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Protein

Phospholipid phosphatase 2

Gene

PLPP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

Activity regulationi

Inhibited by sphingosine, zinc ions and propanolol.

GO - Molecular functioni

  • lipid phosphatase activity Source: GO_Central
  • phosphatase activity Source: GO_Central
  • phosphatidate phosphatase activity Source: GO_Central
  • phosphoprotein phosphatase activity Source: ProtInc
  • sphingosine-1-phosphate phosphatase activity Source: Reactome

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-HSA-1660661 Sphingolipid de novo biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase 2Imported (EC:3.1.3.4)
Alternative name(s):
Lipid phosphate phosphohydrolase 2
PAP2-gamma
Short name:
PAP2-G
Phosphatidate phosphohydrolase type 2c
Phosphatidic acid phosphatase 2c
Short name:
PAP-2c
Short name:
PAP2c
Gene namesi
Name:PLPP2Imported
Synonyms:LPP2, PPAP2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000141934.9
HGNCiHGNC:9230 PLPP2
MIMi607126 gene
neXtProtiNX_O43688

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8612
OpenTargetsiENSG00000141934
PharmGKBiPA33554

Polymorphism and mutation databases

BioMutaiPPAP2C

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209091 – 288Phospholipid phosphatase 2Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO43688
MaxQBiO43688
PaxDbiO43688
PeptideAtlasiO43688
PRIDEiO43688
ProteomicsDBi49117
49118 [O43688-2]

PTM databases

DEPODiO43688
GlyConnecti1460
iPTMnetiO43688
PhosphoSitePlusiO43688

Expressioni

Tissue specificityi

Found mainly in brain, pancreas and placenta.

Gene expression databases

BgeeiENSG00000141934 Expressed in 147 organ(s), highest expression level in minor salivary gland
CleanExiHS_PPAP2C
ExpressionAtlasiO43688 baseline and differential
GenevisibleiO43688 HS

Organism-specific databases

HPAiHPA055540

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi114170, 9 interactors
IntActiO43688, 11 interactors
STRINGi9606.ENSP00000329697

Structurei

3D structure databases

ProteinModelPortaliO43688
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3030 Eukaryota
COG0671 LUCA
GeneTreeiENSGT00620000087654
HOGENOMiHOG000041307
HOVERGENiHBG002048
InParanoidiO43688
KOiK01080
OMAiKADTITH
OrthoDBiEOG091G0K5H
PhylomeDBiO43688
TreeFamiTF316040

Family and domain databases

InterProiView protein in InterPro
IPR028674 LPP2
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PANTHERiPTHR10165:SF25 PTHR10165:SF25, 1 hit
PfamiView protein in Pfam
PF01569 PAP2, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43688-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRRWVFVLL DVLCLLVASL PFAILTLVNA PYKRGFYCGD DSIRYPYRPD
60 70 80 90 100
TITHGLMAGV TITATVILVS AGEAYLVYTD RLYSRSDFNN YVAAVYKVLG
110 120 130 140 150
TFLFGAAVSQ SLTDLAKYMI GRLRPNFLAV CDPDWSRVNC SVYVQLEKVC
160 170 180 190 200
RGNPADVTEA RLSFYSGHSS FGMYCMVFLA LYVQARLCWK WARLLRPTVQ
210 220 230 240 250
FFLVAFALYV GYTRVSDYKH HWSDVLVGLL QGALVAALTV CYISDFFKAR
260 270 280
PPQHCLKEEE LERKPSLSLT LTLGEADHNH YGYPHSSS
Length:288
Mass (Da):32,574
Last modified:June 1, 1998 - v1
Checksum:iF7C6A09A28DA9AC8
GO
Isoform 2 (identifier: O43688-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MQRRWVFVLLDVLCLLV → MGVARGPGSRGQHPPPRQQEVCAEGPRARLHPAPPGLG

Note: No experimental confirmation available.
Show »
Length:309
Mass (Da):34,393
Checksum:i18E2A8A78FEB815A
GO
Isoform 3 (identifier: O43688-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Note: Gene prediction based on EST data.
Show »
Length:232
Mass (Da):26,103
Checksum:i672A852905D493C5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMK9K7EMK9_HUMAN
Phospholipid phosphatase 2
PLPP2
178Annotation score:
K7ENH4K7ENH4_HUMAN
Phospholipid phosphatase 2
PLPP2
136Annotation score:
A0A0J9YXA3A0A0J9YXA3_HUMAN
Phospholipid phosphatase 2
PLPP2
208Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061541180A → V. Corresponds to variant dbSNP:rs1138439Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0473661 – 56Missing in isoform 3. CuratedAdd BLAST56
Alternative sequenceiVSP_0377651 – 17MQRRW…LCLLV → MGVARGPGSRGQHPPPRQQE VCAEGPRARLHPAPPGLG in isoform 2. CuratedAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035959 mRNA Translation: AAC15968.1
AF047760 mRNA Translation: AAC32104.1
AF056083 mRNA Translation: AAC25666.1
BT007021 mRNA Translation: AAP35667.1
AC016588 Genomic DNA No translation available.
BC002806 mRNA Translation: AAH02806.1
CCDSiCCDS12023.1 [O43688-1]
CCDS12024.1 [O43688-2]
CCDS45889.1 [O43688-3]
RefSeqiNP_003703.1, NM_003712.3 [O43688-1]
NP_803545.1, NM_177526.2 [O43688-3]
NP_808211.1, NM_177543.2 [O43688-2]
UniGeneiHs.465506

Genome annotation databases

EnsembliENST00000269812; ENSP00000269812; ENSG00000141934 [O43688-3]
ENST00000327790; ENSP00000329697; ENSG00000141934 [O43688-2]
ENST00000434325; ENSP00000388565; ENSG00000141934 [O43688-1]
GeneIDi8612
KEGGihsa:8612
UCSCiuc002loh.5 human [O43688-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035959 mRNA Translation: AAC15968.1
AF047760 mRNA Translation: AAC32104.1
AF056083 mRNA Translation: AAC25666.1
BT007021 mRNA Translation: AAP35667.1
AC016588 Genomic DNA No translation available.
BC002806 mRNA Translation: AAH02806.1
CCDSiCCDS12023.1 [O43688-1]
CCDS12024.1 [O43688-2]
CCDS45889.1 [O43688-3]
RefSeqiNP_003703.1, NM_003712.3 [O43688-1]
NP_803545.1, NM_177526.2 [O43688-3]
NP_808211.1, NM_177543.2 [O43688-2]
UniGeneiHs.465506

3D structure databases

ProteinModelPortaliO43688
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114170, 9 interactors
IntActiO43688, 11 interactors
STRINGi9606.ENSP00000329697

PTM databases

DEPODiO43688
GlyConnecti1460
iPTMnetiO43688
PhosphoSitePlusiO43688

Polymorphism and mutation databases

BioMutaiPPAP2C

Proteomic databases

EPDiO43688
MaxQBiO43688
PaxDbiO43688
PeptideAtlasiO43688
PRIDEiO43688
ProteomicsDBi49117
49118 [O43688-2]

Protocols and materials databases

DNASUi8612
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269812; ENSP00000269812; ENSG00000141934 [O43688-3]
ENST00000327790; ENSP00000329697; ENSG00000141934 [O43688-2]
ENST00000434325; ENSP00000388565; ENSG00000141934 [O43688-1]
GeneIDi8612
KEGGihsa:8612
UCSCiuc002loh.5 human [O43688-1]

Organism-specific databases

CTDi8612
DisGeNETi8612
EuPathDBiHostDB:ENSG00000141934.9
GeneCardsiPLPP2
HGNCiHGNC:9230 PLPP2
HPAiHPA055540
MIMi607126 gene
neXtProtiNX_O43688
OpenTargetsiENSG00000141934
PharmGKBiPA33554
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3030 Eukaryota
COG0671 LUCA
GeneTreeiENSGT00620000087654
HOGENOMiHOG000041307
HOVERGENiHBG002048
InParanoidiO43688
KOiK01080
OMAiKADTITH
OrthoDBiEOG091G0K5H
PhylomeDBiO43688
TreeFamiTF316040

Enzyme and pathway databases

ReactomeiR-HSA-1660661 Sphingolipid de novo biosynthesis

Miscellaneous databases

ChiTaRSiPLPP2 human
GeneWikiiPhosphatidic_acid_phosphatase_2c
GenomeRNAii8612
PROiPR:O43688
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141934 Expressed in 147 organ(s), highest expression level in minor salivary gland
CleanExiHS_PPAP2C
ExpressionAtlasiO43688 baseline and differential
GenevisibleiO43688 HS

Family and domain databases

InterProiView protein in InterPro
IPR028674 LPP2
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PANTHERiPTHR10165:SF25 PTHR10165:SF25, 1 hit
PfamiView protein in Pfam
PF01569 PAP2, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLPP2_HUMAN
AccessioniPrimary (citable) accession number: O43688
Secondary accession number(s): A6NLV0, E9PAY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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