UniProtKB - O43687 (AKA7A_HUMAN)
A-kinase anchor protein 7 isoforms alpha and beta
AKAP7
Functioni
GO - Molecular functioni
- protein kinase A binding Source: UniProtKB
GO - Biological processi
- action potential Source: BHF-UCL
- cellular response to cAMP Source: BHF-UCL
- intracellular signal transduction Source: UniProtKB
- ion transport Source: ProtInc
- positive regulation of delayed rectifier potassium channel activity Source: BHF-UCL
- positive regulation of potassium ion transmembrane transport Source: BHF-UCL
- protein localization Source: UniProtKB
- regulation of membrane repolarization Source: BHF-UCL
Enzyme and pathway databases
PathwayCommonsi | O43687 |
Names & Taxonomyi
Protein namesi | Recommended name: A-kinase anchor protein 7 isoforms alpha and betaShort name: AKAP-7 isoforms alpha and beta Alternative name(s): A-kinase anchor protein 18 kDa Short name: AKAP 18 Protein kinase A-anchoring protein 7 isoforms alpha/beta Short name: PRKA7 isoforms alpha/beta |
Gene namesi | Name:AKAP7 Synonyms:AKAP15, AKAP18 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000118507.15 |
HGNCi | HGNC:377, AKAP7 |
MIMi | 604693, gene |
neXtProti | NX_O43687 |
Subcellular locationi
Plasma membrane
Note: Targeted predominantly to the lateral membrane.
Plasma membrane
Note: Targeted predominantly to the apical membrane.
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- lateral plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2 – 6 | GQLCC → AQLAA: Abolishes membrane localization and affects its ability to inhibit ENaC activity in a sodium-dependent manner. 1 Publication | 5 |
Organism-specific databases
DisGeNETi | 9465 |
OpenTargetsi | ENSG00000118507 |
PharmGKBi | PA24671 |
Miscellaneous databases
Pharosi | O43687, Tbio |
Polymorphism and mutation databases
BioMutai | AKAP7 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000064522 | 2 – 104 | A-kinase anchor protein 7 isoforms alpha and betaAdd BLAST | 103 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine1 Publication | 1 | |
Lipidationi | 5 | S-palmitoyl cysteine1 Publication | 1 | |
Lipidationi | 6 | S-palmitoyl cysteine1 Publication | 1 |
Keywords - PTMi
Lipoprotein, Myristate, PalmitateProteomic databases
jPOSTi | O43687 |
MassIVEi | O43687 |
PeptideAtlasi | O43687 |
PRIDEi | O43687 |
ProteomicsDBi | 49115 [O43687-1] 49116 [O43687-2] |
PTM databases
iPTMneti | O43687 |
SwissPalmi | O43687 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000118507, Expressed in frontal cortex and 225 other tissues |
ExpressionAtlasi | O43687, baseline and differential |
Genevisiblei | O43687, HS |
Organism-specific databases
HPAi | ENSG00000118507, Tissue enhanced (adrenal gland, pancreas) |
Interactioni
Subunit structurei
Binds cAMP-dependent protein kinase (PKA).
Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA.
1 PublicationBinary interactionsi
Hide detailsIsoform Alpha [O43687-2]
GO - Molecular functioni
- protein kinase A binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114851, 30 interactors |
CORUMi | O43687 |
IntActi | O43687, 9 interactors |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 11 | Required for membrane localization | 10 | |
Regioni | 18 – 40 | Required for apical membrane localizationAdd BLAST | 23 | |
Regioni | 52 – 65 | RII-bindingAdd BLAST | 14 |
Phylogenomic databases
GeneTreei | ENSGT00390000012756 |
HOGENOMi | CLU_177905_0_0_1 |
OrthoDBi | 606751at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR019511, AKAP7_RI-RII-bd_dom |
Pfami | View protein in Pfam PF10470, AKAP7_RIRII_bdg, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGQLCCFPFS RDEGKISELE SSSSAVLQRY SKDIPSWSSG EKNGGEPDDA
60 70 80 90 100
ELVRLSKRLV ENAVLKAVQQ YLEETQNKNK PGEGSSVKTE AADQNGNDNE
NNRK
The sequence of this isoform differs from the canonical sequence as follows:
18-40: Missing.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KN37 | J3KN37_HUMAN | A-kinase anchor protein 7 isoform g... | AKAP7 | 84 | Annotation score: | ||
F5GXD1 | F5GXD1_HUMAN | A-kinase anchor protein 7 isoform g... | AKAP7 | 350 | Annotation score: | ||
F5H4P9 | F5H4P9_HUMAN | A-kinase anchor protein 7 isoform g... | AKAP7 | 87 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004101 | 18 – 40 | Missing in isoform Alpha. 2 PublicationsAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF047715 mRNA Translation: AAC39715.1 AF161075 mRNA Translation: AAF26676.1 AK290271 mRNA Translation: BAF82960.1 AL136110 Genomic DNA No translation available. AL137063 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48057.1 BC016927 mRNA Translation: AAH16927.1 BC073847 mRNA Translation: AAH73847.1 BC094732 mRNA Translation: AAH94732.1 |
CCDSi | CCDS5143.1 [O43687-2] CCDS5144.1 [O43687-1] |
RefSeqi | NP_004833.1, NM_004842.3 [O43687-2] NP_619539.1, NM_138633.2 [O43687-1] |
Genome annotation databases
Ensembli | ENST00000342266; ENSP00000345149; ENSG00000118507 [O43687-2] ENST00000474850; ENSP00000418208; ENSG00000118507 [O43687-1] |
GeneIDi | 9465 |
UCSCi | uc003qcm.3, human [O43687-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF047715 mRNA Translation: AAC39715.1 AF161075 mRNA Translation: AAF26676.1 AK290271 mRNA Translation: BAF82960.1 AL136110 Genomic DNA No translation available. AL137063 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48057.1 BC016927 mRNA Translation: AAH16927.1 BC073847 mRNA Translation: AAH73847.1 BC094732 mRNA Translation: AAH94732.1 |
CCDSi | CCDS5143.1 [O43687-2] CCDS5144.1 [O43687-1] |
RefSeqi | NP_004833.1, NM_004842.3 [O43687-2] NP_619539.1, NM_138633.2 [O43687-1] |
3D structure databases
SMRi | O43687 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114851, 30 interactors |
CORUMi | O43687 |
IntActi | O43687, 9 interactors |
PTM databases
iPTMneti | O43687 |
SwissPalmi | O43687 |
Polymorphism and mutation databases
BioMutai | AKAP7 |
Proteomic databases
jPOSTi | O43687 |
MassIVEi | O43687 |
PeptideAtlasi | O43687 |
PRIDEi | O43687 |
ProteomicsDBi | 49115 [O43687-1] 49116 [O43687-2] |
Protocols and materials databases
Antibodypediai | 19674, 280 antibodies |
DNASUi | 9465 |
Genome annotation databases
Ensembli | ENST00000342266; ENSP00000345149; ENSG00000118507 [O43687-2] ENST00000474850; ENSP00000418208; ENSG00000118507 [O43687-1] |
GeneIDi | 9465 |
UCSCi | uc003qcm.3, human [O43687-1] |
Organism-specific databases
CTDi | 9465 |
DisGeNETi | 9465 |
EuPathDBi | HostDB:ENSG00000118507.15 |
GeneCardsi | AKAP7 |
HGNCi | HGNC:377, AKAP7 |
HPAi | ENSG00000118507, Tissue enhanced (adrenal gland, pancreas) |
MIMi | 604693, gene |
neXtProti | NX_O43687 |
OpenTargetsi | ENSG00000118507 |
PharmGKBi | PA24671 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000012756 |
HOGENOMi | CLU_177905_0_0_1 |
OrthoDBi | 606751at2759 |
Enzyme and pathway databases
PathwayCommonsi | O43687 |
Miscellaneous databases
BioGRID-ORCSi | 9465, 4 hits in 845 CRISPR screens |
ChiTaRSi | AKAP7, human |
GeneWikii | AKAP7 |
GenomeRNAii | 9465 |
Pharosi | O43687, Tbio |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118507, Expressed in frontal cortex and 225 other tissues |
ExpressionAtlasi | O43687, baseline and differential |
Genevisiblei | O43687, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019511, AKAP7_RI-RII-bd_dom |
Pfami | View protein in Pfam PF10470, AKAP7_RIRII_bdg, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AKA7A_HUMAN | |
Accessioni | O43687Primary (citable) accession number: O43687 Secondary accession number(s): A8K2K6 Q9P0G4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 155 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot