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Protein

BUB3-interacting and GLEBS motif-containing protein ZNF207

Gene

ZNF207

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 34C2H2-type 1Add BLAST24
Zinc fingeri35 – 58C2H2-type 2Add BLAST24

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: UniProtKB
  • heparin binding Source: Ensembl
  • microtubule binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Chromosome partition, Mitosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
BUB3-interacting and GLEBS motif-containing protein ZNF2072 Publications
Short name:
BuGZ2 Publications
Short name:
hBuGZ1 Publication
Alternative name(s):
Zinc finger protein 207
Gene namesi
Name:ZNF207Imported
Synonyms:BUGZ2 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000010244.16
HGNCiHGNC:12998 ZNF207
MIMi603428 gene
neXtProtiNX_O43670

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi373 – 374EE → AA in BuGZAA: Abolishes interaction with BUB3. 2 Publications2

Organism-specific databases

DisGeNETi7756
OpenTargetsiENSG00000010244
PharmGKBiPA37578

Polymorphism and mutation databases

BioMutaiZNF207

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474531 – 478BUB3-interacting and GLEBS motif-containing protein ZNF207Add BLAST478

Proteomic databases

EPDiO43670
MaxQBiO43670
PaxDbiO43670
PeptideAtlasiO43670
PRIDEiO43670
ProteomicsDBi49099
49100 [O43670-2]
49101 [O43670-3]

PTM databases

iPTMnetiO43670
PhosphoSitePlusiO43670

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000010244 Expressed in 234 organ(s), highest expression level in lung
CleanExiHS_ZNF207
ExpressionAtlasiO43670 baseline and differential
GenevisibleiO43670 HS

Organism-specific databases

HPAiHPA017013
HPA063908

Interactioni

Subunit structurei

Interacts (via GLEBS region) with BUB3.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113540, 42 interactors
CORUMiO43670
IntActiO43670, 24 interactors
MINTiO43670
STRINGi9606.ENSP00000378165

Structurei

3D structure databases

ProteinModelPortaliO43670
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 92Microtubule-binding region1 PublicationAdd BLAST92
Regioni359 – 391GLEBS2 PublicationsAdd BLAST33

Domaini

The GLEBS region mediates interaction with BUB3 (PubMed:24462186, PubMed:24462187).2 Publications
The microtubule-binding region is required for efficient loading of BUB3 onto kinetochores and proper mitosis.1 Publication
Mainly composed of disordered low-complexity regions outside of the C2H2-type zinc fingers. Coacervation depends on hydrophobic and aromatic Phe and Tyr in the disordered low-complexity region, that may promote coacervation by forming intermolecular hydrophobic interactions.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 34C2H2-type 1Add BLAST24
Zinc fingeri35 – 58C2H2-type 2Add BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2893 Eukaryota
ENOG410ZJGQ LUCA
GeneTreeiENSGT00730000111057
HOVERGENiHBG054182
InParanoidiO43670
PhylomeDBiO43670
TreeFamiTF313844

Family and domain databases

InterProiView protein in InterPro
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43670-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRKKKKQLK PWCWYCNRDF DDEKILIQHQ KAKHFKCHIC HKKLYTGPGL
60 70 80 90 100
AIHCMQVHKE TIDAVPNAIP GRTDIELEIY GMEGIPEKDM DERRRLLEQK
110 120 130 140 150
TQESQKKKQQ DDSDEYDDDD SAASTSFQPQ PVQPQQGYIP PMAQPGLPPV
160 170 180 190 200
PGAPGMPPGI PPLMPGVPPL MPGMPPVMPG MPPGMMPMGG MMPPGPGIPP
210 220 230 240 250
LMPGMPPGMP PPVPRPGIPP MTQAQAVSAP GILNRPPAPT ATVPAPQPPV
260 270 280 290 300
TKPLFPSAGQ MGTPVTSSST ASSNSESLSA SSKALFPSTA QAQAAVQGPV
310 320 330 340 350
GTDFKPLNST PATTTEPPKP TFPAYTQSTA STTSTTNSTA AKPAASITSK
360 370 380 390 400
PATLTTTSAT SKLIHPDEDI SLEERRAQLP KYQRNLPRPG QAPIGNPPVG
410 420 430 440 450
PIGGMMPPQP GIPQQQGMRP PMPPHGQYGG HHQGMPGYLP GAMPPYGQGP
460 470
PMVPPYQGGP PRPPMGMRPP VMSQGGRY
Length:478
Mass (Da):50,751
Last modified:June 1, 1998 - v1
Checksum:i308B0303059052F7
GO
Isoform 2 (identifier: O43670-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-184: G → GLHHQRKYTQSFCGENI
     261-291: Missing.

Show »
Length:463
Mass (Da):49,692
Checksum:i21DC067E59CD808C
GO
Isoform 3 (identifier: O43670-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-146: Missing.
     184-184: G → GLHHQRKYTQSFCGENI

Show »
Length:395
Mass (Da):41,559
Checksum:i626A315EA03A5C3E
GO
Isoform 4 (identifier: O43670-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-184: G → GLHHQRKYTQSFCGENI

Note: No experimental confirmation available.
Show »
Length:494
Mass (Da):52,694
Checksum:iB77B795197A9D6E1
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R4W8X6R4W8_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
497Annotation score:
J3QRS9J3QRS9_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
493Annotation score:
H0Y3M2H0Y3M2_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
198Annotation score:
J3KRB6J3KRB6_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
93Annotation score:
J3KTL1J3KTL1_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
74Annotation score:
J3KRW6J3KRW6_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
95Annotation score:
J3QS27J3QS27_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
46Annotation score:
J3KS31J3KS31_HUMAN
BUB3-interacting and GLEBS motif-co...
ZNF207
341Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019974224A → S. Corresponds to variant dbSNP:rs3795244Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00690348 – 146Missing in isoform 3. 2 PublicationsAdd BLAST99
Alternative sequenceiVSP_006904184G → GLHHQRKYTQSFCGENI in isoform 2, isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_006905261 – 291Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046001 mRNA Translation: AAC78561.1
BT007365 mRNA Translation: AAP36029.1
AK291801 mRNA Translation: BAF84490.1
AK226172 mRNA No translation available.
AC005899 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80231.1
CH471147 Genomic DNA Translation: EAW80233.1
CH471147 Genomic DNA Translation: EAW80234.1
CH471147 Genomic DNA Translation: EAW80235.1
CH471147 Genomic DNA Translation: EAW80236.1
CH471147 Genomic DNA Translation: EAW80237.1
BC002372 mRNA Translation: AAH02372.1
BC008023 mRNA Translation: AAH08023.1
CCDSiCCDS11271.1 [O43670-1]
CCDS32614.1 [O43670-2]
CCDS42294.1 [O43670-4]
RefSeqiNP_001027464.1, NM_001032293.2 [O43670-2]
NP_001091977.1, NM_001098507.1 [O43670-4]
NP_003448.1, NM_003457.3 [O43670-1]
XP_016880508.1, XM_017025019.1 [O43670-4]
UniGeneiHs.500775

Genome annotation databases

EnsembliENST00000321233; ENSP00000322777; ENSG00000010244 [O43670-1]
ENST00000394670; ENSP00000378165; ENSG00000010244 [O43670-4]
ENST00000394673; ENSP00000378168; ENSG00000010244 [O43670-2]
GeneIDi7756
KEGGihsa:7756
UCSCiuc002hhh.5 human [O43670-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046001 mRNA Translation: AAC78561.1
BT007365 mRNA Translation: AAP36029.1
AK291801 mRNA Translation: BAF84490.1
AK226172 mRNA No translation available.
AC005899 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80231.1
CH471147 Genomic DNA Translation: EAW80233.1
CH471147 Genomic DNA Translation: EAW80234.1
CH471147 Genomic DNA Translation: EAW80235.1
CH471147 Genomic DNA Translation: EAW80236.1
CH471147 Genomic DNA Translation: EAW80237.1
BC002372 mRNA Translation: AAH02372.1
BC008023 mRNA Translation: AAH08023.1
CCDSiCCDS11271.1 [O43670-1]
CCDS32614.1 [O43670-2]
CCDS42294.1 [O43670-4]
RefSeqiNP_001027464.1, NM_001032293.2 [O43670-2]
NP_001091977.1, NM_001098507.1 [O43670-4]
NP_003448.1, NM_003457.3 [O43670-1]
XP_016880508.1, XM_017025019.1 [O43670-4]
UniGeneiHs.500775

3D structure databases

ProteinModelPortaliO43670
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113540, 42 interactors
CORUMiO43670
IntActiO43670, 24 interactors
MINTiO43670
STRINGi9606.ENSP00000378165

PTM databases

iPTMnetiO43670
PhosphoSitePlusiO43670

Polymorphism and mutation databases

BioMutaiZNF207

Proteomic databases

EPDiO43670
MaxQBiO43670
PaxDbiO43670
PeptideAtlasiO43670
PRIDEiO43670
ProteomicsDBi49099
49100 [O43670-2]
49101 [O43670-3]

Protocols and materials databases

DNASUi7756
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321233; ENSP00000322777; ENSG00000010244 [O43670-1]
ENST00000394670; ENSP00000378165; ENSG00000010244 [O43670-4]
ENST00000394673; ENSP00000378168; ENSG00000010244 [O43670-2]
GeneIDi7756
KEGGihsa:7756
UCSCiuc002hhh.5 human [O43670-1]

Organism-specific databases

CTDi7756
DisGeNETi7756
EuPathDBiHostDB:ENSG00000010244.16
GeneCardsiZNF207
HGNCiHGNC:12998 ZNF207
HPAiHPA017013
HPA063908
MIMi603428 gene
neXtProtiNX_O43670
OpenTargetsiENSG00000010244
PharmGKBiPA37578
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2893 Eukaryota
ENOG410ZJGQ LUCA
GeneTreeiENSGT00730000111057
HOVERGENiHBG054182
InParanoidiO43670
PhylomeDBiO43670
TreeFamiTF313844

Miscellaneous databases

ChiTaRSiZNF207 human
GenomeRNAii7756
PROiPR:O43670
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000010244 Expressed in 234 organ(s), highest expression level in lung
CleanExiHS_ZNF207
ExpressionAtlasiO43670 baseline and differential
GenevisibleiO43670 HS

Family and domain databases

InterProiView protein in InterPro
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN207_HUMAN
AccessioniPrimary (citable) accession number: O43670
Secondary accession number(s): A8K6Y6
, E1P660, E1P661, E1P662, Q53XS9, Q96HW5, Q9BUQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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