UniProtKB - O43660 (PLRG1_HUMAN)

BLAST

>sp|O43660|PLRG1_HUMAN Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1
MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPT
SKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSE
SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK
KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL
SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI
DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV
AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT
VNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA
EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF

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History
Entry version 163 (07 Nov 2018)
Sequence version 1 (01 Jun 1998)
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Protein

Pleiotropic regulator 1

Gene

PLRG1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257).4 Publications

GO - Biological processⁱ

mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from direct assayⁱ
- 28076346
positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
protein localization to nucleus Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing

Biological process

mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway
SignaLinkⁱ	O43660
SIGNORⁱ	O43660

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pleiotropic regulator 1
Gene namesⁱ	Name:PLRG1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171566.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9089 PLRG1
MIMⁱ	605961 gene
neXtProtⁱ	NX_O43660

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5356
Open Targets More...OpenTargetsⁱ	ENSG00000171566
PharmGKBⁱ	PA33416

Polymorphism and mutation databases

BioMutaⁱ	PLRG1

BioMutaⁱ

PLRG1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051133	1 – 514	Pleiotropic regulator 1Add BLAST		514

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	119	PhosphoserineCombined sources	1
Modified residueⁱ	201	PhosphoserineCombined sources	1
Modified residueⁱ	391	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O43660
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43660
PaxDbⁱ	O43660
PeptideAtlas More...PeptideAtlasⁱ	O43660
PRIDEⁱ	O43660
ProteomicsDBⁱ	49091 49092 [O43660-2]

PTM databases

iPTMnetⁱ	O43660
PhosphoSitePlusⁱ	O43660
SwissPalmⁱ	O43660

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171566 Expressed in 199 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_PLRG1
ExpressionAtlasⁱ	O43660 baseline and differential
Genevisibleⁱ	O43660 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035931 HPA035932 HPA061486

HPAⁱ

HPA035931
HPA035932
HPA061486

Interactionⁱ

Subunit structureⁱ

Identified in the spliceosome C complex (PubMed:12176931, PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8 (PubMed:11101529, PubMed:20176811). Interacts (via its WD40 repeat domain) directly with CDC5L (via its C-terminal); the interaction is required for mRNA splicing but not for spliceosome assembly (PubMed:11544257). Also interacts directly in the complex with BCAS2 and PRPF19 (PubMed:20176811).6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CDC5L	Q99459	2	EBI-1051504,EBI-374880
HNRNPM	P52272	5	EBI-1051504,EBI-486809

Protein-protein interaction databases

BioGridⁱ	111370, 85 interactors
CORUMⁱ	O43660
IntActⁱ	O43660, 26 interactors
Molecular INTeraction database More...MINTⁱ	O43660
STRINGⁱ	9606.ENSP00000424417

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	194 – 200	Combined sources	7
Beta strandⁱ	207 – 212	Combined sources	6
Beta strandⁱ	216 – 223	Combined sources	8
Beta strandⁱ	228 – 232	Combined sources	5
Turnⁱ	233 – 235	Combined sources	3
Beta strandⁱ	238 – 242	Combined sources	5
Beta strandⁱ	249 – 254	Combined sources	6
Beta strandⁱ	256 – 265	Combined sources	10
Beta strandⁱ	270 – 274	Combined sources	5
Turnⁱ	275 – 278	Combined sources	4
Beta strandⁱ	279 – 283	Combined sources	5
Beta strandⁱ	291 – 296	Combined sources	6
Beta strandⁱ	298 – 307	Combined sources	10
Beta strandⁱ	310 – 316	Combined sources	7
Turnⁱ	317 – 319	Combined sources	3
Beta strandⁱ	322 – 327	Combined sources	6
Beta strandⁱ	333 – 338	Combined sources	6
Beta strandⁱ	340 – 343	Combined sources	4
Beta strandⁱ	345 – 349	Combined sources	5
Beta strandⁱ	354 – 358	Combined sources	5
Turnⁱ	359 – 362	Combined sources	4
Beta strandⁱ	363 – 368	Combined sources	6
Beta strandⁱ	377 – 380	Combined sources	4
Beta strandⁱ	384 – 390	Combined sources	7
Beta strandⁱ	395 – 399	Combined sources	5
Turnⁱ	400 – 403	Combined sources	4
Beta strandⁱ	404 – 409	Combined sources	6
Beta strandⁱ	416 – 421	Combined sources	6
Beta strandⁱ	426 – 431	Combined sources	6
Beta strandⁱ	436 – 440	Combined sources	5
Turnⁱ	441 – 443	Combined sources	3
Beta strandⁱ	446 – 450	Combined sources	5
Beta strandⁱ	465 – 470	Combined sources	6
Beta strandⁱ	476 – 481	Combined sources	6
Beta strandⁱ	486 – 491	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	O43660
SMRⁱ	O43660
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	202 – 241	WD 1Add BLAST	40
Repeatⁱ	244 – 283	WD 2Add BLAST	40
Repeatⁱ	286 – 325	WD 3Add BLAST	40
Repeatⁱ	328 – 367	WD 4Add BLAST	40
Repeatⁱ	370 – 410	WD 5Add BLAST	41
Repeatⁱ	411 – 449	WD 6Add BLAST	39
Repeatⁱ	460 – 499	WD 7Add BLAST	40

Sequence similaritiesⁱ

Belongs to the WD repeat PRL1/PRL2 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0285 Eukaryota ENOG410XQV9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150962
HOGENOMⁱ	HOG000207595
HOVERGENⁱ	HBG053621
InParanoidⁱ	O43660
KEGG Orthology (KO) More...KOⁱ	K12862
OMAⁱ	FAMCFDQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08RE
PhylomeDBⁱ	O43660
TreeFamⁱ	TF105684

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 5 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 2 hits PS50082 WD_REPEATS_2, 5 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O43660-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN 
        60         70         80         90        100
EYGPVLHMPT SKENLKEKGP QNATDSYVHK QYPANQGQEV EYFVAGTHPY 
       110        120        130        140        150
PPGPGVALTA DTKIQRMPSE SAAQSLAVAL PLQTKADANR TAPSGSEYRH 
       160        170        180        190        200
PGASDRPQPT AMNSIVMETG NTKNSALMAK KAPTMPKPQW HPPWKLYRVI 
       210        220        230        240        250
SGHLGWVRCI AVEPGNQWFV TGSADRTIKI WDLASGKLKL SLTGHISTVR 
       260        270        280        290        300
GVIVSTRSPY LFSCGEDKQV KCWDLEYNKV IRHYHGHLSA VYGLDLHPTI 
       310        320        330        340        350
DVLVTCSRDS TARIWDVRTK ASVHTLSGHT NAVATVRCQA AEPQIITGSH 
       360        370        380        390        400
DTTIRLWDLV AGKTRVTLTN HKKSVRAVVL HPRHYTFASG SPDNIKQWKF 
       410        420        430        440        450
PDGSFIQNLS GHNAIINTLT VNSDGVLVSG ADNGTMHLWD WRTGYNFQRV 
       460        470        480        490        500
HAAVQPGSLD SESGIFACAF DQSESRLLTA EADKTIKVYR EDDTATEETH 
       510 
PVSWKPEIIK RKRF

Length:514

Mass (Da):57,194

Last modified:June 1, 1998 - v1

Checksum:ⁱ8C914CAF5F7887BD

Isoform 2 (identifier: O43660-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
96-104: Missing.

« Hide

        10         20         30         40         50
MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN 
        60         70         80         90        100
EYGPVLHMPT SKENLKEKGP QNATDSYVHK QYPANQGQEV EYFVAGVALT 
       110        120        130        140        150
ADTKIQRMPS ESAAQSLAVA LPLQTKADAN RTAPSGSEYR HPGASDRPQP 
       160        170        180        190        200
TAMNSIVMET GNTKNSALMA KKAPTMPKPQ WHPPWKLYRV ISGHLGWVRC 
       210        220        230        240        250
IAVEPGNQWF VTGSADRTIK IWDLASGKLK LSLTGHISTV RGVIVSTRSP 
       260        270        280        290        300
YLFSCGEDKQ VKCWDLEYNK VIRHYHGHLS AVYGLDLHPT IDVLVTCSRD 
       310        320        330        340        350
STARIWDVRT KASVHTLSGH TNAVATVRCQ AAEPQIITGS HDTTIRLWDL 
       360        370        380        390        400
VAGKTRVTLT NHKKSVRAVV LHPRHYTFAS GSPDNIKQWK FPDGSFIQNL 
       410        420        430        440        450
SGHNAIINTL TVNSDGVLVS GADNGTMHLW DWRTGYNFQR VHAAVQPGSL 
       460        470        480        490        500
DSESGIFACA FDQSESRLLT AEADKTIKVY REDDTATEET HPVSWKPEII 

KRKRF

Note: May be due to a competing donor splice site. No experimental confirmation available.

Show »

Length:505

Mass (Da):56,290

Checksum:ⁱ65F7E135A4026411

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RA26	D6RA26_HUMAN	Pleiotropic regulator 1 Pleiotropic regulator 1	PLRG1	212	Annotation score:
D6RE04	D6RE04_HUMAN	Pleiotropic regulator 1 Pleiotropic regulator 1	PLRG1	58	Annotation score:
H0YA24	H0YA24_HUMAN	Pleiotropic regulator 1 Pleiotropic regulator 1	PLRG1	156	Annotation score:
H0YAA2	H0YAA2_HUMAN	Pleiotropic regulator 1 Pleiotropic regulator 1	PLRG1	106	Annotation score:
B7Z982	B7Z982_HUMAN	cDNA FLJ57451, highly similar to Pl... cDNA FLJ57451, highly similar to Pleiotropic regulator 1	PLRG1	131	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_008804	96 – 104	Missing in isoform 2. 1 Publication		9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044333 mRNA Translation: AAD09407.1 AK002108 mRNA Translation: BAG51016.1 CH471056 Genomic DNA Translation: EAX04941.1 BC020786 mRNA Translation: AAH20786.1 BC106004 mRNA Translation: AAI06005.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34083.1 [O43660-1] CCDS56341.1 [O43660-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001188493.1, NM_001201564.1 [O43660-2] NP_002660.1, NM_002669.3 [O43660-1]
UniGeneⁱ	Hs.249996

Genome annotation databases

Ensemblⁱ	ENST00000302078; ENSP00000303191; ENSG00000171566 [O43660-2] ENST00000499023; ENSP00000424417; ENSG00000171566 [O43660-1]
GeneIDⁱ	5356
KEGGⁱ	hsa:5356
UCSC genome browser More...UCSCⁱ	uc003iny.4 human [O43660-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43660	Pleiotropic regulator 1		MOUSE		513	UniRef90_O43660
Pleiotropic regulator 1		MYOBR		608
Pleiotropic regulator 1		MYODS		529
PLRG1 isoform 1		PONAB		514
Uncharacterized protein		PAPAN		514
+26

Protein	Similar proteins		Species	Score	Length	Source
O43660	Pleiotropic regulator 1		MOUSE		513	UniRef50_O43660
Pleiotropic regulator 1		RAT		514
Pleiotropic regulator 1		BOVIN		513
Pleiotropic regulator 1		MYOBR		608
Pleiotropic regulator 1		MYODS		529
+506

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044333 mRNA Translation: AAD09407.1 AK002108 mRNA Translation: BAG51016.1 CH471056 Genomic DNA Translation: EAX04941.1 BC020786 mRNA Translation: AAH20786.1 BC106004 mRNA Translation: AAI06005.1
CCDSⁱ	CCDS34083.1 [O43660-1] CCDS56341.1 [O43660-2]
RefSeqⁱ	NP_001188493.1, NM_001201564.1 [O43660-2] NP_002660.1, NM_002669.3 [O43660-1]
UniGeneⁱ	Hs.249996

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4YVD	X-ray	1.70	A	141-514	[»]
	5MQF	electron microscopy	5.90	D	1-514	[»]
	5XJC	electron microscopy	3.60	T	1-514	[»]
	5YZG	electron microscopy	4.10	T	1-514	[»]
	5Z56	electron microscopy	5.10	T	1-514	[»]
	5Z57	electron microscopy	6.50	T	1-514	[»]
	5Z58	electron microscopy	4.90	T	1-514	[»]
	6FF4	electron microscopy	16.00	D	1-514	[»]
ProteinModelPortalⁱ	O43660
SMRⁱ	O43660
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111370, 85 interactors
CORUMⁱ	O43660
IntActⁱ	O43660, 26 interactors
MINTⁱ	O43660
STRINGⁱ	9606.ENSP00000424417

PTM databases

iPTMnetⁱ	O43660
PhosphoSitePlusⁱ	O43660
SwissPalmⁱ	O43660

Polymorphism and mutation databases

BioMutaⁱ	PLRG1

BioMutaⁱ

PLRG1

Proteomic databases

EPDⁱ	O43660
MaxQBⁱ	O43660
PaxDbⁱ	O43660
PeptideAtlasⁱ	O43660
PRIDEⁱ	O43660
ProteomicsDBⁱ	49091 49092 [O43660-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000302078; ENSP00000303191; ENSG00000171566 [O43660-2] ENST00000499023; ENSP00000424417; ENSG00000171566 [O43660-1]
GeneIDⁱ	5356
KEGGⁱ	hsa:5356
UCSCⁱ	uc003iny.4 human [O43660-1]

Organism-specific databases

CTDⁱ	5356
DisGeNETⁱ	5356
EuPathDBⁱ	HostDB:ENSG00000171566.11
GeneCardsⁱ	PLRG1
HGNCⁱ	HGNC:9089 PLRG1
HPAⁱ	HPA035931 HPA035932 HPA061486
MIMⁱ	605961 gene
neXtProtⁱ	NX_O43660
OpenTargetsⁱ	ENSG00000171566
PharmGKBⁱ	PA33416
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0285 Eukaryota ENOG410XQV9 LUCA
GeneTreeⁱ	ENSGT00930000150962
HOGENOMⁱ	HOG000207595
HOVERGENⁱ	HBG053621
InParanoidⁱ	O43660
KOⁱ	K12862
OMAⁱ	FAMCFDQ
OrthoDBⁱ	EOG091G08RE
PhylomeDBⁱ	O43660
TreeFamⁱ	TF105684

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway
SignaLinkⁱ	O43660
SIGNORⁱ	O43660

Miscellaneous databases

ChiTaRSⁱ	PLRG1 human
GeneWikiⁱ	PLRG1
GenomeRNAiⁱ	5356
Protein Ontology More...PROⁱ	PR:O43660
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171566 Expressed in 199 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_PLRG1
ExpressionAtlasⁱ	O43660 baseline and differential
Genevisibleⁱ	O43660 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF00400 WD40, 5 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 2 hits PS50082 WD_REPEATS_2, 5 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLRG1_HUMAN
Accessionⁱ	O43660Primary (citable) accession number: O43660 Secondary accession number(s): B3KMK4, Q3KQY5, Q8WUD8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
	Last sequence update:	June 1, 1998
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43660 (PLRG1_HUMAN)

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Pleiotropic regulator 1

PLRG1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ