Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O43747 (AP1G1_HUMAN)

Entry version 202 (10 Feb 2021)
Sequence version 5 (01 May 2007)
Previous versions | rss
Add a publicationFeedback
Protein

AP-1 complex subunit gamma-1

Gene

AP1G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43747

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-164940, Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-2132295, MHC class II antigen presentation
R-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-432722, Golgi Associated Vesicle Biogenesis

SIGNOR Signaling Network Open Resource

More...SIGNORi		O43747

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.278.1.1, the organellar-targeting adaptor protein complex (o-apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP-1 complex subunit gamma-1
Alternative name(s):
Adaptor protein complex AP-1 subunit gamma-1
Adaptor-related protein complex 1 subunit gamma-1
Clathrin assembly protein complex 1 gamma-1 large chain
Gamma1-adaptin
Golgi adaptor HA1/AP1 adaptin subunit gamma-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AP1G1
Synonyms:ADTG, CLAPG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:555, AP1G1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603533, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43747

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166747.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		164

Open Targets

More...OpenTargetsi		ENSG00000166747

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24845

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43747, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AP1G1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001937581 – 822AP-1 complex subunit gamma-1Add BLAST822

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43747

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43747

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43747

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43747

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43747

PeptideAtlas

More...PeptideAtlasi		O43747

PRoteomics IDEntifications database

More...PRIDEi		O43747

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49146 [O43747-1]
49147 [O43747-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43747

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43747

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O43747

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166747, Expressed in stomach and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43747, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43747, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166747, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds RABEP1 and SYNRG.

Interacts (via GAE domain) with AP1AR (via coiled-coil domain).

Interacts with CLN3 (via dileucine motif); this interaction facilitates lysosomal targeting (PubMed:15598649).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106673, 74 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5047, Ubiquitous AP-1 Adaptor complex, sigma1a variant
CPX-5048, Ubiquitous AP-1 Adaptor complex, sigma1b variant
CPX-5049, Ubiquitous AP-1 Adaptor complex, sigma1c variant
CPX-5050, Endothelial AP-1 Adaptor complex, sigma1a variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O43747

Protein interaction database and analysis system

More...IntActi		O43747, 41 interactors

Molecular INTeraction database

More...MINTi		O43747

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377148

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43747, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1822
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		O43747

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43747

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O43747

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini702 – 817GAEPROSITE-ProRule annotationAdd BLAST116

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adaptor complexes large subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1062, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182838

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003824_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43747

Identification of Orthologs from Complete Genome Data

More...OMAi		ATWVIGE

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43747

TreeFam database of animal gene trees

More...TreeFami		TF300367

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017107, AP1_complex_gsu
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002553, Clathrin/coatomer_adapt-like_N
IPR008152, Clathrin_a/b/g-adaptin_app_Ig
IPR013041, Clathrin_app_Ig-like_sf
IPR008153, GAE_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01602, Adaptin_N, 1 hit
PF02883, Alpha_adaptinC2, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037094, AP1_complex_gamma, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00809, Alpha_adaptinC2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF49348, SSF49348, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50180, GAE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43747-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAPIRLREL IRTIRTARTQ AEEREMIQKE CAAIRSSFRE EDNTYRCRNV 
        60         70         80         90        100
AKLLYMHMLG YPAHFGQLEC LKLIASQKFT DKRIGYLGAM LLLDERQDVH 
       110        120        130        140        150
LLMTNCIKND LNHSTQFVQG LALCTLGCMG SSEMCRDLAG EVEKLLKTSN 
       160        170        180        190        200
SYLRKKAALC AVHVIRKVPE LMEMFLPATK NLLNEKNHGV LHTSVVLLTE 
       210        220        230        240        250
MCERSPDMLA HFRKLVPQLV RILKNLIMSG YSPEHDVSGI SDPFLQVRIL 
       260        270        280        290        300
RLLRILGRND DDSSEAMNDI LAQVATNTET SKNVGNAILY ETVLTIMDIK 
       310        320        330        340        350
SESGLRVLAI NILGRFLLNN DKNIRYVALT SLLKTVQTDH NAVQRHRSTI 
       360        370        380        390        400
VDCLKDLDVS IKRRAMELSF ALVNGNNIRG MMKELLYFLD SCEPEFKADC 
       410        420        430        440        450
ASGIFLAAEK YAPSKRWHID TIMRVLTTAG SYVRDDAVPN LIQLITNSVE 
       460        470        480        490        500
MHAYTVQRLY KAILGDYSQQ PLVQVAAWCI GEYGDLLVSG QCEEEEPIQV 
       510        520        530        540        550
TEDEVLDILE SVLISNMSTS VTRGYALTAI MKLSTRFTCT VNRIKKVVSI 
       560        570        580        590        600
YGSSIDVELQ QRAVEYNALF KKYDHMRSAL LERMPVMEKV TTNGPTEIVQ 
       610        620        630        640        650
TNGETEPAPL ETKPPPSGPQ PTSQANDLLD LLGGNDITPV IPTAPTSKPS 
       660        670        680        690        700
SAGGELLDLL GDINLTGAPA AAPAPASVPQ ISQPPFLLDG LSSQPLFNDI 
       710        720        730        740        750
AAGIPSITAY SKNGLKIEFT FERSNTNPSV TVITIQASNS TELDMTDFVF 
       760        770        780        790        800
QAAVPKTFQL QLLSPSSSIV PAFNTGTITQ VIKVLNPQKQ QLRMRIKLTY 
       810        820 
NHKGSAMQDL AEVNNFPPQS WQ
Length:822
Mass (Da):91,351
Last modified:May 1, 2007 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42EF40223DFBA5E9
GO
Isoform 2 (identifier: O43747-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-213: R → RKNE

Show »
Length:825
Mass (Da):91,723
Checksum:i1F5EA713F104978C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KNW1B3KNW1_HUMAN
AP-1 complex subunit gamma-1
AP1G1
247Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNR4H3BNR4_HUMAN
AP-1 complex subunit gamma-1
AP1G1
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR36H3BR36_HUMAN
AP-1 complex subunit gamma-1
AP1G1
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUN9H3BUN9_HUMAN
AP-1 complex subunit gamma-1
AP1G1
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DGE1B4DGE1_HUMAN
AP-1 complex subunit gamma-1
AP1G1
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN71H3BN71_HUMAN
AP-1 complex subunit gamma-1
AP1G1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS13H3BS13_HUMAN
AP-1 complex subunit gamma-1
AP1G1
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV30H3BV30_HUMAN
AP-1 complex subunit gamma-1
AP1G1
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRM7H3BRM7_HUMAN
AP-1 complex subunit gamma-1
AP1G1
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN75H3BN75_HUMAN
AP-1 complex subunit gamma-1
AP1G1
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61Y → N in CAA11832 (PubMed:9653655).Curated1
Sequence conflicti141E → K in CAA11832 (PubMed:9653655).Curated1
Sequence conflicti154R → K in CAA11832 (PubMed:9653655).Curated1
Sequence conflicti174 – 175MF → NV in CAA11832 (PubMed:9653655).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048194195V → G. Corresponds to variant dbSNP:rs36037071Ensembl.1
Natural variantiVAR_013572685P → H1 PublicationCorresponds to variant dbSNP:rs904763Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040133213R → RKNE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y12226 mRNA Translation: CAA72902.1
AJ224112, AJ224113, AJ224114 Genomic DNA Translation: CAA11832.1
AB015317 mRNA Translation: BAA33389.1
AC009097 Genomic DNA No translation available.
AC010653 Genomic DNA No translation available.
AL050025 mRNA No translation available.
AL110198 mRNA Translation: CAB53673.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32480.1 [O43747-1]
CCDS45522.1 [O43747-2]

NCBI Reference Sequences

More...RefSeqi		NP_001025178.1, NM_001030007.1 [O43747-2]
NP_001119.3, NM_001128.5 [O43747-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000299980; ENSP00000299980; ENSG00000166747 [O43747-1]
ENST00000393512; ENSP00000377148; ENSG00000166747 [O43747-2]
ENST00000569748; ENSP00000454523; ENSG00000166747 [O43747-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		164

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:164

UCSC genome browser

More...UCSCi		uc010cgg.4, human [O43747-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12226 mRNA Translation: CAA72902.1
AJ224112, AJ224113, AJ224114 Genomic DNA Translation: CAA11832.1
AB015317 mRNA Translation: BAA33389.1
AC009097 Genomic DNA No translation available.
AC010653 Genomic DNA No translation available.
AL050025 mRNA No translation available.
AL110198 mRNA Translation: CAB53673.1
CCDSiCCDS32480.1 [O43747-1]
CCDS45522.1 [O43747-2]
RefSeqiNP_001025178.1, NM_001030007.1 [O43747-2]
NP_001119.3, NM_001128.5 [O43747-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IU1X-ray1.80A/B677-822[»]
BMRBiO43747
SMRiO43747
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106673, 74 interactors
ComplexPortaliCPX-5047, Ubiquitous AP-1 Adaptor complex, sigma1a variant
CPX-5048, Ubiquitous AP-1 Adaptor complex, sigma1b variant
CPX-5049, Ubiquitous AP-1 Adaptor complex, sigma1c variant
CPX-5050, Endothelial AP-1 Adaptor complex, sigma1a variant
CORUMiO43747
IntActiO43747, 41 interactors
MINTiO43747
STRINGi9606.ENSP00000377148

Protein family/group databases

TCDBi9.B.278.1.1, the organellar-targeting adaptor protein complex (o-apc) family

PTM databases

iPTMnetiO43747
PhosphoSitePlusiO43747
SwissPalmiO43747

Genetic variation databases

BioMutaiAP1G1

Proteomic databases

EPDiO43747
jPOSTiO43747
MassIVEiO43747
MaxQBiO43747
PaxDbiO43747
PeptideAtlasiO43747
PRIDEiO43747
ProteomicsDBi49146 [O43747-1]
49147 [O43747-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3960, 236 antibodies

The DNASU plasmid repository

More...DNASUi		164

Genome annotation databases

EnsembliENST00000299980; ENSP00000299980; ENSG00000166747 [O43747-1]
ENST00000393512; ENSP00000377148; ENSG00000166747 [O43747-2]
ENST00000569748; ENSP00000454523; ENSG00000166747 [O43747-1]
GeneIDi164
KEGGihsa:164
UCSCiuc010cgg.4, human [O43747-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		164
DisGeNETi164

GeneCards: human genes, protein and diseases

More...GeneCardsi		AP1G1
HGNCiHGNC:555, AP1G1
HPAiENSG00000166747, Low tissue specificity
MIMi603533, gene
neXtProtiNX_O43747
OpenTargetsiENSG00000166747
PharmGKBiPA24845
VEuPathDBiHostDB:ENSG00000166747.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1062, Eukaryota
GeneTreeiENSGT00950000182838
HOGENOMiCLU_003824_0_0_1
InParanoidiO43747
OMAiATWVIGE
PhylomeDBiO43747
TreeFamiTF300367

Enzyme and pathway databases

PathwayCommonsiO43747
ReactomeiR-HSA-164940, Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-2132295, MHC class II antigen presentation
R-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-432722, Golgi Associated Vesicle Biogenesis
SIGNORiO43747

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		164, 60 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AP1G1, human
EvolutionaryTraceiO43747

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		AP1G1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		164
PharosiO43747, Tbio

Protein Ontology

More...PROi		PR:O43747
RNActiO43747, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166747, Expressed in stomach and 240 other tissues
ExpressionAtlasiO43747, baseline and differential
GenevisibleiO43747, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR017107, AP1_complex_gsu
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002553, Clathrin/coatomer_adapt-like_N
IPR008152, Clathrin_a/b/g-adaptin_app_Ig
IPR013041, Clathrin_app_Ig-like_sf
IPR008153, GAE_dom
PfamiView protein in Pfam
PF01602, Adaptin_N, 1 hit
PF02883, Alpha_adaptinC2, 1 hit
PIRSFiPIRSF037094, AP1_complex_gamma, 1 hit
SMARTiView protein in SMART
SM00809, Alpha_adaptinC2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF49348, SSF49348, 1 hit
PROSITEiView protein in PROSITE
PS50180, GAE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP1G1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43747
Secondary accession number(s): O75709
, O75842, Q9UG09, Q9Y3U4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 2007
Last modified: February 10, 2021
This is version 202 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again