UniProtKB - O43776 (SYNC_HUMAN)

BLAST

>sp|O43776|SYNC_HUMAN Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS PE=1 SV=1
MVLAELYVSDREGSDATGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKENERWNVISK
SQLKNIKKMWHREQMKSESREKKEAEDSLRREKNLEEAKKITIKNDPSLPEPKCVKIGAL
EGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLADELCQCYNGVLLSTESSVA
VYGMLNLTPKGKQAPGGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNRHMMIRGE
NMSKILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATLFKLDYFGEEAFLTQSS
QLYLETCLPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLNRLEDLVCD
VVDRILKSPAGSIVHELNPNFQPPKRPFKRMNYSDAIVWLKEHDVKKEDGTFYEFGEDIP
EAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIF
DSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYP
RFVQRCTP

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History
Entry version 168 (07 Nov 2018)
Sequence version 1 (01 Jun 1998)
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Protein

Asparagine--tRNA ligase, cytoplasmic

Gene

NARS

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalytic activityⁱ

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

GO - Molecular functionⁱ

asparagine-tRNA ligase activity Source: Reactome
ATP binding Source: UniProtKB-KW
nucleic acid binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

asparaginyl-tRNA aminoacylation Source: InterPro
tRNA aminoacylation for protein translation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aminoacyl-tRNA synthetase, Ligase
Biological process	Protein biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	6.1.1.22 2681
Reactomeⁱ	R-HSA-379716 Cytosolic tRNA aminoacylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Asparagine--tRNA ligase, cytoplasmic (EC:6.1.1.22) Alternative name(s): Asparaginyl-tRNA synthetase Short name: AsnRS
Gene namesⁱ	Name:NARS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134440.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7643 NARS
MIMⁱ	108410 gene
neXtProtⁱ	NX_O43776

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4677
Open Targets More...OpenTargetsⁱ	ENSG00000134440
PharmGKBⁱ	PA31447

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00174 L-Asparagine

DrugBankⁱ

DB00174 L-Asparagine

Polymorphism and mutation databases

BioMutaⁱ	NARS

BioMutaⁱ

NARS

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000176496	1 – 548	Asparagine--tRNA ligase, cytoplasmicAdd BLAST		548

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	61	PhosphoserineCombined sources	1
Modified residueⁱ	244	N6-acetyllysineCombined sources	1
Modified residueⁱ	482	PhosphoserineBy similarity	1
Modified residueⁱ	490	N6-acetyllysineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O43776
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43776
PaxDbⁱ	O43776
PeptideAtlas More...PeptideAtlasⁱ	O43776
PRIDEⁱ	O43776
ProteomicsDBⁱ	49167

PTM databases

iPTMnetⁱ	O43776
PhosphoSitePlusⁱ	O43776
SwissPalmⁱ	O43776

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000134440 Expressed in 234 organ(s), highest expression level in metanephros
CleanExⁱ	HS_ASNS HS_NARS
ExpressionAtlasⁱ	O43776 baseline and differential
Genevisibleⁱ	O43776 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB034257 HPA040017

HPAⁱ

CAB034257
HPA040017

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	110758, 68 interactors
IntActⁱ	O43776, 12 interactors
Molecular INTeraction database More...MINTⁱ	O43776
STRINGⁱ	9606.ENSP00000256854

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 8	Combined sources	4
Turnⁱ	10 – 12	Combined sources	3
Turnⁱ	15 – 17	Combined sources	3
Beta strandⁱ	20 – 24	Combined sources	5
Helixⁱ	29 – 34	Combined sources	6
Beta strandⁱ	38 – 40	Combined sources	3
Beta strandⁱ	43 – 47	Combined sources	5
Beta strandⁱ	55 – 57	Combined sources	3
Helixⁱ	60 – 73	Combined sources	14
Helixⁱ	117 – 123	Combined sources	7
Beta strandⁱ	126 – 140	Combined sources	15
Turnⁱ	141 – 143	Combined sources	3
Beta strandⁱ	144 – 150	Combined sources	7
Beta strandⁱ	155 – 161	Combined sources	7
Helixⁱ	163 – 166	Combined sources	4
Helixⁱ	168 – 172	Combined sources	5
Beta strandⁱ	178 – 187	Combined sources	10
Helixⁱ	195 – 197	Combined sources	3
Beta strandⁱ	198 – 209	Combined sources	12
Helixⁱ	226 – 231	Combined sources	6
Helixⁱ	233 – 236	Combined sources	4
Helixⁱ	240 – 262	Combined sources	23
Beta strandⁱ	272 – 275	Combined sources	4
Beta strandⁱ	286 – 289	Combined sources	4
Beta strandⁱ	292 – 296	Combined sources	5
Helixⁱ	301 – 311	Combined sources	11
Beta strandⁱ	312 – 321	Combined sources	10
Beta strandⁱ	333 – 344	Combined sources	12
Helixⁱ	347 – 367	Combined sources	21
Helixⁱ	371 – 377	Combined sources	7
Beta strandⁱ	389 – 392	Combined sources	4
Helixⁱ	393 – 402	Combined sources	10
Beta strandⁱ	408 – 410	Combined sources	3
Helixⁱ	421 – 431	Combined sources	11
Beta strandⁱ	435 – 438	Combined sources	4
Helixⁱ	442 – 444	Combined sources	3
Beta strandⁱ	455 – 466	Combined sources	12
Turnⁱ	467 – 469	Combined sources	3
Beta strandⁱ	470 – 478	Combined sources	9
Helixⁱ	482 – 492	Combined sources	11
Helixⁱ	497 – 499	Combined sources	3
Helixⁱ	500 – 503	Combined sources	4
Helixⁱ	504 – 506	Combined sources	3
Beta strandⁱ	513 – 519	Combined sources	7
Helixⁱ	520 – 527	Combined sources	8
Helixⁱ	533 – 536	Combined sources	4
Beta strandⁱ	537 – 539	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	O43776
SMRⁱ	O43776
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the class-II aminoacyl-tRNA synthetase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0555 Eukaryota COG0017 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074893
HOGENOMⁱ	HOG000226035
HOVERGENⁱ	HBG059844
InParanoidⁱ	O43776
KEGG Orthology (KO) More...KOⁱ	K01893
OMAⁱ	SCDFWEL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G065Q
PhylomeDBⁱ	O43776
TreeFamⁱ	TF105664

Family and domain databases

InterProⁱ	View protein in InterPro IPR004364 aa-tRNA-synt_II IPR006195 aa-tRNA-synth_II IPR004522 Asn-tRNA-ligase IPR002312 Asp/Asn-tRNA-synth_IIb IPR012340 NA-bd_OB-fold IPR004365 NA-bd_OB_tRNA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00152 tRNA-synt_2, 1 hit PF01336 tRNA_anti-codon, 1 hit
PRINTSⁱ	PR01042 TRNASYNTHASP
SUPFAMⁱ	SSF50249 SSF50249, 1 hit
TIGRFAMsⁱ	TIGR00457 asnS, 1 hit
PROSITEⁱ	View protein in PROSITE PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O43776-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLAELYVSD REGSDATGDG TKEKPFKTGL KALMTVGKEP FPTIYVDSQK 
        60         70         80         90        100
ENERWNVISK SQLKNIKKMW HREQMKSESR EKKEAEDSLR REKNLEEAKK 
       110        120        130        140        150
ITIKNDPSLP EPKCVKIGAL EGYRGQRVKV FGWVHRLRRQ GKNLMFLVLR 
       160        170        180        190        200
DGTGYLQCVL ADELCQCYNG VLLSTESSVA VYGMLNLTPK GKQAPGGHEL 
       210        220        230        240        250
SCDFWELIGL APAGGADNLI NEESDVDVQL NNRHMMIRGE NMSKILKARS 
       260        270        280        290        300
MVTRCFRDHF FDRGYYEVTP PTLVQTQVEG GATLFKLDYF GEEAFLTQSS 
       310        320        330        340        350
QLYLETCLPA LGDVFCIAQS YRAEQSRTRR HLAEYTHVEA ECPFLTFDDL 
       360        370        380        390        400
LNRLEDLVCD VVDRILKSPA GSIVHELNPN FQPPKRPFKR MNYSDAIVWL 
       410        420        430        440        450
KEHDVKKEDG TFYEFGEDIP EAPERLMTDT INEPILLCRF PVEIKSFYMQ 
       460        470        480        490        500
RCPEDSRLTE SVDVLMPNVG EIVGGSMRIF DSEEILAGYK REGIDPTPYY 
       510        520        530        540 
WYTDQRKYGT CPHGGYGLGL ERFLTWILNR YHIRDVCLYP RFVQRCTP

Length:548

Mass (Da):62,943

Last modified:June 1, 1998 - v1

Checksum:ⁱCDD442C4E962CDDB

Isoform 2 (identifier: O43776-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
141-173: GKNLMFLVLRDGTGYLQCVLADELCQCYNGVLL → VSVLQWSSLVHGEQCCSVWNAKSYPKGQAGSRW
174-547: Missing.

« Hide

        10         20         30         40         50
MVLAELYVSD REGSDATGDG TKEKPFKTGL KALMTVGKEP FPTIYVDSQK 
        60         70         80         90        100
ENERWNVISK SQLKNIKKMW HREQMKSESR EKKEAEDSLR REKNLEEAKK 
       110        120        130        140        150
ITIKNDPSLP EPKCVKIGAL EGYRGQRVKV FGWVHRLRRQ VSVLQWSSLV 
       160        170 
HGEQCCSVWN AKSYPKGQAG SRWP

Note: No experimental confirmation available.

Show »

Length:174

Mass (Da):20,033

Checksum:ⁱ594E9ED90ED09E4B

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EMQ6	K7EMQ6_HUMAN	Asparagine--tRNA ligase, cytoplasmi... Asparagine--tRNA ligase, cytoplasmic	NARS	128	Annotation score:
K7EPK2	K7EPK2_HUMAN	Asparagine--tRNA ligase, cytoplasmi... Asparagine--tRNA ligase, cytoplasmic	NARS	163	Annotation score:
K7EIU7	K7EIU7_HUMAN	Asparagine--tRNA ligase, cytoplasmi... Asparagine--tRNA ligase, cytoplasmic	NARS	162	Annotation score:
K7EJ19	K7EJ19_HUMAN	Asparagine--tRNA ligase, cytoplasmi... Asparagine--tRNA ligase, cytoplasmic	NARS	136	Annotation score:
K7EQ35	K7EQ35_HUMAN	Asparagine--tRNA ligase, cytoplasmi... Asparagine--tRNA ligase, cytoplasmic	NARS	167	Annotation score:
K7ENF0	K7ENF0_HUMAN	Asparagine--tRNA ligase, cytoplasmi... Asparagine--tRNA ligase, cytoplasmic	NARS	47	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	391	M → V in BAD96555 (Ref. 4) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056201	141 – 173	GKNLM…NGVLL → VSVLQWSSLVHGEQCCSVWN AKSYPKGQAGSRW in isoform 2. 1 PublicationAdd BLAST		33
Alternative sequenceⁱVSP_056202	174 – 547	Missing in isoform 2. 1 PublicationAdd BLAST		374

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ000334 mRNA Translation: CAA04008.1 D84273 mRNA Translation: BAA34600.1 AK294364 mRNA Translation: BAG57627.1 AC100847 Genomic DNA No translation available. AK222835 mRNA Translation: BAD96555.1 BC001687 mRNA Translation: AAH01687.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32837.1 [O43776-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_004530.1, NM_004539.3 [O43776-1]
UniGeneⁱ	Hs.465224

Genome annotation databases

Ensemblⁱ	ENST00000256854; ENSP00000256854; ENSG00000134440 [O43776-1] ENST00000540592; ENSP00000442496; ENSG00000134440 [O43776-2]
GeneIDⁱ	4677
KEGGⁱ	hsa:4677
UCSC genome browser More...UCSCⁱ	uc002lgs.4 human [O43776-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43776	Asparagine--tRNA ligase, cytoplasmic (Fragment)		HUMAN		128	UniRef100_O43776
Asparagine--tRNA ligase, cytoplasmic (Fragment)		HUMAN		163
O43776-2	Asparagine--tRNA ligase, cytoplasmic (Fragment)		HUMAN		162	UniRef100_O43776-2

Protein	Similar proteins		Species	Score	Length	Source
O43776	Asparagine--tRNA ligase, cytoplasmic		MOUSE		559	UniRef90_O43776
Asparagine--tRNA ligase, cytoplasmic		BOVIN		559
Asparagine--tRNA ligase, cytoplasmic		MACFA		558
Asparagine--tRNA ligase, cytoplasmic (Fragment)		HUMAN		128
Asparaginyl-tRNA synthetase, cytoplasmic		HETGA		622
+196
O43776-2	Asparagine--tRNA ligase, cytoplasmic (Fragment)		HUMAN		162	UniRef90_O43776-2
NARS isoform 7		PONAB		174
NARS isoform 7		PANTR		174
NARS isoform 10 (Fragment)		PONAB		162
NARS isoform 6 (Fragment)		PANTR		162

Protein	Similar proteins		Species	Score	Length	Source
O43776	Asparagine--tRNA ligase, cytoplasmic		MOUSE		559	UniRef50_O43776
Asparagine--tRNA ligase, cytoplasmic		BOVIN		559
Asparagine--tRNA ligase, cytoplasmic		MACFA		558
Asparagine--tRNA ligase, cytoplasmic (Fragment)		HUMAN		128
Asparaginyl-tRNA synthetase, cytoplasmic		HETGA		622
+360
O43776-2	Asparagine--tRNA ligase, cytoplasmic (Fragment)		HUMAN		162	UniRef50_O43776-2
NARS isoform 7		PONAB		174
NARS isoform 7		PANTR		174
Asparaginyl-tRNA synthetase (Fragment)		ICTPU		152
Uncharacterized protein		ONCMY		174
+5

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ000334 mRNA Translation: CAA04008.1 D84273 mRNA Translation: BAA34600.1 AK294364 mRNA Translation: BAG57627.1 AC100847 Genomic DNA No translation available. AK222835 mRNA Translation: BAD96555.1 BC001687 mRNA Translation: AAH01687.1
CCDSⁱ	CCDS32837.1 [O43776-1]
RefSeqⁱ	NP_004530.1, NM_004539.3 [O43776-1]
UniGeneⁱ	Hs.465224

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4ZYA	X-ray	1.65	A/B	4-77	[»]
	5XIX	X-ray	2.25	A/B/C/D	98-548	[»]
ProteinModelPortalⁱ	O43776
SMRⁱ	O43776
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110758, 68 interactors
IntActⁱ	O43776, 12 interactors
MINTⁱ	O43776
STRINGⁱ	9606.ENSP00000256854

Chemistry databases

DrugBankⁱ	DB00174 L-Asparagine

DrugBankⁱ

DB00174 L-Asparagine

PTM databases

iPTMnetⁱ	O43776
PhosphoSitePlusⁱ	O43776
SwissPalmⁱ	O43776

Polymorphism and mutation databases

BioMutaⁱ	NARS

BioMutaⁱ

NARS

Proteomic databases

EPDⁱ	O43776
MaxQBⁱ	O43776
PaxDbⁱ	O43776
PeptideAtlasⁱ	O43776
PRIDEⁱ	O43776
ProteomicsDBⁱ	49167

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000256854; ENSP00000256854; ENSG00000134440 [O43776-1] ENST00000540592; ENSP00000442496; ENSG00000134440 [O43776-2]
GeneIDⁱ	4677
KEGGⁱ	hsa:4677
UCSCⁱ	uc002lgs.4 human [O43776-1]

Organism-specific databases

CTDⁱ	4677
DisGeNETⁱ	4677
EuPathDBⁱ	HostDB:ENSG00000134440.11
GeneCardsⁱ	NARS
HGNCⁱ	HGNC:7643 NARS
HPAⁱ	CAB034257 HPA040017
MIMⁱ	108410 gene
neXtProtⁱ	NX_O43776
OpenTargetsⁱ	ENSG00000134440
PharmGKBⁱ	PA31447
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0555 Eukaryota COG0017 LUCA
GeneTreeⁱ	ENSGT00550000074893
HOGENOMⁱ	HOG000226035
HOVERGENⁱ	HBG059844
InParanoidⁱ	O43776
KOⁱ	K01893
OMAⁱ	SCDFWEL
OrthoDBⁱ	EOG091G065Q
PhylomeDBⁱ	O43776
TreeFamⁱ	TF105664

Enzyme and pathway databases

BRENDAⁱ	6.1.1.22 2681
Reactomeⁱ	R-HSA-379716 Cytosolic tRNA aminoacylation

Miscellaneous databases

ChiTaRSⁱ	NARS human
GeneWikiⁱ	NARS_(gene)
GenomeRNAiⁱ	4677
Protein Ontology More...PROⁱ	PR:O43776
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134440 Expressed in 234 organ(s), highest expression level in metanephros
CleanExⁱ	HS_ASNS HS_NARS
ExpressionAtlasⁱ	O43776 baseline and differential
Genevisibleⁱ	O43776 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004364 aa-tRNA-synt_II IPR006195 aa-tRNA-synth_II IPR004522 Asn-tRNA-ligase IPR002312 Asp/Asn-tRNA-synth_IIb IPR012340 NA-bd_OB-fold IPR004365 NA-bd_OB_tRNA
Pfamⁱ	View protein in Pfam PF00152 tRNA-synt_2, 1 hit PF01336 tRNA_anti-codon, 1 hit
PRINTSⁱ	PR01042 TRNASYNTHASP
SUPFAMⁱ	SSF50249 SSF50249, 1 hit
TIGRFAMsⁱ	TIGR00457 asnS, 1 hit
PROSITEⁱ	View protein in PROSITE PS50862 AA_TRNA_LIGASE_II, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYNC_HUMAN
Accessionⁱ	O43776Primary (citable) accession number: O43776 Secondary accession number(s): B4DG16, Q53GU6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	June 1, 1998
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries

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Supporting data

UniProtKB - O43776 (SYNC_HUMAN)

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Asparagine--tRNA ligase, cytoplasmic

NARS

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ