UniProtKB - O43665 (RGS10_HUMAN)
Protein
Regulator of G-protein signaling 10
Gene
RGS10
Organism
Homo sapiens (Human)
Status
Functioni
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).5 Publications
GO - Molecular functioni
- G-protein alpha-subunit binding Source: UniProtKB
- GTPase activator activity Source: UniProtKB
- GTPase activity Source: Reactome
GO - Biological processi
- G protein-coupled acetylcholine receptor signaling pathway Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of signal transduction Source: UniProtKB-KW
- positive regulation of GTPase activity Source: UniProtKB
- regulation of G protein-coupled receptor signaling pathway Source: InterPro
- response to amphetamine Source: Ensembl
Keywordsi
Molecular function | GTPase activation, Signal transduction inhibitor |
Enzyme and pathway databases
PathwayCommonsi | O43665 |
Reactomei | R-HSA-418594, G alpha (i) signalling events |
SignaLinki | O43665 |
SIGNORi | O43665 |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of G-protein signaling 10Short name: RGS10 |
Gene namesi | Name:RGS10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000148908.14 |
HGNCi | HGNC:9992, RGS10 |
MIMi | 602856, gene |
neXtProti | NX_O43665 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- axon terminus Source: Ensembl
- dendritic spine Source: Ensembl
- neuronal cell body Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 176 | S → A: Abolishes phosphorylation site and leads to strongly reduced overall phosphorylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6001 |
OpenTargetsi | ENSG00000148908 |
PharmGKBi | PA34362 |
Miscellaneous databases
Pharosi | O43665, Tbio |
Polymorphism and mutation databases
BioMutai | RGS10 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204207 | 1 – 181 | Regulator of G-protein signaling 10Add BLAST | 181 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | PhosphoserineCombined sources | 1 | |
Modified residuei | 41 | PhosphoserineBy similarity | 1 | |
Lipidationi | 74 | S-palmitoyl cysteine1 Publication | 1 | |
Modified residuei | 176 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
Lipoprotein, Palmitate, PhosphoproteinProteomic databases
EPDi | O43665 |
jPOSTi | O43665 |
MassIVEi | O43665 |
MaxQBi | O43665 |
PaxDbi | O43665 |
PeptideAtlasi | O43665 |
PRIDEi | O43665 |
ProteomicsDBi | 49096 [O43665-1] 49097 [O43665-2] 49098 [O43665-3] |
TopDownProteomicsi | O43665-3 [O43665-3] |
2D gel databases
OGPi | O43665 |
PTM databases
iPTMneti | O43665 |
PhosphoSitePlusi | O43665 |
SwissPalmi | O43665 |
Expressioni
Gene expression databases
Bgeei | ENSG00000148908, Expressed in monocyte and 231 other tissues |
Genevisiblei | O43665, HS |
Organism-specific databases
HPAi | ENSG00000148908, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Binary interactionsi
O43665
With | #Exp. | IntAct |
---|---|---|
PLEKHF2 [Q9H8W4] | 3 | EBI-1057034,EBI-742388 |
GO - Molecular functioni
- G-protein alpha-subunit binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111933, 9 interactors |
DIPi | DIP-50368N |
IntActi | O43665, 2 interactors |
STRINGi | 9606.ENSP00000358099 |
Miscellaneous databases
RNActi | O43665, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | O43665 |
SMRi | O43665 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O43665 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 156 | RGSPROSITE-ProRule annotationAdd BLAST | 116 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000161426 |
HOGENOMi | CLU_059863_1_4_1 |
InParanoidi | O43665 |
OMAi | DPPDTQT |
OrthoDBi | 275783at2759 |
PhylomeDBi | O43665 |
TreeFami | TF315837 |
Family and domain databases
CDDi | cd08741, RGS_RGS10, 1 hit |
Gene3Di | 1.10.196.10, 1 hit |
InterProi | View protein in InterPro IPR016137, RGS IPR037879, RGS10_RGS IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 3 (identifier: O43665-3) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFNRAVSRLS RKRPPSDIHD SDGSSSSSHQ SLKSTAKWAA SLENLLEDPE
60 70 80 90 100
GVKRFREFLK KEFSEENVLF WLACEDFKKM QDKTQMQEKA KEIYMTFLSS
110 120 130 140 150
KASSQVNVEG QSRLNEKILE EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD
160 170 180
LFLKHKRTEE EEEDLPDAQT AAKRASRIYN T
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011896 | 102 | A → V. Corresponds to variant dbSNP:rs1802228Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060087 | 1 – 17 | MFNRA…RPPSD → MEH in isoform 2. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_060088 | 1 – 16 | MFNRA…KRPPS → MQSELCFA in isoform 1. 2 PublicationsAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF368902 mRNA Translation: AAK52979.1 AF045229 mRNA Translation: AAC03783.1 AF493934 mRNA Translation: AAM12648.1 AK290773 mRNA Translation: BAF83462.1 CR457008 mRNA Translation: CAG33289.1 AC012468 Genomic DNA No translation available. AL355273 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49389.1 CH471066 Genomic DNA Translation: EAW49390.1 BC009361 mRNA Translation: AAH09361.1 |
CCDSi | CCDS31294.1 [O43665-3] CCDS41572.1 [O43665-2] |
PIRi | S71812 |
RefSeqi | NP_001005339.1, NM_001005339.1 [O43665-3] NP_002916.1, NM_002925.3 [O43665-2] |
Genome annotation databases
Ensembli | ENST00000369101; ENSP00000358097; ENSG00000148908 [O43665-1] ENST00000369103; ENSP00000358099; ENSG00000148908 [O43665-3] ENST00000392865; ENSP00000376605; ENSG00000148908 [O43665-2] |
GeneIDi | 6001 |
KEGGi | hsa:6001 |
UCSCi | uc001lee.4, human [O43665-3] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF368902 mRNA Translation: AAK52979.1 AF045229 mRNA Translation: AAC03783.1 AF493934 mRNA Translation: AAM12648.1 AK290773 mRNA Translation: BAF83462.1 CR457008 mRNA Translation: CAG33289.1 AC012468 Genomic DNA No translation available. AL355273 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49389.1 CH471066 Genomic DNA Translation: EAW49390.1 BC009361 mRNA Translation: AAH09361.1 |
CCDSi | CCDS31294.1 [O43665-3] CCDS41572.1 [O43665-2] |
PIRi | S71812 |
RefSeqi | NP_001005339.1, NM_001005339.1 [O43665-3] NP_002916.1, NM_002925.3 [O43665-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DLR | NMR | - | A | 31-166 | [»] | |
2I59 | NMR | - | A | 30-165 | [»] | |
2IHB | X-ray | 2.71 | B | 10-160 | [»] | |
BMRBi | O43665 | |||||
SMRi | O43665 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111933, 9 interactors |
DIPi | DIP-50368N |
IntActi | O43665, 2 interactors |
STRINGi | 9606.ENSP00000358099 |
PTM databases
iPTMneti | O43665 |
PhosphoSitePlusi | O43665 |
SwissPalmi | O43665 |
Polymorphism and mutation databases
BioMutai | RGS10 |
2D gel databases
OGPi | O43665 |
Proteomic databases
EPDi | O43665 |
jPOSTi | O43665 |
MassIVEi | O43665 |
MaxQBi | O43665 |
PaxDbi | O43665 |
PeptideAtlasi | O43665 |
PRIDEi | O43665 |
ProteomicsDBi | 49096 [O43665-1] 49097 [O43665-2] 49098 [O43665-3] |
TopDownProteomicsi | O43665-3 [O43665-3] |
Protocols and materials databases
Antibodypediai | 3878, 213 antibodies |
DNASUi | 6001 |
Genome annotation databases
Ensembli | ENST00000369101; ENSP00000358097; ENSG00000148908 [O43665-1] ENST00000369103; ENSP00000358099; ENSG00000148908 [O43665-3] ENST00000392865; ENSP00000376605; ENSG00000148908 [O43665-2] |
GeneIDi | 6001 |
KEGGi | hsa:6001 |
UCSCi | uc001lee.4, human [O43665-3] |
Organism-specific databases
CTDi | 6001 |
DisGeNETi | 6001 |
EuPathDBi | HostDB:ENSG00000148908.14 |
GeneCardsi | RGS10 |
HGNCi | HGNC:9992, RGS10 |
HPAi | ENSG00000148908, Tissue enhanced (blood, lymphoid tissue) |
MIMi | 602856, gene |
neXtProti | NX_O43665 |
OpenTargetsi | ENSG00000148908 |
PharmGKBi | PA34362 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000161426 |
HOGENOMi | CLU_059863_1_4_1 |
InParanoidi | O43665 |
OMAi | DPPDTQT |
OrthoDBi | 275783at2759 |
PhylomeDBi | O43665 |
TreeFami | TF315837 |
Enzyme and pathway databases
PathwayCommonsi | O43665 |
Reactomei | R-HSA-418594, G alpha (i) signalling events |
SignaLinki | O43665 |
SIGNORi | O43665 |
Miscellaneous databases
BioGRID-ORCSi | 6001, 5 hits in 847 CRISPR screens |
ChiTaRSi | RGS10, human |
EvolutionaryTracei | O43665 |
GeneWikii | RGS10 |
GenomeRNAii | 6001 |
Pharosi | O43665, Tbio |
PROi | PR:O43665 |
RNActi | O43665, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148908, Expressed in monocyte and 231 other tissues |
Genevisiblei | O43665, HS |
Family and domain databases
CDDi | cd08741, RGS_RGS10, 1 hit |
Gene3Di | 1.10.196.10, 1 hit |
InterProi | View protein in InterPro IPR016137, RGS IPR037879, RGS10_RGS IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RGS10_HUMAN | |
Accessioni | O43665Primary (citable) accession number: O43665 Secondary accession number(s): A8K408 Q96GN0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 178 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations