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Protein

A-kinase anchor protein 7 isoforms alpha and beta

Gene

AKAP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.3 Publications

GO - Molecular functioni

  • protein kinase A binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 7 isoforms alpha and beta
Short name:
AKAP-7 isoforms alpha and beta
Alternative name(s):
A-kinase anchor protein 18 kDa
Short name:
AKAP 18
Protein kinase A-anchoring protein 7 isoforms alpha/beta
Short name:
PRKA7 isoforms alpha/beta
Gene namesi
Name:AKAP7
Synonyms:AKAP15, AKAP18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000118507.15
HGNCiHGNC:377 AKAP7
MIMi604693 gene
neXtProtiNX_O43687

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2 – 6GQLCC → AQLAA: Abolishes membrane localization and affects its ability to inhibit ENaC activity in a sodium-dependent manner. 1 Publication5

Organism-specific databases

DisGeNETi9465
OpenTargetsiENSG00000118507
PharmGKBiPA24671

Polymorphism and mutation databases

BioMutaiEPB41L2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000645222 – 104A-kinase anchor protein 7 isoforms alpha and betaAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Lipidationi5S-palmitoyl cysteine1 Publication1
Lipidationi6S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

EPDiO43687
PeptideAtlasiO43687
PRIDEiO43687
ProteomicsDBi49115
49116 [O43687-2]

PTM databases

iPTMnetiO43687
SwissPalmiO43687

Expressioni

Tissue specificityi

Expressed in brain, heart, lung, pancreas and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000118507 Expressed in 215 organ(s), highest expression level in frontal cortex
CleanExiHS_AKAP7
ExpressionAtlasiO43687 baseline and differential
GenevisibleiO43687 HS

Interactioni

Subunit structurei

Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114851, 25 interactors
CORUMiO43687
IntActiO43687, 8 interactors

Structurei

3D structure databases

ProteinModelPortaliO43687
SMRiO43687
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 11Required for membrane localization10
Regioni18 – 40Required for apical membrane localizationAdd BLAST23
Regioni52 – 65RII-bindingAdd BLAST14

Phylogenomic databases

eggNOGiKOG2814 Eukaryota
ENOG4111FMP LUCA
GeneTreeiENSGT00390000012756
HOGENOMiHOG000013043
HOVERGENiHBG050474

Family and domain databases

InterProiView protein in InterPro
IPR019511 AKAP7_RI-RII-bd_dom
PfamiView protein in Pfam
PF10470 AKAP7_RIRII_bdg, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform Beta (identifier: O43687-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQLCCFPFS RDEGKISELE SSSSAVLQRY SKDIPSWSSG EKNGGEPDDA
60 70 80 90 100
ELVRLSKRLV ENAVLKAVQQ YLEETQNKNK PGEGSSVKTE AADQNGNDNE

NNRK
Length:104
Mass (Da):11,465
Last modified:January 23, 2007 - v4
Checksum:i6F84ED8E032AF954
GO
Isoform Alpha (identifier: O43687-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-40: Missing.

Show »
Length:81
Mass (Da):8,969
Checksum:iFEDE53F9E2205548
GO
Isoform Gamma (identifier: Q9P0M2-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9P0M2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:348
Mass (Da):39,518
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00410118 – 40Missing in isoform Alpha. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047715 mRNA Translation: AAC39715.1
AF161075 mRNA Translation: AAF26676.1
AK290271 mRNA Translation: BAF82960.1
AL136110 Genomic DNA No translation available.
AL137063 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48057.1
BC016927 mRNA Translation: AAH16927.1
BC073847 mRNA Translation: AAH73847.1
BC094732 mRNA Translation: AAH94732.1
CCDSiCCDS5143.1 [O43687-2]
CCDS5144.1 [O43687-1]
RefSeqiNP_004833.1, NM_004842.3 [O43687-2]
NP_619539.1, NM_138633.2 [O43687-1]
UniGeneiHs.486483
Hs.732515

Genome annotation databases

EnsembliENST00000342266; ENSP00000345149; ENSG00000118507 [O43687-2]
ENST00000474850; ENSP00000418208; ENSG00000118507 [O43687-1]
GeneIDi9465
UCSCiuc003qcm.3 human [O43687-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047715 mRNA Translation: AAC39715.1
AF161075 mRNA Translation: AAF26676.1
AK290271 mRNA Translation: BAF82960.1
AL136110 Genomic DNA No translation available.
AL137063 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48057.1
BC016927 mRNA Translation: AAH16927.1
BC073847 mRNA Translation: AAH73847.1
BC094732 mRNA Translation: AAH94732.1
CCDSiCCDS5143.1 [O43687-2]
CCDS5144.1 [O43687-1]
RefSeqiNP_004833.1, NM_004842.3 [O43687-2]
NP_619539.1, NM_138633.2 [O43687-1]
UniGeneiHs.486483
Hs.732515

3D structure databases

ProteinModelPortaliO43687
SMRiO43687
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114851, 25 interactors
CORUMiO43687
IntActiO43687, 8 interactors

PTM databases

iPTMnetiO43687
SwissPalmiO43687

Polymorphism and mutation databases

BioMutaiEPB41L2

Proteomic databases

EPDiO43687
PeptideAtlasiO43687
PRIDEiO43687
ProteomicsDBi49115
49116 [O43687-2]

Protocols and materials databases

DNASUi9465
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342266; ENSP00000345149; ENSG00000118507 [O43687-2]
ENST00000474850; ENSP00000418208; ENSG00000118507 [O43687-1]
GeneIDi9465
UCSCiuc003qcm.3 human [O43687-1]

Organism-specific databases

CTDi9465
DisGeNETi9465
EuPathDBiHostDB:ENSG00000118507.15
GeneCardsiAKAP7
HGNCiHGNC:377 AKAP7
MIMi604693 gene
neXtProtiNX_O43687
OpenTargetsiENSG00000118507
PharmGKBiPA24671
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2814 Eukaryota
ENOG4111FMP LUCA
GeneTreeiENSGT00390000012756
HOGENOMiHOG000013043
HOVERGENiHBG050474

Miscellaneous databases

ChiTaRSiAKAP7 human
GeneWikiiAKAP7
GenomeRNAii9465
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118507 Expressed in 215 organ(s), highest expression level in frontal cortex
CleanExiHS_AKAP7
ExpressionAtlasiO43687 baseline and differential
GenevisibleiO43687 HS

Family and domain databases

InterProiView protein in InterPro
IPR019511 AKAP7_RI-RII-bd_dom
PfamiView protein in Pfam
PF10470 AKAP7_RIRII_bdg, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAKA7A_HUMAN
AccessioniPrimary (citable) accession number: O43687
Secondary accession number(s): A8K2K6
, Q5TBR9, Q5TBS0, Q9HCZ8, Q9P0G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 141 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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