UniProtKB - O43752 (STX6_HUMAN)
Syntaxin-6
STX6
Functioni
GO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: GO_Central
- syntaxin binding Source: UniProtKB
GO - Biological processi
- endocytic recycling Source: MGI
- endosome organization Source: Ensembl
- Golgi ribbon formation Source: UniProtKB
- Golgi vesicle transport Source: InterPro
- intracellular protein transport Source: GO_Central
- regulation of cellular protein localization Source: Ensembl
- regulation of protein localization Source: UniProtKB
- retrograde transport, endosome to Golgi Source: UniProtKB
- synaptic vesicle to endosome fusion Source: Ensembl
- vesicle docking Source: GO_Central
- vesicle fusion Source: UniProtKB
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | O43752 |
Reactomei | R-HSA-6811438, Intra-Golgi traffic R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
Protein family/group databases
TCDBi | 1.F.1.1.5, the synaptosomal vesicle fusion pore (svf-pore) family |
Names & Taxonomyi
Protein namesi | Recommended name: Syntaxin-6 |
Gene namesi | Name:STX6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11441, STX6 |
MIMi | 603944, gene |
neXtProti | NX_O43752 |
VEuPathDBi | HostDB:ENSG00000135823.13 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane Curated; Single-pass type IV membrane protein Curated
Cytosol
- cytosol Source: HPA
Endosome
- early endosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: Reactome
- trans-Golgi network Source: UniProtKB
- trans-Golgi network membrane Source: BHF-UCL
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- clathrin-coated vesicle Source: UniProtKB
- endomembrane system Source: GO_Central
- integral component of membrane Source: GO_Central
- integral component of synaptic vesicle membrane Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB
- phagocytic vesicle Source: Ensembl
- SNARE complex Source: MGI
- synaptic vesicle Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 234 | CytoplasmicSequence analysisAdd BLAST | 233 | |
Transmembranei | 235 – 255 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10228 |
OpenTargetsi | ENSG00000135823 |
PharmGKBi | PA36238 |
Miscellaneous databases
Pharosi | O43752, Tbio |
Genetic variation databases
BioMutai | STX6 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000210208 | 2 – 255 | Syntaxin-6Add BLAST | 254 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Modified residuei | 129 | PhosphoserineCombined sources | 1 | |
Modified residuei | 152 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O43752 |
jPOSTi | O43752 |
MassIVEi | O43752 |
MaxQBi | O43752 |
PaxDbi | O43752 |
PeptideAtlasi | O43752 |
PRIDEi | O43752 |
ProteomicsDBi | 49149 [O43752-1] 4918 |
PTM databases
iPTMneti | O43752 |
PhosphoSitePlusi | O43752 |
SwissPalmi | O43752 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135823, Expressed in secondary oocyte and 227 other tissues |
Genevisiblei | O43752, HS |
Organism-specific databases
HPAi | ENSG00000135823, Low tissue specificity |
Interactioni
Subunit structurei
Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (PubMed:17159904). Binds EEA1 (By similarity).
Interacts with VPS45A (By similarity).
Interacts with MARCHF2 and MARCHF3 (By similarity).
Interacts with GOPC (PubMed:11384996).
Interacts with UHRF1BP1L (via C-terminal coiled-coil domain) (PubMed:20163565).
Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000).
By similarity4 PublicationsBinary interactionsi
Hide detailsO43752
GO - Molecular functioni
- SNARE binding Source: GO_Central
- syntaxin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115522, 106 interactors |
CORUMi | O43752 |
DIPi | DIP-44224N |
IntActi | O43752, 76 interactors |
MINTi | O43752 |
STRINGi | 9606.ENSP00000258301 |
Miscellaneous databases
RNActi | O43752, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O43752 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O43752 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 163 – 225 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 41 – 74 | Sequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3202, Eukaryota |
GeneTreei | ENSGT00940000157639 |
HOGENOMi | CLU_061883_2_1_1 |
InParanoidi | O43752 |
OMAi | HEMDSTQ |
OrthoDBi | 1563292at2759 |
PhylomeDBi | O43752 |
TreeFami | TF313254 |
Family and domain databases
InterProi | View protein in InterPro IPR010989, SNARE IPR015260, Syntaxin-6_N IPR006012, Syntaxin/epimorphin_CS IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF09177, Syntaxin-6_N, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQDPSTATR EEIDWTTNEL
60 70 80 90 100
RNNLRSIEWD LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQVVR
110 120 130 140 150
DMKDQMSTSS VQALAERKNR QALLGDSGSQ NWSTGTTDKY GRLDRELQRA
160 170 180 190 200
NSHFIEEQQA QQQLIVEQQD EQLELVSGSI GVLKNMSQRI GGELEEQAVM
210 220 230 240 250
LEDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI LFAVLLVVLI
LFLVL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 77 | K → R in CAG46654 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054763 | 1 – 101 | Missing in isoform 2. 1 PublicationAdd BLAST | 101 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ002078 mRNA Translation: CAA05177.1 CR541856 mRNA Translation: CAG46654.1 CR541873 mRNA Translation: CAG46671.1 AK299063 mRNA Translation: BAG61129.1 AK312440 mRNA Translation: BAG35349.1 AL356267 Genomic DNA No translation available. AL162431 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91091.1 BC009944 mRNA Translation: AAH09944.1 |
CCDSi | CCDS1341.1 [O43752-1] CCDS65738.1 [O43752-2] |
RefSeqi | NP_001273139.1, NM_001286210.1 [O43752-2] NP_005810.1, NM_005819.5 [O43752-1] XP_016855496.1, XM_017000007.1 [O43752-2] |
Genome annotation databases
Ensembli | ENST00000258301; ENSP00000258301; ENSG00000135823 [O43752-1] ENST00000542060; ENSP00000440188; ENSG00000135823 [O43752-2] |
GeneIDi | 10228 |
KEGGi | hsa:10228 |
UCSCi | uc010pnr.4, human [O43752-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ002078 mRNA Translation: CAA05177.1 CR541856 mRNA Translation: CAG46654.1 CR541873 mRNA Translation: CAG46671.1 AK299063 mRNA Translation: BAG61129.1 AK312440 mRNA Translation: BAG35349.1 AL356267 Genomic DNA No translation available. AL162431 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91091.1 BC009944 mRNA Translation: AAH09944.1 |
CCDSi | CCDS1341.1 [O43752-1] CCDS65738.1 [O43752-2] |
RefSeqi | NP_001273139.1, NM_001286210.1 [O43752-2] NP_005810.1, NM_005819.5 [O43752-1] XP_016855496.1, XM_017000007.1 [O43752-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2NPS | X-ray | 2.50 | D | 169-234 | [»] | |
4J2C | X-ray | 1.80 | A/C | 3-110 | [»] | |
SMRi | O43752 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115522, 106 interactors |
CORUMi | O43752 |
DIPi | DIP-44224N |
IntActi | O43752, 76 interactors |
MINTi | O43752 |
STRINGi | 9606.ENSP00000258301 |
Protein family/group databases
TCDBi | 1.F.1.1.5, the synaptosomal vesicle fusion pore (svf-pore) family |
PTM databases
iPTMneti | O43752 |
PhosphoSitePlusi | O43752 |
SwissPalmi | O43752 |
Genetic variation databases
BioMutai | STX6 |
Proteomic databases
EPDi | O43752 |
jPOSTi | O43752 |
MassIVEi | O43752 |
MaxQBi | O43752 |
PaxDbi | O43752 |
PeptideAtlasi | O43752 |
PRIDEi | O43752 |
ProteomicsDBi | 49149 [O43752-1] 4918 |
Protocols and materials databases
Antibodypediai | 34430, 283 antibodies |
DNASUi | 10228 |
Genome annotation databases
Ensembli | ENST00000258301; ENSP00000258301; ENSG00000135823 [O43752-1] ENST00000542060; ENSP00000440188; ENSG00000135823 [O43752-2] |
GeneIDi | 10228 |
KEGGi | hsa:10228 |
UCSCi | uc010pnr.4, human [O43752-1] |
Organism-specific databases
CTDi | 10228 |
DisGeNETi | 10228 |
GeneCardsi | STX6 |
HGNCi | HGNC:11441, STX6 |
HPAi | ENSG00000135823, Low tissue specificity |
MIMi | 603944, gene |
neXtProti | NX_O43752 |
OpenTargetsi | ENSG00000135823 |
PharmGKBi | PA36238 |
VEuPathDBi | HostDB:ENSG00000135823.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3202, Eukaryota |
GeneTreei | ENSGT00940000157639 |
HOGENOMi | CLU_061883_2_1_1 |
InParanoidi | O43752 |
OMAi | HEMDSTQ |
OrthoDBi | 1563292at2759 |
PhylomeDBi | O43752 |
TreeFami | TF313254 |
Enzyme and pathway databases
PathwayCommonsi | O43752 |
Reactomei | R-HSA-6811438, Intra-Golgi traffic R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
Miscellaneous databases
BioGRID-ORCSi | 10228, 7 hits in 875 CRISPR screens |
ChiTaRSi | STX6, human |
EvolutionaryTracei | O43752 |
GeneWikii | STX6 |
GenomeRNAii | 10228 |
Pharosi | O43752, Tbio |
PROi | PR:O43752 |
RNActi | O43752, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135823, Expressed in secondary oocyte and 227 other tissues |
Genevisiblei | O43752, HS |
Family and domain databases
InterProi | View protein in InterPro IPR010989, SNARE IPR015260, Syntaxin-6_N IPR006012, Syntaxin/epimorphin_CS IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF09177, Syntaxin-6_N, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STX6_HUMAN | |
Accessioni | O43752Primary (citable) accession number: O43752 Secondary accession number(s): B2R652 Q6FH83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | June 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families