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Protein

Peptidase inhibitor 15

Gene

PI15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May play a role in facial patterning during embryonic development (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase inhibitor 15
Short name:
PI-15
Alternative name(s):
25 kDa trypsin inhibitor
Short name:
p25TI
Cysteine-rich secretory protein 8
Short name:
CRISP-8
SugarCrisp
Gene namesi
Name:PI15
Synonyms:CRISP8, P25TI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000137558.7
HGNCiHGNC:8946 PI15
MIMi607076 gene
neXtProtiNX_O43692

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51050
OpenTargetsiENSG00000137558
PharmGKBiPA33282

Polymorphism and mutation databases

BioMutaiPI15

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000028762220 – 601 PublicationAdd BLAST41
ChainiPRO_000028762361 – 258Peptidase inhibitor 15Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO43692
PaxDbiO43692
PeptideAtlasiO43692
PRIDEiO43692
ProteomicsDBi49119

PTM databases

iPTMnetiO43692
PhosphoSitePlusiO43692

Expressioni

Tissue specificityi

Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and thyroid gland.2 Publications

Gene expression databases

BgeeiENSG00000137558 Expressed in 149 organ(s), highest expression level in uterine cervix
CleanExiHS_PI15
GenevisibleiO43692 HS

Organism-specific databases

HPAiHPA006593
HPA030057

Interactioni

Protein-protein interaction databases

BioGridi119244, 13 interactors
STRINGi9606.ENSP00000260113

Structurei

3D structure databases

ProteinModelPortaliO43692
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 211SCPAdd BLAST141

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000111978
HOVERGENiHBG079090
InParanoidiO43692
OMAiNMNVWGA
OrthoDBiEOG091G048D
PhylomeDBiO43692
TreeFamiTF316148

Family and domain databases

Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01010 CRISP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43692-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIAISAVSSA LLFSLLCEAS TVVLLNSTDS SPPTNNFTDI EAALKAQLDS
60 70 80 90 100
ADIPKARRKR YISQNDMIAI LDYHNQVRGK VFPPAANMEY MVWDENLAKS
110 120 130 140 150
AEAWAATCIW DHGPSYLLRF LGQNLSVRTG RYRSILQLVK PWYDEVKDYA
160 170 180 190 200
FPYPQDCNPR CPMRCFGPMC THYTQMVWAT SNRIGCAIHT CQNMNVWGSV
210 220 230 240 250
WRRAVYLVCN YAPKGNWIGE APYKVGVPCS SCPPSYGGSC TDNLCFPGVT

SNYLYWFK
Length:258
Mass (Da):29,065
Last modified:June 1, 1998 - v1
Checksum:i1915A5831637795F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45027 mRNA Translation: BAA25066.1
CR749657 mRNA Translation: CAH18451.2
BC074931 mRNA Translation: AAH74931.1
BC074932 mRNA Translation: AAH74932.1
BC126290 mRNA Translation: AAI26291.1
BC126292 mRNA Translation: AAI26293.1
CCDSiCCDS6218.1
RefSeqiNP_001311332.1, NM_001324403.1
NP_056970.1, NM_015886.4
UniGeneiHs.98558

Genome annotation databases

EnsembliENST00000260113; ENSP00000260113; ENSG00000137558
ENST00000523773; ENSP00000428567; ENSG00000137558
GeneIDi51050
KEGGihsa:51050
UCSCiuc003yal.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45027 mRNA Translation: BAA25066.1
CR749657 mRNA Translation: CAH18451.2
BC074931 mRNA Translation: AAH74931.1
BC074932 mRNA Translation: AAH74932.1
BC126290 mRNA Translation: AAI26291.1
BC126292 mRNA Translation: AAI26293.1
CCDSiCCDS6218.1
RefSeqiNP_001311332.1, NM_001324403.1
NP_056970.1, NM_015886.4
UniGeneiHs.98558

3D structure databases

ProteinModelPortaliO43692
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119244, 13 interactors
STRINGi9606.ENSP00000260113

PTM databases

iPTMnetiO43692
PhosphoSitePlusiO43692

Polymorphism and mutation databases

BioMutaiPI15

Proteomic databases

MaxQBiO43692
PaxDbiO43692
PeptideAtlasiO43692
PRIDEiO43692
ProteomicsDBi49119

Protocols and materials databases

DNASUi51050
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260113; ENSP00000260113; ENSG00000137558
ENST00000523773; ENSP00000428567; ENSG00000137558
GeneIDi51050
KEGGihsa:51050
UCSCiuc003yal.3 human

Organism-specific databases

CTDi51050
DisGeNETi51050
EuPathDBiHostDB:ENSG00000137558.7
GeneCardsiPI15
HGNCiHGNC:8946 PI15
HPAiHPA006593
HPA030057
MIMi607076 gene
neXtProtiNX_O43692
OpenTargetsiENSG00000137558
PharmGKBiPA33282
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000111978
HOVERGENiHBG079090
InParanoidiO43692
OMAiNMNVWGA
OrthoDBiEOG091G048D
PhylomeDBiO43692
TreeFamiTF316148

Miscellaneous databases

GenomeRNAii51050
PROiPR:O43692
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137558 Expressed in 149 organ(s), highest expression level in uterine cervix
CleanExiHS_PI15
GenevisibleiO43692 HS

Family and domain databases

Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01010 CRISP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPI15_HUMAN
AccessioniPrimary (citable) accession number: O43692
Secondary accession number(s): Q68CY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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