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UniProtKB - O43711 (TLX3_HUMAN)
Protein
T-cell leukemia homeobox protein 3
Gene
TLX3
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 166 – 225 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- animal organ development Source: GO_Central
- central nervous system development Source: Ensembl
- negative regulation of neuron differentiation Source: Ensembl
- neuron fate specification Source: Ensembl
- neuron migration Source: Ensembl
- regulation of respiratory gaseous exchange by nervous system process Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- respiratory gaseous exchange by respiratory system Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | O43711 |
SignaLinki | O43711 |
SIGNORi | O43711 |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell leukemia homeobox protein 3Alternative name(s): Homeobox protein Hox-11L2 |
Gene namesi | Name:TLX3 Synonyms:HOX11L2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13532, TLX3 |
MIMi | 604640, gene |
neXtProti | NX_O43711 |
VEuPathDBi | HostDB:ENSG00000164438 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 30012 |
MalaCardsi | TLX3 |
OpenTargetsi | ENSG00000164438 |
Orphaneti | 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA37797 |
Miscellaneous databases
Pharosi | O43711, Tbio |
Genetic variation databases
BioMutai | TLX3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049338 | 1 – 291 | T-cell leukemia homeobox protein 3Add BLAST | 291 |
Proteomic databases
MassIVEi | O43711 |
PaxDbi | O43711 |
PeptideAtlasi | O43711 |
PRIDEi | O43711 |
ProteomicsDBi | 49130 |
PTM databases
iPTMneti | O43711 |
PhosphoSitePlusi | O43711 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164438, Expressed in cerebellar hemisphere and 19 other tissues |
Genevisiblei | O43711, HS |
Organism-specific databases
HPAi | ENSG00000164438, Tissue enriched (brain) |
Interactioni
Binary interactionsi
O43711
Protein-protein interaction databases
BioGRIDi | 119030, 110 interactors |
ELMi | O43711 |
IntActi | O43711, 246 interactors |
STRINGi | 9606.ENSP00000296921 |
Miscellaneous databases
RNActi | O43711, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 56 | DisorderedSequence analysisAdd BLAST | 56 |
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0488, Eukaryota |
GeneTreei | ENSGT00940000160629 |
HOGENOMi | CLU_053409_1_0_1 |
InParanoidi | O43711 |
OMAi | TPHQHEP |
OrthoDBi | 1391465at2759 |
PhylomeDBi | O43711 |
TreeFami | TF325347 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR042247, TLX1/2/3 |
PANTHERi | PTHR45921, PTHR45921, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O43711-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG
60 70 80 90 100
RPGATYPSLP ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV
110 120 130 140 150
PPPLPSALPA MPSVPTVSSL GGLNFPWMES SRRFVKDRFT AAAALTPFTV
160 170 180 190 200
TRRIGHPYQN RTPPKRKKPR TSFSRVQICE LEKRFHRQKY LASAERAALA
210 220 230 240 250
KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM LQLQHDAFQK
260 270 280 290
SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 66 | L → P in CAA11550 (Ref. 1) Curated | 1 | |
Sequence conflicti | 122 | G → R in CAA11550 (Ref. 1) Curated | 1 | |
Sequence conflicti | 232 – 233 | ER → DG in CAA11550 (Ref. 1) Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ223798, AJ223799, AJ223800 Genomic DNA Translation: CAA11550.1 BC017291 mRNA Translation: AAH17291.1 |
CCDSi | CCDS34288.1 |
RefSeqi | NP_066305.2, NM_021025.3 |
Genome annotation databases
Ensembli | ENST00000296921.6; ENSP00000296921.5; ENSG00000164438.6 |
GeneIDi | 30012 |
KEGGi | hsa:30012 |
MANE-Selecti | ENST00000296921.6; ENSP00000296921.5; NM_021025.4; NP_066305.2 |
UCSCi | uc003mbf.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ223798, AJ223799, AJ223800 Genomic DNA Translation: CAA11550.1 BC017291 mRNA Translation: AAH17291.1 |
CCDSi | CCDS34288.1 |
RefSeqi | NP_066305.2, NM_021025.3 |
3D structure databases
AlphaFoldDBi | O43711 |
SMRi | O43711 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119030, 110 interactors |
ELMi | O43711 |
IntActi | O43711, 246 interactors |
STRINGi | 9606.ENSP00000296921 |
PTM databases
iPTMneti | O43711 |
PhosphoSitePlusi | O43711 |
Genetic variation databases
BioMutai | TLX3 |
Proteomic databases
MassIVEi | O43711 |
PaxDbi | O43711 |
PeptideAtlasi | O43711 |
PRIDEi | O43711 |
ProteomicsDBi | 49130 |
Protocols and materials databases
Antibodypediai | 28858, 161 antibodies from 25 providers |
DNASUi | 30012 |
Genome annotation databases
Ensembli | ENST00000296921.6; ENSP00000296921.5; ENSG00000164438.6 |
GeneIDi | 30012 |
KEGGi | hsa:30012 |
MANE-Selecti | ENST00000296921.6; ENSP00000296921.5; NM_021025.4; NP_066305.2 |
UCSCi | uc003mbf.3, human |
Organism-specific databases
CTDi | 30012 |
DisGeNETi | 30012 |
GeneCardsi | TLX3 |
HGNCi | HGNC:13532, TLX3 |
HPAi | ENSG00000164438, Tissue enriched (brain) |
MalaCardsi | TLX3 |
MIMi | 604640, gene |
neXtProti | NX_O43711 |
OpenTargetsi | ENSG00000164438 |
Orphaneti | 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA37797 |
VEuPathDBi | HostDB:ENSG00000164438 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0488, Eukaryota |
GeneTreei | ENSGT00940000160629 |
HOGENOMi | CLU_053409_1_0_1 |
InParanoidi | O43711 |
OMAi | TPHQHEP |
OrthoDBi | 1391465at2759 |
PhylomeDBi | O43711 |
TreeFami | TF325347 |
Enzyme and pathway databases
PathwayCommonsi | O43711 |
SignaLinki | O43711 |
SIGNORi | O43711 |
Miscellaneous databases
BioGRID-ORCSi | 30012, 14 hits in 1093 CRISPR screens |
ChiTaRSi | TLX3, human |
GeneWikii | TLX3 |
GenomeRNAii | 30012 |
Pharosi | O43711, Tbio |
PROi | PR:O43711 |
RNActi | O43711, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164438, Expressed in cerebellar hemisphere and 19 other tissues |
Genevisiblei | O43711, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR042247, TLX1/2/3 |
PANTHERi | PTHR45921, PTHR45921, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TLX3_HUMAN | |
Accessioni | O43711Primary (citable) accession number: O43711 Secondary accession number(s): Q96AD3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | October 3, 2006 | |
Last modified: | May 25, 2022 | |
This is version 178 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot