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Protein

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Gene

NDUFC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: ProtInc

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: ProtInc
  • mitochondrial respiratory chain complex I assembly Source: UniProtKB

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Alternative name(s):
Complex I-KFYI
Short name:
CI-KFYI
NADH-ubiquinone oxidoreductase KFYI subunit
Gene namesi
Name:NDUFC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109390.11
HGNCiHGNC:7705 NDUFC1
MIMi603844 gene
neXtProtiNX_O43677

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 59HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109390
PharmGKBiPA31516

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiNDUFC1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionBy similarityAdd BLAST27
ChainiPRO_000002004928 – 76NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialAdd BLAST49

Proteomic databases

EPDiO43677
MaxQBiO43677
PaxDbiO43677
PeptideAtlasiO43677
PRIDEiO43677
ProteomicsDBi49105
TopDownProteomicsiO43677

Expressioni

Gene expression databases

BgeeiENSG00000109390 Expressed in 244 organ(s), highest expression level in myocardium
CleanExiHS_NDUFC1
GenevisibleiO43677 HS

Organism-specific databases

HPAiHPA044556

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiO43677
STRINGi9606.ENSP00000265500

Structurei

3D structure databases

ProteinModelPortaliO43677
SMRiO43677
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC1 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0MG Eukaryota
ENOG410XUGS LUCA
GeneTreeiENSGT00390000002565
HOGENOMiHOG000013086
HOVERGENiHBG006500
InParanoidiO43677
KOiK03967
OMAiFYVRDPP
OrthoDBiEOG091G14QE
PhylomeDBiO43677
TreeFamiTF338333

Family and domain databases

InterProiView protein in InterPro
IPR026192 NDUFC1
PANTHERiPTHR17097 PTHR17097, 1 hit
PfamiView protein in Pfam
PF15088 NADH_dh_m_C1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43677-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPSALLRPL SRLLAPARLP SGPSVRSKFY VREPPNAKPD WLKVGFTLGT
60 70
TVFLWIYLIK QHNEDILEYK RRNGLE
Length:76
Mass (Da):8,734
Last modified:June 1, 1998 - v1
Checksum:i7EEDEDE477E12B5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047184 mRNA Translation: AAC04269.1
AF047435 mRNA Translation: AAC39886.1
AK291147 mRNA Translation: BAF83836.1
CH471056 Genomic DNA Translation: EAX05121.1
BC101798 mRNA Translation: AAI01799.1
BC107682 mRNA Translation: AAI07683.1
BC112061 mRNA Translation: AAI12062.1
CCDSiCCDS3746.1
PIRiJC5823
RefSeqiNP_001171915.1, NM_001184986.1
NP_001171916.1, NM_001184987.1
NP_001171917.1, NM_001184988.1
NP_001171918.1, NM_001184989.1
NP_001171919.1, NM_001184990.1
NP_001171920.1, NM_001184991.1
NP_002485.1, NM_002494.3
UniGeneiHs.84549

Genome annotation databases

EnsembliENST00000394223; ENSP00000377770; ENSG00000109390
ENST00000394228; ENSP00000377775; ENSG00000109390
ENST00000503997; ENSP00000425882; ENSG00000109390
ENST00000505036; ENSP00000421195; ENSG00000109390
ENST00000539002; ENSP00000440133; ENSG00000109390
ENST00000539387; ENSP00000439882; ENSG00000109390
ENST00000544855; ENSP00000441126; ENSG00000109390
GeneIDi4717
KEGGihsa:4717
UCSCiuc003ihs.3 human

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047184 mRNA Translation: AAC04269.1
AF047435 mRNA Translation: AAC39886.1
AK291147 mRNA Translation: BAF83836.1
CH471056 Genomic DNA Translation: EAX05121.1
BC101798 mRNA Translation: AAI01799.1
BC107682 mRNA Translation: AAI07683.1
BC112061 mRNA Translation: AAI12062.1
CCDSiCCDS3746.1
PIRiJC5823
RefSeqiNP_001171915.1, NM_001184986.1
NP_001171916.1, NM_001184987.1
NP_001171917.1, NM_001184988.1
NP_001171918.1, NM_001184989.1
NP_001171919.1, NM_001184990.1
NP_001171920.1, NM_001184991.1
NP_002485.1, NM_002494.3
UniGeneiHs.84549

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTCelectron microscopy3.70f28-74[»]
5XTDelectron microscopy3.70f28-74[»]
5XTHelectron microscopy3.90f28-74[»]
5XTIelectron microscopy17.40Bf/f28-74[»]
ProteinModelPortaliO43677
SMRiO43677
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiO43677
STRINGi9606.ENSP00000265500

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiNDUFC1

Proteomic databases

EPDiO43677
MaxQBiO43677
PaxDbiO43677
PeptideAtlasiO43677
PRIDEiO43677
ProteomicsDBi49105
TopDownProteomicsiO43677

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394223; ENSP00000377770; ENSG00000109390
ENST00000394228; ENSP00000377775; ENSG00000109390
ENST00000503997; ENSP00000425882; ENSG00000109390
ENST00000505036; ENSP00000421195; ENSG00000109390
ENST00000539002; ENSP00000440133; ENSG00000109390
ENST00000539387; ENSP00000439882; ENSG00000109390
ENST00000544855; ENSP00000441126; ENSG00000109390
GeneIDi4717
KEGGihsa:4717
UCSCiuc003ihs.3 human

Organism-specific databases

CTDi4717
EuPathDBiHostDB:ENSG00000109390.11
GeneCardsiNDUFC1
H-InvDBiHIX0004505
HGNCiHGNC:7705 NDUFC1
HPAiHPA044556
MIMi603844 gene
neXtProtiNX_O43677
OpenTargetsiENSG00000109390
PharmGKBiPA31516
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0MG Eukaryota
ENOG410XUGS LUCA
GeneTreeiENSGT00390000002565
HOGENOMiHOG000013086
HOVERGENiHBG006500
InParanoidiO43677
KOiK03967
OMAiFYVRDPP
OrthoDBiEOG091G14QE
PhylomeDBiO43677
TreeFamiTF338333

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Miscellaneous databases

ChiTaRSiNDUFC1 human
GeneWikiiNDUFC1
GenomeRNAii4717
PROiPR:O43677
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109390 Expressed in 244 organ(s), highest expression level in myocardium
CleanExiHS_NDUFC1
GenevisibleiO43677 HS

Family and domain databases

InterProiView protein in InterPro
IPR026192 NDUFC1
PANTHERiPTHR17097 PTHR17097, 1 hit
PfamiView protein in Pfam
PF15088 NADH_dh_m_C1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDUC1_HUMAN
AccessioniPrimary (citable) accession number: O43677
Secondary accession number(s): A8K532, Q3MIJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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