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UniProtKB - O43680 (TCF21_HUMAN)
Protein
Transcription factor 21
Gene
TCF21
Organism
Homo sapiens (Human)
Status
Functioni
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.
GO - Molecular functioni
- androgen receptor binding Source: BHF-UCL
- bHLH transcription factor binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: UniProtKB
- E-box binding Source: BHF-UCL
- histone deacetylase binding Source: Ensembl
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- branching involved in ureteric bud morphogenesis Source: BHF-UCL
- branchiomeric skeletal muscle development Source: UniProtKB
- bronchiole development Source: UniProtKB
- developmental process Source: GO_Central
- diaphragm development Source: UniProtKB
- embryonic digestive tract morphogenesis Source: UniProtKB
- epithelial cell differentiation Source: UniProtKB
- gland development Source: UniProtKB
- glomerulus development Source: UniProtKB
- kidney development Source: BHF-UCL
- lung alveolus development Source: UniProtKB
- lung morphogenesis Source: UniProtKB
- lung vasculature development Source: UniProtKB
- metanephric glomerular capillary formation Source: UniProtKB
- metanephric mesenchymal cell differentiation Source: UniProtKB
- morphogenesis of a branching structure Source: BHF-UCL
- negative regulation of androgen receptor signaling pathway Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- reproductive structure development Source: UniProtKB
- respiratory system development Source: UniProtKB
- roof of mouth development Source: UniProtKB
- Sertoli cell differentiation Source: UniProtKB
- sex determination Source: UniProtKB
- spleen development Source: UniProtKB
- ureteric bud development Source: BHF-UCL
- vasculature development Source: BHF-UCL
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | O43680 |
SignaLinki | O43680 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor 21Short name: TCF-21 Alternative name(s): Capsulin Class A basic helix-loop-helix protein 23 Short name: bHLHa23 Epicardin Podocyte-expressed 1 Short name: Pod-1 |
Gene namesi | Name:TCF21 Synonyms:BHLHA23, POD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11632, TCF21 |
MIMi | 603306, gene |
neXtProti | NX_O43680 |
VEuPathDBi | HostDB:ENSG00000118526 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: UniProtKB
Other locations
- chromatin Source: NTNU_SB
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6943 |
OpenTargetsi | ENSG00000118526 |
PharmGKBi | PA36387 |
Miscellaneous databases
Pharosi | O43680, Tbio |
Genetic variation databases
BioMutai | TCF21 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127464 | 1 – 179 | Transcription factor 21Add BLAST | 179 |
Proteomic databases
jPOSTi | O43680 |
MassIVEi | O43680 |
PaxDbi | O43680 |
PeptideAtlasi | O43680 |
PRIDEi | O43680 |
ProteomicsDBi | 49110 |
PTM databases
iPTMneti | O43680 |
PhosphoSitePlusi | O43680 |
Expressioni
Gene expression databases
Bgeei | ENSG00000118526, Expressed in metanephros and 126 other tissues |
Genevisiblei | O43680, HS |
Organism-specific databases
HPAi | ENSG00000118526, Tissue enhanced (lymphoid tissue, ovary, placenta) |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
Forms a heterodimer with TCF3 and binds the E box (5'-CANNTG-3').
Binary interactionsi
O43680
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 3 | EBI-723267,EBI-77613 |
MYOD1 [P15172] | 3 | EBI-723267,EBI-488878 |
SDCBP [O00560] | 3 | EBI-723267,EBI-727004 |
TCF12 - isoform 3 [Q99081-3] | 3 | EBI-723267,EBI-11952764 |
GO - Molecular functioni
- androgen receptor binding Source: BHF-UCL
- bHLH transcription factor binding Source: UniProtKB
- histone deacetylase binding Source: Ensembl
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 112803, 12 interactors |
IntActi | O43680, 15 interactors |
MINTi | O43680 |
STRINGi | 9606.ENSP00000356857 |
Miscellaneous databases
RNActi | O43680, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 79 – 131 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 20 – 87 | DisorderedSequence analysisAdd BLAST | 68 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 28 – 49 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 67 – 81 | Polar residuesSequence analysisAdd BLAST | 15 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000160174 |
HOGENOMi | CLU_092663_0_0_1 |
InParanoidi | O43680 |
OMAi | CEGPCAN |
OrthoDBi | 1374128at2759 |
PhylomeDBi | O43680 |
TreeFami | TF350742 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
O43680-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTGSLSDVE DLQEVEMLEC DGLKMDSNKE FVTSNESTEE SSNCENGSPQ
60 70 80 90 100
KGRGGLGKRR KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS
110 120 130 140 150
RLKTTLPWVP PDTKLSKLDT LRLASSYIAH LRQILANDKY ENGYIHPVNL
160 170
TWPFMVAGKP ESDLKEVVTA SRLCGTTAS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 | K → R in AAC62514 (PubMed:10572052).Curated | 1 | |
Sequence conflicti | 83 | A → T in AAC62532 (PubMed:9733105).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF047419 mRNA Translation: AAC62532.1 AF035718 mRNA Translation: AAC62514.1 BT019660 mRNA Translation: AAV38466.1 CR450293 mRNA Translation: CAG29289.1 AL356109 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48000.1 CH471051 Genomic DNA Translation: EAW48001.1 BC025697 mRNA Translation: AAH25697.1 |
CCDSi | CCDS5167.1 |
RefSeqi | NP_003197.2, NM_003206.3 NP_938206.1, NM_198392.2 |
Genome annotation databases
Ensembli | ENST00000237316.3; ENSP00000237316.3; ENSG00000118526.7 ENST00000367882.5; ENSP00000356857.5; ENSG00000118526.7 |
GeneIDi | 6943 |
KEGGi | hsa:6943 |
MANE-Selecti | ENST00000367882.5; ENSP00000356857.5; NM_003206.4; NP_003197.2 |
UCSCi | uc003qei.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF047419 mRNA Translation: AAC62532.1 AF035718 mRNA Translation: AAC62514.1 BT019660 mRNA Translation: AAV38466.1 CR450293 mRNA Translation: CAG29289.1 AL356109 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48000.1 CH471051 Genomic DNA Translation: EAW48001.1 BC025697 mRNA Translation: AAH25697.1 |
CCDSi | CCDS5167.1 |
RefSeqi | NP_003197.2, NM_003206.3 NP_938206.1, NM_198392.2 |
3D structure databases
AlphaFoldDBi | O43680 |
SMRi | O43680 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112803, 12 interactors |
IntActi | O43680, 15 interactors |
MINTi | O43680 |
STRINGi | 9606.ENSP00000356857 |
PTM databases
iPTMneti | O43680 |
PhosphoSitePlusi | O43680 |
Genetic variation databases
BioMutai | TCF21 |
Proteomic databases
jPOSTi | O43680 |
MassIVEi | O43680 |
PaxDbi | O43680 |
PeptideAtlasi | O43680 |
PRIDEi | O43680 |
ProteomicsDBi | 49110 |
Protocols and materials databases
Antibodypediai | 19727, 157 antibodies from 22 providers |
DNASUi | 6943 |
Genome annotation databases
Ensembli | ENST00000237316.3; ENSP00000237316.3; ENSG00000118526.7 ENST00000367882.5; ENSP00000356857.5; ENSG00000118526.7 |
GeneIDi | 6943 |
KEGGi | hsa:6943 |
MANE-Selecti | ENST00000367882.5; ENSP00000356857.5; NM_003206.4; NP_003197.2 |
UCSCi | uc003qei.5, human |
Organism-specific databases
CTDi | 6943 |
DisGeNETi | 6943 |
GeneCardsi | TCF21 |
HGNCi | HGNC:11632, TCF21 |
HPAi | ENSG00000118526, Tissue enhanced (lymphoid tissue, ovary, placenta) |
MIMi | 603306, gene |
neXtProti | NX_O43680 |
OpenTargetsi | ENSG00000118526 |
PharmGKBi | PA36387 |
VEuPathDBi | HostDB:ENSG00000118526 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000160174 |
HOGENOMi | CLU_092663_0_0_1 |
InParanoidi | O43680 |
OMAi | CEGPCAN |
OrthoDBi | 1374128at2759 |
PhylomeDBi | O43680 |
TreeFami | TF350742 |
Enzyme and pathway databases
PathwayCommonsi | O43680 |
SignaLinki | O43680 |
Miscellaneous databases
BioGRID-ORCSi | 6943, 10 hits in 1092 CRISPR screens |
GeneWikii | TCF21_(gene) |
GenomeRNAii | 6943 |
Pharosi | O43680, Tbio |
PROi | PR:O43680 |
RNActi | O43680, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118526, Expressed in metanephros and 126 other tissues |
Genevisiblei | O43680, HS |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TCF21_HUMAN | |
Accessioni | O43680Primary (citable) accession number: O43680 Secondary accession number(s): E1P581 Q9BZ14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 14, 2001 |
Last sequence update: | August 14, 2001 | |
Last modified: | May 25, 2022 | |
This is version 174 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot