SLC25A20

Functionⁱ

Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.

GO - Molecular functionⁱ

acyl carnitine transmembrane transporter activity
Source: Reactome
Inferred from experimentⁱ
- 9399886

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carnitine shuttle Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000178537-MONOMER
Reactomeⁱ	R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix
SIGNORⁱ	O43772

Protein family/group databases

TCDBⁱ	2.A.29.8.3 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.8.3 the mitochondrial carrier (mc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitochondrial carnitine/acylcarnitine carrier protein Alternative name(s): Carnitine/acylcarnitine translocase Short name: CAC Solute carrier family 25 member 20
Gene namesⁱ	Name:SLC25A20 Synonyms:CAC, CACT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000178537.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1421 SLC25A20
MIMⁱ	613698 gene
neXtProtⁱ	NX_O43772

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	2 – 12	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	13 – 31	Helical; Name=1Sequence analysisAdd BLAST	19
Topological domainⁱ	32 – 73	Mitochondrial matrixSequence analysisAdd BLAST	42
Transmembraneⁱ	74 – 93	Helical; Name=2Sequence analysisAdd BLAST	20
Topological domainⁱ	94 – 112	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	113 – 131	Helical; Name=3Sequence analysisAdd BLAST	19
Topological domainⁱ	132 – 170	Mitochondrial matrixSequence analysisAdd BLAST	39
Transmembraneⁱ	171 – 190	Helical; Name=4Sequence analysisAdd BLAST	20
Topological domainⁱ	191 – 211	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	212 – 230	Helical; Name=5Sequence analysisAdd BLAST	19
Topological domainⁱ	231 – 267	Mitochondrial matrixSequence analysisAdd BLAST	37
Transmembraneⁱ	268 – 287	Helical; Name=6Sequence analysisAdd BLAST	20
Topological domainⁱ	288 – 301	CytoplasmicSequence analysisAdd BLAST	14

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Carnitine-acylcarnitine translocase deficiency (CACTD)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare long-chain fatty acid oxidation disorder. Metabolic consequences include hypoketotic hypoglycemia under fasting conditions, hyperammonemia, elevated creatine kinase and transaminases, dicarboxylic aciduria, very low free carnitine and abnormal acylcarnitine profile with marked elevation of the long-chain acylcarnitines. Clinical features include neurologic abnormalities, cardiomyopathy, arrhythmias, skeletal muscle damage, liver dysfunction and episodes of life-threatening coma, which eventually lead to death. Most patients become symptomatic in the neonatal period with a rapidly progressive deterioration and a high mortality rate.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	788
MalaCards human disease database More...MalaCardsⁱ	SLC25A20
MIMⁱ	212138 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000178537
Orphanetⁱ	159 Carnitine-acylcarnitine translocase deficiency
PharmGKBⁱ	PA35031

Chemistry databases

ChEMBLⁱ	CHEMBL2216740
Drug and drug target database More...DrugBankⁱ	DB00583 L-Carnitine

Polymorphism and mutation databases

BioMutaⁱ	SLC25A20

BioMutaⁱ

SLC25A20

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000090628	2 – 301	Mitochondrial carnitine/acylcarnitine carrier proteinAdd BLAST		300

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	148	N6-acetyllysineBy similarity	1
Modified residueⁱ	157	N6-acetyllysineBy similarity	1
Modified residueⁱ	170	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	170	N6-succinyllysine; alternateBy similarity	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	O43772
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43772
PaxDbⁱ	O43772
PeptideAtlas More...PeptideAtlasⁱ	O43772
PRIDEⁱ	O43772
ProteomicsDBⁱ	49166
TopDownProteomicsⁱ	O43772

PTM databases

iPTMnetⁱ	O43772
PhosphoSitePlusⁱ	O43772

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000178537 Expressed in 223 organ(s), highest expression level in liver
CleanExⁱ	HS_SLC25A20
ExpressionAtlasⁱ	O43772 baseline and differential
Genevisibleⁱ	O43772 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA016862 HPA029863

HPAⁱ

HPA016862
HPA029863

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107241, 22 interactors
IntActⁱ	O43772, 6 interactors
STRINGⁱ	9606.ENSP00000326305

Chemistry databases

BindingDBⁱ

O43772

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43772
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	8 – 99	Solcar 1Add BLAST	92
Repeatⁱ	108 – 196	Solcar 2Add BLAST	89
Repeatⁱ	207 – 293	Solcar 3Add BLAST	87

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0758 Eukaryota ENOG410XS86 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104295
HOGENOMⁱ	HOG000168307
HOVERGENⁱ	HBG003500
InParanoidⁱ	O43772
KEGG Orthology (KO) More...KOⁱ	K15109
OMAⁱ	NIVAPNF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HVE
PhylomeDBⁱ	O43772
TreeFamⁱ	TF300894

Family and domain databases

Gene3Dⁱ	1.50.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

O43772-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADQPKPISP LKNLLAGGFG GVCLVFVGHP LDTVKVRLQT QPPSLPGQPP 
        60         70         80         90        100
MYSGTFDCFR KTLFREGITG LYRGMAAPII GVTPMFAVCF FGFGLGKKLQ 
       110        120        130        140        150
QKHPEDVLSY PQLFAAGMLS GVFTTGIMTP GERIKCLLQI QASSGESKYT 
       160        170        180        190        200
GTLDCAKKLY QEFGIRGIYK GTVLTLMRDV PASGMYFMTY EWLKNIFTPE 
       210        220        230        240        250
GKRVSELSAP RILVAGGIAG IFNWAVAIPP DVLKSRFQTA PPGKYPNGFR 
       260        270        280        290        300
DVLRELIRDE GVTSLYKGFN AVMIRAFPAN AACFLGFEVA MKFLNWATPN 

L

Length:301

Mass (Da):32,944

Last modified:June 1, 1998 - v1

Checksum:ⁱAEB34E4E335102B0

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JPE1	C9JPE1_HUMAN	Mitochondrial carnitine/acylcarniti... Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	228	Annotation score:
F8WEF6	F8WEF6_HUMAN	Mitochondrial carnitine/acylcarniti... Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	76	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	203	R → S in CAB55356 (PubMed:9837782).Curated		1
Sequence conflictⁱ	240	A → G in CAB55356 (PubMed:9837782).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021818	133	R → W in CACTD. 1 PublicationCorresponds to variant dbSNP:rs748394731Ensembl.	1
Natural variantⁱVAR_021819	231	D → H in CACTD. 1 PublicationCorresponds to variant dbSNP:rs577331691Ensembl.	1
Natural variantⁱVAR_021820	238	Q → R in CACTD. 2 PublicationsCorresponds to variant dbSNP:rs28934589EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10319 mRNA Translation: CAA71367.1 Y17775 , Y17776, Y17777, Y17778, Y17779 Genomic DNA Translation: CAB55356.1 AK312962 mRNA Translation: BAG35801.1 BC001689 mRNA Translation: AAH01689.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2779.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000378.1, NM_000387.5
UniGeneⁱ	Hs.13845

Genome annotation databases

Ensemblⁱ	ENST00000319017; ENSP00000326305; ENSG00000178537
GeneIDⁱ	788
KEGGⁱ	hsa:788
UCSC genome browser More...UCSCⁱ	uc003cva.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43772	SLC25A20 isoform 1		PANTR		301	UniRef100_O43772
Uncharacterized protein		PANPA		301
Uncharacterized protein		NOMLE		301
cDNA FLJ53016, highly similar to Mitochondrial carnitine/acylcarnitine carrier protein		HUMAN		251

Protein	Similar proteins		Species	Score	Length	Source
O43772	Mitochondrial carnitine/acylcarnitine carrier protein		MOUSE		301	UniRef90_O43772
Mitochondrial carnitine/acylcarnitine carrier protein		MACFA		301
SLC25A20 isoform 1		PANTR		301
Uncharacterized protein		PANPA		301
Uncharacterized protein		NOMLE		301
+111

Protein	Similar proteins		Species	Score	Length	Source
O43772	Mitochondrial carnitine/acylcarnitine carrier protein		MOUSE		301	UniRef50_O43772
Mitochondrial carnitine/acylcarnitine carrier protein		MACFA		301
SLC25A20 isoform 1		PANTR		301
Uncharacterized protein		PANPA		301
Uncharacterized protein		NOMLE		301
+134

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10319 mRNA Translation: CAA71367.1 Y17775 , Y17776, Y17777, Y17778, Y17779 Genomic DNA Translation: CAB55356.1 AK312962 mRNA Translation: BAG35801.1 BC001689 mRNA Translation: AAH01689.1
CCDSⁱ	CCDS2779.1
RefSeqⁱ	NP_000378.1, NM_000387.5
UniGeneⁱ	Hs.13845

3D structure databases

ProteinModelPortalⁱ	O43772
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107241, 22 interactors
IntActⁱ	O43772, 6 interactors
STRINGⁱ	9606.ENSP00000326305

Chemistry databases

BindingDBⁱ	O43772
ChEMBLⁱ	CHEMBL2216740
DrugBankⁱ	DB00583 L-Carnitine

Protein family/group databases

TCDBⁱ	2.A.29.8.3 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.8.3 the mitochondrial carrier (mc) family

PTM databases

iPTMnetⁱ	O43772
PhosphoSitePlusⁱ	O43772

Polymorphism and mutation databases

BioMutaⁱ	SLC25A20

BioMutaⁱ

SLC25A20

Proteomic databases

EPDⁱ	O43772
MaxQBⁱ	O43772
PaxDbⁱ	O43772
PeptideAtlasⁱ	O43772
PRIDEⁱ	O43772
ProteomicsDBⁱ	49166
TopDownProteomicsⁱ	O43772

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	788
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000319017; ENSP00000326305; ENSG00000178537
GeneIDⁱ	788
KEGGⁱ	hsa:788
UCSCⁱ	uc003cva.5 human

Organism-specific databases

CTDⁱ	788
DisGeNETⁱ	788
EuPathDBⁱ	HostDB:ENSG00000178537.9
GeneCardsⁱ	SLC25A20
HGNCⁱ	HGNC:1421 SLC25A20
HPAⁱ	HPA016862 HPA029863
MalaCardsⁱ	SLC25A20
MIMⁱ	212138 phenotype 613698 gene
neXtProtⁱ	NX_O43772
OpenTargetsⁱ	ENSG00000178537
Orphanetⁱ	159 Carnitine-acylcarnitine translocase deficiency
PharmGKBⁱ	PA35031
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0758 Eukaryota ENOG410XS86 LUCA
GeneTreeⁱ	ENSGT00700000104295
HOGENOMⁱ	HOG000168307
HOVERGENⁱ	HBG003500
InParanoidⁱ	O43772
KOⁱ	K15109
OMAⁱ	NIVAPNF
OrthoDBⁱ	EOG091G0HVE
PhylomeDBⁱ	O43772
TreeFamⁱ	TF300894

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000178537-MONOMER
Reactomeⁱ	R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix
SIGNORⁱ	O43772

Miscellaneous databases

GenomeRNAiⁱ	788
Protein Ontology More...PROⁱ	PR:O43772
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000178537 Expressed in 223 organ(s), highest expression level in liver
CleanExⁱ	HS_SLC25A20
ExpressionAtlasⁱ	O43772 baseline and differential
Genevisibleⁱ	O43772 HS

Family and domain databases

Gene3Dⁱ	1.50.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit
Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MCAT_HUMAN
Accessionⁱ	O43772Primary (citable) accession number: O43772 Secondary accession number(s): B2R7F4, Q9UIQ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	June 1, 1998
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniRef

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Supporting data

UniProtKB - O43772 (MCAT_HUMAN)

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Mitochondrial carnitine/acylcarnitine carrier protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytosol

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ