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Protein

Pleiotropic regulator 1

Gene

PLRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257).4 Publications

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
SignaLinkiO43660
SIGNORiO43660

Names & Taxonomyi

Protein namesi
Recommended name:
Pleiotropic regulator 1
Gene namesi
Name:PLRG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000171566.11
HGNCiHGNC:9089 PLRG1
MIMi605961 gene
neXtProtiNX_O43660

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi5356
OpenTargetsiENSG00000171566
PharmGKBiPA33416

Polymorphism and mutation databases

BioMutaiPLRG1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511331 – 514Pleiotropic regulator 1Add BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei391PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO43660
MaxQBiO43660
PaxDbiO43660
PeptideAtlasiO43660
PRIDEiO43660
ProteomicsDBi49091
49092 [O43660-2]

PTM databases

iPTMnetiO43660
PhosphoSitePlusiO43660
SwissPalmiO43660

Expressioni

Gene expression databases

BgeeiENSG00000171566 Expressed in 199 organ(s), highest expression level in secondary oocyte
CleanExiHS_PLRG1
ExpressionAtlasiO43660 baseline and differential
GenevisibleiO43660 HS

Organism-specific databases

HPAiHPA035931
HPA035932
HPA061486

Interactioni

Subunit structurei

Identified in the spliceosome C complex (PubMed:12176931, PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8 (PubMed:11101529, PubMed:20176811). Interacts (via its WD40 repeat domain) directly with CDC5L (via its C-terminal); the interaction is required for mRNA splicing but not for spliceosome assembly (PubMed:11544257). Also interacts directly in the complex with BCAS2 and PRPF19 (PubMed:20176811).6 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi111370, 85 interactors
CORUMiO43660
IntActiO43660, 26 interactors
MINTiO43660
STRINGi9606.ENSP00000424417

Structurei

Secondary structure

1514
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43660
SMRiO43660
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati202 – 241WD 1Add BLAST40
Repeati244 – 283WD 2Add BLAST40
Repeati286 – 325WD 3Add BLAST40
Repeati328 – 367WD 4Add BLAST40
Repeati370 – 410WD 5Add BLAST41
Repeati411 – 449WD 6Add BLAST39
Repeati460 – 499WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat PRL1/PRL2 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0285 Eukaryota
ENOG410XQV9 LUCA
GeneTreeiENSGT00930000150962
HOGENOMiHOG000207595
HOVERGENiHBG053621
InParanoidiO43660
KOiK12862
OMAiFAMCFDQ
OrthoDBiEOG091G08RE
PhylomeDBiO43660
TreeFamiTF105684

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43660-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN
60 70 80 90 100
EYGPVLHMPT SKENLKEKGP QNATDSYVHK QYPANQGQEV EYFVAGTHPY
110 120 130 140 150
PPGPGVALTA DTKIQRMPSE SAAQSLAVAL PLQTKADANR TAPSGSEYRH
160 170 180 190 200
PGASDRPQPT AMNSIVMETG NTKNSALMAK KAPTMPKPQW HPPWKLYRVI
210 220 230 240 250
SGHLGWVRCI AVEPGNQWFV TGSADRTIKI WDLASGKLKL SLTGHISTVR
260 270 280 290 300
GVIVSTRSPY LFSCGEDKQV KCWDLEYNKV IRHYHGHLSA VYGLDLHPTI
310 320 330 340 350
DVLVTCSRDS TARIWDVRTK ASVHTLSGHT NAVATVRCQA AEPQIITGSH
360 370 380 390 400
DTTIRLWDLV AGKTRVTLTN HKKSVRAVVL HPRHYTFASG SPDNIKQWKF
410 420 430 440 450
PDGSFIQNLS GHNAIINTLT VNSDGVLVSG ADNGTMHLWD WRTGYNFQRV
460 470 480 490 500
HAAVQPGSLD SESGIFACAF DQSESRLLTA EADKTIKVYR EDDTATEETH
510
PVSWKPEIIK RKRF
Length:514
Mass (Da):57,194
Last modified:June 1, 1998 - v1
Checksum:i8C914CAF5F7887BD
GO
Isoform 2 (identifier: O43660-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-104: Missing.

Note: May be due to a competing donor splice site. No experimental confirmation available.
Show »
Length:505
Mass (Da):56,290
Checksum:i65F7E135A4026411
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RA26D6RA26_HUMAN
Pleiotropic regulator 1
PLRG1
212Annotation score:
D6RE04D6RE04_HUMAN
Pleiotropic regulator 1
PLRG1
58Annotation score:
H0YA24H0YA24_HUMAN
Pleiotropic regulator 1
PLRG1
156Annotation score:
H0YAA2H0YAA2_HUMAN
Pleiotropic regulator 1
PLRG1
106Annotation score:
B7Z982B7Z982_HUMAN
cDNA FLJ57451, highly similar to Pl...
PLRG1
131Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00880496 – 104Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044333 mRNA Translation: AAD09407.1
AK002108 mRNA Translation: BAG51016.1
CH471056 Genomic DNA Translation: EAX04941.1
BC020786 mRNA Translation: AAH20786.1
BC106004 mRNA Translation: AAI06005.1
CCDSiCCDS34083.1 [O43660-1]
CCDS56341.1 [O43660-2]
RefSeqiNP_001188493.1, NM_001201564.1 [O43660-2]
NP_002660.1, NM_002669.3 [O43660-1]
UniGeneiHs.249996

Genome annotation databases

EnsembliENST00000302078; ENSP00000303191; ENSG00000171566 [O43660-2]
ENST00000499023; ENSP00000424417; ENSG00000171566 [O43660-1]
GeneIDi5356
KEGGihsa:5356
UCSCiuc003iny.4 human [O43660-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044333 mRNA Translation: AAD09407.1
AK002108 mRNA Translation: BAG51016.1
CH471056 Genomic DNA Translation: EAX04941.1
BC020786 mRNA Translation: AAH20786.1
BC106004 mRNA Translation: AAI06005.1
CCDSiCCDS34083.1 [O43660-1]
CCDS56341.1 [O43660-2]
RefSeqiNP_001188493.1, NM_001201564.1 [O43660-2]
NP_002660.1, NM_002669.3 [O43660-1]
UniGeneiHs.249996

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YVDX-ray1.70A141-514[»]
5MQFelectron microscopy5.90D1-514[»]
5XJCelectron microscopy3.60T1-514[»]
5YZGelectron microscopy4.10T1-514[»]
5Z56electron microscopy5.10T1-514[»]
5Z57electron microscopy6.50T1-514[»]
5Z58electron microscopy4.90T1-514[»]
6FF4electron microscopy16.00D1-514[»]
ProteinModelPortaliO43660
SMRiO43660
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111370, 85 interactors
CORUMiO43660
IntActiO43660, 26 interactors
MINTiO43660
STRINGi9606.ENSP00000424417

PTM databases

iPTMnetiO43660
PhosphoSitePlusiO43660
SwissPalmiO43660

Polymorphism and mutation databases

BioMutaiPLRG1

Proteomic databases

EPDiO43660
MaxQBiO43660
PaxDbiO43660
PeptideAtlasiO43660
PRIDEiO43660
ProteomicsDBi49091
49092 [O43660-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302078; ENSP00000303191; ENSG00000171566 [O43660-2]
ENST00000499023; ENSP00000424417; ENSG00000171566 [O43660-1]
GeneIDi5356
KEGGihsa:5356
UCSCiuc003iny.4 human [O43660-1]

Organism-specific databases

CTDi5356
DisGeNETi5356
EuPathDBiHostDB:ENSG00000171566.11
GeneCardsiPLRG1
HGNCiHGNC:9089 PLRG1
HPAiHPA035931
HPA035932
HPA061486
MIMi605961 gene
neXtProtiNX_O43660
OpenTargetsiENSG00000171566
PharmGKBiPA33416
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0285 Eukaryota
ENOG410XQV9 LUCA
GeneTreeiENSGT00930000150962
HOGENOMiHOG000207595
HOVERGENiHBG053621
InParanoidiO43660
KOiK12862
OMAiFAMCFDQ
OrthoDBiEOG091G08RE
PhylomeDBiO43660
TreeFamiTF105684

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
SignaLinkiO43660
SIGNORiO43660

Miscellaneous databases

ChiTaRSiPLRG1 human
GeneWikiiPLRG1
GenomeRNAii5356
PROiPR:O43660
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171566 Expressed in 199 organ(s), highest expression level in secondary oocyte
CleanExiHS_PLRG1
ExpressionAtlasiO43660 baseline and differential
GenevisibleiO43660 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLRG1_HUMAN
AccessioniPrimary (citable) accession number: O43660
Secondary accession number(s): B3KMK4, Q3KQY5, Q8WUD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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