UniProtKB - O43679 (LDB2_HUMAN)
LIM domain-binding protein 2
LDB2
Functioni
GO - Molecular functioni
- enzyme binding Source: Ensembl
- LIM domain binding Source: UniProtKB
- RNA polymerase II activating transcription factor binding Source: GO_Central
- transcription coregulator activity Source: ProtInc
GO - Biological processi
- epithelial structure maintenance Source: Ensembl
- hair follicle development Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- nervous system development Source: GO_Central
- positive regulation of cellular component biogenesis Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of cell migration Source: UniProtKB
- regulation of kinase activity Source: UniProtKB
- somatic stem cell population maintenance Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | O43679 |
Names & Taxonomyi
Protein namesi | Recommended name: LIM domain-binding protein 2Short name: LDB-2 Alternative name(s): Carboxyl-terminal LIM domain-binding protein 1 Short name: CLIM-1 LIM domain-binding factor CLIM1 |
Gene namesi | Name:LDB2 Synonyms:CLIM1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6533, LDB2 |
MIMi | 603450, gene |
neXtProti | NX_O43679 |
VEuPathDBi | HostDB:ENSG00000169744.12 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cell leading edge Source: UniProtKB
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9079 |
OpenTargetsi | ENSG00000169744 |
PharmGKBi | PA30317 |
Miscellaneous databases
Pharosi | O43679, Tbio |
Genetic variation databases
BioMutai | LDB2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084387 | 1 – 373 | LIM domain-binding protein 2Add BLAST | 373 |
Post-translational modificationi
Keywords - PTMi
Ubl conjugationProteomic databases
EPDi | O43679 |
jPOSTi | O43679 |
MassIVEi | O43679 |
MaxQBi | O43679 |
PaxDbi | O43679 |
PeptideAtlasi | O43679 |
PRIDEi | O43679 |
ProteomicsDBi | 49107 [O43679-1] 49108 [O43679-2] 49109 [O43679-3] |
PTM databases
iPTMneti | O43679 |
MetOSitei | O43679 |
PhosphoSitePlusi | O43679 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169744, Expressed in forebrain and 229 other tissues |
ExpressionAtlasi | O43679, baseline and differential |
Genevisiblei | O43679, HS |
Organism-specific databases
HPAi | ENSG00000169744, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with LHX9 (By similarity).
Interacts with SLK; leading to negatively regulate SLK kinase activity (By similarity).
By similarityBinary interactionsi
Hide detailsO43679
GO - Molecular functioni
- enzyme binding Source: Ensembl
- LIM domain binding Source: UniProtKB
- RNA polymerase II activating transcription factor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114535, 28 interactors |
DIPi | DIP-24262N DIP-41215N |
IntActi | O43679, 28 interactors |
MINTi | O43679 |
STRINGi | 9606.ENSP00000306772 |
Miscellaneous databases
RNActi | O43679, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 298 – 337 | LIM interaction domain (LID)PROSITE-ProRule annotationAdd BLAST | 40 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2181, Eukaryota |
GeneTreei | ENSGT00390000005639 |
InParanoidi | O43679 |
OMAi | NSPWSSK |
OrthoDBi | 849287at2759 |
PhylomeDBi | O43679 |
TreeFami | TF319923 |
Family and domain databases
InterProi | View protein in InterPro IPR030174, LDB2 IPR041363, LID IPR029005, LIM-bd/SEUSS |
PANTHERi | PTHR10378, PTHR10378, 1 hit PTHR10378:SF8, PTHR10378:SF8, 1 hit |
Pfami | View protein in Pfam PF17916, LID, 1 hit PF01803, LIM_bind, 2 hits |
PROSITEi | View protein in PROSITE PS51957, LID, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSTPHDPFY SSPFGPFYRR HTPYMVQPEY RIYEMNKRLQ SRTEDSDNLW
60 70 80 90 100
WDAFATEFFE DDATLTLSFC LEDGPKRYTI GRTLIPRYFS TVFEGGVTDL
110 120 130 140 150
YYILKHSKES YHNSSITVDC DQCTMVTQHG KPMFTKVCTE GRLILEFTFD
160 170 180 190 200
DLMRIKTWHF TIRQYRELVP RSILAMHAQD PQVLDQLSKN ITRMGLTNFT
210 220 230 240 250
LNYLRLCVIL EPMQELMSRH KTYNLSPRDC LKTCLFQKWQ RMVAPPAEPT
260 270 280 290 300
RQPTTKRRKR KNSTSSTSNS SAGNNANSTG SKKKTTAANL SLSSQVPDVM
310 320 330 340 350
VVGEPTLMGG EFGDEDERLI TRLENTQYDA ANGMDDEEDF NNSPALGNNS
360 370
PWNSKPPATQ ETKSENPPPQ ASQ
The sequence of this isoform differs from the canonical sequence as follows:
298-331: DVMVVGEPTLMGGEFGDEDERLITRLENTQYDAA → GLGAIPNCSLNPGRDGDLCHSTAVTPSGQFKEKH
332-373: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E9Y7 | G5E9Y7_HUMAN | LIM domain binding 2, isoform CRA_b | LDB2 hCG_1811661 | 371 | Annotation score: | ||
H0YA09 | H0YA09_HUMAN | LIM domain-binding protein 2 | LDB2 | 294 | Annotation score: | ||
E9PFI4 | E9PFI4_HUMAN | LIM domain-binding protein 2 | LDB2 | 313 | Annotation score: | ||
D6RAT1 | D6RAT1_HUMAN | LIM domain-binding protein 2 | LDB2 | 164 | Annotation score: | ||
E7EX95 | E7EX95_HUMAN | LIM domain-binding protein 2 | LDB2 | 110 | Annotation score: | ||
E9PGU0 | E9PGU0_HUMAN | LIM domain-binding protein 2 | LDB2 | 106 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027825 | 1 – 24 | Missing in isoform 3. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_027828 | 296 – 297 | Missing in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_027826 | 298 – 331 | DVMVV…QYDAA → GLGAIPNCSLNPGRDGDLCH STAVTPSGQFKEKH in isoform 2. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_027827 | 332 – 373 | Missing in isoform 2. 1 PublicationAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF068651 mRNA Translation: AAC77817.1 AF052389 mRNA Translation: AAC13274.1 AF064492 mRNA Translation: AAC28342.1 AF064493 mRNA Translation: AAC28343.1 AF047337 mRNA Translation: AAC83552.1 BC034019 mRNA Translation: AAH34019.1 |
CCDSi | CCDS3420.1 [O43679-1] CCDS47031.1 [O43679-2] |
RefSeqi | NP_001124306.1, NM_001130834.2 [O43679-2] NP_001281.1, NM_001290.4 [O43679-1] |
Genome annotation databases
Ensembli | ENST00000304523; ENSP00000306772; ENSG00000169744 [O43679-1] ENST00000441778; ENSP00000392089; ENSG00000169744 [O43679-2] |
GeneIDi | 9079 |
KEGGi | hsa:9079 |
UCSCi | uc003goz.5, human [O43679-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF068651 mRNA Translation: AAC77817.1 AF052389 mRNA Translation: AAC13274.1 AF064492 mRNA Translation: AAC28342.1 AF064493 mRNA Translation: AAC28343.1 AF047337 mRNA Translation: AAC83552.1 BC034019 mRNA Translation: AAH34019.1 |
CCDSi | CCDS3420.1 [O43679-1] CCDS47031.1 [O43679-2] |
RefSeqi | NP_001124306.1, NM_001130834.2 [O43679-2] NP_001281.1, NM_001290.4 [O43679-1] |
3D structure databases
SMRi | O43679 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114535, 28 interactors |
DIPi | DIP-24262N DIP-41215N |
IntActi | O43679, 28 interactors |
MINTi | O43679 |
STRINGi | 9606.ENSP00000306772 |
PTM databases
iPTMneti | O43679 |
MetOSitei | O43679 |
PhosphoSitePlusi | O43679 |
Genetic variation databases
BioMutai | LDB2 |
Proteomic databases
EPDi | O43679 |
jPOSTi | O43679 |
MassIVEi | O43679 |
MaxQBi | O43679 |
PaxDbi | O43679 |
PeptideAtlasi | O43679 |
PRIDEi | O43679 |
ProteomicsDBi | 49107 [O43679-1] 49108 [O43679-2] 49109 [O43679-3] |
Protocols and materials databases
Antibodypediai | 4310, 234 antibodies |
DNASUi | 9079 |
Genome annotation databases
Ensembli | ENST00000304523; ENSP00000306772; ENSG00000169744 [O43679-1] ENST00000441778; ENSP00000392089; ENSG00000169744 [O43679-2] |
GeneIDi | 9079 |
KEGGi | hsa:9079 |
UCSCi | uc003goz.5, human [O43679-1] |
Organism-specific databases
CTDi | 9079 |
DisGeNETi | 9079 |
GeneCardsi | LDB2 |
HGNCi | HGNC:6533, LDB2 |
HPAi | ENSG00000169744, Low tissue specificity |
MIMi | 603450, gene |
neXtProti | NX_O43679 |
OpenTargetsi | ENSG00000169744 |
PharmGKBi | PA30317 |
VEuPathDBi | HostDB:ENSG00000169744.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2181, Eukaryota |
GeneTreei | ENSGT00390000005639 |
InParanoidi | O43679 |
OMAi | NSPWSSK |
OrthoDBi | 849287at2759 |
PhylomeDBi | O43679 |
TreeFami | TF319923 |
Enzyme and pathway databases
PathwayCommonsi | O43679 |
Miscellaneous databases
BioGRID-ORCSi | 9079, 5 hits in 991 CRISPR screens |
ChiTaRSi | LDB2, human |
GeneWikii | LDB2 |
GenomeRNAii | 9079 |
Pharosi | O43679, Tbio |
PROi | PR:O43679 |
RNActi | O43679, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169744, Expressed in forebrain and 229 other tissues |
ExpressionAtlasi | O43679, baseline and differential |
Genevisiblei | O43679, HS |
Family and domain databases
InterProi | View protein in InterPro IPR030174, LDB2 IPR041363, LID IPR029005, LIM-bd/SEUSS |
PANTHERi | PTHR10378, PTHR10378, 1 hit PTHR10378:SF8, PTHR10378:SF8, 1 hit |
Pfami | View protein in Pfam PF17916, LID, 1 hit PF01803, LIM_bind, 2 hits |
PROSITEi | View protein in PROSITE PS51957, LID, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LDB2_HUMAN | |
Accessioni | O43679Primary (citable) accession number: O43679 Secondary accession number(s): O60619, O75480 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | June 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families