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Protein

Phospholipid phosphatase 2

Gene

PLPP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by sphingosine, zinc ions and propanolol.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lipid phosphatase activity Source: GO_Central
  • phosphatase activity Source: GO_Central
  • phosphatidate phosphatase activity Source: GO_Central
  • phosphoprotein phosphatase activity Source: ProtInc
  • sphingosine-1-phosphate phosphatase activity Source: Reactome

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660661 Sphingolipid de novo biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipid phosphatase 2Imported (EC:3.1.3.4)
Alternative name(s):
Lipid phosphate phosphohydrolase 2
PAP2-gamma
Short name:
PAP2-G
Phosphatidate phosphohydrolase type 2c
Phosphatidic acid phosphatase 2c
Short name:
PAP-2c
Short name:
PAP2c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLPP2Imported
Synonyms:LPP2, PPAP2C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000141934.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9230 PLPP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607126 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43688

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8612

Open Targets

More...
OpenTargetsi
ENSG00000141934

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33554

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLPP2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002209091 – 288Phospholipid phosphatase 2Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43688

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43688

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43688

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43688

PeptideAtlas

More...
PeptideAtlasi
O43688

PRoteomics IDEntifications database

More...
PRIDEi
O43688

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49117
49118 [O43688-2]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
O43688

GlyConnect protein glycosylation platform

More...
GlyConnecti
1460

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43688

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43688

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found mainly in brain, pancreas and placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141934 Expressed in 147 organ(s), highest expression level in minor salivary gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_PPAP2C

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O43688 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43688 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055540

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114170, 9 interactors

Protein interaction database and analysis system

More...
IntActi
O43688, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000329697

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O43688

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3030 Eukaryota
COG0671 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155885

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000041307

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002048

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43688

KEGG Orthology (KO)

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KOi
K01080

Identification of Orthologs from Complete Genome Data

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OMAi
KADTITH

Database of Orthologous Groups

More...
OrthoDBi
1621899at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43688

TreeFam database of animal gene trees

More...
TreeFami
TF316040

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028674 LPP2
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase

The PANTHER Classification System

More...
PANTHERi
PTHR10165:SF25 PTHR10165:SF25, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01569 PAP2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00014 acidPPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48317 SSF48317, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43688-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRRWVFVLL DVLCLLVASL PFAILTLVNA PYKRGFYCGD DSIRYPYRPD
60 70 80 90 100
TITHGLMAGV TITATVILVS AGEAYLVYTD RLYSRSDFNN YVAAVYKVLG
110 120 130 140 150
TFLFGAAVSQ SLTDLAKYMI GRLRPNFLAV CDPDWSRVNC SVYVQLEKVC
160 170 180 190 200
RGNPADVTEA RLSFYSGHSS FGMYCMVFLA LYVQARLCWK WARLLRPTVQ
210 220 230 240 250
FFLVAFALYV GYTRVSDYKH HWSDVLVGLL QGALVAALTV CYISDFFKAR
260 270 280
PPQHCLKEEE LERKPSLSLT LTLGEADHNH YGYPHSSS
Length:288
Mass (Da):32,574
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7C6A09A28DA9AC8
GO
Isoform 2 (identifier: O43688-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MQRRWVFVLLDVLCLLV → MGVARGPGSRGQHPPPRQQEVCAEGPRARLHPAPPGLG

Note: No experimental confirmation available.
Show »
Length:309
Mass (Da):34,393
Checksum:i18E2A8A78FEB815A
GO
Isoform 3 (identifier: O43688-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Note: Gene prediction based on EST data.
Show »
Length:232
Mass (Da):26,103
Checksum:i672A852905D493C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMK9K7EMK9_HUMAN
Phospholipid phosphatase 2
PLPP2
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENH4K7ENH4_HUMAN
Phospholipid phosphatase 2
PLPP2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXA3A0A0J9YXA3_HUMAN
Phospholipid phosphatase 2
PLPP2
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061541180A → V. Corresponds to variant dbSNP:rs1138439Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0473661 – 56Missing in isoform 3. CuratedAdd BLAST56
Alternative sequenceiVSP_0377651 – 17MQRRW…LCLLV → MGVARGPGSRGQHPPPRQQE VCAEGPRARLHPAPPGLG in isoform 2. CuratedAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF035959 mRNA Translation: AAC15968.1
AF047760 mRNA Translation: AAC32104.1
AF056083 mRNA Translation: AAC25666.1
BT007021 mRNA Translation: AAP35667.1
AC016588 Genomic DNA No translation available.
BC002806 mRNA Translation: AAH02806.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12023.1 [O43688-1]
CCDS12024.1 [O43688-2]
CCDS45889.1 [O43688-3]

NCBI Reference Sequences

More...
RefSeqi
NP_003703.1, NM_003712.3 [O43688-1]
NP_803545.1, NM_177526.2 [O43688-3]
NP_808211.1, NM_177543.2 [O43688-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.465506

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000269812; ENSP00000269812; ENSG00000141934 [O43688-3]
ENST00000327790; ENSP00000329697; ENSG00000141934 [O43688-2]
ENST00000434325; ENSP00000388565; ENSG00000141934 [O43688-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8612

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8612

UCSC genome browser

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UCSCi
uc002loh.5 human [O43688-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035959 mRNA Translation: AAC15968.1
AF047760 mRNA Translation: AAC32104.1
AF056083 mRNA Translation: AAC25666.1
BT007021 mRNA Translation: AAP35667.1
AC016588 Genomic DNA No translation available.
BC002806 mRNA Translation: AAH02806.1
CCDSiCCDS12023.1 [O43688-1]
CCDS12024.1 [O43688-2]
CCDS45889.1 [O43688-3]
RefSeqiNP_003703.1, NM_003712.3 [O43688-1]
NP_803545.1, NM_177526.2 [O43688-3]
NP_808211.1, NM_177543.2 [O43688-2]
UniGeneiHs.465506

3D structure databases

ProteinModelPortaliO43688
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114170, 9 interactors
IntActiO43688, 11 interactors
STRINGi9606.ENSP00000329697

PTM databases

DEPODiO43688
GlyConnecti1460
iPTMnetiO43688
PhosphoSitePlusiO43688

Polymorphism and mutation databases

BioMutaiPLPP2

Proteomic databases

EPDiO43688
jPOSTiO43688
MaxQBiO43688
PaxDbiO43688
PeptideAtlasiO43688
PRIDEiO43688
ProteomicsDBi49117
49118 [O43688-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8612
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269812; ENSP00000269812; ENSG00000141934 [O43688-3]
ENST00000327790; ENSP00000329697; ENSG00000141934 [O43688-2]
ENST00000434325; ENSP00000388565; ENSG00000141934 [O43688-1]
GeneIDi8612
KEGGihsa:8612
UCSCiuc002loh.5 human [O43688-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8612
DisGeNETi8612
EuPathDBiHostDB:ENSG00000141934.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLPP2
HGNCiHGNC:9230 PLPP2
HPAiHPA055540
MIMi607126 gene
neXtProtiNX_O43688
OpenTargetsiENSG00000141934
PharmGKBiPA33554

GenAtlas: human gene database

More...
GenAtlasi
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Phylogenomic databases

eggNOGiKOG3030 Eukaryota
COG0671 LUCA
GeneTreeiENSGT00940000155885
HOGENOMiHOG000041307
HOVERGENiHBG002048
InParanoidiO43688
KOiK01080
OMAiKADTITH
OrthoDBi1621899at2759
PhylomeDBiO43688
TreeFamiTF316040

Enzyme and pathway databases

ReactomeiR-HSA-1660661 Sphingolipid de novo biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLPP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Phosphatidic_acid_phosphatase_2c

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8612

Protein Ontology

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PROi
PR:O43688

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000141934 Expressed in 147 organ(s), highest expression level in minor salivary gland
CleanExiHS_PPAP2C
ExpressionAtlasiO43688 baseline and differential
GenevisibleiO43688 HS

Family and domain databases

InterProiView protein in InterPro
IPR028674 LPP2
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PANTHERiPTHR10165:SF25 PTHR10165:SF25, 1 hit
PfamiView protein in Pfam
PF01569 PAP2, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLPP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43688
Secondary accession number(s): A6NLV0, E9PAY8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 1998
Last modified: January 16, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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