Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tetraspanin-6

Gene

TSPAN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-6
Short name:
Tspan-6
Alternative name(s):
A15 homolog
Putative NF-kappa-B-activating protein 321
T245 protein
Tetraspanin TM4-D
Transmembrane 4 superfamily member 6
Gene namesi
Name:TSPAN6
Synonyms:TM4SF6
ORF Names:UNQ767/PRO1560
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000000003.14
HGNCiHGNC:11858 TSPAN6
MIMi300191 gene
neXtProtiNX_O43657

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 59ExtracellularSequence analysisAdd BLAST19
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 93CytoplasmicSequence analysisAdd BLAST13
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 208ExtracellularSequence analysisAdd BLAST94
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 245CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000000003
PharmGKBiPA36559

Polymorphism and mutation databases

BioMutaiTSPAN6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192461 – 245Tetraspanin-6Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO43657
MaxQBiO43657
PaxDbiO43657
PeptideAtlasiO43657
PRIDEiO43657
ProteomicsDBi49090

PTM databases

iPTMnetiO43657
PhosphoSitePlusiO43657
SwissPalmiO43657

Expressioni

Gene expression databases

BgeeiENSG00000000003 Expressed in 219 organ(s), highest expression level in sperm
CleanExiHS_TSPAN6
ExpressionAtlasiO43657 baseline and differential
GenevisibleiO43657 HS

Organism-specific databases

HPAiHPA004109

Interactioni

Protein-protein interaction databases

BioGridi112960, 20 interactors
IntActiO43657, 3 interactors
MINTiO43657
STRINGi9606.ENSP00000362111

Structurei

3D structure databases

ProteinModelPortaliO43657
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOVERGENiHBG107306
InParanoidiO43657
KOiK17295
OMAiIQRTLHC
OrthoDBiEOG091G0NJA
PhylomeDBiO43657
TreeFamiTF352891

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

O43657-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPSRRLQT KPVITCFKSV LLIYTFIFWI TGVILLAVGI WGKVSLENYF
60 70 80 90 100
SLLNEKATNV PFVLIATGTV IILLGTFGCF ATCRASAWML KLYAMFLTLV
110 120 130 140 150
FLVELVAAIV GFVFRHEIKN SFKNNYEKAL KQYNSTGDYR SHAVDKIQNT
160 170 180 190 200
LHCCGVTDYR DWTDTNYYSE KGFPKSCCKL EDCTPQRDAD KVNNEGCFIK
210 220 230 240
VMTIIESEMG VVAGISFGVA CFQLIGIFLA YCLSRAITNN QYEIV
Length:245
Mass (Da):27,563
Last modified:June 1, 1998 - v1
Checksum:i811FAB19C2805BE2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZU5A0A087WZU5_HUMAN
Tetraspanin-6
TSPAN6
137Annotation score:
A0A087WYV6A0A087WYV6_HUMAN
Tetraspanin-6
TSPAN6
129Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014494108A → T1 PublicationCorresponds to variant dbSNP:rs1802288Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053453 mRNA Translation: AAC69710.1
AF043906 mRNA Translation: AAC64257.1
U84895 mRNA Translation: AAD00560.1
AF133426 mRNA Translation: AAF08365.1
AY358825 mRNA Translation: AAQ89184.1
AB097016 mRNA Translation: BAC77369.1
BT006977 mRNA Translation: AAP35623.1
CR457115 mRNA Translation: CAG33396.1
AL035608 Genomic DNA No translation available.
CH471115 Genomic DNA Translation: EAX02811.1
BC012389 mRNA Translation: AAH12389.1
CCDSiCCDS14470.1
PIRiA59258
RefSeqiNP_001265672.1, NM_001278743.1
NP_003261.1, NM_003270.3
UniGeneiHs.43233
Hs.587521

Genome annotation databases

EnsembliENST00000373020; ENSP00000362111; ENSG00000000003
GeneIDi7105
KEGGihsa:7105
UCSCiuc004ega.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTSN6_HUMAN
AccessioniPrimary (citable) accession number: O43657
Secondary accession number(s): Q54A42, Q6IAN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again