AKAP7

Functionⁱ

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.3 Publications

GO - Molecular functionⁱ

protein kinase A binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9545239

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

action potential
Source: BHF-UCL
Inferred by curatorⁱ
- 11299204
cellular response to cAMP
Source: BHF-UCL
Inferred from direct assayⁱ
- 11299204
intracellular signal transduction
Source: UniProtKB
Traceable author statementⁱ
- 10613906
ion transport
Source: ProtInc
Traceable author statementⁱ
- 9545239
positive regulation of delayed rectifier potassium channel activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11299204
positive regulation of potassium ion transmembrane transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 11299204
protein localization
Source: UniProtKB
Inferred by curatorⁱ
- 9545239
regulation of membrane repolarization
Source: BHF-UCL
Inferred from direct assayⁱ
- 11299204

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: A-kinase anchor protein 7 isoforms alpha and beta Short name: AKAP-7 isoforms alpha and beta Alternative name(s): A-kinase anchor protein 18 kDa Short name: AKAP 18 Protein kinase A-anchoring protein 7 isoforms alpha/beta Short name: PRKA7 isoforms alpha/beta
Gene namesⁱ	Name:AKAP7 Synonyms:AKAP15, AKAP18
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000118507.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:377 AKAP7
MIMⁱ	604693 gene
neXtProtⁱ	NX_O43687

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	2 – 6	GQLCC → AQLAA: Abolishes membrane localization and affects its ability to inhibit ENaC activity in a sodium-dependent manner. 1 Publication		5

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9465
Open Targets More...OpenTargetsⁱ	ENSG00000118507
PharmGKBⁱ	PA24671

Polymorphism and mutation databases

BioMutaⁱ	EPB41L2

BioMutaⁱ

EPB41L2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed
ChainⁱPRO_0000064522	2 – 104	A-kinase anchor protein 7 isoforms alpha and betaAdd BLAST		103

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycine1 Publication	1
Lipidationⁱ	5	S-palmitoyl cysteine1 Publication	1
Lipidationⁱ	6	S-palmitoyl cysteine1 Publication	1

Keywords - PTMⁱ

Lipoprotein, Myristate, Palmitate

Proteomic databases

EPDⁱ	O43687
PeptideAtlas More...PeptideAtlasⁱ	O43687
PRIDEⁱ	O43687
ProteomicsDBⁱ	49115 49116 [O43687-2]

PTM databases

iPTMnetⁱ	O43687
SwissPalmⁱ	O43687

Expressionⁱ

Tissue specificityⁱ

Expressed in brain, heart, lung, pancreas and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000118507 Expressed in 215 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_AKAP7
ExpressionAtlasⁱ	O43687 baseline and differential
Genevisibleⁱ	O43687 HS

Interactionⁱ

Subunit structureⁱ

Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CEP76	Q8TAP6	5	EBI-10185182,EBI-742887
PRKAR1A	P10644	4	EBI-10185182,EBI-476431
PRKAR2B	P31323	4	EBI-10185182,EBI-2930670
PRKAR2B	Q6DHZ2	4	EBI-10185182,EBI-10185196
ROPN1	Q9HAT0	7	EBI-10185182,EBI-1378139
SPA17	Q15506	5	EBI-10185182,EBI-1377865

GO - Molecular functionⁱ

protein kinase A binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9545239

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114851, 25 interactors
CORUMⁱ	O43687
IntActⁱ	O43687, 8 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43687
SMRⁱ	O43687
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	2 – 11	Required for membrane localization	10
Regionⁱ	18 – 40	Required for apical membrane localizationAdd BLAST	23
Regionⁱ	52 – 65	RII-bindingAdd BLAST	14

Phylogenomic databases

eggNOGⁱ	KOG2814 Eukaryota ENOG4111FMP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012756
HOGENOMⁱ	HOG000013043
HOVERGENⁱ	HBG050474

Family and domain databases

InterProⁱ	View protein in InterPro IPR019511 AKAP7_RI-RII-bd_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10470 AKAP7_RIRII_bdg, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

Isoform Beta (identifier: O43687-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQLCCFPFS RDEGKISELE SSSSAVLQRY SKDIPSWSSG EKNGGEPDDA 
        60         70         80         90        100
ELVRLSKRLV ENAVLKAVQQ YLEETQNKNK PGEGSSVKTE AADQNGNDNE 

NNRK

Length:104

Mass (Da):11,465

Last modified:January 23, 2007 - v4

Checksum:ⁱ6F84ED8E032AF954

GO

Isoform Alpha (identifier: O43687-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
18-40: Missing.

« Hide

        10         20         30         40         50
MGQLCCFPFS RDEGKISEKN GGEPDDAELV RLSKRLVENA VLKAVQQYLE 
        60         70         80 
ETQNKNKPGE GSSVKTEAAD QNGNDNENNR K

Show »

Length:81

Mass (Da):8,969

Checksum:ⁱFEDE53F9E2205548

GO

Isoform Gamma (identifier: Q9P0M2-1) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry Q9P0M2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:348

Mass (Da):39,518

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_004101	18 – 40	Missing in isoform Alpha. 2 PublicationsAdd BLAST		23

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF047715 mRNA Translation: AAC39715.1 AF161075 mRNA Translation: AAF26676.1 AK290271 mRNA Translation: BAF82960.1 AL136110 Genomic DNA No translation available. AL137063 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48057.1 BC016927 mRNA Translation: AAH16927.1 BC073847 mRNA Translation: AAH73847.1 BC094732 mRNA Translation: AAH94732.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5143.1 [O43687-2] CCDS5144.1 [O43687-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_004833.1, NM_004842.3 [O43687-2] NP_619539.1, NM_138633.2 [O43687-1]
UniGeneⁱ	Hs.486483 Hs.732515

Genome annotation databases

Ensemblⁱ	ENST00000342266; ENSP00000345149; ENSG00000118507 [O43687-2] ENST00000474850; ENSP00000418208; ENSG00000118507 [O43687-1]
GeneIDⁱ	9465
UCSC genome browser More...UCSCⁱ	uc003qcm.3 human [O43687-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43687	A-kinase anchoring protein 7		PANTR		104	UniRef100_O43687
AKAP7 isoform 10		PONAB		104
Uncharacterized protein		PANPA		104
A-kinase anchoring protein 7		GORGO		104
O43687-2	A kinase (PRKA) anchor protein 7		HUMAN		81	UniRef100_Q2TAJ5
A-kinase anchoring protein 7		PANTR		81
AKAP7 isoform 9		PONAB		81
Uncharacterized protein		PANPA		81
Uncharacterized protein		NOMLE		81
+1

Protein	Similar proteins		Species	Score	Length	Source
O43687	A-kinase anchoring protein 7		PANTR		104	UniRef90_O43687
AKAP7 isoform 10		PONAB		104
Uncharacterized protein		PANPA		104
A-kinase anchoring protein 7		GORGO		104
Uncharacterized protein		PROCO		104
+15
O43687-2	A kinase (PRKA) anchor protein 7		HUMAN		81	UniRef90_Q2TAJ5
A-kinase anchoring protein 7		PANTR		81
AKAP7 isoform 9		PONAB		81
Uncharacterized protein		PANPA		81
Uncharacterized protein		NOMLE		81
+16

Protein	Similar proteins		Species	Score	Length	Source
O43687	A-kinase anchoring protein 7		PANTR		104	UniRef50_O43687
AKAP7 isoform 10		PONAB		104
Uncharacterized protein		PANPA		104
A-kinase anchoring protein 7		GORGO		104
Uncharacterized protein		NOMLE		104
+68
O43687-2	A-kinase anchor protein 7 isoform alpha		MOUSE		81	UniRef50_O55074
A-kinase anchor protein 7 isoform gamma isoform X6		MESAU		81
Protein kinase A anchor protein, RI-RII subunit-binding domain containing protein		CRIGR		81
Uncharacterized protein		MANLE		81
Uncharacterized protein		PROCO		81
+60

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF047715 mRNA Translation: AAC39715.1 AF161075 mRNA Translation: AAF26676.1 AK290271 mRNA Translation: BAF82960.1 AL136110 Genomic DNA No translation available. AL137063 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48057.1 BC016927 mRNA Translation: AAH16927.1 BC073847 mRNA Translation: AAH73847.1 BC094732 mRNA Translation: AAH94732.1
CCDSⁱ	CCDS5143.1 [O43687-2] CCDS5144.1 [O43687-1]
RefSeqⁱ	NP_004833.1, NM_004842.3 [O43687-2] NP_619539.1, NM_138633.2 [O43687-1]
UniGeneⁱ	Hs.486483 Hs.732515

3D structure databases

ProteinModelPortalⁱ	O43687
SMRⁱ	O43687
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114851, 25 interactors
CORUMⁱ	O43687
IntActⁱ	O43687, 8 interactors

PTM databases

iPTMnetⁱ	O43687
SwissPalmⁱ	O43687

Polymorphism and mutation databases

BioMutaⁱ	EPB41L2

BioMutaⁱ

EPB41L2

Proteomic databases

EPDⁱ	O43687
PeptideAtlasⁱ	O43687
PRIDEⁱ	O43687
ProteomicsDBⁱ	49115 49116 [O43687-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9465
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000342266; ENSP00000345149; ENSG00000118507 [O43687-2] ENST00000474850; ENSP00000418208; ENSG00000118507 [O43687-1]
GeneIDⁱ	9465
UCSCⁱ	uc003qcm.3 human [O43687-1]

Organism-specific databases

CTDⁱ	9465
DisGeNETⁱ	9465
EuPathDBⁱ	HostDB:ENSG00000118507.15
GeneCardsⁱ	AKAP7
HGNCⁱ	HGNC:377 AKAP7
MIMⁱ	604693 gene
neXtProtⁱ	NX_O43687
OpenTargetsⁱ	ENSG00000118507
PharmGKBⁱ	PA24671
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2814 Eukaryota ENOG4111FMP LUCA
GeneTreeⁱ	ENSGT00390000012756
HOGENOMⁱ	HOG000013043
HOVERGENⁱ	HBG050474

Miscellaneous databases

ChiTaRSⁱ	AKAP7 human
GeneWikiⁱ	AKAP7
GenomeRNAiⁱ	9465
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000118507 Expressed in 215 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_AKAP7
ExpressionAtlasⁱ	O43687 baseline and differential
Genevisibleⁱ	O43687 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019511 AKAP7_RI-RII-bd_dom
Pfamⁱ	View protein in Pfam PF10470 AKAP7_RIRII_bdg, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AKA7A_HUMAN
Accessionⁱ	O43687Primary (citable) accession number: O43687 Secondary accession number(s): A8K2K6 , Q5TBR9, Q5TBS0, Q9HCZ8, Q9P0G4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 141 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43687 (AKA7A_HUMAN)

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A-kinase anchor protein 7 isoforms alpha and beta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma membrane

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ