TCF21

Functionⁱ

Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.

GO - Molecular functionⁱ

androgen receptor binding Source: BHF-UCL
bHLH transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12493738
E-box binding Source: BHF-UCL
histone deacetylase binding Source: Ensembl
protein dimerization activity Source: UniProtKB
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12493738

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

branching involved in ureteric bud morphogenesis Source: BHF-UCL
branchiomeric skeletal muscle development Source: UniProtKB
bronchiole development Source: UniProtKB
diaphragm development Source: UniProtKB
embryonic digestive tract morphogenesis Source: UniProtKB
epithelial cell differentiation Source: UniProtKB
gland development Source: UniProtKB
glomerulus development Source: UniProtKB
kidney development Source: BHF-UCL
lung alveolus development Source: UniProtKB
lung morphogenesis Source: UniProtKB
lung vasculature development Source: UniProtKB
metanephric glomerular capillary formation Source: UniProtKB
metanephric mesenchymal cell differentiation Source: UniProtKB
morphogenesis of a branching structure Source: BHF-UCL
negative regulation of androgen receptor signaling pathway Source: BHF-UCL
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 12493738
positive regulation of transcription by RNA polymerase II Source: UniProtKB
reproductive structure development Source: UniProtKB
respiratory system development Source: UniProtKB
roof of mouth development Source: UniProtKB
Sertoli cell differentiation Source: UniProtKB
sex determination Source: UniProtKB
spleen development Source: UniProtKB
ureteric bud development Source: BHF-UCL
vasculature development Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor 21 Short name: TCF-21 Alternative name(s): Capsulin Class A basic helix-loop-helix protein 23 Short name: bHLHa23 Epicardin Podocyte-expressed 1 Short name: Pod-1
Gene namesⁱ	Name:TCF21 Synonyms:BHLHA23, POD1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000118526.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11632 TCF21
MIMⁱ	603306 gene
neXtProtⁱ	NX_O43680

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6943
Open Targets More...OpenTargetsⁱ	ENSG00000118526
PharmGKBⁱ	PA36387

Polymorphism and mutation databases

BioMutaⁱ	TCF21

BioMutaⁱ

TCF21

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127464	1 – 179	Transcription factor 21Add BLAST		179

Proteomic databases

PaxDbⁱ	O43680
PeptideAtlas More...PeptideAtlasⁱ	O43680
PRIDEⁱ	O43680
ProteomicsDBⁱ	49110

PTM databases

iPTMnetⁱ	O43680
PhosphoSitePlusⁱ	O43680

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000118526 Expressed in 116 organ(s), highest expression level in metanephros
CleanExⁱ	HS_TCF21
Genevisibleⁱ	O43680 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA013189

HPAⁱ

HPA013189

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 and binds the E box (5'-CANNTG-3').

GO - Molecular functionⁱ

androgen receptor binding Source: BHF-UCL
bHLH transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12493738
histone deacetylase binding Source: Ensembl
protein dimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112803, 9 interactors
IntActⁱ	O43680, 10 interactors
Molecular INTeraction database More...MINTⁱ	O43680
STRINGⁱ	9606.ENSP00000237316

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43680
SMRⁱ	O43680
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	79 – 131	bHLHPROSITE-ProRule annotationAdd BLAST		53

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00710000106684
HOGENOMⁱ	HOG000261670
HOVERGENⁱ	HBG105298
InParanoidⁱ	O43680
OMAⁱ	SSNCEGA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N6P
PhylomeDBⁱ	O43680
TreeFamⁱ	TF350742

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O43680-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTGSLSDVE DLQEVEMLEC DGLKMDSNKE FVTSNESTEE SSNCENGSPQ 
        60         70         80         90        100
KGRGGLGKRR KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS 
       110        120        130        140        150
RLKTTLPWVP PDTKLSKLDT LRLASSYIAH LRQILANDKY ENGYIHPVNL 
       160        170 
TWPFMVAGKP ESDLKEVVTA SRLCGTTAS

Length:179

Mass (Da):19,715

Last modified:August 14, 2001 - v2

Checksum:ⁱA26F496C536B6F04

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	61	K → R in AAC62514 (PubMed:10572052).Curated		1
Sequence conflictⁱ	83	A → T in AAC62532 (PubMed:9733105).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF047419 mRNA Translation: AAC62532.1 AF035718 mRNA Translation: AAC62514.1 BT019660 mRNA Translation: AAV38466.1 CR450293 mRNA Translation: CAG29289.1 AL356109 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48000.1 CH471051 Genomic DNA Translation: EAW48001.1 BC025697 mRNA Translation: AAH25697.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5167.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003197.2, NM_003206.3 NP_938206.1, NM_198392.2
UniGeneⁱ	Hs.78061

Genome annotation databases

Ensemblⁱ	ENST00000237316; ENSP00000237316; ENSG00000118526 ENST00000367882; ENSP00000356857; ENSG00000118526
GeneIDⁱ	6943
KEGGⁱ	hsa:6943
UCSC genome browser More...UCSCⁱ	uc003qei.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43680	TCF21 isoform 1		PANTR		179	UniRef100_O43680
TCF21 isoform 1		PONAB		179
Uncharacterized protein		PROCO		179
Uncharacterized protein		PANPA		179
Transcription factor 21		GORGO		179

Protein	Similar proteins		Species	Score	Length	Source
O43680	Transcription factor 21		MOUSE		179	UniRef90_O35437
Transcription factor 21		BOVIN		179
Uncharacterized protein		COLVI		196
Uncharacterized protein		CALSU		196
Uncharacterized protein		CHICK		179
+83

Protein	Similar proteins		Species	Score	Length	Source
O43680	Transcription factor 21		MOUSE		179	UniRef50_O35437
Transcription factor 21		BOVIN		179
Transcription factor 21		XENLA		179
Transcription factor 21		XENTR		179
Uncharacterized protein		COLVI		196
+186

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF047419 mRNA Translation: AAC62532.1 AF035718 mRNA Translation: AAC62514.1 BT019660 mRNA Translation: AAV38466.1 CR450293 mRNA Translation: CAG29289.1 AL356109 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48000.1 CH471051 Genomic DNA Translation: EAW48001.1 BC025697 mRNA Translation: AAH25697.1
CCDSⁱ	CCDS5167.1
RefSeqⁱ	NP_003197.2, NM_003206.3 NP_938206.1, NM_198392.2
UniGeneⁱ	Hs.78061

3D structure databases

ProteinModelPortalⁱ	O43680
SMRⁱ	O43680
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112803, 9 interactors
IntActⁱ	O43680, 10 interactors
MINTⁱ	O43680
STRINGⁱ	9606.ENSP00000237316

PTM databases

iPTMnetⁱ	O43680
PhosphoSitePlusⁱ	O43680

Polymorphism and mutation databases

BioMutaⁱ	TCF21

BioMutaⁱ

TCF21

Proteomic databases

PaxDbⁱ	O43680
PeptideAtlasⁱ	O43680
PRIDEⁱ	O43680
ProteomicsDBⁱ	49110

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6943
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000237316; ENSP00000237316; ENSG00000118526 ENST00000367882; ENSP00000356857; ENSG00000118526
GeneIDⁱ	6943
KEGGⁱ	hsa:6943
UCSCⁱ	uc003qei.5 human

Organism-specific databases

CTDⁱ	6943
DisGeNETⁱ	6943
EuPathDBⁱ	HostDB:ENSG00000118526.6
GeneCardsⁱ	TCF21
HGNCⁱ	HGNC:11632 TCF21
HPAⁱ	HPA013189
MIMⁱ	603306 gene
neXtProtⁱ	NX_O43680
OpenTargetsⁱ	ENSG00000118526
PharmGKBⁱ	PA36387
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
GeneTreeⁱ	ENSGT00710000106684
HOGENOMⁱ	HOG000261670
HOVERGENⁱ	HBG105298
InParanoidⁱ	O43680
OMAⁱ	SSNCEGA
OrthoDBⁱ	EOG091G0N6P
PhylomeDBⁱ	O43680
TreeFamⁱ	TF350742

Miscellaneous databases

GeneWikiⁱ	TCF21_(gene)
GenomeRNAiⁱ	6943
Protein Ontology More...PROⁱ	PR:O43680
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000118526 Expressed in 116 organ(s), highest expression level in metanephros
CleanExⁱ	HS_TCF21
Genevisibleⁱ	O43680 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TCF21_HUMAN
Accessionⁱ	O43680Primary (citable) accession number: O43680 Secondary accession number(s): E1P581 , O43545, Q6ICV0, Q9BZ14
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
	Last sequence update:	August 14, 2001
	Last modified:	September 12, 2018
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43680 (TCF21_HUMAN)

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Transcription factor 21

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ