UniProtKB - O43736 (ITM2A_HUMAN)
Protein
Integral membrane protein 2A
Gene
ITM2A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- amyloid-beta binding Source: GO_Central
GO - Biological processi
- immunoglobulin production Source: Ensembl
- negative regulation of amyloid precursor protein biosynthetic process Source: GO_Central
- plasma cell differentiation Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | O43736 |
Names & Taxonomyi
Protein namesi | Recommended name: Integral membrane protein 2AAlternative name(s): Protein E25 |
Gene namesi | Name:ITM2A ORF Names:UNQ603/PRO1189 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6173, ITM2A |
MIMi | 300222, gene |
neXtProti | NX_O43736 |
VEuPathDBi | HostDB:ENSG00000078596.10 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type II membrane protein Curated
Golgi apparatus
- Golgi apparatus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 54 – 74 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9452 |
OpenTargetsi | ENSG00000078596 |
Orphaneti | 2227, NON RARE IN EUROPE: Hypodontia |
PharmGKBi | PA29970 |
Miscellaneous databases
Pharosi | O43736, Tbio |
Genetic variation databases
BioMutai | ITM2A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000154818 | 1 – 263 | Integral membrane protein 2AAdd BLAST | 263 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 160 ↔ 219 | By similarity | ||
Glycosylationi | 166 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | O43736 |
jPOSTi | O43736 |
MassIVEi | O43736 |
MaxQBi | O43736 |
PaxDbi | O43736 |
PeptideAtlasi | O43736 |
PRIDEi | O43736 |
ProteomicsDBi | 49140 [O43736-1] 49141 [O43736-2] |
PTM databases
GlyGeni | O43736, 1 site |
iPTMneti | O43736 |
PhosphoSitePlusi | O43736 |
SwissPalmi | O43736 |
Expressioni
Gene expression databases
Bgeei | ENSG00000078596, Expressed in colon and 252 other tissues |
Genevisiblei | O43736, HS |
Organism-specific databases
HPAi | ENSG00000078596, Tissue enhanced (lymphoid) |
Interactioni
Binary interactionsi
Hide detailsO43736
Protein-protein interaction databases
BioGRIDi | 114841, 21 interactors |
IntActi | O43736, 19 interactors |
STRINGi | 9606.ENSP00000362395 |
Miscellaneous databases
RNActi | O43736, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 133 – 227 | BRICHOSPROSITE-ProRule annotationAdd BLAST | 95 |
Sequence similaritiesi
Belongs to the ITM2 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4681, Eukaryota |
GeneTreei | ENSGT00950000183115 |
HOGENOMi | CLU_074596_0_0_1 |
InParanoidi | O43736 |
OMAi | ETRICKA |
OrthoDBi | 1322680at2759 |
PhylomeDBi | O43736 |
TreeFami | TF317770 |
Family and domain databases
InterProi | View protein in InterPro IPR007084, BRICHOS_dom IPR040145, ITM2 |
PANTHERi | PTHR10962, PTHR10962, 1 hit |
Pfami | View protein in Pfam PF04089, BRICHOS, 1 hit |
SMARTi | View protein in SMART SM01039, BRICHOS, 1 hit |
PROSITEi | View protein in PROSITE PS50869, BRICHOS, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O43736-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVKIAFNTPT AVQKEEARQD VEALLSRTVR TQILTGKELR VATQEKEGSS
60 70 80 90 100
GRCMLTLLGL SFILAGLIVG GACIYKYFMP KSTIYRGEMC FFDSEDPANS
110 120 130 140 150
LRGGEPNFLP VTEEADIRED DNIAIIDVPV PSFSDSDPAA IIHDFEKGMT
160 170 180 190 200
AYLDLLLGNC YLMPLNTSIV MPPKNLVELF GKLASGRYLP QTYVVREDLV
210 220 230 240 250
AVEEIRDVSN LGIFIYQLCN NRKSFRLRRR DLLLGFNKRA IDKCWKIRHF
260
PNEFIVETKI CQE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 263 | E → D in CAG33156 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034029 | 72 | A → V. Corresponds to variant dbSNP:rs35056863Ensembl. | 1 | |
Natural variantiVAR_034030 | 230 | R → T. Corresponds to variant dbSNP:rs35629312Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042562 | 37 – 80 | Missing in isoform 2. 1 PublicationAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038953 mRNA Translation: AAC39867.1 AY359051 mRNA Translation: AAQ89410.1 AK303238 mRNA Translation: BAG64324.1 AK313154 mRNA Translation: BAG35972.1 CR456875 mRNA Translation: CAG33156.1 AL009028 Genomic DNA No translation available. AL021786 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98591.1 BC040437 mRNA Translation: AAH40437.1 |
CCDSi | CCDS14444.1 [O43736-1] CCDS55455.1 [O43736-2] |
RefSeqi | NP_001165052.1, NM_001171581.1 [O43736-2] NP_004858.1, NM_004867.4 [O43736-1] |
Genome annotation databases
Ensembli | ENST00000373298; ENSP00000362395; ENSG00000078596 [O43736-1] ENST00000434584; ENSP00000415533; ENSG00000078596 [O43736-2] |
GeneIDi | 9452 |
KEGGi | hsa:9452 |
UCSCi | uc004edh.4, human [O43736-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038953 mRNA Translation: AAC39867.1 AY359051 mRNA Translation: AAQ89410.1 AK303238 mRNA Translation: BAG64324.1 AK313154 mRNA Translation: BAG35972.1 CR456875 mRNA Translation: CAG33156.1 AL009028 Genomic DNA No translation available. AL021786 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98591.1 BC040437 mRNA Translation: AAH40437.1 |
CCDSi | CCDS14444.1 [O43736-1] CCDS55455.1 [O43736-2] |
RefSeqi | NP_001165052.1, NM_001171581.1 [O43736-2] NP_004858.1, NM_004867.4 [O43736-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114841, 21 interactors |
IntActi | O43736, 19 interactors |
STRINGi | 9606.ENSP00000362395 |
PTM databases
GlyGeni | O43736, 1 site |
iPTMneti | O43736 |
PhosphoSitePlusi | O43736 |
SwissPalmi | O43736 |
Genetic variation databases
BioMutai | ITM2A |
Proteomic databases
EPDi | O43736 |
jPOSTi | O43736 |
MassIVEi | O43736 |
MaxQBi | O43736 |
PaxDbi | O43736 |
PeptideAtlasi | O43736 |
PRIDEi | O43736 |
ProteomicsDBi | 49140 [O43736-1] 49141 [O43736-2] |
Protocols and materials databases
Antibodypediai | 493, 134 antibodies |
DNASUi | 9452 |
Genome annotation databases
Ensembli | ENST00000373298; ENSP00000362395; ENSG00000078596 [O43736-1] ENST00000434584; ENSP00000415533; ENSG00000078596 [O43736-2] |
GeneIDi | 9452 |
KEGGi | hsa:9452 |
UCSCi | uc004edh.4, human [O43736-1] |
Organism-specific databases
CTDi | 9452 |
DisGeNETi | 9452 |
GeneCardsi | ITM2A |
HGNCi | HGNC:6173, ITM2A |
HPAi | ENSG00000078596, Tissue enhanced (lymphoid) |
MIMi | 300222, gene |
neXtProti | NX_O43736 |
OpenTargetsi | ENSG00000078596 |
Orphaneti | 2227, NON RARE IN EUROPE: Hypodontia |
PharmGKBi | PA29970 |
VEuPathDBi | HostDB:ENSG00000078596.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4681, Eukaryota |
GeneTreei | ENSGT00950000183115 |
HOGENOMi | CLU_074596_0_0_1 |
InParanoidi | O43736 |
OMAi | ETRICKA |
OrthoDBi | 1322680at2759 |
PhylomeDBi | O43736 |
TreeFami | TF317770 |
Enzyme and pathway databases
PathwayCommonsi | O43736 |
Miscellaneous databases
BioGRID-ORCSi | 9452, 2 hits in 500 CRISPR screens |
ChiTaRSi | ITM2A, human |
GeneWikii | ITM2A |
GenomeRNAii | 9452 |
Pharosi | O43736, Tbio |
PROi | PR:O43736 |
RNActi | O43736, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000078596, Expressed in colon and 252 other tissues |
Genevisiblei | O43736, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007084, BRICHOS_dom IPR040145, ITM2 |
PANTHERi | PTHR10962, PTHR10962, 1 hit |
Pfami | View protein in Pfam PF04089, BRICHOS, 1 hit |
SMARTi | View protein in SMART SM01039, BRICHOS, 1 hit |
PROSITEi | View protein in PROSITE PS50869, BRICHOS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ITM2A_HUMAN | |
Accessioni | O43736Primary (citable) accession number: O43736 Secondary accession number(s): B2R7X5, B4E062, Q6IBC9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 15, 1999 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants