TLX3

Protein namesⁱ	Recommended name: T-cell leukemia homeobox protein 3 Alternative name(s): Homeobox protein Hox-11L2
Gene namesⁱ	Name:TLX3 Synonyms:HOX11L2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000164438.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13532 TLX3
MIMⁱ	604640 gene
neXtProtⁱ	NX_O43711

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	30012
MalaCards human disease database More...MalaCardsⁱ	TLX3
Open Targets More...OpenTargetsⁱ	ENSG00000164438
Orphanetⁱ	99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBⁱ	PA37797

Polymorphism and mutation databases

BioMutaⁱ	TLX3

BioMutaⁱ

TLX3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000049338	1 – 291	T-cell leukemia homeobox protein 3Add BLAST		291

Proteomic databases

PaxDbⁱ	O43711
PRIDEⁱ	O43711
ProteomicsDBⁱ	49130

PTM databases

iPTMnetⁱ	O43711
PhosphoSitePlusⁱ	O43711

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000164438 Expressed in 12 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_TLX3
Genevisibleⁱ	O43711 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030504 HPA060957 HPA069359

HPAⁱ

HPA030504
HPA060957
HPA069359

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Ets1	P27577	2	EBI-3939165,EBI-4289053	From Mus musculus.

With

Entry

#Exp.

IntAct

Notes

Ets1

P27577

2

EBI-3939165,EBI-4289053

From Mus musculus.

Protein-protein interaction databases

BioGridⁱ	119030, 15 interactors
ELMⁱ	O43711
IntActⁱ	O43711, 96 interactors
STRINGⁱ	9606.ENSP00000296921

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43711
SMRⁱ	O43711
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0488 Eukaryota ENOG411188D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143996
HOGENOMⁱ	HOG000116280
HOVERGENⁱ	HBG036206
InParanoidⁱ	O43711
KEGG Orthology (KO) More...KOⁱ	K15607
OMAⁱ	YNPACSM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RNV
PhylomeDBⁱ	O43711
TreeFamⁱ	TF325347

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O43711-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG 
        60         70         80         90        100
RPGATYPSLP ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV 
       110        120        130        140        150
PPPLPSALPA MPSVPTVSSL GGLNFPWMES SRRFVKDRFT AAAALTPFTV 
       160        170        180        190        200
TRRIGHPYQN RTPPKRKKPR TSFSRVQICE LEKRFHRQKY LASAERAALA 
       210        220        230        240        250
KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM LQLQHDAFQK 
       260        270        280        290 
SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V

Length:291

Mass (Da):31,867

Last modified:October 3, 2006 - v3

Checksum:ⁱB5E3B910393EB4F3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	66	L → P in CAA11550 (Ref. 1) Curated	1
Sequence conflictⁱ	122	G → R in CAA11550 (Ref. 1) Curated	1
Sequence conflictⁱ	232 – 233	ER → DG in CAA11550 (Ref. 1) Curated	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ223798, AJ223799, AJ223800 Genomic DNA Translation: CAA11550.1 BC017291 mRNA Translation: AAH17291.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34288.1
NCBI Reference Sequences More...RefSeqⁱ	NP_066305.2, NM_021025.3
UniGeneⁱ	Hs.249125

Genome annotation databases

Ensemblⁱ	ENST00000296921; ENSP00000296921; ENSG00000164438
GeneIDⁱ	30012
KEGGⁱ	hsa:30012
UCSC genome browser More...UCSCⁱ	uc003mbf.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43711	Uncharacterized protein		PONAB		338	UniRef100_O43711
TLX3 isoform 1		PANTR		291
Uncharacterized protein		CERAT		291
Uncharacterized protein		PAPAN		291
T cell leukemia homeobox 3		CHLSB		291
+1

Protein	Similar proteins		Species	Score	Length	Source
O43711	T-cell leukemia homeobox protein 3		MOUSE		291	UniRef90_O55144
Uncharacterized protein		NEOLE		338
T-cell leukemia homeobox protein 3		TARSY		95
T-cell leukemia homeobox protein 3		PTEAL		291
Similar to HOX11L2 (Predicted), isoform CRA_a		RAT		291
+74

Protein	Similar proteins		Species	Score	Length	Source
O43711	T-cell leukemia homeobox protein 3		MOUSE		291	UniRef50_O55144
Uncharacterized protein		NEOLE		338
T-cell leukemia homeobox protein 3		TARSY		95
T-cell leukemia homeobox protein 3		PTEAL		291
Similar to HOX11L2 (Predicted), isoform CRA_a		RAT		291
+75

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ223798, AJ223799, AJ223800 Genomic DNA Translation: CAA11550.1 BC017291 mRNA Translation: AAH17291.1
CCDSⁱ	CCDS34288.1
RefSeqⁱ	NP_066305.2, NM_021025.3
UniGeneⁱ	Hs.249125

3D structure databases

ProteinModelPortalⁱ	O43711
SMRⁱ	O43711
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119030, 15 interactors
ELMⁱ	O43711
IntActⁱ	O43711, 96 interactors
STRINGⁱ	9606.ENSP00000296921

PTM databases

iPTMnetⁱ	O43711
PhosphoSitePlusⁱ	O43711

Polymorphism and mutation databases

BioMutaⁱ	TLX3

BioMutaⁱ

TLX3

Proteomic databases

PaxDbⁱ	O43711
PRIDEⁱ	O43711
ProteomicsDBⁱ	49130

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	30012
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000296921; ENSP00000296921; ENSG00000164438
GeneIDⁱ	30012
KEGGⁱ	hsa:30012
UCSCⁱ	uc003mbf.3 human

Organism-specific databases

CTDⁱ	30012
DisGeNETⁱ	30012
EuPathDBⁱ	HostDB:ENSG00000164438.5
GeneCardsⁱ	TLX3
HGNCⁱ	HGNC:13532 TLX3
HPAⁱ	HPA030504 HPA060957 HPA069359
MalaCardsⁱ	TLX3
MIMⁱ	604640 gene
neXtProtⁱ	NX_O43711
OpenTargetsⁱ	ENSG00000164438
Orphanetⁱ	99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBⁱ	PA37797
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0488 Eukaryota ENOG411188D LUCA
GeneTreeⁱ	ENSGT00910000143996
HOGENOMⁱ	HOG000116280
HOVERGENⁱ	HBG036206
InParanoidⁱ	O43711
KOⁱ	K15607
OMAⁱ	YNPACSM
OrthoDBⁱ	EOG091G0RNV
PhylomeDBⁱ	O43711
TreeFamⁱ	TF325347

Enzyme and pathway databases

SignaLinkⁱ	O43711

SignaLinkⁱ

O43711

Miscellaneous databases

ChiTaRSⁱ	TLX3 human
GeneWikiⁱ	TLX3
GenomeRNAiⁱ	30012
Protein Ontology More...PROⁱ	PR:O43711
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000164438 Expressed in 12 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_TLX3
Genevisibleⁱ	O43711 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TLX3_HUMAN
Accessionⁱ	O43711Primary (citable) accession number: O43711 Secondary accession number(s): Q96AD3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	October 3, 2006
	Last modified:	November 7, 2018
	This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43711 (TLX3_HUMAN)

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T-cell leukemia homeobox protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ