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Protein

Alpha-endosulfine

Gene

ENSA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ion channel inhibitor activity Source: ProtInc
  • phosphatase inhibitor activity Source: UniProtKB
  • potassium channel inhibitor activity Source: MGI
  • protein phosphatase 2A binding Source: UniProtKB
  • protein phosphatase inhibitor activity Source: GO_Central
  • protein phosphatase regulator activity Source: UniProtKB
  • signaling receptor binding Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtein phosphatase inhibitor
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2465910 MASTL Facilitates Mitotic Progression

SIGNOR Signaling Network Open Resource

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SIGNORi
O43768

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-endosulfine
Alternative name(s):
ARPP-19e
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENSA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000143420.17

Human Gene Nomenclature Database

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HGNCi
HGNC:3360 ENSA

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603061 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O43768

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi109S → E: Mimicks a phosphorylated state and impairs interaction with SNCA. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2029

Open Targets

More...
OpenTargetsi
ENSG00000143420

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27796

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ENSA

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001467582 – 121Alpha-endosulfineAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei21PhosphothreonineCombined sources1
Modified residuei43PhosphoserineCombined sources1
Modified residuei67Phosphoserine; by GWLBy similarity1
Modified residuei109Phosphoserine; by PKACombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.By similarity2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O43768

MaxQB - The MaxQuant DataBase

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MaxQBi
O43768

PeptideAtlas

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PeptideAtlasi
O43768

PRoteomics IDEntifications database

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PRIDEi
O43768

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49158
49159 [O43768-2]
49160 [O43768-3]
49161 [O43768-4]
49162 [O43768-5]
49163 [O43768-6]
49164 [O43768-7]
49165 [O43768-8]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O43768-1 [O43768-1]
O43768-2 [O43768-2]
O43768-3 [O43768-3]
O43768-5 [O43768-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43768

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43768

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000143420 Expressed in 235 organ(s), highest expression level in vagina

CleanEx database of gene expression profiles

More...
CleanExi
HS_ENSA

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O43768 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43768 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051294

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (when phosphorylated at Ser-67) with PPP2R2D (By similarity). Interacts with ABCC8. Interacts with SNCA; interaction is disrupted when phosphorylated at Ser-109.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ACDQ96AP02EBI-714511,EBI-717666

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108343, 34 interactors

Protein interaction database and analysis system

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IntActi
O43768, 10 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O43768

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the endosulfine family.Curated

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155413

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000297

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43768

Database for complete collections of gene phylogenies

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PhylomeDBi
O43768

TreeFam database of animal gene trees

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TreeFami
TF314718

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006760 Endosulphine

The PANTHER Classification System

More...
PANTHERi
PTHR10358 PTHR10358, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04667 Endosulfine, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43768-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG
60 70 80 90 100
SDFLMKRLQK GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP
110 120
QDLPQRKSSL VTSKLAGGQV E
Length:121
Mass (Da):13,389
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C76315AA17E7542
GO
Isoform 2 (identifier: O43768-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     118-121: Missing.

Show »
Length:117
Mass (Da):12,976
Checksum:iD17E754219767472
GO
Isoform 3 (identifier: O43768-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-61: G → GDYKSLHWSVLLCADEM

Show »
Length:137
Mass (Da):15,281
Checksum:iE9CF169C48A1FC1B
GO
Isoform 4 (identifier: O43768-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-61: G → GVWGIASYPLSLGLKEVLRMKSVE
     118-121: Missing.

Show »
Length:140
Mass (Da):15,534
Checksum:i2AB6570AFD91E54D
GO
Isoform 5 (identifier: O43768-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.
     5-19: QEEENPAEETGEEKQ → MAGGLGCDVCYWFVE

Show »
Length:117
Mass (Da):12,818
Checksum:iEEE3B2739FD70FC2
GO
Isoform 6 (identifier: O43768-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.
     5-19: QEEENPAEETGEEKQ → MAGGLGCDVCYWFVE
     118-121: Missing.

Show »
Length:113
Mass (Da):12,404
Checksum:iCFD70FC2E5FE760C
GO
Isoform 7 (identifier: O43768-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.
     5-19: QEEENPAEETGEEKQ → MAGGLGCDVCYWFVE
     61-61: G → GDYKSLHWSVLLCADEM

Show »
Length:133
Mass (Da):14,710
Checksum:i852736F0B466D4AB
GO
Isoform 8 (identifier: O43768-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-121: QKYFDSGDYN...TSKLAGGQVE → VWGIVSYPLS...LNRSRGEFEI

Show »
Length:105
Mass (Da):11,990
Checksum:iE6306F60528ECCA4
GO
Isoform 9 (identifier: O43768-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-61: G → GDYKSLHWSVLLCADEM
     118-121: Missing.

Note: No experimental confirmation available.
Show »
Length:133
Mass (Da):14,868
Checksum:i28A1FC1BE09A3895
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NMQ3A6NMQ3_HUMAN
Alpha-endosulfine
ENSA
140Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRU0A0A1W2PRU0_HUMAN
Alpha-endosulfine
ENSA
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T5H1Q5T5H1_HUMAN
Alpha-endosulfine
ENSA
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5Q → R in CAG38815 (Ref. 8) Curated1
Sequence conflicti21T → M in BAF82753 (PubMed:14702039).Curated1
Sequence conflicti22Q → L in AAH68544 (PubMed:15489334).Curated1
Sequence conflicti114K → Q in CAG33411 (Ref. 8) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0370631 – 4Missing in isoform 5, isoform 6 and isoform 7. 1 Publication4
Alternative sequenceiVSP_0370645 – 19QEEEN…GEEKQ → MAGGLGCDVCYWFVE in isoform 5, isoform 6 and isoform 7. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_03706561G → GDYKSLHWSVLLCADEM in isoform 3, isoform 7 and isoform 9. 1 Publication1
Alternative sequenceiVSP_03706661G → GVWGIASYPLSLGLKEVLRM KSVE in isoform 4. 1 Publication1
Alternative sequenceiVSP_03706762 – 121QKYFD…GGQVE → VWGIVSYPLSLELKEVLRMK SVEVLLDPFLEVLLLNRSRG EFEI in isoform 8. CuratedAdd BLAST60
Alternative sequenceiVSP_001443118 – 121Missing in isoform 2, isoform 4, isoform 6 and isoform 9. 5 Publications4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X99906 mRNA Translation: CAA68180.1
AJ010966 Genomic DNA Translation: CAB65125.1
AY326403
, AY326400, AY326401, AY326402 Genomic DNA Translation: AAQ73827.1
AY326403
, AY326400, AY326401, AY326402 Genomic DNA Translation: AAQ73828.1
AY326402, AY326400, AY326401 Genomic DNA Translation: AAQ73829.1
AY326401, AY326400 Genomic DNA Translation: AAQ73830.1
AY326403
, AY326400, AY326401, AY326402 Genomic DNA Translation: AAQ73831.1
AY326403
, AY326400, AY326401, AY326402 Genomic DNA Translation: AAQ73832.1
AF067170 mRNA Translation: AAD32454.1
AF157509 mRNA Translation: AAF80340.1
AF157510 mRNA Translation: AAF80341.1
AK001981 mRNA Translation: BAG50998.1
AK290064 mRNA Translation: BAF82753.1
DA888224 mRNA No translation available.
CR749580 mRNA Translation: CAH18372.1
CR457130 mRNA Translation: CAG33411.1
CR536578 mRNA Translation: CAG38815.1
AL356356 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53528.1
CH471121 Genomic DNA Translation: EAW53529.1
CH471121 Genomic DNA Translation: EAW53530.1
CH471121 Genomic DNA Translation: EAW53532.1
CH471121 Genomic DNA Translation: EAW53533.1
BC000436 mRNA Translation: AAH00436.1
BC004461 mRNA Translation: AAH04461.1
BC068544 mRNA Translation: AAH68544.1
BC069208 mRNA Translation: AAH69208.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS958.1 [O43768-1]
CCDS959.1 [O43768-3]
CCDS960.1 [O43768-7]
CCDS961.1 [O43768-5]
CCDS962.1 [O43768-9]
CCDS963.1 [O43768-2]
CCDS964.1 [O43768-6]
CCDS965.1 [O43768-8]

NCBI Reference Sequences

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RefSeqi
NP_004427.1, NM_004436.2 [O43768-1]
NP_996925.1, NM_207042.1 [O43768-3]
NP_996926.1, NM_207043.1 [O43768-9]
NP_996927.1, NM_207044.1 [O43768-2]
NP_996928.1, NM_207045.1 [O43768-7]
NP_996929.1, NM_207046.1 [O43768-5]
NP_996930.1, NM_207047.1 [O43768-6]
NP_997051.1, NM_207168.1 [O43768-8]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.632456

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000271690; ENSP00000271690; ENSG00000143420 [O43768-2]
ENST00000339643; ENSP00000341743; ENSG00000143420 [O43768-3]
ENST00000361532; ENSP00000354835; ENSG00000143420 [O43768-5]
ENST00000361631; ENSP00000355239; ENSG00000143420 [O43768-7]
ENST00000362052; ENSP00000355220; ENSG00000143420 [O43768-8]
ENST00000369014; ENSP00000358010; ENSG00000143420 [O43768-1]
ENST00000503241; ENSP00000424242; ENSG00000143420 [O43768-9]
ENST00000503345; ENSP00000421458; ENSG00000143420 [O43768-8]
ENST00000509582; ENSP00000426110; ENSG00000143420 [O43768-8]
ENST00000513281; ENSP00000422343; ENSG00000143420 [O43768-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2029

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2029

UCSC genome browser

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UCSCi
uc001evb.4 human [O43768-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99906 mRNA Translation: CAA68180.1
AJ010966 Genomic DNA Translation: CAB65125.1
AY326403
, AY326400, AY326401, AY326402 Genomic DNA Translation: AAQ73827.1
AY326403
, AY326400, AY326401, AY326402 Genomic DNA Translation: AAQ73828.1
AY326402, AY326400, AY326401 Genomic DNA Translation: AAQ73829.1
AY326401, AY326400 Genomic DNA Translation: AAQ73830.1
AY326403
, AY326400, AY326401, AY326402 Genomic DNA Translation: AAQ73831.1
AY326403
, AY326400, AY326401, AY326402 Genomic DNA Translation: AAQ73832.1
AF067170 mRNA Translation: AAD32454.1
AF157509 mRNA Translation: AAF80340.1
AF157510 mRNA Translation: AAF80341.1
AK001981 mRNA Translation: BAG50998.1
AK290064 mRNA Translation: BAF82753.1
DA888224 mRNA No translation available.
CR749580 mRNA Translation: CAH18372.1
CR457130 mRNA Translation: CAG33411.1
CR536578 mRNA Translation: CAG38815.1
AL356356 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53528.1
CH471121 Genomic DNA Translation: EAW53529.1
CH471121 Genomic DNA Translation: EAW53530.1
CH471121 Genomic DNA Translation: EAW53532.1
CH471121 Genomic DNA Translation: EAW53533.1
BC000436 mRNA Translation: AAH00436.1
BC004461 mRNA Translation: AAH04461.1
BC068544 mRNA Translation: AAH68544.1
BC069208 mRNA Translation: AAH69208.1
CCDSiCCDS958.1 [O43768-1]
CCDS959.1 [O43768-3]
CCDS960.1 [O43768-7]
CCDS961.1 [O43768-5]
CCDS962.1 [O43768-9]
CCDS963.1 [O43768-2]
CCDS964.1 [O43768-6]
CCDS965.1 [O43768-8]
RefSeqiNP_004427.1, NM_004436.2 [O43768-1]
NP_996925.1, NM_207042.1 [O43768-3]
NP_996926.1, NM_207043.1 [O43768-9]
NP_996927.1, NM_207044.1 [O43768-2]
NP_996928.1, NM_207045.1 [O43768-7]
NP_996929.1, NM_207046.1 [O43768-5]
NP_996930.1, NM_207047.1 [O43768-6]
NP_997051.1, NM_207168.1 [O43768-8]
UniGeneiHs.632456

3D structure databases

ProteinModelPortaliO43768
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108343, 34 interactors
IntActiO43768, 10 interactors

PTM databases

iPTMnetiO43768
PhosphoSitePlusiO43768

Polymorphism and mutation databases

BioMutaiENSA

Proteomic databases

EPDiO43768
MaxQBiO43768
PeptideAtlasiO43768
PRIDEiO43768
ProteomicsDBi49158
49159 [O43768-2]
49160 [O43768-3]
49161 [O43768-4]
49162 [O43768-5]
49163 [O43768-6]
49164 [O43768-7]
49165 [O43768-8]
TopDownProteomicsiO43768-1 [O43768-1]
O43768-2 [O43768-2]
O43768-3 [O43768-3]
O43768-5 [O43768-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2029
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271690; ENSP00000271690; ENSG00000143420 [O43768-2]
ENST00000339643; ENSP00000341743; ENSG00000143420 [O43768-3]
ENST00000361532; ENSP00000354835; ENSG00000143420 [O43768-5]
ENST00000361631; ENSP00000355239; ENSG00000143420 [O43768-7]
ENST00000362052; ENSP00000355220; ENSG00000143420 [O43768-8]
ENST00000369014; ENSP00000358010; ENSG00000143420 [O43768-1]
ENST00000503241; ENSP00000424242; ENSG00000143420 [O43768-9]
ENST00000503345; ENSP00000421458; ENSG00000143420 [O43768-8]
ENST00000509582; ENSP00000426110; ENSG00000143420 [O43768-8]
ENST00000513281; ENSP00000422343; ENSG00000143420 [O43768-6]
GeneIDi2029
KEGGihsa:2029
UCSCiuc001evb.4 human [O43768-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2029
DisGeNETi2029
EuPathDBiHostDB:ENSG00000143420.17

GeneCards: human genes, protein and diseases

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GeneCardsi
ENSA
HGNCiHGNC:3360 ENSA
HPAiHPA051294
MIMi603061 gene
neXtProtiNX_O43768
OpenTargetsiENSG00000143420
PharmGKBiPA27796

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155413
HOVERGENiHBG000297
InParanoidiO43768
PhylomeDBiO43768
TreeFamiTF314718

Enzyme and pathway databases

ReactomeiR-HSA-2465910 MASTL Facilitates Mitotic Progression
SIGNORiO43768

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ENSA human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ENSA_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2029

Protein Ontology

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PROi
PR:O43768

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143420 Expressed in 235 organ(s), highest expression level in vagina
CleanExiHS_ENSA
ExpressionAtlasiO43768 baseline and differential
GenevisibleiO43768 HS

Family and domain databases

InterProiView protein in InterPro
IPR006760 Endosulphine
PANTHERiPTHR10358 PTHR10358, 1 hit
PfamiView protein in Pfam
PF04667 Endosulfine, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENSA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43768
Secondary accession number(s): A8K1Z9
, E9PB69, Q5T5H2, Q68D48, Q6FHW0, Q6IAM4, Q6NUL2, Q6VUC6, Q6VUC7, Q6VUC8, Q6VUC9, Q6VUD0, Q6VUD1, Q9NRZ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 1, 1998
Last modified: December 5, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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