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Entry version 173 (16 Oct 2019)
Sequence version 1 (01 Jun 1998)
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Protein

BUB3-interacting and GLEBS motif-containing protein ZNF207

Gene

ZNF207

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri11 – 34C2H2-type 1Add BLAST24
Zinc fingeri35 – 58C2H2-type 2Add BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Chromosome partition, Mitosis
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BUB3-interacting and GLEBS motif-containing protein ZNF2072 Publications
Short name:
BuGZ2 Publications
Short name:
hBuGZ1 Publication
Alternative name(s):
Zinc finger protein 207
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF207Imported
Synonyms:BUGZ2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12998 ZNF207

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603428 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O43670

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi373 – 374EE → AA in BuGZAA: Abolishes interaction with BUB3. 2 Publications2

Organism-specific databases

DisGeNET

More...
DisGeNETi
7756

Open Targets

More...
OpenTargetsi
ENSG00000010244

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37578

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O43670

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF207

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474531 – 478BUB3-interacting and GLEBS motif-containing protein ZNF207Add BLAST478

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43670

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43670

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O43670

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43670

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43670

PeptideAtlas

More...
PeptideAtlasi
O43670

PRoteomics IDEntifications database

More...
PRIDEi
O43670

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
15215
49099 [O43670-1]
49100 [O43670-2]
49101 [O43670-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43670

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O43670

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O43670

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000010244 Expressed in 234 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O43670 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43670 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA017013
HPA063908

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via GLEBS region) with BUB3.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113540, 50 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O43670

Protein interaction database and analysis system

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IntActi
O43670, 25 interactors

Molecular INTeraction database

More...
MINTi
O43670

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378165

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 92Microtubule-binding region1 PublicationAdd BLAST92
Regioni359 – 391GLEBS2 PublicationsAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The GLEBS region mediates interaction with BUB3 (PubMed:24462186, PubMed:24462187).2 Publications
The microtubule-binding region is required for efficient loading of BUB3 onto kinetochores and proper mitosis.1 Publication
Mainly composed of disordered low-complexity regions outside of the C2H2-type zinc fingers. Coacervation depends on hydrophobic and aromatic Phe and Tyr in the disordered low-complexity region, that may promote coacervation by forming intermolecular hydrophobic interactions.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 34C2H2-type 1Add BLAST24
Zinc fingeri35 – 58C2H2-type 2Add BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2893 Eukaryota
ENOG410ZJGQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111057

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43670

Database of Orthologous Groups

More...
OrthoDBi
1224540at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43670

TreeFam database of animal gene trees

More...
TreeFami
TF313844

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013087 Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43670-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRKKKKQLK PWCWYCNRDF DDEKILIQHQ KAKHFKCHIC HKKLYTGPGL
60 70 80 90 100
AIHCMQVHKE TIDAVPNAIP GRTDIELEIY GMEGIPEKDM DERRRLLEQK
110 120 130 140 150
TQESQKKKQQ DDSDEYDDDD SAASTSFQPQ PVQPQQGYIP PMAQPGLPPV
160 170 180 190 200
PGAPGMPPGI PPLMPGVPPL MPGMPPVMPG MPPGMMPMGG MMPPGPGIPP
210 220 230 240 250
LMPGMPPGMP PPVPRPGIPP MTQAQAVSAP GILNRPPAPT ATVPAPQPPV
260 270 280 290 300
TKPLFPSAGQ MGTPVTSSST ASSNSESLSA SSKALFPSTA QAQAAVQGPV
310 320 330 340 350
GTDFKPLNST PATTTEPPKP TFPAYTQSTA STTSTTNSTA AKPAASITSK
360 370 380 390 400
PATLTTTSAT SKLIHPDEDI SLEERRAQLP KYQRNLPRPG QAPIGNPPVG
410 420 430 440 450
PIGGMMPPQP GIPQQQGMRP PMPPHGQYGG HHQGMPGYLP GAMPPYGQGP
460 470
PMVPPYQGGP PRPPMGMRPP VMSQGGRY
Length:478
Mass (Da):50,751
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i308B0303059052F7
GO
Isoform 2 (identifier: O43670-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-184: G → GLHHQRKYTQSFCGENI
     261-291: Missing.

Show »
Length:463
Mass (Da):49,692
Checksum:i21DC067E59CD808C
GO
Isoform 3 (identifier: O43670-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-146: Missing.
     184-184: G → GLHHQRKYTQSFCGENI

Show »
Length:395
Mass (Da):41,559
Checksum:i626A315EA03A5C3E
GO
Isoform 4 (identifier: O43670-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-184: G → GLHHQRKYTQSFCGENI

Note: No experimental confirmation available.
Show »
Length:494
Mass (Da):52,694
Checksum:iB77B795197A9D6E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R4W8X6R4W8_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
497Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRS9J3QRS9_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
493Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3M2H0Y3M2_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRB6J3KRB6_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS31J3KS31_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
341Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTL1J3KTL1_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRW6J3KRW6_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS27J3QS27_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019974224A → S. Corresponds to variant dbSNP:rs3795244Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00690348 – 146Missing in isoform 3. 2 PublicationsAdd BLAST99
Alternative sequenceiVSP_006904184G → GLHHQRKYTQSFCGENI in isoform 2, isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_006905261 – 291Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF046001 mRNA Translation: AAC78561.1
BT007365 mRNA Translation: AAP36029.1
AK291801 mRNA Translation: BAF84490.1
AK226172 mRNA No translation available.
AC005899 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80231.1
CH471147 Genomic DNA Translation: EAW80233.1
CH471147 Genomic DNA Translation: EAW80234.1
CH471147 Genomic DNA Translation: EAW80235.1
CH471147 Genomic DNA Translation: EAW80236.1
CH471147 Genomic DNA Translation: EAW80237.1
BC002372 mRNA Translation: AAH02372.1
BC008023 mRNA Translation: AAH08023.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11271.1 [O43670-1]
CCDS32614.1 [O43670-2]
CCDS42294.1 [O43670-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001027464.1, NM_001032293.2 [O43670-2]
NP_001091977.1, NM_001098507.1 [O43670-4]
NP_003448.1, NM_003457.3 [O43670-1]
XP_016880508.1, XM_017025019.1 [O43670-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000321233; ENSP00000322777; ENSG00000010244 [O43670-1]
ENST00000394670; ENSP00000378165; ENSG00000010244 [O43670-4]
ENST00000394673; ENSP00000378168; ENSG00000010244 [O43670-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7756

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7756

UCSC genome browser

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UCSCi
uc002hhh.5 human [O43670-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046001 mRNA Translation: AAC78561.1
BT007365 mRNA Translation: AAP36029.1
AK291801 mRNA Translation: BAF84490.1
AK226172 mRNA No translation available.
AC005899 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80231.1
CH471147 Genomic DNA Translation: EAW80233.1
CH471147 Genomic DNA Translation: EAW80234.1
CH471147 Genomic DNA Translation: EAW80235.1
CH471147 Genomic DNA Translation: EAW80236.1
CH471147 Genomic DNA Translation: EAW80237.1
BC002372 mRNA Translation: AAH02372.1
BC008023 mRNA Translation: AAH08023.1
CCDSiCCDS11271.1 [O43670-1]
CCDS32614.1 [O43670-2]
CCDS42294.1 [O43670-4]
RefSeqiNP_001027464.1, NM_001032293.2 [O43670-2]
NP_001091977.1, NM_001098507.1 [O43670-4]
NP_003448.1, NM_003457.3 [O43670-1]
XP_016880508.1, XM_017025019.1 [O43670-4]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi113540, 50 interactors
CORUMiO43670
IntActiO43670, 25 interactors
MINTiO43670
STRINGi9606.ENSP00000378165

PTM databases

iPTMnetiO43670
PhosphoSitePlusiO43670
SwissPalmiO43670

Polymorphism and mutation databases

BioMutaiZNF207

Proteomic databases

EPDiO43670
jPOSTiO43670
MassIVEiO43670
MaxQBiO43670
PaxDbiO43670
PeptideAtlasiO43670
PRIDEiO43670
ProteomicsDBi15215
49099 [O43670-1]
49100 [O43670-2]
49101 [O43670-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7756

Genome annotation databases

EnsembliENST00000321233; ENSP00000322777; ENSG00000010244 [O43670-1]
ENST00000394670; ENSP00000378165; ENSG00000010244 [O43670-4]
ENST00000394673; ENSP00000378168; ENSG00000010244 [O43670-2]
GeneIDi7756
KEGGihsa:7756
UCSCiuc002hhh.5 human [O43670-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7756
DisGeNETi7756

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF207
HGNCiHGNC:12998 ZNF207
HPAiHPA017013
HPA063908
MIMi603428 gene
neXtProtiNX_O43670
OpenTargetsiENSG00000010244
PharmGKBiPA37578

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2893 Eukaryota
ENOG410ZJGQ LUCA
GeneTreeiENSGT00730000111057
InParanoidiO43670
OrthoDBi1224540at2759
PhylomeDBiO43670
TreeFamiTF313844

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF207 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7756
PharosiO43670

Protein Ontology

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PROi
PR:O43670

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000010244 Expressed in 234 organ(s), highest expression level in lung
ExpressionAtlasiO43670 baseline and differential
GenevisibleiO43670 HS

Family and domain databases

InterProiView protein in InterPro
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN207_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43670
Secondary accession number(s): A8K6Y6
, E1P660, E1P661, E1P662, Q53XS9, Q96HW5, Q9BUQ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: October 16, 2019
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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