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Protein

Prostate stem cell antigen

Gene

PSCA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.1 Publication
May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.1 Publication

GO - Molecular functioni

  • acetylcholine receptor binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate stem cell antigen
Gene namesi
Name:PSCA
ORF Names:UNQ206/PRO232
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000167653.4
HGNCiHGNC:9500 PSCA
MIMi602470 gene
neXtProtiNX_O43653

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8000
OpenTargetsiENSG00000167653

Chemistry databases

ChEMBLiCHEMBL3712961

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 111 PublicationAdd BLAST11
ChainiPRO_000003616212 – 86Prostate stem cell antigenAdd BLAST75
PropeptideiPRO_000003616386 – 114Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14 ↔ 39By similarity
Disulfide bondi17 ↔ 26By similarity
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi61 ↔ 77By similarity
Disulfide bondi78 ↔ 83By similarity
Lipidationi86GPI-anchor amidated serineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiO43653
MaxQBiO43653
PaxDbiO43653
PeptideAtlasiO43653
PRIDEiO43653
ProteomicsDBi49089

PTM databases

iPTMnetiO43653
PhosphoSitePlusiO43653

Expressioni

Tissue specificityi

Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). Expressed in brain cortex; expression is significantly increased in the front cortex of Alzheimer disease patients.3 Publications

Inductioni

Down-regulated in gastric cancer cells.1 Publication

Gene expression databases

BgeeiENSG00000167653 Expressed in 85 organ(s), highest expression level in fundus of stomach
CleanExiHS_PSCA
ExpressionAtlasiO43653 baseline and differential

Organism-specific databases

HPAiHPA030783
HPA056418

Interactioni

Subunit structurei

Interacts with CHRNA4.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiO43653, 6 interactors
STRINGi9606.ENSP00000301258

Structurei

3D structure databases

ProteinModelPortaliO43653
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 86UPAR/Ly6Add BLAST75

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCNA Eukaryota
ENOG4111DN6 LUCA
GeneTreeiENSGT00730000111451
HOGENOMiHOG000035114
HOVERGENiHBG008309
InParanoidiO43653
OrthoDBiEOG091G0V2A
PhylomeDBiO43653
TreeFamiTF336080

Family and domain databases

InterProiView protein in InterPro
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O43653-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGLALQPGT ALLCYSCKAQ VSNEDCLQVE NCTQLGEQCW TARIRAVGLL
60 70 80 90 100
TVISKGCSLN CVDDSQDYYV GKKNITCCDT DLCNASGAHA LQPAAAILAL
110
LPALGLLLWG PGQL
Length:114
Mass (Da):11,959
Last modified:October 10, 2018 - v2
Checksum:i65B3683767990740
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAA6H0YAA6_HUMAN
Prostate stem cell antigen
PSCA
54Annotation score:

Sequence cautioni

The sequence AAC39607 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH23582 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH65183 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAQ89271 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB97347 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → T in AC108002 (PubMed:16421571).Curated1

Polymorphismi

Genetic variations in PSCA may influence susceptibility to some cancers. A polymorphism gives rise to an upstream methionine which produces a longer protein of 123 residues associated with various cancers including diffuse-type gastric cancer and urinary bladder cancer.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0807771M → MKAVLLALLM2 PublicationsCorresponds to variant dbSNP:rs2294008Ensembl.1
Natural variantiVAR_02017330E → K1 PublicationCorresponds to variant dbSNP:rs3736001Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043498 mRNA Translation: AAC39607.1 Different initiation.
AJ297436 mRNA Translation: CAB97347.1 Different initiation.
AC108002 Genomic DNA No translation available.
AY358912 mRNA Translation: AAQ89271.1 Different initiation.
BC023582 mRNA Translation: AAH23582.1 Different initiation.
BC065183 mRNA Translation: AAH65183.1 Different initiation.
RefSeqiNP_005663.2, NM_005672.4
UniGeneiHs.652235

Genome annotation databases

EnsembliENST00000301258; ENSP00000301258; ENSG00000167653
GeneIDi8000
UCSCiuc003ywu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043498 mRNA Translation: AAC39607.1 Different initiation.
AJ297436 mRNA Translation: CAB97347.1 Different initiation.
AC108002 Genomic DNA No translation available.
AY358912 mRNA Translation: AAQ89271.1 Different initiation.
BC023582 mRNA Translation: AAH23582.1 Different initiation.
BC065183 mRNA Translation: AAH65183.1 Different initiation.
RefSeqiNP_005663.2, NM_005672.4
UniGeneiHs.652235

3D structure databases

ProteinModelPortaliO43653
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO43653, 6 interactors
STRINGi9606.ENSP00000301258

Chemistry databases

ChEMBLiCHEMBL3712961

PTM databases

iPTMnetiO43653
PhosphoSitePlusiO43653

Proteomic databases

EPDiO43653
MaxQBiO43653
PaxDbiO43653
PeptideAtlasiO43653
PRIDEiO43653
ProteomicsDBi49089

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301258; ENSP00000301258; ENSG00000167653
GeneIDi8000
UCSCiuc003ywu.4 human

Organism-specific databases

DisGeNETi8000
EuPathDBiHostDB:ENSG00000167653.4
GeneCardsiPSCA
H-InvDBiHIX0007826
HIX0034247
HGNCiHGNC:9500 PSCA
HPAiHPA030783
HPA056418
MIMi602470 gene
neXtProtiNX_O43653
OpenTargetsiENSG00000167653
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCNA Eukaryota
ENOG4111DN6 LUCA
GeneTreeiENSGT00730000111451
HOGENOMiHOG000035114
HOVERGENiHBG008309
InParanoidiO43653
OrthoDBiEOG091G0V2A
PhylomeDBiO43653
TreeFamiTF336080

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRSiPSCA human
PROiPR:O43653
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167653 Expressed in 85 organ(s), highest expression level in fundus of stomach
CleanExiHS_PSCA
ExpressionAtlasiO43653 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSCA_HUMAN
AccessioniPrimary (citable) accession number: O43653
Secondary accession number(s): Q6UW92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 10, 2018
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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