RGS10

Functionⁱ

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).5 Publications

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G-protein coupled acetylcholine receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11443111
negative regulation of signal transduction Source: UniProtKB-KW
positive regulation of GTPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18434541
regulation of G-protein coupled receptor protein signaling pathway Source: InterPro
response to amphetamine Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation, Signal transduction inhibitor

Molecular function

GTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events
SignaLinkⁱ	O43665
SIGNORⁱ	O43665

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of G-protein signaling 10 Short name: RGS10
Gene namesⁱ	Name:RGS10
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148908.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9992 RGS10
MIMⁱ	602856 gene
neXtProtⁱ	NX_O43665

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	168	S → A: Abolishes phosphorylation site and leads to strongly reduced overall phosphorylation. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6001
Open Targets More...OpenTargetsⁱ	ENSG00000148908
PharmGKBⁱ	PA34362

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204207	1 – 173	Regulator of G-protein signaling 10Add BLAST		173

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	33	PhosphoserineBy similarity	1
Lipidationⁱ	66	S-palmitoyl cysteine1 Publication	1
Modified residueⁱ	168	Phosphoserine1 Publication	1
Isoform 3 (identifier: O43665-3)
Modified residueⁱ	16	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Isoform 3 is phosphorylated on Ser-16.

Keywords - PTMⁱ

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDⁱ	O43665
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43665
PaxDbⁱ	O43665
PeptideAtlas More...PeptideAtlasⁱ	O43665
PRIDEⁱ	O43665
ProteomicsDBⁱ	49096 49097 [O43665-2] 49098 [O43665-3]
TopDownProteomicsⁱ	O43665-3 [O43665-3]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	O43665

OGPⁱ

O43665

PTM databases

iPTMnetⁱ	O43665
PhosphoSitePlusⁱ	O43665
SwissPalmⁱ	O43665

Miscellaneous databases

PMAP-CutDBⁱ	O43665

PMAP-CutDBⁱ

O43665

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000148908
CleanExⁱ	HS_RGS10
Genevisibleⁱ	O43665 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004559 HPA021305 HPA058485

HPAⁱ

CAB004559
HPA021305
HPA058485

Interactionⁱ

Subunit structureⁱ

Interacts with GNAZ, GNAI1 and GNAI3 (PubMed:8774883, PubMed:11443111, PubMed:18434541). Associates specifically with the activated, GTP-bound forms of GNAZ and GNAI3 (PubMed:8774883).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SAP18	O00422	2	EBI-1057034,EBI-1044156

With

Entry

#Exp.

IntAct

Notes

SAP18

O00422

2

EBI-1057034,EBI-1044156

GO - Molecular functionⁱ

G-protein alpha-subunit binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18434541

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111933, 8 interactors
Database of interacting proteins More...DIPⁱ	DIP-50368N
IntActⁱ	O43665, 5 interactors
STRINGⁱ	9606.ENSP00000358099

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	25 – 32	Combined sources	8
Helixⁱ	34 – 39	Combined sources	6
Helixⁱ	41 – 53	Combined sources	13
Helixⁱ	58 – 71	Combined sources	14
Helixⁱ	75 – 89	Combined sources	15
Helixⁱ	94 – 96	Combined sources	3
Helixⁱ	103 – 105	Combined sources	3
Helixⁱ	108 – 112	Combined sources	5
Turnⁱ	116 – 119	Combined sources	4
Helixⁱ	120 – 132	Combined sources	13
Helixⁱ	134 – 138	Combined sources	5
Turnⁱ	142 – 144	Combined sources	3
Turnⁱ	146 – 150	Combined sources	5

3D structure databases

ProteinModelPortalⁱ	O43665
SMRⁱ	O43665
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O43665

EvolutionaryTraceⁱ

O43665

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	33 – 148	RGSPROSITE-ProRule annotationAdd BLAST		116

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119142
HOGENOMⁱ	HOG000233512
HOVERGENⁱ	HBG013233
InParanoidⁱ	O43665
KEGG Orthology (KO) More...KOⁱ	K16449
OMAⁱ	PKSTAKW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	O43665
TreeFamⁱ	TF315837

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08741 RGS_RGS10, 1 hit
Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR016137 RGS IPR037879 RGS10_RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: O43665-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQSELCFADI HDSDGSSSSS HQSLKSTAKW AASLENLLED PEGVKRFREF 
        60         70         80         90        100
LKKEFSEENV LFWLACEDFK KMQDKTQMQE KAKEIYMTFL SSKASSQVNV 
       110        120        130        140        150
EGQSRLNEKI LEEPHPLMFQ KLQDQIFNLM KYDSYSRFLK SDLFLKHKRT 
       160        170 
EEEEEDLPDA QTAAKRASRI YNT

Length:173

Mass (Da):20,236

Last modified:August 14, 2001 - v2

Checksum:ⁱCA73D1E38F551EF1

GO

Isoform 2 (identifier: O43665-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-9: MQSELCFAD → MEH

« Hide

        10         20         30         40         50
MEHIHDSDGS SSSSHQSLKS TAKWAASLEN LLEDPEGVKR FREFLKKEFS 
        60         70         80         90        100
EENVLFWLAC EDFKKMQDKT QMQEKAKEIY MTFLSSKASS QVNVEGQSRL 
       110        120        130        140        150
NEKILEEPHP LMFQKLQDQI FNLMKYDSYS RFLKSDLFLK HKRTEEEEED 
       160 
LPDAQTAAKR ASRIYNT

Show »

Length:167

Mass (Da):19,608

Checksum:ⁱEF36915F1AA23F3B

GO

Isoform 3 (identifier: O43665-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-8: MQSELCFA → MFNRAVSRLSRKRPPS

« Hide

        10         20         30         40         50
MFNRAVSRLS RKRPPSDIHD SDGSSSSSHQ SLKSTAKWAA SLENLLEDPE 
        60         70         80         90        100
GVKRFREFLK KEFSEENVLF WLACEDFKKM QDKTQMQEKA KEIYMTFLSS 
       110        120        130        140        150
KASSQVNVEG QSRLNEKILE EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD 
       160        170        180 
LFLKHKRTEE EEEDLPDAQT AAKRASRIYN T

Show »

Length:181

Mass (Da):21,210

Checksum:ⁱD83CCB98A6EE2182

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_011896	94	A → V. Corresponds to variant dbSNP:rs1802228Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_005681	1 – 9	MQSELCFAD → MEH in isoform 2. 2 Publications		9
Alternative sequenceⁱVSP_027366	1 – 8	MQSELCFA → MFNRAVSRLSRKRPPS in isoform 3. 2 Publications		8

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF368902 mRNA Translation: AAK52979.1 AF045229 mRNA Translation: AAC03783.1 AF493934 mRNA Translation: AAM12648.1 AK290773 mRNA Translation: BAF83462.1 CR457008 mRNA Translation: CAG33289.1 AC012468 Genomic DNA No translation available. AL355273 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49389.1 CH471066 Genomic DNA Translation: EAW49390.1 BC009361 mRNA Translation: AAH09361.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31294.1 [O43665-3] CCDS41572.1 [O43665-2]
PIRⁱ	S71812
NCBI Reference Sequences More...RefSeqⁱ	NP_001005339.1, NM_001005339.1 [O43665-3] NP_002916.1, NM_002925.3 [O43665-2]
UniGeneⁱ	Hs.501200

Genome annotation databases

Ensemblⁱ	ENST00000369101; ENSP00000358097; ENSG00000148908 [O43665-1] ENST00000369103; ENSP00000358099; ENSG00000148908 [O43665-3] ENST00000392865; ENSP00000376605; ENSG00000148908 [O43665-2]
GeneIDⁱ	6001
KEGGⁱ	hsa:6001
UCSC genome browser More...UCSCⁱ	uc001lee.4 human [O43665-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
O43665	Regulator of G-protein signaling 10		MYODS		216
UPI0002C68C24		southern white rhinoceros		181
Regulator of G protein signaling 10		Cebus capucinus imitator		177
Regulator of G protein signaling 10		PANTR		177
Regulator of G protein signaling 10		PANPA		177
+14
O43665-2	UPI0004433DF0		MONDO		188
UPI000A285697		PHACI		188
Regulator of G protein signaling 10		AOTNA		168
Regulator of G protein signaling 10		SAIBB		168
regulator of G-protein signaling 10 isoform X3		ODORO		167
+21
O43665-3	UPI0007DB9C4B		PANTR		222
UPI00083F37C6		PAPAN		212
UPI00045E0D2F		CHLSB		212
Regulator of G protein signaling 10		NOMLE		184
Regulator of G protein signaling 10		Cebus capucinus imitator		181
+30

Protein	Similar proteins		Species	Score	Length
O43665	Regulator of G-protein signaling 10		MYODS		216
UPI0002C68C24		southern white rhinoceros		181
Regulator of G protein signaling 10		Cebus capucinus imitator		177
Regulator of G protein signaling 10		PANTR		177
Regulator of G protein signaling 10		PANPA		177
+102
O43665-2	UPI000A285697		PHACI		188
UPI0004433DF0		MONDO		188
Regulator of G protein signaling 10		AOTNA		168
Regulator of G protein signaling 10		SAIBB		168
regulator of G-protein signaling 10 isoform X3		ODORO		167
+146
O43665-3	UPI0007DB9C4B		PANTR		222
UPI00045E0D2F		CHLSB		212
UPI00083F37C6		PAPAN		212
Regulator of G protein signaling 10		NOMLE		184
Regulator of G protein signaling 10		CALJA		181
+32

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF368902 mRNA Translation: AAK52979.1 AF045229 mRNA Translation: AAC03783.1 AF493934 mRNA Translation: AAM12648.1 AK290773 mRNA Translation: BAF83462.1 CR457008 mRNA Translation: CAG33289.1 AC012468 Genomic DNA No translation available. AL355273 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49389.1 CH471066 Genomic DNA Translation: EAW49390.1 BC009361 mRNA Translation: AAH09361.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31294.1 [O43665-3] CCDS41572.1 [O43665-2]
PIRⁱ	S71812
NCBI Reference Sequences More...RefSeqⁱ	NP_001005339.1, NM_001005339.1 [O43665-3] NP_002916.1, NM_002925.3 [O43665-2]
UniGeneⁱ	Hs.501200

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DLR	NMR	-	A	23-158	[»]
	2I59	NMR	-	A	22-157	[»]
	2IHB	X-ray	2.71	B	9-152	[»]
ProteinModelPortalⁱ	O43665
SMRⁱ	O43665
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111933, 8 interactors
Database of interacting proteins More...DIPⁱ	DIP-50368N
IntActⁱ	O43665, 5 interactors
STRINGⁱ	9606.ENSP00000358099

PTM databases

iPTMnetⁱ	O43665
PhosphoSitePlusⁱ	O43665
SwissPalmⁱ	O43665

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	O43665

OGPⁱ

O43665

Proteomic databases

EPDⁱ	O43665
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43665
PaxDbⁱ	O43665
PeptideAtlas More...PeptideAtlasⁱ	O43665
PRIDEⁱ	O43665
ProteomicsDBⁱ	49096 49097 [O43665-2] 49098 [O43665-3]
TopDownProteomicsⁱ	O43665-3 [O43665-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6001
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369101; ENSP00000358097; ENSG00000148908 [O43665-1] ENST00000369103; ENSP00000358099; ENSG00000148908 [O43665-3] ENST00000392865; ENSP00000376605; ENSG00000148908 [O43665-2]
GeneIDⁱ	6001
KEGGⁱ	hsa:6001
UCSC genome browser More...UCSCⁱ	uc001lee.4 human [O43665-1]

Organism-specific databases

CTDⁱ	6001
DisGeNET More...DisGeNETⁱ	6001
EuPathDBⁱ	HostDB:ENSG00000148908.14
GeneCardsⁱ	RGS10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9992 RGS10
Human Protein Atlas More...HPAⁱ	CAB004559 HPA021305 HPA058485
MIMⁱ	602856 gene
neXtProtⁱ	NX_O43665
Open Targets More...OpenTargetsⁱ	ENSG00000148908
PharmGKBⁱ	PA34362
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119142
HOGENOMⁱ	HOG000233512
HOVERGENⁱ	HBG013233
InParanoidⁱ	O43665
KEGG Orthology (KO) More...KOⁱ	K16449
OMAⁱ	PKSTAKW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	O43665
TreeFamⁱ	TF315837

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events
SignaLinkⁱ	O43665
SIGNORⁱ	O43665

Miscellaneous databases

ChiTaRSⁱ	RGS10 human
EvolutionaryTraceⁱ	O43665
GeneWikiⁱ	RGS10
GenomeRNAiⁱ	6001
PMAP-CutDBⁱ	O43665
Protein Ontology More...PROⁱ	PR:O43665
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148908
CleanExⁱ	HS_RGS10
Genevisibleⁱ	O43665 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08741 RGS_RGS10, 1 hit
Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR016137 RGS IPR037879 RGS10_RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGS10_HUMAN
Accessionⁱ	O43665Primary (citable) accession number: O43665 Secondary accession number(s): A8K408 , B1AMR8, Q6IAZ6, Q96GN0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	August 14, 2001
	Last modified:	July 18, 2018
	This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O43665 (RGS10_HUMAN)

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Regulator of G-protein signaling 10

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Nucleus

Cytosol

Nucleus

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ