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UniProtKB - O43747 (AP1G1_HUMAN)

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Protein

AP-1 complex subunit gamma-1

Gene

AP1G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

GO - Molecular functioni

  • GTP-dependent protein binding Source: ParkinsonsUK-UCL
  • kinesin binding Source: UniProtKB
  • Rab GTPase binding Source: ParkinsonsUK-UCL
  • transporter activity Source: ProtInc
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  • endosome to melanosome transport Source: ParkinsonsUK-UCL
  • Golgi to lysosome transport Source: UniProtKB
  • intracellular protein transport Source: ProtInc
  • melanosome organization Source: ParkinsonsUK-UCL
  • positive regulation of natural killer cell degranulation Source: UniProtKB
  • positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
  • regulation of defense response to virus by virus Source: Reactome
View the complete GO annotation on QuickGO ...

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-2132295 MHC class II antigen presentation
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis

Protein family/group databases

TCDBi9.B.278.1.1 the organellar-targeting adaptor protein complex (o-apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit gamma-1
Alternative name(s):
Adaptor protein complex AP-1 subunit gamma-1
Adaptor-related protein complex 1 subunit gamma-1
Clathrin assembly protein complex 1 gamma-1 large chain
Gamma1-adaptin
Golgi adaptor HA1/AP1 adaptin subunit gamma-1
Gene namesi
Name:AP1G1
Synonyms:ADTG, CLAPG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000166747.12
HGNCiHGNC:555 AP1G1
MIMi603533 gene
neXtProtiNX_O43747

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi164
OpenTargetsiENSG00000166747
PharmGKBiPA24845

Polymorphism and mutation databases

BioMutaiAP1G1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937581 – 822AP-1 complex subunit gamma-1Add BLAST822

Proteomic databases

EPDiO43747
MaxQBiO43747
PaxDbiO43747
PeptideAtlasiO43747
PRIDEiO43747
ProteomicsDBi49146
49147 [O43747-2]

PTM databases

iPTMnetiO43747
PhosphoSitePlusiO43747
SwissPalmiO43747

Miscellaneous databases

PMAP-CutDBiO43747

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000166747
CleanExiHS_AP1G1
ExpressionAtlasiO43747 baseline and differential
GenevisibleiO43747 HS

Organism-specific databases

HPAiCAB009049
HPA041224

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds RABEP1 and SYNRG. Interacts (via GAE domain) with AP1AR (via coiled-coil domain).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • GTP-dependent protein binding Source: ParkinsonsUK-UCL
  • kinesin binding Source: UniProtKB
  • Rab GTPase binding Source: ParkinsonsUK-UCL
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi106673, 55 interactors
CORUMiO43747
IntActiO43747, 31 interactors
MINTiO43747
STRINGi9606.ENSP00000377148

Structurei

Secondary structure

1822
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi707 – 712Combined sources6
Beta strandi715 – 723Combined sources9
Beta strandi730 – 739Combined sources10
Beta strandi741 – 743Combined sources3
Beta strandi745 – 753Combined sources9
Beta strandi758 – 762Combined sources5
Helixi772 – 774Combined sources3
Beta strandi778 – 785Combined sources8
Beta strandi795 – 802Combined sources8
Beta strandi805 – 812Combined sources8
Helixi818 – 820Combined sources3

3D structure databases

ProteinModelPortaliO43747
SMRiO43747
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43747

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini702 – 817GAEPROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Belongs to the adaptor complexes large subunit family.Curated

Phylogenomic databases

eggNOGiKOG1062 Eukaryota
ENOG410XPKK LUCA
GeneTreeiENSGT00390000012618
HOGENOMiHOG000210271
HOVERGENiHBG067473
InParanoidiO43747
KOiK12391
OMAiWHVDTML
OrthoDBiEOG091G01RV
PhylomeDBiO43747
TreeFamiTF300367

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR017107 AP1_complex_gsu
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR008153 GAE_dom
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PIRSFiPIRSF037094 AP1_complex_gamma, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
PROSITEiView protein in PROSITE
PS50180 GAE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43747-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAPIRLREL IRTIRTARTQ AEEREMIQKE CAAIRSSFRE EDNTYRCRNV 
        60         70         80         90        100
AKLLYMHMLG YPAHFGQLEC LKLIASQKFT DKRIGYLGAM LLLDERQDVH 
       110        120        130        140        150
LLMTNCIKND LNHSTQFVQG LALCTLGCMG SSEMCRDLAG EVEKLLKTSN 
       160        170        180        190        200
SYLRKKAALC AVHVIRKVPE LMEMFLPATK NLLNEKNHGV LHTSVVLLTE 
       210        220        230        240        250
MCERSPDMLA HFRKLVPQLV RILKNLIMSG YSPEHDVSGI SDPFLQVRIL 
       260        270        280        290        300
RLLRILGRND DDSSEAMNDI LAQVATNTET SKNVGNAILY ETVLTIMDIK 
       310        320        330        340        350
SESGLRVLAI NILGRFLLNN DKNIRYVALT SLLKTVQTDH NAVQRHRSTI 
       360        370        380        390        400
VDCLKDLDVS IKRRAMELSF ALVNGNNIRG MMKELLYFLD SCEPEFKADC 
       410        420        430        440        450
ASGIFLAAEK YAPSKRWHID TIMRVLTTAG SYVRDDAVPN LIQLITNSVE 
       460        470        480        490        500
MHAYTVQRLY KAILGDYSQQ PLVQVAAWCI GEYGDLLVSG QCEEEEPIQV 
       510        520        530        540        550
TEDEVLDILE SVLISNMSTS VTRGYALTAI MKLSTRFTCT VNRIKKVVSI 
       560        570        580        590        600
YGSSIDVELQ QRAVEYNALF KKYDHMRSAL LERMPVMEKV TTNGPTEIVQ 
       610        620        630        640        650
TNGETEPAPL ETKPPPSGPQ PTSQANDLLD LLGGNDITPV IPTAPTSKPS 
       660        670        680        690        700
SAGGELLDLL GDINLTGAPA AAPAPASVPQ ISQPPFLLDG LSSQPLFNDI 
       710        720        730        740        750
AAGIPSITAY SKNGLKIEFT FERSNTNPSV TVITIQASNS TELDMTDFVF 
       760        770        780        790        800
QAAVPKTFQL QLLSPSSSIV PAFNTGTITQ VIKVLNPQKQ QLRMRIKLTY 
       810        820 
NHKGSAMQDL AEVNNFPPQS WQ
Length:822
Mass (Da):91,351
Last modified:May 1, 2007 - v5
Checksum:i42EF40223DFBA5E9
GO
Isoform 2 (identifier: O43747-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-213: R → RKNE

Show »
Length:825
Mass (Da):91,723
Checksum:i1F5EA713F104978C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61Y → N in CAA11832 (PubMed:9653655).Curated1
Sequence conflicti141E → K in CAA11832 (PubMed:9653655).Curated1
Sequence conflicti154R → K in CAA11832 (PubMed:9653655).Curated1
Sequence conflicti174 – 175MF → NV in CAA11832 (PubMed:9653655).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048194195V → G. Corresponds to variant dbSNP:rs36037071Ensembl.1
Natural variantiVAR_013572685P → H1 PublicationCorresponds to variant dbSNP:rs904763Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040133213R → RKNE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12226 mRNA Translation: CAA72902.1
AJ224112, AJ224113, AJ224114 Genomic DNA Translation: CAA11832.1
AB015317 mRNA Translation: BAA33389.1
AC009097 Genomic DNA No translation available.
AC010653 Genomic DNA No translation available.
AL050025 mRNA No translation available.
AL110198 mRNA Translation: CAB53673.1
CCDSiCCDS32480.1 [O43747-1]
CCDS45522.1 [O43747-2]
RefSeqiNP_001025178.1, NM_001030007.1 [O43747-2]
NP_001119.3, NM_001128.5 [O43747-1]
UniGeneiHs.461253

Genome annotation databases

EnsembliENST00000299980; ENSP00000299980; ENSG00000166747 [O43747-1]
ENST00000393512; ENSP00000377148; ENSG00000166747 [O43747-2]
ENST00000569748; ENSP00000454523; ENSG00000166747 [O43747-1]
GeneIDi164
KEGGihsa:164
UCSCiuc010cgg.4 human [O43747-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAP1G1_HUMAN
AccessioniPrimary (citable) accession number: O43747
Secondary accession number(s): O75709
, O75842, Q9UG09, Q9Y3U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 2007
Last modified: July 18, 2018
This is version 182 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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