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Protein

Synaptogyrin-3

Gene

SYNGR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptogyrin-3Curated
Gene namesi
Name:SYNGR3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000127561.14
HGNCiHGNC:11501 SYNGR3
MIMi603927 gene
neXtProtiNX_O43761

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127561
PharmGKBiPA36283

Polymorphism and mutation databases

BioMutaiSYNGR3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839961 – 229Synaptogyrin-3Add BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO43761
MaxQBiO43761
PaxDbiO43761
PeptideAtlasiO43761
PRIDEiO43761
ProteomicsDBi49154

PTM databases

iPTMnetiO43761
PhosphoSitePlusiO43761

Expressioni

Tissue specificityi

Expressed in brain and placenta.1 Publication

Gene expression databases

BgeeiENSG00000127561 Expressed in 144 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_SYNGR3
ExpressionAtlasiO43761 baseline and differential
GenevisibleiO43761 HS

Organism-specific databases

HPAiCAB034278
HPA042842

Interactioni

Subunit structurei

Interacts (via N-terminus) with SLC6A3 (via N-terminus). May interact with VMAT2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114590, 4 interactors
IntActiO43761, 14 interactors
MINTiO43761
STRINGi9606.ENSP00000248121

Structurei

3D structure databases

ProteinModelPortaliO43761
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 172MARVELPROSITE-ProRule annotationAdd BLAST153

Sequence similaritiesi

Belongs to the synaptogyrin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4016 Eukaryota
ENOG4111F8S LUCA
GeneTreeiENSGT00510000046450
HOGENOMiHOG000220816
HOVERGENiHBG000896
InParanoidiO43761
OMAiANQWQQT
PhylomeDBiO43761
TreeFamiTF320995

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR016579 Synaptogyrin
PANTHERiPTHR10838 PTHR10838, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PIRSFiPIRSF011282 Synaptogyrin, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

O43761-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGASFGAGR AGAALDPVSF ARRPQTLLRV ASWVFSIAVF GPIVNEGYVN
60 70 80 90 100
TDSGPELRCV FNGNAGACRF GVALGLGAFL ACAAFLLLDV RFQQISSVRD
110 120 130 140 150
RRRAVLLDLG FSGLWSFLWF VGFCFLTNQW QRTAPGPATT QAGDAARAAI
160 170 180 190 200
AFSFFSILSW VALTVKALQR FRLGTDMSLF ATEQLSTGAS QAYPGYPVGS
210 220
GVEGTETYQS PPFTETLDTS PKGYQVPAY
Length:229
Mass (Da):24,555
Last modified:July 11, 2001 - v2
Checksum:i0755812EDD4AD4C5
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96L30Q96L30_HUMAN
SYNGR3 protein
SYNGR3
145Annotation score:
H3BNA6H3BNA6_HUMAN
Synaptogyrin-3
SYNGR3
177Annotation score:
H3BPJ5H3BPJ5_HUMAN
Synaptogyrin-3
SYNGR3
239Annotation score:
H3BQ28H3BQ28_HUMAN
Synaptogyrin-3
SYNGR3
76Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002309 mRNA Translation: CAA05326.2
AK313894 mRNA Translation: BAG36617.1
CH471112 Genomic DNA Translation: EAW85577.1
BC014087 mRNA Translation: AAH14087.1
CCDSiCCDS10456.1
RefSeqiNP_004200.2, NM_004209.5
UniGeneiHs.435277

Genome annotation databases

EnsembliENST00000248121; ENSP00000248121; ENSG00000127561
GeneIDi9143
KEGGihsa:9143
UCSCiuc002cod.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002309 mRNA Translation: CAA05326.2
AK313894 mRNA Translation: BAG36617.1
CH471112 Genomic DNA Translation: EAW85577.1
BC014087 mRNA Translation: AAH14087.1
CCDSiCCDS10456.1
RefSeqiNP_004200.2, NM_004209.5
UniGeneiHs.435277

3D structure databases

ProteinModelPortaliO43761
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114590, 4 interactors
IntActiO43761, 14 interactors
MINTiO43761
STRINGi9606.ENSP00000248121

PTM databases

iPTMnetiO43761
PhosphoSitePlusiO43761

Polymorphism and mutation databases

BioMutaiSYNGR3

Proteomic databases

EPDiO43761
MaxQBiO43761
PaxDbiO43761
PeptideAtlasiO43761
PRIDEiO43761
ProteomicsDBi49154

Protocols and materials databases

DNASUi9143
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248121; ENSP00000248121; ENSG00000127561
GeneIDi9143
KEGGihsa:9143
UCSCiuc002cod.3 human

Organism-specific databases

CTDi9143
EuPathDBiHostDB:ENSG00000127561.14
GeneCardsiSYNGR3
HGNCiHGNC:11501 SYNGR3
HPAiCAB034278
HPA042842
MIMi603927 gene
neXtProtiNX_O43761
OpenTargetsiENSG00000127561
PharmGKBiPA36283
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4016 Eukaryota
ENOG4111F8S LUCA
GeneTreeiENSGT00510000046450
HOGENOMiHOG000220816
HOVERGENiHBG000896
InParanoidiO43761
OMAiANQWQQT
PhylomeDBiO43761
TreeFamiTF320995

Miscellaneous databases

GenomeRNAii9143
PROiPR:O43761
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127561 Expressed in 144 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_SYNGR3
ExpressionAtlasiO43761 baseline and differential
GenevisibleiO43761 HS

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR016579 Synaptogyrin
PANTHERiPTHR10838 PTHR10838, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PIRSFiPIRSF011282 Synaptogyrin, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNG3_HUMAN
AccessioniPrimary (citable) accession number: O43761
Secondary accession number(s): B2R9S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 11, 2001
Last modified: September 12, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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