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Protein

Sulfotransferase family cytosolic 1B member 1

Gene

SULT1B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei109Proton acceptorBy similarity1
Binding sitei131PAPS1
Binding sitei139PAPS1
Binding sitei194PAPS1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 53PAPS6
Nucleotide bindingi228 – 233PAPS6
Nucleotide bindingi258 – 260PAPS3

GO - Molecular functioni

  • aryl sulfotransferase activity Source: CAFA
  • sulfotransferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid metabolism, Steroid metabolism

Enzyme and pathway databases

BRENDAi2.8.2.1 2681
ReactomeiR-HSA-156584 Cytosolic sulfonation of small molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase family cytosolic 1B member 1 (EC:2.8.2.-)
Short name:
ST1B1
Short name:
Sulfotransferase 1B1
Alternative name(s):
Sulfotransferase 1B2
Short name:
ST1B2
Thyroid hormone sulfotransferase
Gene namesi
Name:SULT1B1
Synonyms:ST1B2, SULT1B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000173597.8
HGNCiHGNC:17845 SULT1B1
MIMi608436 gene
neXtProtiNX_O43704

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi27284
OpenTargetsiENSG00000173597
PharmGKBiPA415

Chemistry databases

ChEMBLiCHEMBL1743294
DrugBankiDB01812 Adenosine-3'-5'-Diphosphate

Polymorphism and mutation databases

BioMutaiSULT1B1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851611 – 296Sulfotransferase family cytosolic 1B member 1Add BLAST296

Proteomic databases

EPDiO43704
MaxQBiO43704
PaxDbiO43704
PeptideAtlasiO43704
PRIDEiO43704
ProteomicsDBi49124

PTM databases

iPTMnetiO43704
PhosphoSitePlusiO43704

Expressioni

Tissue specificityi

Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus.1 Publication

Gene expression databases

BgeeiENSG00000173597 Expressed in 101 organ(s), highest expression level in intestine
CleanExiHS_SULT1B1
ExpressionAtlasiO43704 baseline and differential
GenevisibleiO43704 HS

Organism-specific databases

HPAiHPA002107

Interactioni

Subunit structurei

Monomer.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi118108, 4 interactors
IntActiO43704, 4 interactors

Structurei

Secondary structure

1296
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43704
SMRiO43704
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43704

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 109Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584 Eukaryota
ENOG4111H56 LUCA
GeneTreeiENSGT00760000118932
HOGENOMiHOG000037209
HOVERGENiHBG001195
InParanoidiO43704
KOiK01025
OMAiLMNNLQP
OrthoDBiEOG091G0D5F
PhylomeDBiO43704
TreeFamiTF321745

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
IPR033289 SULT1B1
PANTHERiPTHR11783:SF14 PTHR11783:SF14, 1 hit
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O43704-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSPKDILRK DLKLVHGYPM TCAFASNWEK IEQFHSRPDD IVIATYPKSG
60 70 80 90 100
TTWVSEIIDM ILNDGDIEKC KRGFITEKVP MLEMTLPGLR TSGIEQLEKN
110 120 130 140 150
PSPRIVKTHL PTDLLPKSFW ENNCKMIYLA RNAKDVSVSY YHFDLMNNLQ
160 170 180 190 200
PFPGTWEEYL EKFLTGKVAY GSWFTHVKNW WKKKEEHPIL FLYYEDMKEN
210 220 230 240 250
PKEEIKKIIR FLEKNLNDEI LDRIIHHTSF EVMKDNPLVN YTHLPTTVMD
260 270 280 290
HSKSPFMRKG TAGDWKNYFT VAQNEKFDAI YETEMSKTAL QFRTEI
Length:296
Mass (Da):34,899
Last modified:January 4, 2005 - v2
Checksum:iAFEB61B21DBD782C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RD70D6RD70_HUMAN
Sulfotransferase
SULT1B1
155Annotation score:
D6RIA8D6RIA8_HUMAN
Sulfotransferase
SULT1B1
73Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183K → R in AAH10895 (PubMed:15489334).Curated1
Sequence conflicti186E → G in BAA24547 (PubMed:9443824).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89479 mRNA Translation: BAA24547.1
U95726 mRNA Translation: AAB65154.1
BC010895 mRNA Translation: AAH10895.1
AF184894 Genomic DNA Translation: AAF05917.1
CCDSiCCDS3530.1
PIRiJC5885
RefSeqiNP_055280.2, NM_014465.3
XP_005265734.1, XM_005265677.3
UniGeneiHs.129742

Genome annotation databases

EnsembliENST00000310613; ENSP00000308770; ENSG00000173597
GeneIDi27284
KEGGihsa:27284
UCSCiuc003hen.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89479 mRNA Translation: BAA24547.1
U95726 mRNA Translation: AAB65154.1
BC010895 mRNA Translation: AAH10895.1
AF184894 Genomic DNA Translation: AAF05917.1
CCDSiCCDS3530.1
PIRiJC5885
RefSeqiNP_055280.2, NM_014465.3
XP_005265734.1, XM_005265677.3
UniGeneiHs.129742

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z5FX-ray2.10A/B1-296[»]
3CKLX-ray2.00A/B1-296[»]
ProteinModelPortaliO43704
SMRiO43704
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118108, 4 interactors
IntActiO43704, 4 interactors

Chemistry databases

ChEMBLiCHEMBL1743294
DrugBankiDB01812 Adenosine-3'-5'-Diphosphate

PTM databases

iPTMnetiO43704
PhosphoSitePlusiO43704

Polymorphism and mutation databases

BioMutaiSULT1B1

Proteomic databases

EPDiO43704
MaxQBiO43704
PaxDbiO43704
PeptideAtlasiO43704
PRIDEiO43704
ProteomicsDBi49124

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310613; ENSP00000308770; ENSG00000173597
GeneIDi27284
KEGGihsa:27284
UCSCiuc003hen.4 human

Organism-specific databases

CTDi27284
DisGeNETi27284
EuPathDBiHostDB:ENSG00000173597.8
GeneCardsiSULT1B1
HGNCiHGNC:17845 SULT1B1
HPAiHPA002107
MIMi608436 gene
neXtProtiNX_O43704
OpenTargetsiENSG00000173597
PharmGKBiPA415
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1584 Eukaryota
ENOG4111H56 LUCA
GeneTreeiENSGT00760000118932
HOGENOMiHOG000037209
HOVERGENiHBG001195
InParanoidiO43704
KOiK01025
OMAiLMNNLQP
OrthoDBiEOG091G0D5F
PhylomeDBiO43704
TreeFamiTF321745

Enzyme and pathway databases

BRENDAi2.8.2.1 2681
ReactomeiR-HSA-156584 Cytosolic sulfonation of small molecules

Miscellaneous databases

EvolutionaryTraceiO43704
GeneWikiiSULT1B1
GenomeRNAii27284
PROiPR:O43704
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173597 Expressed in 101 organ(s), highest expression level in intestine
CleanExiHS_SULT1B1
ExpressionAtlasiO43704 baseline and differential
GenevisibleiO43704 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
IPR033289 SULT1B1
PANTHERiPTHR11783:SF14 PTHR11783:SF14, 1 hit
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiST1B1_HUMAN
AccessioniPrimary (citable) accession number: O43704
Secondary accession number(s): O15497, Q96FI1, Q9UK34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: November 7, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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