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Protein

HIV Tat-specific factor 1

Gene

HTATSF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.8 Publications

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • regulation of DNA-templated transcription, elongation Source: ProtInc
  • regulation of transcription by RNA polymerase II Source: ProtInc
  • viral genome replication Source: ProtInc

Keywordsi

Molecular functionActivator, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HIV Tat-specific factor 1
Short name:
Tat-SF1
Gene namesi
Name:HTATSF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102241.11
HGNCiHGNC:5276 HTATSF1
MIMi300346 gene
neXtProtiNX_O43719

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi136Y → D: Loss of interaction with U snRNPs. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000102241
PharmGKBiPA29540

Polymorphism and mutation databases

BioMutaiHTATSF1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002486042 – 755HIV Tat-specific factor 1Add BLAST754

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei297N6-acetyllysineBy similarity1
Modified residuei387PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei409PhosphoserineBy similarity1
Cross-linki429Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei445PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei453PhosphoserineCombined sources1
Modified residuei481PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1
Modified residuei494PhosphoserineCombined sources1
Modified residuei498PhosphoserineCombined sources1
Modified residuei521PhosphoserineCombined sources1
Modified residuei529PhosphoserineCombined sources1
Modified residuei557PhosphoserineCombined sources1
Modified residuei561PhosphoserineCombined sources1
Modified residuei579PhosphoserineCombined sources1
Modified residuei597PhosphoserineCombined sources1
Modified residuei600PhosphoserineCombined sources1
Modified residuei607PhosphoserineCombined sources1
Modified residuei616PhosphoserineCombined sources1
Modified residuei624PhosphoserineCombined sources1
Modified residuei633PhosphothreonineCombined sources1
Modified residuei642PhosphoserineCombined sources1
Modified residuei676PhosphoserineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Modified residuei713PhosphoserineCombined sources1
Modified residuei714PhosphoserineCombined sources1
Modified residuei721PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43719
MaxQBiO43719
PaxDbiO43719
PeptideAtlasiO43719
PRIDEiO43719
ProteomicsDBi49133

PTM databases

iPTMnetiO43719
PhosphoSitePlusiO43719

Miscellaneous databases

PMAP-CutDBiO43719

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000102241 Expressed in 245 organ(s), highest expression level in pituitary gland
CleanExiHS_HTATSF1
ExpressionAtlasiO43719 baseline and differential
GenevisibleiO43719 HS

Organism-specific databases

HPAiHPA000504

Interactioni

Subunit structurei

Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with GTF2F2/RAP30 and POLR2A. Interacts with TCERG1/CA150. Interacts with SF3A2/SAP62 and the spliceosomal U small nuclear ribonucleoproteins (snRNPs).7 Publications

Protein-protein interaction databases

BioGridi118149, 53 interactors
CORUMiO43719
DIPiDIP-42095N
IntActiO43719, 19 interactors
MINTiO43719
STRINGi9606.ENSP00000218364

Structurei

Secondary structure

1755
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43719
SMRiO43719
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43719

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 218RRM 1PROSITE-ProRule annotationAdd BLAST86
Domaini264 – 349RRM 2PROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni381 – 755Mediates interaction with the P-TEFb complexAdd BLAST375

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi228 – 234Poly-Lys7
Compositional biasi423 – 754Asp/Glu-rich (acidic)Add BLAST332

Domaini

The RRM domains mediate interaction with U snRNPs.1 Publication

Sequence similaritiesi

Belongs to the HTATSF1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1548 Eukaryota
ENOG410YD7P LUCA
GeneTreeiENSGT00390000009902
HOGENOMiHOG000049201
HOVERGENiHBG059454
InParanoidiO43719
KOiK13093
OMAiITAEAWD
OrthoDBiEOG091G0O8I
PhylomeDBiO43719
TreeFamiTF313623

Family and domain databases

CDDicd12281 RRM1_TatSF1_like, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034393 TatSF1-like
IPR034392 TatSF1-like_RRM1
PANTHERiPTHR15608 PTHR15608, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O43719-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTNLDGND EFDEQLRMQE LYGDGKDGDT QTDAGGEPDS LGQQPTDTPY
60 70 80 90 100
EWDLDKKAWF PKITEDFIAT YQANYGFSND GASSSTANVE DVHARTAEEP
110 120 130 140 150
PQEKAPEPTD ARKKGEKRKA ESGWFHVEED RNTNVYVSGL PPDITVDEFI
160 170 180 190 200
QLMSKFGIIM RDPQTEEFKV KLYKDNQGNL KGDGLCCYLK RESVELALKL
210 220 230 240 250
LDEDEIRGYK LHVEVAKFQL KGEYDASKKK KKCKDYKKKL SMQQKQLDWR
260 270 280 290 300
PERRAGPSRM RHERVVIIKN MFHPMDFEDD PLVLNEIRED LRVECSKFGQ
310 320 330 340 350
IRKLLLFDRH PDGVASVSFR DPEEADYCIQ TLDGRWFGGR QITAQAWDGT
360 370 380 390 400
TDYQVEETSR EREERLRGWE AFLNAPEANR GLRRSDSVSA SERAGPSRAR
410 420 430 440 450
HFSEHPSTSK MNAQETATGM AFEEPIDEKK FEKTEDGGEF EEGASENNAK
460 470 480 490 500
ESSPEKEAEE GCPEKESEEG CPKRGFEGSC SQKESEEGNP VRGSEEDSPK
510 520 530 540 550
KESKKKTLKN DCEENGLAKE SEDDLNKESE EEVGPTKESE EDDSEKESDE
560 570 580 590 600
DCSEKQSEDG SEREFEENGL EKDLDEEGSE KELHENVLDK ELEENDSENS
610 620 630 640 650
EFEDDGSEKV LDEEGSEREF DEDSDEKEEE EDTYEKVFDD ESDEKEDEEY
660 670 680 690 700
ADEKGLEAAD KKAEEGDADE KLFEESDDKE DEDADGKEVE DADEKLFEDD
710 720 730 740 750
DSNEKLFDEE EDSSEKLFDD SDERGTLGGF GSVEEGPLST GSSFILSSDD

DDDDI
Length:755
Mass (Da):85,853
Last modified:June 1, 1998 - v1
Checksum:iC9CA6C89E4F2A319
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5H919Q5H919_HUMAN
HIV Tat-specific factor 1
HTATSF1
223Annotation score:
Q5H918Q5H918_HUMAN
HIV Tat-specific factor 1
HTATSF1
244Annotation score:

Sequence cautioni

The sequence AAB18823 differs from that shown. Reason: Frameshift at positions 383, 391 and 393.Curated
The sequence BAD92540 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125F → V in BAD92540 (Ref. 3) Curated1
Sequence conflicti587V → I in BAD92540 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027362478G → A1 PublicationCorresponds to variant dbSNP:rs2071913Ensembl.1
Natural variantiVAR_052206526N → T. Corresponds to variant dbSNP:rs12852634Ensembl.1
Natural variantiVAR_052207678D → G. Corresponds to variant dbSNP:rs17339410Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76992 mRNA Translation: AAB18823.1 Frameshift.
BT006886 mRNA Translation: AAP35532.1
AB209303 mRNA Translation: BAD92540.1 Different initiation.
Z97632 Genomic DNA No translation available.
CH471150 Genomic DNA Translation: EAW88468.1
CH471150 Genomic DNA Translation: EAW88469.1
BC009896 mRNA Translation: AAH09896.1
CCDSiCCDS14657.1
RefSeqiNP_001156752.1, NM_001163280.1
NP_055315.2, NM_014500.4
XP_005262461.1, XM_005262404.3
UniGeneiHs.204475

Genome annotation databases

EnsembliENST00000218364; ENSP00000218364; ENSG00000102241
ENST00000535601; ENSP00000442699; ENSG00000102241
GeneIDi27336
KEGGihsa:27336
UCSCiuc004ezw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76992 mRNA Translation: AAB18823.1 Frameshift.
BT006886 mRNA Translation: AAP35532.1
AB209303 mRNA Translation: BAD92540.1 Different initiation.
Z97632 Genomic DNA No translation available.
CH471150 Genomic DNA Translation: EAW88468.1
CH471150 Genomic DNA Translation: EAW88469.1
BC009896 mRNA Translation: AAH09896.1
CCDSiCCDS14657.1
RefSeqiNP_001156752.1, NM_001163280.1
NP_055315.2, NM_014500.4
XP_005262461.1, XM_005262404.3
UniGeneiHs.204475

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DITNMR-A256-354[»]
ProteinModelPortaliO43719
SMRiO43719
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118149, 53 interactors
CORUMiO43719
DIPiDIP-42095N
IntActiO43719, 19 interactors
MINTiO43719
STRINGi9606.ENSP00000218364

PTM databases

iPTMnetiO43719
PhosphoSitePlusiO43719

Polymorphism and mutation databases

BioMutaiHTATSF1

Proteomic databases

EPDiO43719
MaxQBiO43719
PaxDbiO43719
PeptideAtlasiO43719
PRIDEiO43719
ProteomicsDBi49133

Protocols and materials databases

DNASUi27336
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218364; ENSP00000218364; ENSG00000102241
ENST00000535601; ENSP00000442699; ENSG00000102241
GeneIDi27336
KEGGihsa:27336
UCSCiuc004ezw.4 human

Organism-specific databases

CTDi27336
EuPathDBiHostDB:ENSG00000102241.11
GeneCardsiHTATSF1
HGNCiHGNC:5276 HTATSF1
HPAiHPA000504
MIMi300346 gene
neXtProtiNX_O43719
OpenTargetsiENSG00000102241
PharmGKBiPA29540
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1548 Eukaryota
ENOG410YD7P LUCA
GeneTreeiENSGT00390000009902
HOGENOMiHOG000049201
HOVERGENiHBG059454
InParanoidiO43719
KOiK13093
OMAiITAEAWD
OrthoDBiEOG091G0O8I
PhylomeDBiO43719
TreeFamiTF313623

Miscellaneous databases

ChiTaRSiHTATSF1 human
EvolutionaryTraceiO43719
GeneWikiiHTATSF1
GenomeRNAii27336
PMAP-CutDBiO43719
PROiPR:O43719
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102241 Expressed in 245 organ(s), highest expression level in pituitary gland
CleanExiHS_HTATSF1
ExpressionAtlasiO43719 baseline and differential
GenevisibleiO43719 HS

Family and domain databases

CDDicd12281 RRM1_TatSF1_like, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034393 TatSF1-like
IPR034392 TatSF1-like_RRM1
PANTHERiPTHR15608 PTHR15608, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHTSF1_HUMAN
AccessioniPrimary (citable) accession number: O43719
Secondary accession number(s): D3DWG9, Q59G06, Q99730
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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