UniProtKB - O43759 (SNG1_HUMAN)
Synaptogyrin-1
SYNGR1
Functioni
May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity).
Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
By similarityGO - Biological processi
- cellular response to leukemia inhibitory factor Source: Ensembl
- protein targeting Source: Ensembl
- regulated exocytosis Source: UniProtKB
- regulation of long-term neuronal synaptic plasticity Source: UniProtKB
- regulation of short-term neuronal synaptic plasticity Source: UniProtKB
- synaptic vesicle membrane organization Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | O43759 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | O43759 |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptogyrin-1Curated |
Gene namesi | Name:SYNGR1Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11498, SYNGR1 |
MIMi | 603925, gene |
neXtProti | NX_O43759 |
VEuPathDBi | HostDB:ENSG00000100321 |
Subcellular locationi
Other locations
- synaptic vesicle membrane By similarity; Multi-pass membrane protein By similarity
- Melanosome 1 Publication
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.1 Publication
Lysosome
- azurophil granule membrane Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB
- integral component of synaptic vesicle membrane Source: Ensembl
- melanosome Source: UniProtKB-SubCell
- neuromuscular junction Source: GO_Central
- synaptic vesicle membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 23 | CytoplasmicBy similarityAdd BLAST | 23 | |
Transmembranei | 24 – 44 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 45 – 71 | LumenalBy similarityAdd BLAST | 27 | |
Transmembranei | 72 – 92 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 93 – 103 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 104 – 124 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 125 – 148 | LumenalBy similarityAdd BLAST | 24 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 233 | CytoplasmicBy similarityAdd BLAST | 64 |
Keywords - Cellular componenti
Cell junction, Cytoplasmic vesicle, Membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 9145 |
OpenTargetsi | ENSG00000100321 |
PharmGKBi | PA36280 |
Miscellaneous databases
Pharosi | O43759, Tbio |
Genetic variation databases
BioMutai | SYNGR1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183990 | 1 – 233 | Synaptogyrin-1Add BLAST | 233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O43759 |
jPOSTi | O43759 |
MassIVEi | O43759 |
MaxQBi | O43759 |
PaxDbi | O43759 |
PeptideAtlasi | O43759 |
PRIDEi | O43759 |
ProteomicsDBi | 49150 [O43759-1] 49151 [O43759-2] 49152 [O43759-3] |
TopDownProteomicsi | O43759-1 [O43759-1] |
PTM databases
iPTMneti | O43759 |
PhosphoSitePlusi | O43759 |
SwissPalmi | O43759 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100321, Expressed in anterior cingulate cortex and 245 other tissues |
ExpressionAtlasi | O43759, baseline and differential |
Genevisiblei | O43759, HS |
Organism-specific databases
HPAi | ENSG00000100321, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
O43759
With | #Exp. | IntAct |
---|---|---|
FATE1 [Q969F0] | 3 | EBI-6269521,EBI-743099 |
Isoform 1B [O43759-2]
Protein-protein interaction databases
BioGRIDi | 114592, 97 interactors |
IntActi | O43759, 33 interactors |
MINTi | O43759 |
STRINGi | 9606.ENSP00000332287 |
Miscellaneous databases
RNActi | O43759, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 173 | MARVELPROSITE-ProRule annotationAdd BLAST | 154 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 194 – 233 | DisorderedSequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 213 – 233 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4016, Eukaryota |
GeneTreei | ENSGT00950000182935 |
HOGENOMi | CLU_079186_0_1_1 |
InParanoidi | O43759 |
OMAi | NEQYSAS |
OrthoDBi | 1549362at2759 |
PhylomeDBi | O43759 |
TreeFami | TF320995 |
Family and domain databases
InterProi | View protein in InterPro IPR008253, Marvel IPR016579, Synaptogyrin |
PANTHERi | PTHR10838, PTHR10838, 1 hit |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit |
PIRSFi | PIRSF011282, Synaptogyrin, 1 hit |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEGGAYGAGK AGGAFDPYTL VRQPHTILRV VSWLFSIVVF GSIVNEGYLN
60 70 80 90 100
SASEGEEFCI YNRNPNACSY GVAVGVLAFL TCLLYLALDV YFPQISSVKD
110 120 130 140 150
RKKAVLSDIG VSAFWAFLWF VGFCYLANQW QVSKPKDNPL NEGTDAARAA
160 170 180 190 200
IAFSFFSIFT WAGQAVLAFQ RYQIGADSAL FSQDYMDPSQ DSSMPYAPYV
210 220 230
EPTGPDPAGM GGTYQQPANT FDTEPQGYQS QGY
The sequence of this isoform differs from the canonical sequence as follows:
162-233: AGQAVLAFQR...EPQGYQSQGY → SLTAALAVRRFKDLSFQEEYSTLFPASAQP
The sequence of this isoform differs from the canonical sequence as follows:
1-33: MEGGAYGAGKAGGAFDPYTLVRQPHTILRVVSW → MLTLEFGILEFDPSWIGSWTQRSWVSWRSRPGCE
162-233: AGQAVLAFQR...EPQGYQSQGY → SLTAALAVRRFKDLSFQEEYSTLFPASAQP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2A283 | A2A283_HUMAN | Synaptogyrin-1 | SYNGR1 | 118 | Annotation score: | ||
F8WCE4 | F8WCE4_HUMAN | Synaptogyrin-1 | SYNGR1 | 144 | Annotation score: | ||
B5MCD7 | B5MCD7_HUMAN | Synaptogyrin-1 | SYNGR1 | 169 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060489 | 202 | P → PN4 Publications | 1 | |
Natural variantiVAR_060490 | 222 | D → G in a patient affected by schizophrenia. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006331 | 1 – 33 | MEGGA…RVVSW → MLTLEFGILEFDPSWIGSWT QRSWVSWRSRPGCE in isoform 1C. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_006332 | 162 – 233 | AGQAV…QSQGY → SLTAALAVRRFKDLSFQEEY STLFPASAQP in isoform 1B and isoform 1C. 3 PublicationsAdd BLAST | 72 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ002303 mRNA Translation: CAA05320.1 AJ002304 mRNA Translation: CAA05321.1 AJ002305 mRNA Translation: CAA05322.1 CR456590 mRNA Translation: CAG30476.1 BT007135 mRNA Translation: AAP35799.1 AK289507 mRNA Translation: BAF82196.1 AL022326 Genomic DNA No translation available. BC000731 mRNA Translation: AAH00731.1 |
CCDSi | CCDS13989.1 [O43759-1] CCDS13990.1 [O43759-2] CCDS13991.1 [O43759-3] |
RefSeqi | NP_004702.2, NM_004711.4 [O43759-1] NP_663783.1, NM_145731.3 [O43759-2] NP_663791.1, NM_145738.2 [O43759-3] |
Genome annotation databases
Ensembli | ENST00000318801; ENSP00000318845; ENSG00000100321 [O43759-2] ENST00000328933; ENSP00000332287; ENSG00000100321 ENST00000381535; ENSP00000370946; ENSG00000100321 [O43759-3] |
GeneIDi | 9145 |
KEGGi | hsa:9145 |
MANE-Selecti | ENST00000328933.10; ENSP00000332287.5; NM_004711.5; NP_004702.2 |
UCSCi | uc003axo.5, human [O43759-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ002303 mRNA Translation: CAA05320.1 AJ002304 mRNA Translation: CAA05321.1 AJ002305 mRNA Translation: CAA05322.1 CR456590 mRNA Translation: CAG30476.1 BT007135 mRNA Translation: AAP35799.1 AK289507 mRNA Translation: BAF82196.1 AL022326 Genomic DNA No translation available. BC000731 mRNA Translation: AAH00731.1 |
CCDSi | CCDS13989.1 [O43759-1] CCDS13990.1 [O43759-2] CCDS13991.1 [O43759-3] |
RefSeqi | NP_004702.2, NM_004711.4 [O43759-1] NP_663783.1, NM_145731.3 [O43759-2] NP_663791.1, NM_145738.2 [O43759-3] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114592, 97 interactors |
IntActi | O43759, 33 interactors |
MINTi | O43759 |
STRINGi | 9606.ENSP00000332287 |
PTM databases
iPTMneti | O43759 |
PhosphoSitePlusi | O43759 |
SwissPalmi | O43759 |
Genetic variation databases
BioMutai | SYNGR1 |
Proteomic databases
EPDi | O43759 |
jPOSTi | O43759 |
MassIVEi | O43759 |
MaxQBi | O43759 |
PaxDbi | O43759 |
PeptideAtlasi | O43759 |
PRIDEi | O43759 |
ProteomicsDBi | 49150 [O43759-1] 49151 [O43759-2] 49152 [O43759-3] |
TopDownProteomicsi | O43759-1 [O43759-1] |
Protocols and materials databases
Antibodypediai | 26612, 177 antibodies from 31 providers |
DNASUi | 9145 |
Genome annotation databases
Ensembli | ENST00000318801; ENSP00000318845; ENSG00000100321 [O43759-2] ENST00000328933; ENSP00000332287; ENSG00000100321 ENST00000381535; ENSP00000370946; ENSG00000100321 [O43759-3] |
GeneIDi | 9145 |
KEGGi | hsa:9145 |
MANE-Selecti | ENST00000328933.10; ENSP00000332287.5; NM_004711.5; NP_004702.2 |
UCSCi | uc003axo.5, human [O43759-1] |
Organism-specific databases
CTDi | 9145 |
DisGeNETi | 9145 |
GeneCardsi | SYNGR1 |
HGNCi | HGNC:11498, SYNGR1 |
HPAi | ENSG00000100321, Tissue enhanced (brain) |
MIMi | 603925, gene |
neXtProti | NX_O43759 |
OpenTargetsi | ENSG00000100321 |
PharmGKBi | PA36280 |
VEuPathDBi | HostDB:ENSG00000100321 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4016, Eukaryota |
GeneTreei | ENSGT00950000182935 |
HOGENOMi | CLU_079186_0_1_1 |
InParanoidi | O43759 |
OMAi | NEQYSAS |
OrthoDBi | 1549362at2759 |
PhylomeDBi | O43759 |
TreeFami | TF320995 |
Enzyme and pathway databases
PathwayCommonsi | O43759 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | O43759 |
Miscellaneous databases
BioGRID-ORCSi | 9145, 11 hits in 1039 CRISPR screens |
ChiTaRSi | SYNGR1, human |
GeneWikii | SYNGR1 |
GenomeRNAii | 9145 |
Pharosi | O43759, Tbio |
PROi | PR:O43759 |
RNActi | O43759, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100321, Expressed in anterior cingulate cortex and 245 other tissues |
ExpressionAtlasi | O43759, baseline and differential |
Genevisiblei | O43759, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008253, Marvel IPR016579, Synaptogyrin |
PANTHERi | PTHR10838, PTHR10838, 1 hit |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit |
PIRSFi | PIRSF011282, Synaptogyrin, 1 hit |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SNG1_HUMAN | |
Accessioni | O43759Primary (citable) accession number: O43759 Secondary accession number(s): A6NP69 Q9UGZ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | October 3, 2006 | |
Last modified: | February 23, 2022 | |
This is version 174 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families