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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

Gene

NDUFB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: ProtInc

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: ProtInc
  • mitochondrial respiratory chain complex I assembly Source: UniProtKB

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Alternative name(s):
Complex I-SGDH
Short name:
CI-SGDH
NADH-ubiquinone oxidoreductase SGDH subunit
Gene namesi
Name:NDUFB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000136521.12
HGNCiHGNC:7700 NDUFB5
MIMi603841 gene
neXtProtiNX_O43674

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4711
OpenTargetsiENSG00000136521
PharmGKBiPA31511

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiNDUFB5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionBy similarityAdd BLAST46
ChainiPRO_000002005247 – 189NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialAdd BLAST143

Proteomic databases

EPDiO43674
MaxQBiO43674
PaxDbiO43674
PeptideAtlasiO43674
PRIDEiO43674
ProteomicsDBi49102
49103 [O43674-2]
TopDownProteomicsiO43674-1 [O43674-1]
O43674-2 [O43674-2]

PTM databases

iPTMnetiO43674
PhosphoSitePlusiO43674

Expressioni

Gene expression databases

BgeeiENSG00000136521 Expressed in 236 organ(s), highest expression level in biceps brachii
CleanExiHS_NDUFB5
ExpressionAtlasiO43674 baseline and differential
GenevisibleiO43674 HS

Organism-specific databases

HPAiHPA005640

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

BioGridi110791, 62 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiO43674
IntActiO43674, 16 interactors
MINTiO43674
STRINGi9606.ENSP00000259037

Structurei

3D structure databases

ProteinModelPortaliO43674
SMRiO43674
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB5 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4632 Eukaryota
ENOG4111HCK LUCA
GeneTreeiENSGT00390000009980
HOGENOMiHOG000004849
HOVERGENiHBG003008
InParanoidiO43674
KOiK03961
PhylomeDBiO43674
TreeFamiTF313997

Family and domain databases

InterProiView protein in InterPro
IPR019173 NADH_UbQ_OxRdtase_B5_su
PANTHERiPTHR13178 PTHR13178, 1 hit
PfamiView protein in Pfam
PF09781 NDUF_B5, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: O43674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAMSLLRRV SVTAVAALSG RPLGTRLGFG GFLTRGFPKA AAPVRHSGDH
60 70 80 90 100
GKRLFVIRPS RFYDRRFLKL LRFYIALTGI PVAIFITLVN VFIGQAELAE
110 120 130 140 150
IPEGYVPEHW EYYKHPISRW IARNFYDSPE KIYERTMAVL QIEAEKAELR
160 170 180
VKELEVRKLM HVRGDGPWYY YETIDKELID HSPKATPDN
Length:189
Mass (Da):21,750
Last modified:June 1, 1998 - v1
Checksum:i66D288F7AB7FD5C5
GO
Isoform 2 (identifier: O43674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-93: Missing.

Note: No experimental confirmation available.
Show »
Length:137
Mass (Da):15,667
Checksum:iCD8C5524D8116C46
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y886H0Y886_HUMAN
NADH dehydrogenase [ubiquinone] 1 b...
NDUFB5
206Annotation score:
E7EWP0E7EWP0_HUMAN
NADH dehydrogenase [ubiquinone] 1 b...
NDUFB5
177Annotation score:
H7C568H7C568_HUMAN
NADH dehydrogenase [ubiquinone] 1 b...
NDUFB5
100Annotation score:
A0A087WYD0A0A087WYD0_HUMAN
NADH dehydrogenase (Ubiquinone) 1 b...
NDUFB5 hCG_1787208
135Annotation score:
H7C5C1H7C5C1_HUMAN
NADH dehydrogenase [ubiquinone] 1 b...
NDUFB5
56Annotation score:
F8WDD2F8WDD2_HUMAN
NADH dehydrogenase [ubiquinone] 1 b...
NDUFB5
66Annotation score:
F8WDZ2F8WDZ2_HUMAN
NADH dehydrogenase [ubiquinone] 1 b...
NDUFB5
42Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050590133Y → H. Corresponds to variant dbSNP:rs4147793Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04251642 – 93Missing in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047181 mRNA Translation: AAC04266.1
AC090425 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78393.1
BC005271 mRNA Translation: AAH05271.1
BC093071 mRNA Translation: AAH93071.1
BC009796 mRNA Translation: AAH09796.1
CCDSiCCDS3234.1 [O43674-1]
CCDS56297.1 [O43674-2]
PIRiJC5820
RefSeqiNP_001186886.1, NM_001199957.1 [O43674-2]
NP_001186887.1, NM_001199958.1
NP_002483.1, NM_002492.3 [O43674-1]
UniGeneiHs.730674

Genome annotation databases

EnsembliENST00000259037; ENSP00000259037; ENSG00000136521 [O43674-1]
ENST00000493866; ENSP00000419656; ENSG00000136521 [O43674-2]
GeneIDi4711
KEGGihsa:4711
UCSCiuc003fkc.4 human [O43674-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNDUB5_HUMAN
AccessioniPrimary (citable) accession number: O43674
Secondary accession number(s): Q561V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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