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UniProtKB - O43765 (SGTA_HUMAN)

Entry version 205 (25 May 2022)
Sequence version 1 (01 Jun 1998)
Previous versions | rss
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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Gene

SGTA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892).

Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892).

Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373).

It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605).

Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484).

Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).

6 Publications

(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processHost-virus interaction

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43765

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9609523, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O43765

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Alternative name(s):
Alpha-SGT
Vpu-binding protein
Short name:
UBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SGTA
Synonyms:SGT, SGT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10819, SGTA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603419, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43765

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000104969

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38C → A: Reduces tail-anchored proteins transfer. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6449

Open Targets

More...OpenTargetsi		ENSG00000104969

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35727

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43765, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SGTA

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001063651 – 313Small glutamine-rich tetratricopeptide repeat-containing protein alphaAdd BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei77PhosphoserineCombined sources1
Modified residuei81PhosphothreonineCombined sources1
Modified residuei84PhosphoserineBy similarity1
Modified residuei137N6-acetyllysineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei303PhosphothreonineCombined sources1
Modified residuei305PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43765

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43765

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43765

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43765

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43765

PeptideAtlas

More...PeptideAtlasi		O43765

PRoteomics IDEntifications database

More...PRIDEi		O43765

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49156

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O43765

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O43765, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43765

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43765

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O43765

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000104969, Expressed in C1 segment of cervical spinal cord and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43765, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43765, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000104969, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:15708368). Homooligomer (By similarity).

Interacts with DNAJC5 and DNAJC5B.

Interacts (via TPR repeats) with HSP90AA1 (PubMed:15708368).

Interacts (via Gln-rich region) with SLC2A1 (PubMed:15708368).

Interacts with HSP90AB1 (PubMed:16580629).

Interacts (via TPR repeats) with HSPA8/Hsc70; the interaction is direct (PubMed:24675744).

Interacts with BAG6 (via ubiquitin-like domain); interaction prevents interaction between BAG6 and RNF126 (PubMed:23129660, PubMed:25179605, PubMed:27193484).

Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct (PubMed:24675744).

By similarity8 Publications

(Microbial infection) Interacts with Vpu and Gag from HIV-1.

2 Publications

(Microbial infection) Interacts with SARS-CoV accessory protein 7a.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O43765
With#Exp.IntAct
ADAM21 [Q9UKJ8]3EBI-347996,EBI-12046857
ADIPOQ [A8K660]3EBI-347996,EBI-10174479
ADIPOQ [Q15848]7EBI-347996,EBI-10827839
AGR2 [O95994]3EBI-347996,EBI-712648
AGR3 [Q8TD06]6EBI-347996,EBI-3925742
AOC3 [Q16853]3EBI-347996,EBI-3921628
BAG2 [O95816]2EBI-347996,EBI-355275
BAG6 [P46379]6EBI-347996,EBI-347552
BAG6 - isoform 2 [P46379-2]3EBI-347996,EBI-10988864
BTC [P35070]6EBI-347996,EBI-6590057
C1QL4 [Q86Z23]3EBI-347996,EBI-12062109
C1QTNF1 [Q9BXJ1]4EBI-347996,EBI-750200
C1QTNF5 [Q9BXJ0]3EBI-347996,EBI-19947914
C1QTNF6 [Q9BXI9]9EBI-347996,EBI-10301084
C5orf46 [Q6UWT4]3EBI-347996,EBI-11986083
CD79B [P40259]6EBI-347996,EBI-2873732
CD99L2 [Q8TCZ2]8EBI-347996,EBI-2824782
CDH15 [P55291]8EBI-347996,EBI-10215061
CHRNG - isoform 2 [P07510-2]3EBI-347996,EBI-11979451
COL1A2 [A0A0S2Z3K0]3EBI-347996,EBI-16431143
COL1A2 [P08123]11EBI-347996,EBI-983038
COL8A2 [Q4VAQ0]3EBI-347996,EBI-10241815
CREB3L3 [Q68CJ9]3EBI-347996,EBI-852194
CSF1 [P09603]6EBI-347996,EBI-2872294
CST1 [P01037]3EBI-347996,EBI-1056240
CTAG1B [P78358]3EBI-347996,EBI-1188472
CTSL [P07711]3EBI-347996,EBI-1220160
CYB5R1 [Q9UHQ9]3EBI-347996,EBI-953870
DEFB131A [P59861]5EBI-347996,EBI-12304807
DKK3 [Q9UBP4]3EBI-347996,EBI-954409
DMKN [Q6E0U4]3EBI-347996,EBI-7943171
EDA2R [Q9HAV5]3EBI-347996,EBI-526033
EDAR - isoform 2 [Q9UNE0-2]3EBI-347996,EBI-12964110
EFEMP1 [A0A0S2Z3V1]3EBI-347996,EBI-16434097
EFEMP1 [Q12805]14EBI-347996,EBI-536772
EFEMP2 [O95967]7EBI-347996,EBI-743414
ERP27 [Q96DN0]7EBI-347996,EBI-953772
ERP29 [P30040]3EBI-347996,EBI-946830
ETNK1 [Q9HBU6]3EBI-347996,EBI-2834493
EVA1B [Q9NVM1]6EBI-347996,EBI-10314666
F11R [Q9Y624]11EBI-347996,EBI-742600
FERD3L [Q96RJ6]3EBI-347996,EBI-10183007
FGF21 [Q9NSA1]3EBI-347996,EBI-3909329
FKBP7 [Q9Y680]6EBI-347996,EBI-3918971
FSTL1 [Q12841]3EBI-347996,EBI-2349801
FXYD2 - isoform 2 [P54710-2]5EBI-347996,EBI-13084584
FXYD7 [P58549]8EBI-347996,EBI-10216171
FZD7 [O75084]3EBI-347996,EBI-746917
GAL [P22466]6EBI-347996,EBI-6624768
GALP [Q9UBC7]3EBI-347996,EBI-12244186
GIP [P09681]6EBI-347996,EBI-8588553
GPErik [Q14440]3EBI-347996,EBI-10232920
GPX7 [Q96SL4]7EBI-347996,EBI-749411
GRN [P28799]7EBI-347996,EBI-747754
GUCA2A [Q02747]8EBI-347996,EBI-12244272
GYPA [A0A0C4DFT7]3EBI-347996,EBI-12044847
GYPA [B8Q183]4EBI-347996,EBI-10176190
GYPA [P02724]3EBI-347996,EBI-702665
HSPA13 [P48723]8EBI-347996,EBI-750892
IER3 [P46695]6EBI-347996,EBI-1748945
IGFBP6 [P24592]3EBI-347996,EBI-947015
IGL@ [Q6PIQ7]3EBI-347996,EBI-6677651
IGL@ [Q8N355]4EBI-347996,EBI-748681
IL6ST [P40189]3EBI-347996,EBI-1030834
IRF3 [Q14653]3EBI-347996,EBI-2650369
IRF5 [Q13568]3EBI-347996,EBI-3931258
ITPRIPL1 [Q6GPH6]3EBI-347996,EBI-953819
ITPRIPL1 - isoform 2 [Q6GPH6-2]3EBI-347996,EBI-12337095
KASH5 [Q8N6L0]8EBI-347996,EBI-749265
KCNA1 [Q09470]3EBI-347996,EBI-8286599
KCNA10 [Q16322]3EBI-347996,EBI-12265328
KCNE5 [Q9UJ90]3EBI-347996,EBI-11981259
KRT6A [P02538]3EBI-347996,EBI-702198
KTN1 [Q86UP2]3EBI-347996,EBI-359761
KTN1 - isoform 3 [Q86UP2-3]3EBI-347996,EBI-12007212
LAIR2 [Q6ISS4]6EBI-347996,EBI-10250491
LAT [O43561]3EBI-347996,EBI-1222766
LAT - isoform 2 [O43561-2]3EBI-347996,EBI-8070286
LCN2 [P80188]5EBI-347996,EBI-11911016
LDLRAD4 - isoform Alpha-2 [O15165-2]3EBI-347996,EBI-13302279
LSMEM2 [Q8N112]3EBI-347996,EBI-10264855
MRAP2 [Q96G30]6EBI-347996,EBI-9537218
MS4A3 [Q96HJ5]3EBI-347996,EBI-12806656
MSMB [P08118]3EBI-347996,EBI-10195681
MYDGF [Q969H8]8EBI-347996,EBI-718622
MYOC [Q99972]3EBI-347996,EBI-11692272
NAXD [Q8IW45]7EBI-347996,EBI-8650724
NME3 [Q13232]12EBI-347996,EBI-713684
NPVF [Q9HCQ7]3EBI-347996,EBI-1753111
NRSN2 [Q9GZP1]3EBI-347996,EBI-724857
PAGE3 [Q5JUK9]6EBI-347996,EBI-10244544
PAUF [C3PTT6]3EBI-347996,EBI-3505892
PBXIP1 [Q96AQ6]4EBI-347996,EBI-740845
PCDHA4 [Q9UN74]3EBI-347996,EBI-712273
PCDHGA4 [Q9Y5G9]3EBI-347996,EBI-12956949
PGLYRP2 - isoform 2 [Q96PD5-2]3EBI-347996,EBI-12758027
PLAAT4 [Q9UL19]4EBI-347996,EBI-10323452
PMEPA1 - isoform 2 [Q969W9-2]3EBI-347996,EBI-13318883
PPIB [P23284]6EBI-347996,EBI-359252
PPIC [P45877]6EBI-347996,EBI-953909
PRAP1 [Q96NZ9]9EBI-347996,EBI-2116102
PRRG2 [Q8TAS3]3EBI-347996,EBI-10272071
PSORS1C2 [Q9UIG4]5EBI-347996,EBI-11974061
RCN1 [Q15293]3EBI-347996,EBI-948278
RNASE10 [Q5GAN6]5EBI-347996,EBI-12423312
RNF144A [P50876]3EBI-347996,EBI-2340657
RNF170 - isoform 5 [Q96K19-5]3EBI-347996,EBI-12055631
RPN1 [P04843]7EBI-347996,EBI-355963
SDC4 [P31431]6EBI-347996,EBI-3913237
SDF2L1 [Q9HCN8]3EBI-347996,EBI-2339921
SERPINE1 [P05121]6EBI-347996,EBI-953978
SERPINI2 [O75830]3EBI-347996,EBI-750144
SGCA [Q16586]13EBI-347996,EBI-5663553
SGCA - isoform SGCA-2 [Q16586-2]4EBI-347996,EBI-16434133
itself4EBI-347996,EBI-347996
SGTB [Q96EQ0]3EBI-347996,EBI-744081
SHISA4 [Q96DD7]3EBI-347996,EBI-18035902
SHISA5 - isoform 3 [Q8N114-3]3EBI-347996,EBI-13369834
SLPI [P03973]6EBI-347996,EBI-355293
SMAGP [Q0VAQ4]3EBI-347996,EBI-10226799
SMIM14 [Q96QK8]3EBI-347996,EBI-373430
SMIM5 [Q71RC9]9EBI-347996,EBI-12334905
SOD3 [P08294]3EBI-347996,EBI-10195782
SPINK9 [Q5DT21]3EBI-347996,EBI-13119580
SPN [P16150]5EBI-347996,EBI-10049055
SPP1 [P10451]8EBI-347996,EBI-723648
SPPL2A [Q8TCT8]7EBI-347996,EBI-750784
SRGN [P10124]10EBI-347996,EBI-744915
SRL - isoform 1 [Q86TD4-2]3EBI-347996,EBI-12304565
STMP1 [E0CX11]3EBI-347996,EBI-18397783
SUOX [P51687]3EBI-347996,EBI-3921347
SYT11 [Q9BT88]7EBI-347996,EBI-751770
SYT4 [Q9H2B2]7EBI-347996,EBI-751132
TFF3 [Q07654]3EBI-347996,EBI-10224676
TFRC [P02786]6EBI-347996,EBI-355727
TGFA [P01135]3EBI-347996,EBI-1034374
TGFA - isoform 2 [P01135-2]6EBI-347996,EBI-12367411
TMEM154 [Q6P9G4]3EBI-347996,EBI-13329239
TMEM174 [Q8WUU8]6EBI-347996,EBI-10276729
TMEM230 - isoform 1 [Q96A57-2]3EBI-347996,EBI-17546822
TMEM31 [Q5JXX7]3EBI-347996,EBI-10244617
TMEM98 [Q9Y2Y6]3EBI-347996,EBI-7333781
TMPRSS11D [O60235]3EBI-347996,EBI-7639969
TMUB2 [Q71RG4]3EBI-347996,EBI-2820477
TNFRSF10C [O14798]3EBI-347996,EBI-717441
TNFRSF13B [O14836]3EBI-347996,EBI-519160
TNFRSF13B - isoform 2 [O14836-2]8EBI-347996,EBI-12023110
TNFRSF19 - isoform 2 [Q9NS68-2]3EBI-347996,EBI-12089038
TNFRSF21 [O75509]3EBI-347996,EBI-2313231
TNFSF12 [O43508]3EBI-347996,EBI-6932080
TRIM5 - isoform Gamma [Q9C035-3]3EBI-347996,EBI-12840050
TTMP [Q5BVD1]6EBI-347996,EBI-10243654
TWSG1 [Q9GZX9]3EBI-347996,EBI-10304067
TXNDC12 [O95881]3EBI-347996,EBI-2564581
UBL4A [P11441]5EBI-347996,EBI-356983
UBQLN2 [Q9UHD9]3EBI-347996,EBI-947187
UPK3A [O75631]3EBI-347996,EBI-10188907
VIP [P01282]3EBI-347996,EBI-751454
WBP1L [Q9NX94]3EBI-347996,EBI-10316321
WFDC12 [Q8WWY7]3EBI-347996,EBI-11958577
WFDC13 [Q8IUB5]5EBI-347996,EBI-12041955
WFDC5 [Q8TCV5]3EBI-347996,EBI-12175871
ZBTB8B [Q8NAP8]3EBI-347996,EBI-17494306
ZG16 [O60844]12EBI-347996,EBI-746479
ZG16B [Q96DA0]3EBI-347996,EBI-953824
A0A1U9X8X83EBI-347996,EBI-17234977
7a [P59635] from Severe acute respiratory syndrome coronavirus.3EBI-347996,EBI-25492879
7b [P0DTD8] from Severe acute respiratory syndrome coronavirus 2.3EBI-347996,EBI-25475914
9c [P0DTD3] from Severe acute respiratory syndrome coronavirus 2.3EBI-347996,EBI-25475917

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112347, 265 interactors

Protein interaction database and analysis system

More...IntActi		O43765, 212 interactors

Molecular INTeraction database

More...MINTi		O43765

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000221566

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43765, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O43765

Biological Magnetic Resonance Data Bank

More...BMRBi		O43765

Small Angle Scattering Biological Data Bank

More...SASBDBi		O43765

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43765

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O43765

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati91 – 124TPR 1Add BLAST34
Repeati125 – 158TPR 2Add BLAST34
Repeati159 – 192TPR 3Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni66 – 100DisorderedSequence analysisAdd BLAST35
Regioni250 – 269DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi80 – 100Basic and acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SGT family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0553, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159037

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_044224_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43765

Identification of Orthologs from Complete Genome Data

More...OMAi		MMCNLMS

Database of Orthologous Groups

More...OrthoDBi		687493at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43765

TreeFam database of animal gene trees

More...TreeFami		TF313092

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032374, SGTA_dimer
IPR011990, TPR-like_helical_dom_sf
IPR001440, TPR_1
IPR019734, TPR_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16546, SGTA_dimer, 1 hit
PF00515, TPR_1, 2 hits
PF13181, TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00028, TPR, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50005, TPR, 3 hits
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

O43765-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNKKRLAYA IIQFLHDQLR HGGLSSDAQE SLEVAIQCLE TAFGVTVEDS 
        60         70         80         90        100
DLALPQTLPE IFEAAATGKE MPQDLRSPAR TPPSEEDSAE AERLKTEGNE 
       110        120        130        140        150
QMKVENFEAA VHFYGKAIEL NPANAVYFCN RAAAYSKLGN YAGAVQDCER 
       160        170        180        190        200
AICIDPAYSK AYGRMGLALS SLNKHVEAVA YYKKALELDP DNETYKSNLK 
       210        220        230        240        250
IAELKLREAP SPTGGVGSFD IAGLLNNPGF MSMASNLMNN PQIQQLMSGM 
       260        270        280        290        300
ISGGNNPLGT PGTSPSQNDL ASLIQAGQQF AQQMQQQNPE LIEQLRSQIR 
       310 
SRTPSASNDD QQE
Length:313
Mass (Da):34,063
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80B3C71B41F3CB55
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMD6K7EMD6_HUMAN
Small glutamine-rich tetratricopept...
SGTA
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V4T9A0A7I2V4T9_HUMAN
Small glutamine-rich tetratricopept...
SGTA
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V2U2A0A7I2V2U2_HUMAN
Small glutamine-rich tetratricopept...
SGTA
287Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V588A0A7I2V588_HUMAN
Small glutamine-rich tetratricopept...
SGTA
360Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V5Z3A0A7I2V5Z3_HUMAN
Small glutamine-rich tetratricopept...
SGTA
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V697A0A7I2V697_HUMAN
Small glutamine-rich tetratricopept...
SGTA
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2YQY5A0A7I2YQY5_HUMAN
Small glutamine-rich tetratricopept...
SGTA
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERW5K7ERW5_HUMAN
Small glutamine-rich tetratricopept...
SGTA
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ223828 mRNA Translation: CAA11565.1
AJ133129 mRNA Translation: CAB39725.1
AF408399 mRNA Translation: AAL01051.1
AF368279 mRNA Translation: AAP29457.1
AL050156 mRNA Translation: CAB43297.2
CR533517 mRNA Translation: CAG38548.1
CR542282 mRNA Translation: CAG47077.1
AC006538 Genomic DNA Translation: AAD13117.1
CH471139 Genomic DNA Translation: EAW69366.1
CH471139 Genomic DNA Translation: EAW69367.1
CH471139 Genomic DNA Translation: EAW69368.1
BC000390 mRNA Translation: AAH00390.1
BC002989 mRNA Translation: AAH02989.2
BC005165 mRNA Translation: AAH05165.1
BC008885 mRNA Translation: AAH08885.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12094.1

NCBI Reference Sequences

More...RefSeqi		NP_003012.1, NM_003021.3
XP_011526480.1, XM_011528178.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000221566.7; ENSP00000221566.1; ENSG00000104969.11
ENST00000676943.1; ENSP00000504495.1; ENSG00000104969.11
ENST00000677149.1; ENSP00000503397.1; ENSG00000104969.11

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6449

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6449

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000221566.7; ENSP00000221566.1; NM_003021.4; NP_003012.1

UCSC genome browser

More...UCSCi		uc002lwi.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223828 mRNA Translation: CAA11565.1
AJ133129 mRNA Translation: CAB39725.1
AF408399 mRNA Translation: AAL01051.1
AF368279 mRNA Translation: AAP29457.1
AL050156 mRNA Translation: CAB43297.2
CR533517 mRNA Translation: CAG38548.1
CR542282 mRNA Translation: CAG47077.1
AC006538 Genomic DNA Translation: AAD13117.1
CH471139 Genomic DNA Translation: EAW69366.1
CH471139 Genomic DNA Translation: EAW69367.1
CH471139 Genomic DNA Translation: EAW69368.1
BC000390 mRNA Translation: AAH00390.1
BC002989 mRNA Translation: AAH02989.2
BC005165 mRNA Translation: AAH05165.1
BC008885 mRNA Translation: AAH08885.1
CCDSiCCDS12094.1
RefSeqiNP_003012.1, NM_003021.3
XP_011526480.1, XM_011528178.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VYIX-ray2.40A/B84-210[»]
4CPGNMR-A/B1-69[»]
4GODX-ray1.40A/B4-54[»]
4GOEX-ray1.45A/B4-54[»]
4GOFX-ray1.35A/B4-54[»]
AlphaFoldDBiO43765
BMRBiO43765
SASBDBiO43765
SMRiO43765
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112347, 265 interactors
IntActiO43765, 212 interactors
MINTiO43765
STRINGi9606.ENSP00000221566

PTM databases

GlyGeniO43765, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO43765
PhosphoSitePlusiO43765
SwissPalmiO43765

Genetic variation databases

BioMutaiSGTA

Proteomic databases

EPDiO43765
jPOSTiO43765
MassIVEiO43765
MaxQBiO43765
PaxDbiO43765
PeptideAtlasiO43765
PRIDEiO43765
ProteomicsDBi49156
TopDownProteomicsiO43765

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23040, 273 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		6449

Genome annotation databases

EnsembliENST00000221566.7; ENSP00000221566.1; ENSG00000104969.11
ENST00000676943.1; ENSP00000504495.1; ENSG00000104969.11
ENST00000677149.1; ENSP00000503397.1; ENSG00000104969.11
GeneIDi6449
KEGGihsa:6449
MANE-SelectiENST00000221566.7; ENSP00000221566.1; NM_003021.4; NP_003012.1
UCSCiuc002lwi.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6449
DisGeNETi6449

GeneCards: human genes, protein and diseases

More...GeneCardsi		SGTA
HGNCiHGNC:10819, SGTA
HPAiENSG00000104969, Low tissue specificity
MIMi603419, gene
neXtProtiNX_O43765
OpenTargetsiENSG00000104969
PharmGKBiPA35727
VEuPathDBiHostDB:ENSG00000104969

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0553, Eukaryota
GeneTreeiENSGT00940000159037
HOGENOMiCLU_044224_0_0_1
InParanoidiO43765
OMAiMMCNLMS
OrthoDBi687493at2759
PhylomeDBiO43765
TreeFamiTF313092

Enzyme and pathway databases

PathwayCommonsiO43765
ReactomeiR-HSA-9609523, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
SignaLinkiO43765

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6449, 18 hits in 1079 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SGTA, human
EvolutionaryTraceiO43765

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SGTA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6449
PharosiO43765, Tbio

Protein Ontology

More...PROi		PR:O43765
RNActiO43765, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000104969, Expressed in C1 segment of cervical spinal cord and 205 other tissues
ExpressionAtlasiO43765, baseline and differential
GenevisibleiO43765, HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR032374, SGTA_dimer
IPR011990, TPR-like_helical_dom_sf
IPR001440, TPR_1
IPR019734, TPR_repeat
PfamiView protein in Pfam
PF16546, SGTA_dimer, 1 hit
PF00515, TPR_1, 2 hits
PF13181, TPR_8, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 3 hits
SUPFAMiSSF48452, SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005, TPR, 3 hits
PS50293, TPR_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSGTA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43765
Secondary accession number(s): D6W610, Q6FIA9, Q9BTZ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: May 25, 2022
This is version 205 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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