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Protein

T-cell leukemia homeobox protein 3

Gene

TLX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi166 – 225HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Enzyme and pathway databases

SignaLinkiO43711

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 3
Alternative name(s):
Homeobox protein Hox-11L2
Gene namesi
Name:TLX3
Synonyms:HOX11L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164438.5
HGNCiHGNC:13532 TLX3
MIMi604640 gene
neXtProtiNX_O43711

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi30012
MalaCardsiTLX3
OpenTargetsiENSG00000164438
Orphaneti99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA37797

Polymorphism and mutation databases

BioMutaiTLX3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493381 – 291T-cell leukemia homeobox protein 3Add BLAST291

Proteomic databases

PaxDbiO43711
PRIDEiO43711
ProteomicsDBi49130

PTM databases

iPTMnetiO43711
PhosphoSitePlusiO43711

Expressioni

Gene expression databases

BgeeiENSG00000164438 Expressed in 12 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_TLX3
GenevisibleiO43711 HS

Organism-specific databases

HPAiHPA030504
HPA060957
HPA069359

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Ets1P275772EBI-3939165,EBI-4289053From Mus musculus.

Protein-protein interaction databases

BioGridi119030, 15 interactors
ELMiO43711
IntActiO43711, 96 interactors
STRINGi9606.ENSP00000296921

Structurei

3D structure databases

ProteinModelPortaliO43711
SMRiO43711
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000116280
HOVERGENiHBG036206
InParanoidiO43711
KOiK15607
OMAiYNPACSM
OrthoDBiEOG091G0RNV
PhylomeDBiO43711
TreeFamiTF325347

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O43711-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG
60 70 80 90 100
RPGATYPSLP ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV
110 120 130 140 150
PPPLPSALPA MPSVPTVSSL GGLNFPWMES SRRFVKDRFT AAAALTPFTV
160 170 180 190 200
TRRIGHPYQN RTPPKRKKPR TSFSRVQICE LEKRFHRQKY LASAERAALA
210 220 230 240 250
KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM LQLQHDAFQK
260 270 280 290
SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V
Length:291
Mass (Da):31,867
Last modified:October 3, 2006 - v3
Checksum:iB5E3B910393EB4F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66L → P in CAA11550 (Ref. 1) Curated1
Sequence conflicti122G → R in CAA11550 (Ref. 1) Curated1
Sequence conflicti232 – 233ER → DG in CAA11550 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223798, AJ223799, AJ223800 Genomic DNA Translation: CAA11550.1
BC017291 mRNA Translation: AAH17291.1
CCDSiCCDS34288.1
RefSeqiNP_066305.2, NM_021025.3
UniGeneiHs.249125

Genome annotation databases

EnsembliENST00000296921; ENSP00000296921; ENSG00000164438
GeneIDi30012
KEGGihsa:30012
UCSCiuc003mbf.3 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223798, AJ223799, AJ223800 Genomic DNA Translation: CAA11550.1
BC017291 mRNA Translation: AAH17291.1
CCDSiCCDS34288.1
RefSeqiNP_066305.2, NM_021025.3
UniGeneiHs.249125

3D structure databases

ProteinModelPortaliO43711
SMRiO43711
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119030, 15 interactors
ELMiO43711
IntActiO43711, 96 interactors
STRINGi9606.ENSP00000296921

PTM databases

iPTMnetiO43711
PhosphoSitePlusiO43711

Polymorphism and mutation databases

BioMutaiTLX3

Proteomic databases

PaxDbiO43711
PRIDEiO43711
ProteomicsDBi49130

Protocols and materials databases

DNASUi30012
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296921; ENSP00000296921; ENSG00000164438
GeneIDi30012
KEGGihsa:30012
UCSCiuc003mbf.3 human

Organism-specific databases

CTDi30012
DisGeNETi30012
EuPathDBiHostDB:ENSG00000164438.5
GeneCardsiTLX3
HGNCiHGNC:13532 TLX3
HPAiHPA030504
HPA060957
HPA069359
MalaCardsiTLX3
MIMi604640 gene
neXtProtiNX_O43711
OpenTargetsiENSG00000164438
Orphaneti99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA37797
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000116280
HOVERGENiHBG036206
InParanoidiO43711
KOiK15607
OMAiYNPACSM
OrthoDBiEOG091G0RNV
PhylomeDBiO43711
TreeFamiTF325347

Enzyme and pathway databases

SignaLinkiO43711

Miscellaneous databases

ChiTaRSiTLX3 human
GeneWikiiTLX3
GenomeRNAii30012
PROiPR:O43711
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164438 Expressed in 12 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_TLX3
GenevisibleiO43711 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTLX3_HUMAN
AccessioniPrimary (citable) accession number: O43711
Secondary accession number(s): Q96AD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2006
Last modified: November 7, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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