Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O43665 (RGS10_HUMAN)

Entry version 175 (17 Jun 2020)
Sequence version 3 (10 Apr 2019)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Regulator of G-protein signaling 10

Gene

RGS10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418594 G alpha (i) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O43665

SIGNOR Signaling Network Open Resource

More...SIGNORi		O43665

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of G-protein signaling 10
Short name:
RGS10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGS10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000148908.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:9992 RGS10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602856 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43665

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi176S → A: Abolishes phosphorylation site and leads to strongly reduced overall phosphorylation. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6001

Open Targets

More...OpenTargetsi		ENSG00000148908

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34362

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43665 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RGS10

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002042071 – 181Regulator of G-protein signaling 10Add BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24PhosphoserineCombined sources1
Modified residuei41PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi74S-palmitoyl cysteine1 Publication1
Modified residuei176Phosphoserine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43665

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43665

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43665

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43665

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43665

PeptideAtlas

More...PeptideAtlasi		O43665

PRoteomics IDEntifications database

More...PRIDEi		O43665

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49096 [O43665-1]
49097 [O43665-2]
49098 [O43665-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O43665-3 [O43665-3]

2D gel databases

USC-OGP 2-DE database

More...OGPi		O43665

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43665

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43665

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O43665

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000148908 Expressed in blood and 218 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43665 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000148908 Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GNAZ, GNAI1 and GNAI3 (PubMed:8774883, PubMed:11443111, PubMed:18434541). Associates specifically with the activated, GTP-bound forms of GNAZ and GNAI3 (PubMed:8774883).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111933, 8 interactors

Database of interacting proteins

More...DIPi		DIP-50368N

Protein interaction database and analysis system

More...IntActi		O43665, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358099

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43665 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1181
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43665

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O43665

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 156RGSPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3589 Eukaryota
ENOG410YMJD LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161426

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_059863_1_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43665

KEGG Orthology (KO)

More...KOi		K16449

Identification of Orthologs from Complete Genome Data

More...OMAi		DPPDTQT

Database of Orthologous Groups

More...OrthoDBi		275783at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43665

TreeFam database of animal gene trees

More...TreeFami		TF315837

Family and domain databases

Conserved Domains Database

More...CDDi		cd08741 RGS_RGS10, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.196.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016137 RGS
IPR037879 RGS10_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48097 SSF48097, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 3 (identifier: O43665-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFNRAVSRLS RKRPPSDIHD SDGSSSSSHQ SLKSTAKWAA SLENLLEDPE 
        60         70         80         90        100
GVKRFREFLK KEFSEENVLF WLACEDFKKM QDKTQMQEKA KEIYMTFLSS 
       110        120        130        140        150
KASSQVNVEG QSRLNEKILE EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD 
       160        170        180 
LFLKHKRTEE EEEDLPDAQT AAKRASRIYN T
Length:181
Mass (Da):21,210
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD83CCB98A6EE2182
GO
Isoform 1 (identifier: O43665-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MFNRAVSRLSRKRPPS → MQSELCFA

Show »
Length:173
Mass (Da):20,236
Checksum:iCA73D1E38F551EF1
GO
Isoform 2 (identifier: O43665-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MFNRAVSRLSRKRPPSD → MEH

Show »
Length:167
Mass (Da):19,608
Checksum:iEF36915F1AA23F3B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011896102A → V. Corresponds to variant dbSNP:rs1802228Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0600871 – 17MFNRA…RPPSD → MEH in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0600881 – 16MFNRA…KRPPS → MQSELCFA in isoform 1. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF368902 mRNA Translation: AAK52979.1
AF045229 mRNA Translation: AAC03783.1
AF493934 mRNA Translation: AAM12648.1
AK290773 mRNA Translation: BAF83462.1
CR457008 mRNA Translation: CAG33289.1
AC012468 Genomic DNA No translation available.
AL355273 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49389.1
CH471066 Genomic DNA Translation: EAW49390.1
BC009361 mRNA Translation: AAH09361.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31294.1 [O43665-3]
CCDS41572.1 [O43665-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S71812

NCBI Reference Sequences

More...RefSeqi		NP_001005339.1, NM_001005339.1 [O43665-3]
NP_002916.1, NM_002925.3 [O43665-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369101; ENSP00000358097; ENSG00000148908 [O43665-1]
ENST00000369103; ENSP00000358099; ENSG00000148908 [O43665-3]
ENST00000392865; ENSP00000376605; ENSG00000148908 [O43665-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6001

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6001

UCSC genome browser

More...UCSCi		uc001lee.4 human [O43665-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368902 mRNA Translation: AAK52979.1
AF045229 mRNA Translation: AAC03783.1
AF493934 mRNA Translation: AAM12648.1
AK290773 mRNA Translation: BAF83462.1
CR457008 mRNA Translation: CAG33289.1
AC012468 Genomic DNA No translation available.
AL355273 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49389.1
CH471066 Genomic DNA Translation: EAW49390.1
BC009361 mRNA Translation: AAH09361.1
CCDSiCCDS31294.1 [O43665-3]
CCDS41572.1 [O43665-2]
PIRiS71812
RefSeqiNP_001005339.1, NM_001005339.1 [O43665-3]
NP_002916.1, NM_002925.3 [O43665-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DLRNMR-A31-166[»]
2I59NMR-A30-165[»]
2IHBX-ray2.71B10-160[»]
SMRiO43665
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111933, 8 interactors
DIPiDIP-50368N
IntActiO43665, 2 interactors
STRINGi9606.ENSP00000358099

PTM databases

iPTMnetiO43665
PhosphoSitePlusiO43665
SwissPalmiO43665

Polymorphism and mutation databases

BioMutaiRGS10

2D gel databases

OGPiO43665

Proteomic databases

EPDiO43665
jPOSTiO43665
MassIVEiO43665
MaxQBiO43665
PaxDbiO43665
PeptideAtlasiO43665
PRIDEiO43665
ProteomicsDBi49096 [O43665-1]
49097 [O43665-2]
49098 [O43665-3]
TopDownProteomicsiO43665-3 [O43665-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3878 212 antibodies

The DNASU plasmid repository

More...DNASUi		6001

Genome annotation databases

EnsembliENST00000369101; ENSP00000358097; ENSG00000148908 [O43665-1]
ENST00000369103; ENSP00000358099; ENSG00000148908 [O43665-3]
ENST00000392865; ENSP00000376605; ENSG00000148908 [O43665-2]
GeneIDi6001
KEGGihsa:6001
UCSCiuc001lee.4 human [O43665-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6001
DisGeNETi6001
EuPathDBiHostDB:ENSG00000148908.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		RGS10
HGNCiHGNC:9992 RGS10
HPAiENSG00000148908 Tissue enhanced (blood, lymphoid tissue)
MIMi602856 gene
neXtProtiNX_O43665
OpenTargetsiENSG00000148908
PharmGKBiPA34362

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00940000161426
HOGENOMiCLU_059863_1_4_1
InParanoidiO43665
KOiK16449
OMAiDPPDTQT
OrthoDBi275783at2759
PhylomeDBiO43665
TreeFamiTF315837

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
SignaLinkiO43665
SIGNORiO43665

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6001 2 hits in 791 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RGS10 human
EvolutionaryTraceiO43665

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RGS10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6001
PharosiO43665 Tbio

Protein Ontology

More...PROi		PR:O43665
RNActiO43665 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000148908 Expressed in blood and 218 other tissues
GenevisibleiO43665 HS

Family and domain databases

CDDicd08741 RGS_RGS10, 1 hit
Gene3Di1.10.196.10, 1 hit
InterProiView protein in InterPro
IPR016137 RGS
IPR037879 RGS10_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGS10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43665
Secondary accession number(s): A8K408
, B1AMR8, Q6IAZ6, Q96GN0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 10, 2019
Last modified: June 17, 2020
This is version 175 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again