref. 3) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ000644 mRNA Translation: CAA04199.1 AK222589 mRNA Translation: BAD96309.1 AK312691 mRNA Translation: BAG35570.1 CH471109 Genomic DNA Translation: EAW94671.1 CH471109 Genomic DNA Translation: EAW94672.1 CH471109 Genomic DNA Translation: EAW94673.1 CH471109 Genomic DNA Translation: EAW94674.1 CH471109 Genomic DNA Translation: EAW94675.1 BC001269 mRNA Translation: AAH01269.1 BC003385 mRNA Translation: AAH03385.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11551.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001007227.1, NM_001007226.1 NP_001007228.1, NM_001007227.1 NP_001007229.1, NM_001007228.1 NP_001007230.1, NM_001007229.1 NP_001007231.1, NM_001007230.1 NP_003554.1, NM_003563.3 XP_005257780.1, XM_005257723.4 XP_005257781.1, XM_005257724.4 XP_016880693.1, XM_017025204.1
UniGeneⁱ	Hs.463382 Hs.740407

Genome annotation databases

Ensemblⁱ	ENST00000347630; ENSP00000240327; ENSG00000121067 ENST00000393328; ENSP00000377001; ENSG00000121067 ENST00000503676; ENSP00000420908; ENSG00000121067 ENST00000504102; ENSP00000425905; ENSG00000121067
GeneIDⁱ	8405
KEGGⁱ	hsa:8405
UCSC genome browser More...UCSCⁱ	uc002ipd.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43791	Speckle-type POZ protein		BOVIN		374	UniRef100_O43791
Speckle-type POZ protein		MOUSE		374
Speckle-type POZ protein		PONAB		374
Speckle-type POZ protein (Fragment)		wild yak		377
SPOP isoform 16		PANTR		374
+44

Protein	Similar proteins		Species	Score	Length	Source
O43791	Speckle-type POZ protein		BOVIN		374	UniRef90_O43791
Speckle-type POZ protein		MOUSE		374
Speckle-type POZ protein		PONAB		374
Speckle-type POZ protein		XENTR		374
Speckle-type POZ protein A		XENLA		374
+178

Protein	Similar proteins		Species	Score	Length	Source
O43791	Speckle-type POZ protein		BOVIN		374	UniRef50_O43791
Speckle-type POZ protein		MOUSE		374
Speckle-type POZ protein		PONAB		374
Speckle-type POZ protein		DANRE		374
Speckle-type POZ protein		XENTR		374
+542

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ000644 mRNA Translation: CAA04199.1 AK222589 mRNA Translation: BAD96309.1 AK312691 mRNA Translation: BAG35570.1 CH471109 Genomic DNA Translation: EAW94671.1 CH471109 Genomic DNA Translation: EAW94672.1 CH471109 Genomic DNA Translation: EAW94673.1 CH471109 Genomic DNA Translation: EAW94674.1 CH471109 Genomic DNA Translation: EAW94675.1 BC001269 mRNA Translation: AAH01269.1 BC003385 mRNA Translation: AAH03385.1
CCDSⁱ	CCDS11551.1
RefSeqⁱ	NP_001007227.1, NM_001007226.1 NP_001007228.1, NM_001007227.1 NP_001007229.1, NM_001007228.1 NP_001007230.1, NM_001007229.1 NP_001007231.1, NM_001007230.1 NP_003554.1, NM_003563.3 XP_005257780.1, XM_005257723.4 XP_005257781.1, XM_005257724.4 XP_016880693.1, XM_017025204.1
UniGeneⁱ	Hs.463382 Hs.740407

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CR2	NMR	-	A	28-173	[»]
	3HQH	X-ray	2.30	A	28-166	[»]
	3HQI	X-ray	2.62	A/B	28-329	[»]
	3HQL	X-ray	1.66	A/B	28-166	[»]
	3HQM	X-ray	1.74	A/B	28-166	[»]
	3HSV	X-ray	1.43	A/B	28-166	[»]
	3HTM	X-ray	2.50	A/B/C/D	172-329	[»]
	3HU6	X-ray	2.70	A/B	28-329	[»]
	3IVB	X-ray	1.75	A	28-166	[»]
	3IVQ	X-ray	2.10	A/B	28-166	[»]
	3IVV	X-ray	1.25	A	28-166	[»]
	4EOZ	X-ray	2.40	A/C	177-319	[»]
	4HS2	X-ray	1.53	A	270-374	[»]
	4J8Z	X-ray	2.42	A/B	169-374	[»]
	4O1V	X-ray	2.00	A	28-166	[»]
ProteinModelPortalⁱ	O43791
SMRⁱ	O43791
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113993, 57 interactors
CORUMⁱ	O43791
DIPⁱ	DIP-50517N
ELMⁱ	O43791
IntActⁱ	O43791, 30 interactors
MINTⁱ	O43791
STRINGⁱ	9606.ENSP00000240327

PTM databases

iPTMnetⁱ	O43791
PhosphoSitePlusⁱ	O43791

Polymorphism and mutation databases

BioMutaⁱ	SPOP

BioMutaⁱ

SPOP

Proteomic databases

EPDⁱ	O43791
MaxQBⁱ	O43791
PaxDbⁱ	O43791
PeptideAtlasⁱ	O43791
PRIDEⁱ	O43791
ProteomicsDBⁱ	49171

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8405
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000347630; ENSP00000240327; ENSG00000121067 ENST00000393328; ENSP00000377001; ENSG00000121067 ENST00000503676; ENSP00000420908; ENSG00000121067 ENST00000504102; ENSP00000425905; ENSG00000121067
GeneIDⁱ	8405
KEGGⁱ	hsa:8405
UCSCⁱ	uc002ipd.4 human

Organism-specific databases

CTDⁱ	8405
DisGeNETⁱ	8405
EuPathDBⁱ	HostDB:ENSG00000121067.17
GeneCardsⁱ	SPOP
HGNCⁱ	HGNC:11254 SPOP
MIMⁱ	602650 gene
neXtProtⁱ	NX_O43791
OpenTargetsⁱ	ENSG00000121067
PharmGKBⁱ	PA36084
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1987 Eukaryota ENOG410XQV8 LUCA
GeneTreeⁱ	ENSGT00390000000361
HOGENOMⁱ	HOG000231621
HOVERGENⁱ	HBG001393
InParanoidⁱ	O43791
KOⁱ	K10523
OMAⁱ	FNYMWTI
OrthoDBⁱ	EOG091G07ZM
PhylomeDBⁱ	O43791
TreeFamⁱ	TF313419

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
BRENDAⁱ	6.3.2.19 2681
Reactomeⁱ	R-HSA-5632684 Hedgehog 'on' state
SignaLinkⁱ	O43791
SIGNORⁱ	O43791

Miscellaneous databases

ChiTaRSⁱ	SPOP human
EvolutionaryTraceⁱ	O43791
GeneWikiⁱ	SPOP
GenomeRNAiⁱ	8405
Protein Ontology More...PROⁱ	PR:O43791
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000121067 Expressed in 244 organ(s), highest expression level in vagina
CleanExⁱ	HS_SPOP
ExpressionAtlasⁱ	O43791 baseline and differential
Genevisibleⁱ	O43791 HS

Family and domain databases

CDDⁱ	cd14734 SPOP_C, 1 hit
Gene3Dⁱ	2.60.210.10, 1 hit
InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR002083 MATH/TRAF_dom IPR011333 SKP1/BTB/POZ_sf IPR034089 SPOP_C IPR008974 TRAF-like
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00917 MATH, 1 hit
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00061 MATH, 1 hit
SUPFAMⁱ	SSF49599 SSF49599, 1 hit SSF54695 SSF54695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS50144 MATH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPOP_HUMAN
Accessionⁱ	O43791Primary (citable) accession number: O43791 Secondary accession number(s): B2R6S3, D3DTW7, Q53HJ1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	June 1, 1998
	Last modified:	November 7, 2018
	This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43791 (SPOP_HUMAN)

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Speckle-type POZ protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ