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Protein

Mitotic checkpoint serine/threonine-protein kinase BUB1

Gene

BUB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.8 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Autophosphorylated when the cells enters mitosis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei821ATPPROSITE-ProRule annotation1
Active sitei917Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi793 – 801ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: GO_Central
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cell proliferation Source: Ensembl
  • meiotic sister chromatid cohesion, centromeric Source: GO_Central
  • mitotic cell cycle checkpoint Source: ProtInc
  • mitotic spindle assembly checkpoint Source: GO_Central
  • regulation of chromosome segregation Source: UniProtKB
  • regulation of sister chromatid cohesion Source: UniProtKB
  • viral process Source: UniProtKB-KW

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Cell cycle, Cell division, Chromosome partition, Host-virus interaction, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase
SignaLinkiO43683
SIGNORiO43683

Names & Taxonomyi

Protein namesi
Recommended name:
Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC:2.7.11.1)
Short name:
hBUB1
Alternative name(s):
BUB1A
Gene namesi
Name:BUB1
Synonyms:BUB1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000169679.14
HGNCiHGNC:1148 BUB1
MIMi602452 gene
neXtProtiNX_O43683

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi106A → D or W: Loss of interaction with KNL1. 1 Publication1
Mutagenesisi122L → G: Loss of interaction with KNL1. 1 Publication1
Mutagenesisi130A → S: Partial rescue of the spindle-assembly checkpoint activity. Increased rate of chromosome congression errors. Impaired localization to kinetochores and loss of kinetochore binding of CENPF, SGO1 and BUBR1 but not of MCAK, MAD1L1 or MAD2L1. 1 Publication1
Mutagenesisi535K → A: Loss of ubiquitination and CDH1-dependent degradation; when associated with A-536 and A-537. 1 Publication1
Mutagenesisi536E → A: Loss of ubiquitination and CDH1-dependent degradation; when associated with A-535 and A-537. 1 Publication1
Mutagenesisi537N → A: Loss of ubiquitination and CDH1-dependent degradation; when associated with A-535 and A-536. 1 Publication1
Mutagenesisi609T → A: Diminished interaction with PLK1. 1 Publication1
Mutagenesisi625K → A: Loss of ubiquitination and CDH1-dependent degradation; when associated with A-626 and A-627. 1 Publication1
Mutagenesisi626E → A: Loss of ubiquitination and CDH1-dependent degradation; when associated with A-625 and A-627. 1 Publication1
Mutagenesisi627N → A: Loss of ubiquitination and CDH1-dependent degradation; when associated with A-625 and A-626. 1 Publication1
Mutagenesisi821K → A: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNETi699
MalaCardsiBUB1
OpenTargetsiENSG00000169679
Orphaneti1052 Mosaic variegated aneuploidy syndrome
PharmGKBiPA81

Chemistry databases

ChEMBLiCHEMBL1772932
GuidetoPHARMACOLOGYi1949

Polymorphism and mutation databases

BioMutaiBUB1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856711 – 1085Mitotic checkpoint serine/threonine-protein kinase BUB1Add BLAST1085

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei307PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei375PhosphoserineCombined sources1
Modified residuei525PhosphoserineCombined sources1
Modified residuei563PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei609Phosphothreonine; by CDK11 Publication1
Modified residuei655PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Modified residuei668PhosphoserineCombined sources1
Modified residuei672PhosphoserineCombined sources1

Post-translational modificationi

Upon spindle-assembly checkpoint activation it is hyperphosphorylated and its kinase activity toward CDC20 is stimulated. Phosphorylation at Thr-609 is required for interaction with PLK1, phosphorylation at this site probably creates a binding site for the POLO-box domain of PLK1, thus enhancing the PLK1-BUB1 interaction.3 Publications
Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43683
PaxDbiO43683
PeptideAtlasiO43683
PRIDEiO43683
ProteomicsDBi49112

PTM databases

iPTMnetiO43683
PhosphoSitePlusiO43683

Expressioni

Tissue specificityi

High expression in testis and thymus, less in colon, spleen, lung and small intestine. Expressed in fetal thymus, bone marrow, heart, liver, spleen and thymus. Expression is associated with cells/tissues with a high mitotic index.

Inductioni

Inhibited by phorbol 12-myristate 13-acetate (PMA).

Gene expression databases

BgeeiENSG00000169679 Expressed in 126 organ(s), highest expression level in heart
CleanExiHS_BUB1
ExpressionAtlasiO43683 baseline and differential
GenevisibleiO43683 HS

Organism-specific databases

HPAiHPA006123

Interactioni

Subunit structurei

Interacts with BUB3 and KNL1. Interacts (when phosphorylated) with PLK1. The BUB1-BUB3 complex interacts with MAD1L1.4 Publications
(Microbial infection) Interacts with SV40 Large T antigen; this interaction induces activation of a DNA damage response and promotes p53/TP53 stabilization and phosphorylation.1 Publication
(Microbial infection) Interacts with herpes virus 8 protein LANA1.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi107164, 53 interactors
CORUMiO43683
DIPiDIP-24206N
ELMiO43683
IntActiO43683, 85 interactors
MINTiO43683
STRINGi9606.ENSP00000302530

Chemistry databases

BindingDBiO43683

Structurei

Secondary structure

11085
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43683
SMRiO43683
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43683

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 182BUB1 N-terminalPROSITE-ProRule annotationAdd BLAST172
Domaini787 – 1085Protein kinasePROSITE-ProRule annotationAdd BLAST299

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 146Necessary for kinetochore localizationAdd BLAST146
Regioni99 – 132Necessary for interaction with KNL11 PublicationAdd BLAST34
Regioni229 – 256Necessary for interaction with BUB3Add BLAST28
Regioni458 – 476Essential for loading of BUBR1, MAD1L1 and MAD2L1 to kinetochoresAdd BLAST19

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi58 – 65Nuclear localization signalSequence analysis8
Motifi535 – 537KEN box 13
Motifi625 – 627KEN box 23

Domaini

The KEN box is required for its ubiquitination and degradation.1 Publication
BUB1 N-terminal domain directs kinetochore localization and binding to BUB3.1 Publication

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1166 Eukaryota
ENOG410XQ67 LUCA
GeneTreeiENSGT00520000055622
HOGENOMiHOG000231751
HOVERGENiHBG003709
InParanoidiO43683
KOiK02178
OMAiRNNHETW
OrthoDBiEOG091G00MB
PhylomeDBiO43683
TreeFamiTF105455

Family and domain databases

InterProiView protein in InterPro
IPR015661 Bub1/Mad3
IPR011009 Kinase-like_dom_sf
IPR013212 Mad3/Bub1_I
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR14030 PTHR14030, 1 hit
PfamiView protein in Pfam
PF08311 Mad3_BUB1_I, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00777 Mad3_BUB1_I, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51489 BUB1_N, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43683-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTPENVLQM LEAHMQSYKG NDPLGEWERY IQWVEENFPE NKEYLITLLE
60 70 80 90 100
HLMKEFLDKK KYHNDPRFIS YCLKFAEYNS DLHQFFEFLY NHGIGTLSSP
110 120 130 140 150
LYIAWAGHLE AQGELQHASA VLQRGIQNQA EPREFLQQQY RLFQTRLTET
160 170 180 190 200
HLPAQARTSE PLHNVQVLNQ MITSKSNPGN NMACISKNQG SELSGVISSA
210 220 230 240 250
CDKESNMERR VITISKSEYS VHSSLASKVD VEQVVMYCKE KLIRGESEFS
260 270 280 290 300
FEELRAQKYN QRRKHEQWVN EDRHYMKRKE ANAFEEQLLK QKMDELHKKL
310 320 330 340 350
HQVVETSHED LPASQERSEV NPARMGPSVG SQQELRAPCL PVTYQQTPVN
360 370 380 390 400
MEKNPREAPP VVPPLANAIS AALVSPATSQ SIAPPVPLKA QTVTDSMFAV
410 420 430 440 450
ASKDAGCVNK STHEFKPQSG AEIKEGCETH KVANTSSFHT TPNTSLGMVQ
460 470 480 490 500
ATPSKVQPSP TVHTKEALGF IMNMFQAPTL PDISDDKDEW QSLDQNEDAF
510 520 530 540 550
EAQFQKNVRS SGAWGVNKII SSLSSAFHVF EDGNKENYGL PQPKNKPTGA
560 570 580 590 600
RTFGERSVSR LPSKPKEEVP HAEEFLDDST VWGIRCNKTL APSPKSPGDF
610 620 630 640 650
TSAAQLASTP FHKLPVESVH ILEDKENVVA KQCTQATLDS CEENMVVPSR
660 670 680 690 700
DGKFSPIQEK SPKQALSSHM YSASLLRLSQ PAAGGVLTCE AELGVEACRL
710 720 730 740 750
TDTDAAIAED PPDAIAGLQA EWMQMSSLGT VDAPNFIVGN PWDDKLIFKL
760 770 780 790 800
LSGLSKPVSS YPNTFEWQCK LPAIKPKTEF QLGSKLVYVH HLLGEGAFAQ
810 820 830 840 850
VYEATQGDLN DAKNKQKFVL KVQKPANPWE FYIGTQLMER LKPSMQHMFM
860 870 880 890 900
KFYSAHLFQN GSVLVGELYS YGTLLNAINL YKNTPEKVMP QGLVISFAMR
910 920 930 940 950
MLYMIEQVHD CEIIHGDIKP DNFILGNGFL EQDDEDDLSA GLALIDLGQS
960 970 980 990 1000
IDMKLFPKGT IFTAKCETSG FQCVEMLSNK PWNYQIDYFG VAATVYCMLF
1010 1020 1030 1040 1050
GTYMKVKNEG GECKPEGLFR RLPHLDMWNE FFHVMLNIPD CHHLPSLDLL
1060 1070 1080
RQKLKKVFQQ HYTNKIRALR NRLIVLLLEC KRSRK
Length:1,085
Mass (Da):122,375
Last modified:June 1, 1998 - v1
Checksum:i38AE5E1F88C53BDC
GO
Isoform 2 (identifier: O43683-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     876-932: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,028
Mass (Da):115,843
Checksum:i9D5F967383751D9C
GO
Isoform 3 (identifier: O43683-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-29: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,065
Mass (Da):120,002
Checksum:iE6BD9A1AA4ADAA71
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JRC7C9JRC7_HUMAN
Mitotic checkpoint serine/threonine...
BUB1
134Annotation score:
C9JQA4C9JQA4_HUMAN
Mitotic checkpoint serine/threonine...
BUB1
146Annotation score:
C9IYH4C9IYH4_HUMAN
Mitotic checkpoint serine/threonine...
BUB1
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70S → T in AAC06259 (PubMed:10366450).Curated1
Sequence conflicti276 – 279MKRK → IRHE in AAC39546 (PubMed:9441741).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04040020G → D1 PublicationCorresponds to variant dbSNP:rs35890336Ensembl.1
Natural variantiVAR_00884936E → D in colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs1801328Ensembl.1
Natural variantiVAR_015687259Y → C in pancreatic cancer; associated with N-265; failure to rescue the spindle-assembly checkpoint activity as a result of a deficient recruitment of MAD2L1 and BUBR1 to kinetochores; efficient restoration of chromosome congression; reduced binding to BUB3; rescue of the ability of kinetochores to bind SGO1 and CENPF but not MCAK. 2 Publications1
Natural variantiVAR_015688265H → N in pancreatic cancer; associated with C-259; complete rescue of the spindle-assembly checkpoint activity; increased rate of chromosome congression errors. 2 Publications1
Natural variantiVAR_008850492S → Y in colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs121909055EnsemblClinVar.1
Natural variantiVAR_040401534N → D1 PublicationCorresponds to variant dbSNP:rs36109304Ensembl.1
Natural variantiVAR_008851648P → R in colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs376649190Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05476010 – 29Missing in isoform 3. CuratedAdd BLAST20
Alternative sequenceiVSP_054761876 – 932Missing in isoform 2. CuratedAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046078 mRNA Translation: AAC12729.1
AF043294 mRNA Translation: AAB97855.2
AF053305 mRNA Translation: AAC06259.1
AF047471 mRNA Translation: AAC03122.1
AF139363
, AF139349, AF139350, AF139351, AF139352, AF139353, AF139354, AF139355, AF139356, AF139357, AF139358, AF139359, AF139360, AF139361, AF139362 Genomic DNA Translation: AAD43675.1
AC114776 Genomic DNA Translation: AAY14706.1
AC226101 Genomic DNA No translation available.
CH471237 Genomic DNA Translation: EAW50355.1
BC028201 mRNA Translation: AAH28201.1
AF011387 mRNA Translation: AAC39546.1
CCDSiCCDS33273.1 [O43683-1]
CCDS62984.1 [O43683-3]
CCDS62985.1 [O43683-2]
RefSeqiNP_001265546.1, NM_001278617.1 [O43683-2]
NP_004327.1, NM_004336.4 [O43683-1]
UniGeneiHs.469649

Genome annotation databases

EnsembliENST00000302759; ENSP00000302530; ENSG00000169679 [O43683-1]
ENST00000409311; ENSP00000386701; ENSG00000169679 [O43683-2]
ENST00000535254; ENSP00000441013; ENSG00000169679 [O43683-3]
GeneIDi699
KEGGihsa:699
UCSCiuc002tgc.5 human [O43683-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046078 mRNA Translation: AAC12729.1
AF043294 mRNA Translation: AAB97855.2
AF053305 mRNA Translation: AAC06259.1
AF047471 mRNA Translation: AAC03122.1
AF139363
, AF139349, AF139350, AF139351, AF139352, AF139353, AF139354, AF139355, AF139356, AF139357, AF139358, AF139359, AF139360, AF139361, AF139362 Genomic DNA Translation: AAD43675.1
AC114776 Genomic DNA Translation: AAY14706.1
AC226101 Genomic DNA No translation available.
CH471237 Genomic DNA Translation: EAW50355.1
BC028201 mRNA Translation: AAH28201.1
AF011387 mRNA Translation: AAC39546.1
CCDSiCCDS33273.1 [O43683-1]
CCDS62984.1 [O43683-3]
CCDS62985.1 [O43683-2]
RefSeqiNP_001265546.1, NM_001278617.1 [O43683-2]
NP_004327.1, NM_004336.4 [O43683-1]
UniGeneiHs.469649

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LAHNMR-A1-150[»]
4A1GX-ray2.60A/B/C/D1-150[»]
4QPMX-ray2.20A/B740-1085[»]
4R8QX-ray2.31A724-1085[»]
5DMZX-ray2.40A/B726-1085[»]
ProteinModelPortaliO43683
SMRiO43683
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107164, 53 interactors
CORUMiO43683
DIPiDIP-24206N
ELMiO43683
IntActiO43683, 85 interactors
MINTiO43683
STRINGi9606.ENSP00000302530

Chemistry databases

BindingDBiO43683
ChEMBLiCHEMBL1772932
GuidetoPHARMACOLOGYi1949

PTM databases

iPTMnetiO43683
PhosphoSitePlusiO43683

Polymorphism and mutation databases

BioMutaiBUB1

Proteomic databases

EPDiO43683
PaxDbiO43683
PeptideAtlasiO43683
PRIDEiO43683
ProteomicsDBi49112

Protocols and materials databases

DNASUi699
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302759; ENSP00000302530; ENSG00000169679 [O43683-1]
ENST00000409311; ENSP00000386701; ENSG00000169679 [O43683-2]
ENST00000535254; ENSP00000441013; ENSG00000169679 [O43683-3]
GeneIDi699
KEGGihsa:699
UCSCiuc002tgc.5 human [O43683-1]

Organism-specific databases

CTDi699
DisGeNETi699
EuPathDBiHostDB:ENSG00000169679.14
GeneCardsiBUB1
HGNCiHGNC:1148 BUB1
HPAiHPA006123
MalaCardsiBUB1
MIMi602452 gene
neXtProtiNX_O43683
OpenTargetsiENSG00000169679
Orphaneti1052 Mosaic variegated aneuploidy syndrome
PharmGKBiPA81
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1166 Eukaryota
ENOG410XQ67 LUCA
GeneTreeiENSGT00520000055622
HOGENOMiHOG000231751
HOVERGENiHBG003709
InParanoidiO43683
KOiK02178
OMAiRNNHETW
OrthoDBiEOG091G00MB
PhylomeDBiO43683
TreeFamiTF105455

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase
SignaLinkiO43683
SIGNORiO43683

Miscellaneous databases

ChiTaRSiBUB1 human
EvolutionaryTraceiO43683
GeneWikiiBUB1
GenomeRNAii699
PROiPR:O43683
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169679 Expressed in 126 organ(s), highest expression level in heart
CleanExiHS_BUB1
ExpressionAtlasiO43683 baseline and differential
GenevisibleiO43683 HS

Family and domain databases

InterProiView protein in InterPro
IPR015661 Bub1/Mad3
IPR011009 Kinase-like_dom_sf
IPR013212 Mad3/Bub1_I
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR14030 PTHR14030, 1 hit
PfamiView protein in Pfam
PF08311 Mad3_BUB1_I, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00777 Mad3_BUB1_I, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51489 BUB1_N, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBUB1_HUMAN
AccessioniPrimary (citable) accession number: O43683
Secondary accession number(s): E9PC26
, F5GXI5, O43430, O43643, O60626, Q53QE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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