Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regulator of G-protein signaling 10

Gene

RGS10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).5 Publications

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: UniProtKB
  • GTPase activator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
SignaLinkiO43665
SIGNORiO43665

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 10
Short name:
RGS10
Gene namesi
Name:RGS10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148908.14
HGNCiHGNC:9992 RGS10
MIMi602856 gene
neXtProtiNX_O43665

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi168S → A: Abolishes phosphorylation site and leads to strongly reduced overall phosphorylation. 1 Publication1

Organism-specific databases

DisGeNETi6001
OpenTargetsiENSG00000148908
PharmGKBiPA34362

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042071 – 173Regulator of G-protein signaling 10Add BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1
Lipidationi66S-palmitoyl cysteine1 Publication1
Modified residuei168Phosphoserine1 Publication1
Isoform 3 (identifier: O43665-3)
Modified residuei16PhosphoserineCombined sources1

Post-translational modificationi

Isoform 3 is phosphorylated on Ser-16.

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiO43665
MaxQBiO43665
PaxDbiO43665
PeptideAtlasiO43665
PRIDEiO43665
ProteomicsDBi49096
49097 [O43665-2]
49098 [O43665-3]
TopDownProteomicsiO43665-3 [O43665-3]

2D gel databases

OGPiO43665

PTM databases

iPTMnetiO43665
PhosphoSitePlusiO43665
SwissPalmiO43665

Miscellaneous databases

PMAP-CutDBiO43665

Expressioni

Gene expression databases

BgeeiENSG00000148908 Expressed in 219 organ(s), highest expression level in blood
CleanExiHS_RGS10
GenevisibleiO43665 HS

Organism-specific databases

HPAiCAB004559
HPA021305
HPA058485

Interactioni

Subunit structurei

Interacts with GNAZ, GNAI1 and GNAI3 (PubMed:8774883, PubMed:11443111, PubMed:18434541). Associates specifically with the activated, GTP-bound forms of GNAZ and GNAI3 (PubMed:8774883).3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111933, 8 interactors
DIPiDIP-50368N
IntActiO43665, 2 interactors
STRINGi9606.ENSP00000358099

Structurei

Secondary structure

1173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43665
SMRiO43665
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43665

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 148RGSPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiO43665
KOiK16449
OMAiYMTFLSN
OrthoDBiEOG091G0BDG
PhylomeDBiO43665
TreeFamiTF315837

Family and domain databases

CDDicd08741 RGS_RGS10, 1 hit
Gene3Di1.10.196.10, 1 hit
InterProiView protein in InterPro
IPR016137 RGS
IPR037879 RGS10_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O43665-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQSELCFADI HDSDGSSSSS HQSLKSTAKW AASLENLLED PEGVKRFREF
60 70 80 90 100
LKKEFSEENV LFWLACEDFK KMQDKTQMQE KAKEIYMTFL SSKASSQVNV
110 120 130 140 150
EGQSRLNEKI LEEPHPLMFQ KLQDQIFNLM KYDSYSRFLK SDLFLKHKRT
160 170
EEEEEDLPDA QTAAKRASRI YNT
Length:173
Mass (Da):20,236
Last modified:August 14, 2001 - v2
Checksum:iCA73D1E38F551EF1
GO
Isoform 2 (identifier: O43665-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MQSELCFAD → MEH

Show »
Length:167
Mass (Da):19,608
Checksum:iEF36915F1AA23F3B
GO
Isoform 3 (identifier: O43665-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MQSELCFA → MFNRAVSRLSRKRPPS

Show »
Length:181
Mass (Da):21,210
Checksum:iD83CCB98A6EE2182
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01189694A → V. Corresponds to variant dbSNP:rs1802228Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0056811 – 9MQSELCFAD → MEH in isoform 2. 2 Publications9
Alternative sequenceiVSP_0273661 – 8MQSELCFA → MFNRAVSRLSRKRPPS in isoform 3. 2 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368902 mRNA Translation: AAK52979.1
AF045229 mRNA Translation: AAC03783.1
AF493934 mRNA Translation: AAM12648.1
AK290773 mRNA Translation: BAF83462.1
CR457008 mRNA Translation: CAG33289.1
AC012468 Genomic DNA No translation available.
AL355273 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49389.1
CH471066 Genomic DNA Translation: EAW49390.1
BC009361 mRNA Translation: AAH09361.1
CCDSiCCDS31294.1 [O43665-3]
CCDS41572.1 [O43665-2]
PIRiS71812
RefSeqiNP_001005339.1, NM_001005339.1 [O43665-3]
NP_002916.1, NM_002925.3 [O43665-2]
UniGeneiHs.501200

Genome annotation databases

EnsembliENST00000369101; ENSP00000358097; ENSG00000148908 [O43665-1]
ENST00000369103; ENSP00000358099; ENSG00000148908 [O43665-3]
ENST00000392865; ENSP00000376605; ENSG00000148908 [O43665-2]
GeneIDi6001
KEGGihsa:6001
UCSCiuc001lee.4 human [O43665-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368902 mRNA Translation: AAK52979.1
AF045229 mRNA Translation: AAC03783.1
AF493934 mRNA Translation: AAM12648.1
AK290773 mRNA Translation: BAF83462.1
CR457008 mRNA Translation: CAG33289.1
AC012468 Genomic DNA No translation available.
AL355273 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49389.1
CH471066 Genomic DNA Translation: EAW49390.1
BC009361 mRNA Translation: AAH09361.1
CCDSiCCDS31294.1 [O43665-3]
CCDS41572.1 [O43665-2]
PIRiS71812
RefSeqiNP_001005339.1, NM_001005339.1 [O43665-3]
NP_002916.1, NM_002925.3 [O43665-2]
UniGeneiHs.501200

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DLRNMR-A23-158[»]
2I59NMR-A22-157[»]
2IHBX-ray2.71B9-152[»]
ProteinModelPortaliO43665
SMRiO43665
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111933, 8 interactors
DIPiDIP-50368N
IntActiO43665, 2 interactors
STRINGi9606.ENSP00000358099

PTM databases

iPTMnetiO43665
PhosphoSitePlusiO43665
SwissPalmiO43665

2D gel databases

OGPiO43665

Proteomic databases

EPDiO43665
MaxQBiO43665
PaxDbiO43665
PeptideAtlasiO43665
PRIDEiO43665
ProteomicsDBi49096
49097 [O43665-2]
49098 [O43665-3]
TopDownProteomicsiO43665-3 [O43665-3]

Protocols and materials databases

DNASUi6001
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369101; ENSP00000358097; ENSG00000148908 [O43665-1]
ENST00000369103; ENSP00000358099; ENSG00000148908 [O43665-3]
ENST00000392865; ENSP00000376605; ENSG00000148908 [O43665-2]
GeneIDi6001
KEGGihsa:6001
UCSCiuc001lee.4 human [O43665-1]

Organism-specific databases

CTDi6001
DisGeNETi6001
EuPathDBiHostDB:ENSG00000148908.14
GeneCardsiRGS10
HGNCiHGNC:9992 RGS10
HPAiCAB004559
HPA021305
HPA058485
MIMi602856 gene
neXtProtiNX_O43665
OpenTargetsiENSG00000148908
PharmGKBiPA34362
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiO43665
KOiK16449
OMAiYMTFLSN
OrthoDBiEOG091G0BDG
PhylomeDBiO43665
TreeFamiTF315837

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
SignaLinkiO43665
SIGNORiO43665

Miscellaneous databases

ChiTaRSiRGS10 human
EvolutionaryTraceiO43665
GeneWikiiRGS10
GenomeRNAii6001
PMAP-CutDBiO43665
PROiPR:O43665
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148908 Expressed in 219 organ(s), highest expression level in blood
CleanExiHS_RGS10
GenevisibleiO43665 HS

Family and domain databases

CDDicd08741 RGS_RGS10, 1 hit
Gene3Di1.10.196.10, 1 hit
InterProiView protein in InterPro
IPR016137 RGS
IPR037879 RGS10_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS10_HUMAN
AccessioniPrimary (citable) accession number: O43665
Secondary accession number(s): A8K408
, B1AMR8, Q6IAZ6, Q96GN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 14, 2001
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again