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Protein

T-cell leukemia homeobox protein 2

Gene

TLX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi157 – 216HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiO43763

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 2
Alternative name(s):
Homeobox protein Hox-11L1
Neural crest homeobox protein
Gene namesi
Name:TLX2
Synonyms:HOX11L1, NCX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115297.10
HGNCiHGNC:5057 TLX2
MIMi604240 gene
neXtProtiNX_O43763

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3196
OpenTargetsiENSG00000115297
PharmGKBiPA35096

Polymorphism and mutation databases

BioMutaiTLX2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493361 – 284T-cell leukemia homeobox protein 2Add BLAST284

Proteomic databases

PaxDbiO43763
PRIDEiO43763
ProteomicsDBi49155

PTM databases

iPTMnetiO43763
PhosphoSitePlusiO43763

Expressioni

Gene expression databases

BgeeiENSG00000115297 Expressed in 46 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_TLX2
ExpressionAtlasiO43763 baseline and differential
GenevisibleiO43763 HS

Organism-specific databases

HPAiHPA040969
HPA062254

Interactioni

Protein-protein interaction databases

BioGridi109436, 9 interactors
ELMiO43763
IntActiO43763, 2 interactors
STRINGi9606.ENSP00000233638

Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43763
SMRiO43763
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43763

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 115Gly-richAdd BLAST89

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000116280
HOVERGENiHBG036206
InParanoidiO43763
KOiK15606
OMAiSGYGPSC
OrthoDBiEOG091G0RNV
PhylomeDBiO43763
TreeFamiTF325347

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O43763-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGMLGPHN LPHHEPISFG IDQILSGPET PGGGLGLGRG GQGHGENGAF
60 70 80 90 100
SGGYHGASGY GPAGSLAPLP GSSGVGPGGV IRVPAHRPLP VPPPAGGAPA
110 120 130 140 150
VPGPSGLGGA GGLAGLTFPW MDSGRRFAKD RLTAALSPFS GTRRIGHPYQ
160 170 180 190 200
NRTPPKRKKP RTSFSRSQVL ELERRFLRQK YLASAERAAL AKALRMTDAQ
210 220 230 240 250
VKTWFQNRRT KWRRQTAEER EAERHRAGRL LLHLQQDALP RPLRPPLPPD
260 270 280
PLCLHNSSLF ALQNLQPWAE DNKVASVSGL ASVV
Length:284
Mass (Da):30,251
Last modified:May 10, 2002 - v2
Checksum:i794B07A9E7817939
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1T0F2F1T0F2_HUMAN
T-cell leukemia homeobox protein 2
TLX2
235Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16P → A in CAA05636 (Ref. 2) Curated1
Sequence conflicti30 – 32TPG → PR in CAA05636 (Ref. 2) Curated3
Sequence conflicti37 – 48LGRGG…HGENG → WVAGQVIGEWA in CAA05636 (Ref. 2) CuratedAdd BLAST12
Sequence conflicti100 – 102Missing in CAA05636 (Ref. 2) Curated3
Sequence conflicti131 – 136RLTAAL → PAV in CAA05636 (Ref. 2) Curated6
Sequence conflicti196M → T no nucleotide entry (PubMed:7518789).Curated1
Sequence conflicti219Missing in CAA05636 (Ref. 2) Curated1
Sequence conflicti241R → T in CAA05636 (Ref. 2) Curated1
Sequence conflicti274V → A in CAA05636 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008501 mRNA Translation: BAA83463.1
AJ002607, AJ002608, AJ002609 Genomic DNA Translation: CAA05636.1
AC005041 Genomic DNA No translation available.
BC006356 mRNA Translation: AAH06356.1
CCDSiCCDS1947.1
RefSeqiNP_057254.1, NM_016170.4
UniGeneiHs.168586

Genome annotation databases

EnsembliENST00000233638; ENSP00000233638; ENSG00000115297
GeneIDi3196
KEGGihsa:3196
UCSCiuc002smb.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008501 mRNA Translation: BAA83463.1
AJ002607, AJ002608, AJ002609 Genomic DNA Translation: CAA05636.1
AC005041 Genomic DNA No translation available.
BC006356 mRNA Translation: AAH06356.1
CCDSiCCDS1947.1
RefSeqiNP_057254.1, NM_016170.4
UniGeneiHs.168586

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A03X-ray1.54A162-216[»]
ProteinModelPortaliO43763
SMRiO43763
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109436, 9 interactors
ELMiO43763
IntActiO43763, 2 interactors
STRINGi9606.ENSP00000233638

PTM databases

iPTMnetiO43763
PhosphoSitePlusiO43763

Polymorphism and mutation databases

BioMutaiTLX2

Proteomic databases

PaxDbiO43763
PRIDEiO43763
ProteomicsDBi49155

Protocols and materials databases

DNASUi3196
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233638; ENSP00000233638; ENSG00000115297
GeneIDi3196
KEGGihsa:3196
UCSCiuc002smb.3 human

Organism-specific databases

CTDi3196
DisGeNETi3196
EuPathDBiHostDB:ENSG00000115297.10
GeneCardsiTLX2
HGNCiHGNC:5057 TLX2
HPAiHPA040969
HPA062254
MIMi604240 gene
neXtProtiNX_O43763
OpenTargetsiENSG00000115297
PharmGKBiPA35096
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000116280
HOVERGENiHBG036206
InParanoidiO43763
KOiK15606
OMAiSGYGPSC
OrthoDBiEOG091G0RNV
PhylomeDBiO43763
TreeFamiTF325347

Enzyme and pathway databases

SignaLinkiO43763

Miscellaneous databases

EvolutionaryTraceiO43763
GeneWikiiTLX2
GenomeRNAii3196
PROiPR:O43763
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115297 Expressed in 46 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_TLX2
ExpressionAtlasiO43763 baseline and differential
GenevisibleiO43763 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTLX2_HUMAN
AccessioniPrimary (citable) accession number: O43763
Secondary accession number(s): Q9UD56, Q9UQ48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 10, 2002
Last modified: November 7, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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