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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Gene

SGTA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).6 Publications
(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • BAT3 complex binding Source: ParkinsonsUK-UCL
  • identical protein binding Source: IntAct
  • protein-containing complex scaffold activity Source: GO_Central
  • protein self-association Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processHost-virus interaction

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Alternative name(s):
Alpha-SGT
Vpu-binding protein
Short name:
UBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SGTA
Synonyms:SGT, SGT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000104969.9

Human Gene Nomenclature Database

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HGNCi
HGNC:10819 SGTA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603419 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43765

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38C → A: Reduces tail-anchored proteins transfer. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6449

Open Targets

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OpenTargetsi
ENSG00000104969

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35727

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SGTA

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001063651 – 313Small glutamine-rich tetratricopeptide repeat-containing protein alphaAdd BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei77PhosphoserineCombined sources1
Modified residuei81PhosphothreonineCombined sources1
Modified residuei84PhosphoserineBy similarity1
Modified residuei137N6-acetyllysineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei303PhosphothreonineCombined sources1
Modified residuei305PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43765

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O43765

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43765

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43765

PeptideAtlas

More...
PeptideAtlasi
O43765

PRoteomics IDEntifications database

More...
PRIDEi
O43765

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49156

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O43765

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43765

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43765

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104969 Expressed in 189 organ(s), highest expression level in C1 segment of cervical spinal cord

CleanEx database of gene expression profiles

More...
CleanExi
HS_SGTA

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O43765 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43765 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056309

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:15708368). Homooligomer (By similarity). Interacts with DNAJC5 and DNAJC5B. Interacts (via TPR repeats) with HSP90AA1 (PubMed:15708368). Interacts (via Gln-rich region) with SLC2A1 (PubMed:15708368). Interacts with HSP90AB1 (PubMed:16580629). Interacts (via TPR repeats) with HSPA8/Hsc70; the interaction is direct (PubMed:24675744). Interacts with BAG6 (via ubiquitin-like domain); interaction prevents interaction between BAG6 and RNF126 (PubMed:23129660, PubMed:25179605, PubMed:27193484). Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct (PubMed:24675744).By similarity8 Publications
(Microbial infection) Interacts with Vpu and Gag from HIV-1.2 Publications
(Microbial infection) Interacts with SARS-CoV accessory protein 7a.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-347996,EBI-347996
ADIPOQA8K6603EBI-347996,EBI-10174479
ADIPOQQ158485EBI-347996,EBI-10827839
AGR3Q8TD065EBI-347996,EBI-3925742
BAG2O958162EBI-347996,EBI-355275
BAG6P463795EBI-347996,EBI-347552
BTCP350705EBI-347996,EBI-6590057
C1QTNF1Q9BXJ14EBI-347996,EBI-750200
C1QTNF6Q9BXI93EBI-347996,EBI-10301084
CCDC155Q8N6L07EBI-347996,EBI-749265
CD79BP402596EBI-347996,EBI-2873732
CD99L2Q8TCZ25EBI-347996,EBI-2824782
CDH15P552915EBI-347996,EBI-10215061
COL1A2A0A0S2Z3K03EBI-347996,EBI-16431143
COL1A2P081238EBI-347996,EBI-983038
COL8A2Q4VAQ03EBI-347996,EBI-10241815
CSF1P096035EBI-347996,EBI-2872294
CST1P010373EBI-347996,EBI-1056240
CTSLP077113EBI-347996,EBI-1220160
EFEMP1A0A0S2Z3V13EBI-347996,EBI-16434097
EFEMP1Q1280512EBI-347996,EBI-536772
EFEMP2O959676EBI-347996,EBI-743414
ERP27Q96DN05EBI-347996,EBI-953772
EVA1BQ9NVM15EBI-347996,EBI-10314666
F11RQ9Y6249EBI-347996,EBI-742600
FERD3LQ96RJ63EBI-347996,EBI-10183007
FKBP7Q9Y6805EBI-347996,EBI-3918971
FXYD7P585497EBI-347996,EBI-10216171
GALP224665EBI-347996,EBI-6624768
GIPP096815EBI-347996,EBI-8588553
GPErikQ144403EBI-347996,EBI-10232920
GPX7Q96SL43EBI-347996,EBI-749411
GRNP287996EBI-347996,EBI-747754
GUCA2AQ027474EBI-347996,EBI-12244272
GYPAA0A0C4DFT73EBI-347996,EBI-12044847
GYPAB8Q1834EBI-347996,EBI-10176190
HSPA13P487235EBI-347996,EBI-750892
IER3P466954EBI-347996,EBI-1748945
IGL@Q6PIQ73EBI-347996,EBI-6677651
IGL@Q8N3554EBI-347996,EBI-748681
IRF3Q146533EBI-347996,EBI-2650369
IRF5Q135683EBI-347996,EBI-3931258
ITPRIPL1Q6GPH63EBI-347996,EBI-953819
KRT6AP025383EBI-347996,EBI-702198
KTN1Q86UP23EBI-347996,EBI-359761
LAIR2Q6ISS45EBI-347996,EBI-10250491
LATO435613EBI-347996,EBI-1222766
MSMBP081183EBI-347996,EBI-10195681
MYDGFQ969H85EBI-347996,EBI-718622
NAXDQ8IW456EBI-347996,EBI-8650724
NME3Q132328EBI-347996,EBI-713684
PAGE3Q5JUK94EBI-347996,EBI-10244544
PAUFC3PTT63EBI-347996,EBI-3505892
PBXIP1Q96AQ63EBI-347996,EBI-740845
PCDHA4Q9UN743EBI-347996,EBI-712273
PPIBP232845EBI-347996,EBI-359252
PPICP458775EBI-347996,EBI-953909
PRAP1Q96NZ95EBI-347996,EBI-2116102
RARRES3Q9UL193EBI-347996,EBI-10323452
RPN1P048435EBI-347996,EBI-355963
SDC4P314315EBI-347996,EBI-3913237
SERPINE1P051215EBI-347996,EBI-953978
SGCAQ1658612EBI-347996,EBI-5663553
SGCAQ16586-24EBI-347996,EBI-16434133
SLPIP039733EBI-347996,EBI-355293
SMAGPQ0VAQ43EBI-347996,EBI-10226799
SMIM5Q71RC94EBI-347996,EBI-12334905
SOD3P082943EBI-347996,EBI-10195782
SPP1P104518EBI-347996,EBI-723648
SPPL2AQ8TCT86EBI-347996,EBI-750784
SRGNP101248EBI-347996,EBI-744915
SYT11Q9BT886EBI-347996,EBI-751770
SYT4Q9H2B26EBI-347996,EBI-751132
TFF3Q076543EBI-347996,EBI-10224676
TFRCP027865EBI-347996,EBI-355727
TGFAP011353EBI-347996,EBI-1034374
TGFAP01135-24EBI-347996,EBI-12367411
TMEM174Q8WUU85EBI-347996,EBI-10276729
TMEM31Q5JXX73EBI-347996,EBI-10244617
TMUB2Q71RG43EBI-347996,EBI-2820477
TNFRSF13BO148363EBI-347996,EBI-519160
TNFRSF13BO14836-25EBI-347996,EBI-12023110
TTMPQ5BVD15EBI-347996,EBI-10243654
TWSG1Q9GZX93EBI-347996,EBI-10304067
TXNDC12O958813EBI-347996,EBI-2564581
UBL4AP114414EBI-347996,EBI-356983
UPK3AO756313EBI-347996,EBI-10188907
VIPP012823EBI-347996,EBI-751454
WBP1LQ9NX943EBI-347996,EBI-10316321
ZG16O608448EBI-347996,EBI-746479

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112347, 156 interactors

Protein interaction database and analysis system

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IntActi
O43765, 202 interactors

Molecular INTeraction database

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MINTi
O43765

STRING: functional protein association networks

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STRINGi
9606.ENSP00000221566

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VYIX-ray2.40A/B84-210[»]
4CPGNMR-A/B1-69[»]
4GODX-ray1.40A/B4-54[»]
4GOEX-ray1.45A/B4-54[»]
4GOFX-ray1.35A/B4-54[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O43765

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43765

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O43765

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati91 – 124TPR 1Add BLAST34
Repeati125 – 158TPR 2Add BLAST34
Repeati159 – 192TPR 3Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi275 – 287Gln-richAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SGT family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0553 Eukaryota
COG0457 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159037

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000208193

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000885

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43765

KEGG Orthology (KO)

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KOi
K16365

Identification of Orthologs from Complete Genome Data

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OMAi
NPGFMNM

Database of Orthologous Groups

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OrthoDBi
687493at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43765

TreeFam database of animal gene trees

More...
TreeFami
TF313092

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032374 SGTA_dimer
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16546 SGTA_dimer, 1 hit
PF00515 TPR_1, 2 hits
PF13181 TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O43765-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNKKRLAYA IIQFLHDQLR HGGLSSDAQE SLEVAIQCLE TAFGVTVEDS
60 70 80 90 100
DLALPQTLPE IFEAAATGKE MPQDLRSPAR TPPSEEDSAE AERLKTEGNE
110 120 130 140 150
QMKVENFEAA VHFYGKAIEL NPANAVYFCN RAAAYSKLGN YAGAVQDCER
160 170 180 190 200
AICIDPAYSK AYGRMGLALS SLNKHVEAVA YYKKALELDP DNETYKSNLK
210 220 230 240 250
IAELKLREAP SPTGGVGSFD IAGLLNNPGF MSMASNLMNN PQIQQLMSGM
260 270 280 290 300
ISGGNNPLGT PGTSPSQNDL ASLIQAGQQF AQQMQQQNPE LIEQLRSQIR
310
SRTPSASNDD QQE
Length:313
Mass (Da):34,063
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80B3C71B41F3CB55
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMD6K7EMD6_HUMAN
Small glutamine-rich tetratricopept...
SGTA
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERW5K7ERW5_HUMAN
Small glutamine-rich tetratricopept...
SGTA
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ223828 mRNA Translation: CAA11565.1
AJ133129 mRNA Translation: CAB39725.1
AF408399 mRNA Translation: AAL01051.1
AF368279 mRNA Translation: AAP29457.1
AL050156 mRNA Translation: CAB43297.2
CR533517 mRNA Translation: CAG38548.1
CR542282 mRNA Translation: CAG47077.1
AC006538 Genomic DNA Translation: AAD13117.1
CH471139 Genomic DNA Translation: EAW69366.1
CH471139 Genomic DNA Translation: EAW69367.1
CH471139 Genomic DNA Translation: EAW69368.1
BC000390 mRNA Translation: AAH00390.1
BC002989 mRNA Translation: AAH02989.2
BC005165 mRNA Translation: AAH05165.1
BC008885 mRNA Translation: AAH08885.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12094.1

NCBI Reference Sequences

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RefSeqi
NP_003012.1, NM_003021.3
XP_011526480.1, XM_011528178.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.203910

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000221566; ENSP00000221566; ENSG00000104969

Database of genes from NCBI RefSeq genomes

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GeneIDi
6449

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6449

UCSC genome browser

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UCSCi
uc002lwi.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223828 mRNA Translation: CAA11565.1
AJ133129 mRNA Translation: CAB39725.1
AF408399 mRNA Translation: AAL01051.1
AF368279 mRNA Translation: AAP29457.1
AL050156 mRNA Translation: CAB43297.2
CR533517 mRNA Translation: CAG38548.1
CR542282 mRNA Translation: CAG47077.1
AC006538 Genomic DNA Translation: AAD13117.1
CH471139 Genomic DNA Translation: EAW69366.1
CH471139 Genomic DNA Translation: EAW69367.1
CH471139 Genomic DNA Translation: EAW69368.1
BC000390 mRNA Translation: AAH00390.1
BC002989 mRNA Translation: AAH02989.2
BC005165 mRNA Translation: AAH05165.1
BC008885 mRNA Translation: AAH08885.1
CCDSiCCDS12094.1
RefSeqiNP_003012.1, NM_003021.3
XP_011526480.1, XM_011528178.2
UniGeneiHs.203910

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VYIX-ray2.40A/B84-210[»]
4CPGNMR-A/B1-69[»]
4GODX-ray1.40A/B4-54[»]
4GOEX-ray1.45A/B4-54[»]
4GOFX-ray1.35A/B4-54[»]
ProteinModelPortaliO43765
SMRiO43765
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112347, 156 interactors
IntActiO43765, 202 interactors
MINTiO43765
STRINGi9606.ENSP00000221566

PTM databases

iPTMnetiO43765
PhosphoSitePlusiO43765

Polymorphism and mutation databases

BioMutaiSGTA

Proteomic databases

EPDiO43765
jPOSTiO43765
MaxQBiO43765
PaxDbiO43765
PeptideAtlasiO43765
PRIDEiO43765
ProteomicsDBi49156
TopDownProteomicsiO43765

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6449
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221566; ENSP00000221566; ENSG00000104969
GeneIDi6449
KEGGihsa:6449
UCSCiuc002lwi.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6449
DisGeNETi6449
EuPathDBiHostDB:ENSG00000104969.9

GeneCards: human genes, protein and diseases

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GeneCardsi
SGTA
HGNCiHGNC:10819 SGTA
HPAiHPA056309
MIMi603419 gene
neXtProtiNX_O43765
OpenTargetsiENSG00000104969
PharmGKBiPA35727

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0553 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00940000159037
HOGENOMiHOG000208193
HOVERGENiHBG000885
InParanoidiO43765
KOiK16365
OMAiNPGFMNM
OrthoDBi687493at2759
PhylomeDBiO43765
TreeFamiTF313092

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SGTA human
EvolutionaryTraceiO43765

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SGTA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6449

Protein Ontology

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PROi
PR:O43765

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104969 Expressed in 189 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_SGTA
ExpressionAtlasiO43765 baseline and differential
GenevisibleiO43765 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR032374 SGTA_dimer
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF16546 SGTA_dimer, 1 hit
PF00515 TPR_1, 2 hits
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSGTA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43765
Secondary accession number(s): D6W610, Q6FIA9, Q9BTZ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: January 16, 2019
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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