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Protein

Tetraspanin-6

Gene

TSPAN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
  • negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetraspanin-6
Short name:
Tspan-6
Alternative name(s):
A15 homolog
Putative NF-kappa-B-activating protein 321
T245 protein
Tetraspanin TM4-D
Transmembrane 4 superfamily member 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSPAN6
Synonyms:TM4SF6
ORF Names:UNQ767/PRO1560
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000000003.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11858 TSPAN6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300191 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43657

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 59ExtracellularSequence analysisAdd BLAST19
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 93CytoplasmicSequence analysisAdd BLAST13
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 208ExtracellularSequence analysisAdd BLAST94
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 245CytoplasmicSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000000003

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36559

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TSPAN6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002192461 – 245Tetraspanin-6Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43657

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43657

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43657

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43657

PeptideAtlas

More...
PeptideAtlasi
O43657

PRoteomics IDEntifications database

More...
PRIDEi
O43657

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49090

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43657

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43657

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O43657

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000000003 Expressed in 219 organ(s), highest expression level in sperm

CleanEx database of gene expression profiles

More...
CleanExi
HS_TSPAN6

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O43657 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43657 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004109

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112960, 20 interactors

Protein interaction database and analysis system

More...
IntActi
O43657, 3 interactors

Molecular INTeraction database

More...
MINTi
O43657

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362111

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O43657

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3882 Eukaryota
ENOG4111IRY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159092

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107306

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43657

KEGG Orthology (KO)

More...
KOi
K17295

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDCSPQR

Database of Orthologous Groups

More...
OrthoDBi
1145558at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43657

TreeFam database of animal gene trees

More...
TreeFami
TF352891

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1450.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00335 Tetraspanin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002419 Tetraspanin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00259 TMFOUR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48652 SSF48652, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00421 TM4_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O43657-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPSRRLQT KPVITCFKSV LLIYTFIFWI TGVILLAVGI WGKVSLENYF
60 70 80 90 100
SLLNEKATNV PFVLIATGTV IILLGTFGCF ATCRASAWML KLYAMFLTLV
110 120 130 140 150
FLVELVAAIV GFVFRHEIKN SFKNNYEKAL KQYNSTGDYR SHAVDKIQNT
160 170 180 190 200
LHCCGVTDYR DWTDTNYYSE KGFPKSCCKL EDCTPQRDAD KVNNEGCFIK
210 220 230 240
VMTIIESEMG VVAGISFGVA CFQLIGIFLA YCLSRAITNN QYEIV
Length:245
Mass (Da):27,563
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i811FAB19C2805BE2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZU5A0A087WZU5_HUMAN
Tetraspanin-6
TSPAN6
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYV6A0A087WYV6_HUMAN
Tetraspanin-6
TSPAN6
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014494108A → T1 PublicationCorresponds to variant dbSNP:rs1802288Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF053453 mRNA Translation: AAC69710.1
AF043906 mRNA Translation: AAC64257.1
U84895 mRNA Translation: AAD00560.1
AF133426 mRNA Translation: AAF08365.1
AY358825 mRNA Translation: AAQ89184.1
AB097016 mRNA Translation: BAC77369.1
BT006977 mRNA Translation: AAP35623.1
CR457115 mRNA Translation: CAG33396.1
AL035608 Genomic DNA No translation available.
CH471115 Genomic DNA Translation: EAX02811.1
BC012389 mRNA Translation: AAH12389.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14470.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A59258

NCBI Reference Sequences

More...
RefSeqi
NP_001265672.1, NM_001278743.1
NP_003261.1, NM_003270.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.43233
Hs.587521

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373020; ENSP00000362111; ENSG00000000003

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7105

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7105

UCSC genome browser

More...
UCSCi
uc004ega.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053453 mRNA Translation: AAC69710.1
AF043906 mRNA Translation: AAC64257.1
U84895 mRNA Translation: AAD00560.1
AF133426 mRNA Translation: AAF08365.1
AY358825 mRNA Translation: AAQ89184.1
AB097016 mRNA Translation: BAC77369.1
BT006977 mRNA Translation: AAP35623.1
CR457115 mRNA Translation: CAG33396.1
AL035608 Genomic DNA No translation available.
CH471115 Genomic DNA Translation: EAX02811.1
BC012389 mRNA Translation: AAH12389.1
CCDSiCCDS14470.1
PIRiA59258
RefSeqiNP_001265672.1, NM_001278743.1
NP_003261.1, NM_003270.3
UniGeneiHs.43233
Hs.587521

3D structure databases

ProteinModelPortaliO43657
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112960, 20 interactors
IntActiO43657, 3 interactors
MINTiO43657
STRINGi9606.ENSP00000362111

PTM databases

iPTMnetiO43657
PhosphoSitePlusiO43657
SwissPalmiO43657

Polymorphism and mutation databases

BioMutaiTSPAN6

Proteomic databases

EPDiO43657
jPOSTiO43657
MaxQBiO43657
PaxDbiO43657
PeptideAtlasiO43657
PRIDEiO43657
ProteomicsDBi49090

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7105
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373020; ENSP00000362111; ENSG00000000003
GeneIDi7105
KEGGihsa:7105
UCSCiuc004ega.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7105
EuPathDBiHostDB:ENSG00000000003.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TSPAN6
HGNCiHGNC:11858 TSPAN6
HPAiHPA004109
MIMi300191 gene
neXtProtiNX_O43657
OpenTargetsiENSG00000000003
PharmGKBiPA36559

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00940000159092
HOVERGENiHBG107306
InParanoidiO43657
KOiK17295
OMAiEDCSPQR
OrthoDBi1145558at2759
PhylomeDBiO43657
TreeFamiTF352891

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TSPAN6 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TSPAN6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7105

Protein Ontology

More...
PROi
PR:O43657

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000000003 Expressed in 219 organ(s), highest expression level in sperm
CleanExiHS_TSPAN6
ExpressionAtlasiO43657 baseline and differential
GenevisibleiO43657 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspanin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSN6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43657
Secondary accession number(s): Q54A42, Q6IAN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: January 16, 2019
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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