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Entry version 169 (05 Jun 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Adapter protein CIKS

Gene

TRAF3IP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O43734

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adapter protein CIKS
Alternative name(s):
Connection to IKK and SAPK/JNK
Nuclear factor NF-kappa-B activator 1
Short name:
ACT1
TRAF3-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAF3IP2
Synonyms:C6orf2, C6orf4, C6orf5, C6orf6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:1343 TRAF3IP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607043 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43734

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Psoriasis 13 (PSORS13)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04734919D → N in PSORS13; there is a reducing binding of this variant to TRAF6. 2 PublicationsCorresponds to variant dbSNP:rs33980500Ensembl.1
Candidiasis, familial, 8 (CANDF8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070904536T → I in CANDF8; abolishes homotypic interactions with the SEFIR domain of IL17RA, IL17RB and IL17RC; does not affect homodimerization; does not affect SEFIR-independent interactions with other proteins. 1 PublicationCorresponds to variant dbSNP:rs397518485Ensembl.1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
10758

MalaCards human disease database

More...
MalaCardsi
TRAF3IP2
MIMi614070 phenotype
615527 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000056972

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1334 Chronic mucocutaneous candidiasis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25938

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRAF3IP2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000897511 – 574Adapter protein CIKSAdd BLAST574

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43734

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43734

MaxQB - The MaxQuant DataBase

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MaxQBi
O43734

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O43734

PeptideAtlas

More...
PeptideAtlasi
O43734

PRoteomics IDEntifications database

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PRIDEi
O43734

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49136
49137 [O43734-2]
49138 [O43734-3]
49139 [O43734-4]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
2015

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O43734

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43734

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000056972 Expressed in 210 organ(s), highest expression level in islet of Langerhans

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43734 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA036352

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts with TRAF6.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115979, 41 interactors

Protein interaction database and analysis system

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IntActi
O43734, 16 interactors

Molecular INTeraction database

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MINTi
O43734

STRING: functional protein association networks

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STRINGi
9606.ENSP00000357750

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43734

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini409 – 550SEFIRPROSITE-ProRule annotationAdd BLAST142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 256Mediates interaction with TRAF61 PublicationAdd BLAST256

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF9W Eukaryota
ENOG4111GTJ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161944

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000126819

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43734

KEGG Orthology (KO)

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KOi
K21124

Identification of Orthologs from Complete Genome Data

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OMAi
KTVMIII

Database of Orthologous Groups

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OrthoDBi
1353706at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O43734

TreeFam database of animal gene trees

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TreeFami
TF329063

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013568 SEFIR_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08357 SEFIR, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51534 SEFIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43734-1) [UniParc]FASTAAdd to basket
Also known as: C6ORF4

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPQLQETRM NRSIPVEVDE SEPYPSQLLK PIPEYSPEEE SEPPAPNIRN
60 70 80 90 100
MAPNSLSAPT MLHNSSGDFS QAHSTLKLAN HQRPVSRQVT CLRTQVLEDS
110 120 130 140 150
EDSFCRRHPG LGKAFPSGCS AVSEPASESV VGALPAEHQF SFMEKRNQWL
160 170 180 190 200
VSQLSAASPD TGHDSDKSDQ SLPNASADSL GGSQEMVQRP QPHRNRAGLD
210 220 230 240 250
LPTIDTGYDS QPQDVLGIRQ LERPLPLTSV CYPQDLPRPL RSREFPQFEP
260 270 280 290 300
QRYPACAQML PPNLSPHAPW NYHYHCPGSP DHQVPYGHDY PRAAYQQVIQ
310 320 330 340 350
PALPGQPLPG ASVRGLHPVQ KVILNYPSPW DHEERPAQRD CSFPGLPRHQ
360 370 380 390 400
DQPHHQPPNR AGAPGESLEC PAELRPQVPQ PPSPAAVPRP PSNPPARGTL
410 420 430 440 450
KTSNLPEELR KVFITYSMDT AMEVVKFVNF LLVNGFQTAI DIFEDRIRGI
460 470 480 490 500
DIIKWMERYL RDKTVMIIVA ISPKYKQDVE GAESQLDEDE HGLHTKYIHR
510 520 530 540 550
MMQIEFIKQG SMNFRFIPVL FPNAKKEHVP TWLQNTHVYS WPKNKKNILL
560 570
RLLREEEYVA PPRGPLPTLQ VVPL
Length:574
Mass (Da):64,666
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4985795466D71422
GO
Isoform 2 (identifier: O43734-2) [UniParc]FASTAAdd to basket
Also known as: C6ORF5, C6ORF6

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:565
Mass (Da):63,585
Checksum:iD585DABB3FCA8B1D
GO
Isoform 3 (identifier: O43734-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-421: Missing.

Show »
Length:153
Mass (Da):18,118
Checksum:i7197AC2147A19690
GO
Isoform 4 (identifier: O43734-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-465: Missing.

Show »
Length:109
Mass (Da):12,803
Checksum:i32083D194A68478D
GO
Isoform 5 (identifier: O43734-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.
     463-463: Missing.

Note: No experimental confirmation available.
Show »
Length:564
Mass (Da):63,457
Checksum:iC2592D267AD39699
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494C0R7A0A494C0R7_HUMAN
Adapter protein CIKS
TRAF3IP2
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1J9A0A494C1J9_HUMAN
Adapter protein CIKS
TRAF3IP2
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0I3A0A494C0I3_HUMAN
Adapter protein CIKS
TRAF3IP2
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C172A0A494C172_HUMAN
Adapter protein CIKS
TRAF3IP2
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0G2A0A494C0G2_HUMAN
Adapter protein CIKS
TRAF3IP2
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15507 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti334E → D in AAG15407 (PubMed:10962033).Curated1
Sequence conflicti347P → S in AAF67447 (PubMed:10903453).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04734919D → N in PSORS13; there is a reducing binding of this variant to TRAF6. 2 PublicationsCorresponds to variant dbSNP:rs33980500Ensembl.1
Natural variantiVAR_03122783R → W. Corresponds to variant dbSNP:rs13190932Ensembl.1
Natural variantiVAR_024307332H → Q5 PublicationsCorresponds to variant dbSNP:rs1043730Ensembl.1
Natural variantiVAR_070904536T → I in CANDF8; abolishes homotypic interactions with the SEFIR domain of IL17RA, IL17RB and IL17RC; does not affect homodimerization; does not affect SEFIR-independent interactions with other proteins. 1 PublicationCorresponds to variant dbSNP:rs397518485Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0403741 – 465Missing in isoform 4. 1 PublicationAdd BLAST465
Alternative sequenceiVSP_0357331 – 421Missing in isoform 3. CuratedAdd BLAST421
Alternative sequenceiVSP_0041631 – 9Missing in isoform 2 and isoform 5. 4 Publications9
Alternative sequenceiVSP_047098463Missing in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF136405 mRNA Translation: AAF67445.1
AF136406 mRNA Translation: AAF67446.1
AF136407 mRNA Translation: AAF67447.1
AF274303 mRNA Translation: AAG15367.1
AF272151 mRNA Translation: AAG15407.1
AK025351 mRNA Translation: BAB15117.1
AK026602 mRNA Translation: BAB15507.1 Different initiation.
AK314415 mRNA Translation: BAG37036.1
AL050289 mRNA Translation: CAB43390.1
AL008730 Genomic DNA No translation available.
Z97989 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48285.1
CH471051 Genomic DNA Translation: EAW48287.1
BC002823 mRNA Translation: AAH02823.1
BI856094 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5092.1 [O43734-1]
CCDS5093.1 [O43734-2]
CCDS55049.1 [O43734-4]
CCDS55050.1 [O43734-5]

Protein sequence database of the Protein Information Resource

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PIRi
T08794

NCBI Reference Sequences

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RefSeqi
NP_001157753.1, NM_001164281.2 [O43734-5]
NP_001157755.1, NM_001164283.2 [O43734-4]
NP_671733.2, NM_147200.2 [O43734-1]
NP_679211.2, NM_147686.3 [O43734-2]
XP_006715382.1, XM_006715319.3 [O43734-4]
XP_011533688.1, XM_011535386.1 [O43734-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000340026; ENSP00000345984; ENSG00000056972 [O43734-1]
ENST00000359831; ENSP00000352889; ENSG00000056972 [O43734-5]
ENST00000368730; ENSP00000498323; ENSG00000056972 [O43734-4]
ENST00000368734; ENSP00000498345; ENSG00000056972 [O43734-4]
ENST00000368735; ENSP00000357724; ENSG00000056972 [O43734-4]
ENST00000368761; ENSP00000357750; ENSG00000056972 [O43734-2]
ENST00000392556; ENSP00000376339; ENSG00000056972 [O43734-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10758

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10758

UCSC genome browser

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UCSCi
uc003pvf.5 human [O43734-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136405 mRNA Translation: AAF67445.1
AF136406 mRNA Translation: AAF67446.1
AF136407 mRNA Translation: AAF67447.1
AF274303 mRNA Translation: AAG15367.1
AF272151 mRNA Translation: AAG15407.1
AK025351 mRNA Translation: BAB15117.1
AK026602 mRNA Translation: BAB15507.1 Different initiation.
AK314415 mRNA Translation: BAG37036.1
AL050289 mRNA Translation: CAB43390.1
AL008730 Genomic DNA No translation available.
Z97989 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48285.1
CH471051 Genomic DNA Translation: EAW48287.1
BC002823 mRNA Translation: AAH02823.1
BI856094 mRNA No translation available.
CCDSiCCDS5092.1 [O43734-1]
CCDS5093.1 [O43734-2]
CCDS55049.1 [O43734-4]
CCDS55050.1 [O43734-5]
PIRiT08794
RefSeqiNP_001157753.1, NM_001164281.2 [O43734-5]
NP_001157755.1, NM_001164283.2 [O43734-4]
NP_671733.2, NM_147200.2 [O43734-1]
NP_679211.2, NM_147686.3 [O43734-2]
XP_006715382.1, XM_006715319.3 [O43734-4]
XP_011533688.1, XM_011535386.1 [O43734-1]

3D structure databases

SMRiO43734
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115979, 41 interactors
IntActiO43734, 16 interactors
MINTiO43734
STRINGi9606.ENSP00000357750

PTM databases

GlyConnecti2015
iPTMnetiO43734
PhosphoSitePlusiO43734

Polymorphism and mutation databases

BioMutaiTRAF3IP2

Proteomic databases

EPDiO43734
jPOSTiO43734
MaxQBiO43734
PaxDbiO43734
PeptideAtlasiO43734
PRIDEiO43734
ProteomicsDBi49136
49137 [O43734-2]
49138 [O43734-3]
49139 [O43734-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10758
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340026; ENSP00000345984; ENSG00000056972 [O43734-1]
ENST00000359831; ENSP00000352889; ENSG00000056972 [O43734-5]
ENST00000368730; ENSP00000498323; ENSG00000056972 [O43734-4]
ENST00000368734; ENSP00000498345; ENSG00000056972 [O43734-4]
ENST00000368735; ENSP00000357724; ENSG00000056972 [O43734-4]
ENST00000368761; ENSP00000357750; ENSG00000056972 [O43734-2]
ENST00000392556; ENSP00000376339; ENSG00000056972 [O43734-1]
GeneIDi10758
KEGGihsa:10758
UCSCiuc003pvf.5 human [O43734-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10758
DisGeNETi10758

GeneCards: human genes, protein and diseases

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GeneCardsi
TRAF3IP2
HGNCiHGNC:1343 TRAF3IP2
HPAiHPA036352
MalaCardsiTRAF3IP2
MIMi607043 gene
614070 phenotype
615527 phenotype
neXtProtiNX_O43734
OpenTargetsiENSG00000056972
Orphaneti1334 Chronic mucocutaneous candidiasis
PharmGKBiPA25938

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF9W Eukaryota
ENOG4111GTJ LUCA
GeneTreeiENSGT00940000161944
HOGENOMiHOG000126819
InParanoidiO43734
KOiK21124
OMAiKTVMIII
OrthoDBi1353706at2759
PhylomeDBiO43734
TreeFamiTF329063

Enzyme and pathway databases

SignaLinkiO43734

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRAF3IP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10758

Protein Ontology

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PROi
PR:O43734

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000056972 Expressed in 210 organ(s), highest expression level in islet of Langerhans
GenevisibleiO43734 HS

Family and domain databases

InterProiView protein in InterPro
IPR013568 SEFIR_dom
PfamiView protein in Pfam
PF08357 SEFIR, 1 hit
PROSITEiView protein in PROSITE
PS51534 SEFIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCIKS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43734
Secondary accession number(s): B2RAY9
, E1P555, Q5R3A3, Q7Z6Q1, Q7Z6Q2, Q7Z6Q3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 11, 2011
Last modified: June 5, 2019
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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