Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 192 (13 Feb 2019)
Sequence version 2 (10 May 2002)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Cytoplasmic protein NCK2

Gene

NCK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranslation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-186763 Downstream signal transduction
R-HSA-373753 Nephrin family interactions
R-HSA-3928664 Ephrin signaling
R-HSA-428540 Activation of RAC1
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-8985801 Regulation of cortical dendrite branching

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O43639

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O43639

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
O43639 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic protein NCK2
Alternative name(s):
Growth factor receptor-bound protein 4
NCK adaptor protein 2
Short name:
Nck-2
SH2/SH3 adaptor protein NCK-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCK2
Synonyms:GRB4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000071051.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7665 NCK2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604930 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43639

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi148W → K: Abolishes interaction with DOCK1. 1 Publication1
Mutagenesisi234W → K: Abolishes interaction with DOCK1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8440

Open Targets

More...
OpenTargetsi
ENSG00000071051

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31467

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NCK2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000967672 – 380Cytoplasmic protein NCK2Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei92PhosphothreonineCombined sources1
Modified residuei94PhosphoserineBy similarity1
Modified residuei110PhosphotyrosineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43639

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43639

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43639

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43639

PeptideAtlas

More...
PeptideAtlasi
O43639

PRoteomics IDEntifications database

More...
PRIDEi
O43639

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49088

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43639

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43639

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000071051 Expressed in 223 organ(s), highest expression level in hair follicle

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O43639 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43639 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016116
HPA031004

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DOCK1, LIMS1 and TGFB1I1. Part of a complex containing PPP1R15B, PP1 and NCK2. Interacts with FASLG (By similarity). Interacts with AXL. Interacts with PAK1, PKN2 and SOS1. Interacts (via SH2 domain) with EGFR. Interacts (via SH2 domain) with DDR1.By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB94EBI-713635,EBI-743598
ABI2Q9NYB9-26EBI-713635,EBI-11096309
ABI3Q9P2A45EBI-713635,EBI-742038
ARHGAP32A7KAX93EBI-713635,EBI-308663
BCL11AQ9H165-25EBI-713635,EBI-10183342
CBLBQ131917EBI-713635,EBI-744027
CD3EP077663EBI-713635,EBI-1211297
CHN1P1588213EBI-713635,EBI-718947
CHN2P527574EBI-713635,EBI-714925
CPSF7Q8N6844EBI-713635,EBI-746909
DDR1Q083453EBI-713635,EBI-711879
DLGAP4Q9Y2H0-14EBI-713635,EBI-12000556
DRAP1Q149193EBI-713635,EBI-712941
DVL1Q86TH33EBI-713635,EBI-10185025
EFHC2Q5JST63EBI-713635,EBI-2349927
EFNB2P527997EBI-713635,EBI-7532268
EIF3HO153724EBI-713635,EBI-709735
EIF3S3Q6IB983EBI-713635,EBI-10184995
ERBB2P046262EBI-713635,EBI-641062
ERBB3P218602EBI-713635,EBI-720706
FAM53CQ9NYF35EBI-713635,EBI-1644252
FASLGP480233EBI-713635,EBI-495538
FCRL2Q96LA53EBI-713635,EBI-10185081
FYB1O151173EBI-713635,EBI-1753267
GAB1Q134805EBI-713635,EBI-517684
HOMEZQ8IX15-33EBI-713635,EBI-10172004
HOXC4Q86TF73EBI-713635,EBI-10185009
KITP107212EBI-713635,EBI-1379503
LCP2Q130949EBI-713635,EBI-346946
LIMS1P480592EBI-713635,EBI-306928
LNX1Q8TBB13EBI-713635,EBI-739832
LRRIQ3A6PVS86EBI-713635,EBI-10184751
LZTS2Q9BRK46EBI-713635,EBI-741037
MAGEA6P433605EBI-713635,EBI-1045155
MEOX2P502223EBI-713635,EBI-748397
MEOX2Q6FHY53EBI-713635,EBI-16439278
METP085812EBI-713635,EBI-1039152
NPAS2Q997434EBI-713635,EBI-3932727
NR5A1Q132853EBI-713635,EBI-874629
PAK1Q131536EBI-713635,EBI-1307
PRR20CP864793EBI-713635,EBI-10172814
PSMD10O758322EBI-713635,EBI-752185
RASSF7Q028333EBI-713635,EBI-929013
RBM26Q5T8P63EBI-713635,EBI-3232077
RELQ048643EBI-713635,EBI-307352
RHOUQ7L0Q86EBI-713635,EBI-1638043
RHOVQ96L334EBI-713635,EBI-8538631
RTN4Q9NQC32EBI-713635,EBI-715945
SF3B4Q154276EBI-713635,EBI-348469
SORBS2O948753EBI-713635,EBI-311323
SPRY2O435973EBI-713635,EBI-742487
TCF4P158843EBI-713635,EBI-533224
TNRA1L3063EBI-713635,EBI-10182881
TRIM27P143735EBI-713635,EBI-719493
TRIM41Q8WV445EBI-713635,EBI-725997
TRIP6Q156546EBI-713635,EBI-742327
UBCP0CG482EBI-713635,EBI-3390054
VARS2Q5ST30-43EBI-713635,EBI-10244997
VPS37BQ9H9H45EBI-713635,EBI-4400866
WASP427683EBI-713635,EBI-346375
WASLO004016EBI-713635,EBI-957615
ZBTB7BO151563EBI-713635,EBI-740434

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114020, 140 interactors

Protein interaction database and analysis system

More...
IntActi
O43639, 155 interactors

Molecular INTeraction database

More...
MINTi
O43639

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000233154

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U5SNMR-A192-262[»]
1WX6NMR-A188-265[»]
1Z3KNMR-A283-380[»]
2B86NMR-A1-59[»]
2CIAX-ray1.45A284-380[»]
2FRWNMR-A114-170[»]
2FRYNMR-A198-256[»]
2JXBNMR-A1-59[»]
4E6RX-ray2.20A/B114-170[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O43639

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O43639

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O43639

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 61SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini111 – 170SH3 2PROSITE-ProRule annotationAdd BLAST60
Domaini195 – 257SH3 3PROSITE-ProRule annotationAdd BLAST63
Domaini285 – 380SH2PROSITE-ProRule annotationAdd BLAST96

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4226 Eukaryota
ENOG410XRPF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157728

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290684

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000719

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43639

KEGG Orthology (KO)

More...
KOi
K19862

Identification of Orthologs from Complete Genome Data

More...
OMAi
HSMDELV

Database of Orthologous Groups

More...
OrthoDBi
1097449at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43639

TreeFam database of animal gene trees

More...
TreeFami
TF351631

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10409 SH2_Nck2, 1 hit
cd11899 SH3_Nck2_1, 1 hit
cd11902 SH3_Nck2_2, 1 hit
cd11903 SH3_Nck2_3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017304 NCK
IPR035883 Nck2_SH2
IPR035559 Nck2_SH3_1
IPR035560 Nck2_SH3_2
IPR035561 Nck2_SH3_3
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits
PF14604 SH3_9, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037874 Cytoplasmic_NCK, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401 SH2DOMAIN
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 3 hits
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O43639-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY
60 70 80 90 100
VPSNYVERKN SLKKGSLVKN LKDTLGLGKT RRKTSARDAS PTPSTDAEYP
110 120 130 140 150
ANGSGADRIY DLNIPAFVKF AYVAEREDEL SLVKGSRVTV MEKCSDGWWR
160 170 180 190 200
GSYNGQIGWF PSNYVLEEVD EAAAESPSFL SLRKGASLSN GQGSRVLHVV
210 220 230 240 250
QTLYPFSSVT EEELNFEKGE TMEVIEKPEN DPEWWKCKNA RGQVGLVPKN
260 270 280 290 300
YVVVLSDGPA LHPAHAPQIS YTGPSSSGRF AGREWYYGNV TRHQAECALN
310 320 330 340 350
ERGVEGDFLI RDSESSPSDF SVSLKASGKN KHFKVQLVDN VYCIGQRRFH
360 370 380
TMDELVEHYK KAPIFTSEHG EKLYLVRALQ
Length:380
Mass (Da):42,915
Last modified:May 10, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A211085E46F4452
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERP6E7ERP6_HUMAN
Cytoplasmic protein NCK2
NCK2
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPF5E7EPF5_HUMAN
Cytoplasmic protein NCK2
NCK2
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PEE2E9PEE2_HUMAN
Cytoplasmic protein NCK2
NCK2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25K → KV in AAC04831 (PubMed:9737977).Curated1
Sequence conflicti100P → A in AAC80284 (PubMed:9843575).Curated1
Sequence conflicti296E → Q in AAC04831 (PubMed:9737977).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF043119 mRNA Translation: AAC04831.1
AF047487 mRNA Translation: AAC80284.1
CH471127 Genomic DNA Translation: EAX01753.1
CH471127 Genomic DNA Translation: EAX01754.1
BC000103 mRNA Translation: AAH00103.1
BC007195 mRNA Translation: AAH07195.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33266.1

NCBI Reference Sequences

More...
RefSeqi
NP_001004720.1, NM_001004720.2
NP_003572.2, NM_003581.4
XP_006712860.1, XM_006712797.3
XP_011510293.1, XM_011511991.2
XP_016860592.1, XM_017005103.1
XP_016860593.1, XM_017005104.1
XP_016860594.1, XM_017005105.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.529244
Hs.735723

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000233154; ENSP00000233154; ENSG00000071051
ENST00000393349; ENSP00000377018; ENSG00000071051

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8440

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8440

UCSC genome browser

More...
UCSCi
uc002tdg.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043119 mRNA Translation: AAC04831.1
AF047487 mRNA Translation: AAC80284.1
CH471127 Genomic DNA Translation: EAX01753.1
CH471127 Genomic DNA Translation: EAX01754.1
BC000103 mRNA Translation: AAH00103.1
BC007195 mRNA Translation: AAH07195.1
CCDSiCCDS33266.1
RefSeqiNP_001004720.1, NM_001004720.2
NP_003572.2, NM_003581.4
XP_006712860.1, XM_006712797.3
XP_011510293.1, XM_011511991.2
XP_016860592.1, XM_017005103.1
XP_016860593.1, XM_017005104.1
XP_016860594.1, XM_017005105.1
UniGeneiHs.529244
Hs.735723

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U5SNMR-A192-262[»]
1WX6NMR-A188-265[»]
1Z3KNMR-A283-380[»]
2B86NMR-A1-59[»]
2CIAX-ray1.45A284-380[»]
2FRWNMR-A114-170[»]
2FRYNMR-A198-256[»]
2JXBNMR-A1-59[»]
4E6RX-ray2.20A/B114-170[»]
ProteinModelPortaliO43639
SMRiO43639
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114020, 140 interactors
IntActiO43639, 155 interactors
MINTiO43639
STRINGi9606.ENSP00000233154

Protein family/group databases

MoonDBiO43639 Predicted

PTM databases

iPTMnetiO43639
PhosphoSitePlusiO43639

Polymorphism and mutation databases

BioMutaiNCK2

Proteomic databases

EPDiO43639
jPOSTiO43639
MaxQBiO43639
PaxDbiO43639
PeptideAtlasiO43639
PRIDEiO43639
ProteomicsDBi49088

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233154; ENSP00000233154; ENSG00000071051
ENST00000393349; ENSP00000377018; ENSG00000071051
GeneIDi8440
KEGGihsa:8440
UCSCiuc002tdg.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8440
DisGeNETi8440
EuPathDBiHostDB:ENSG00000071051.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NCK2
HGNCiHGNC:7665 NCK2
HPAiCAB016116
HPA031004
MIMi604930 gene
neXtProtiNX_O43639
OpenTargetsiENSG00000071051
PharmGKBiPA31467

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4226 Eukaryota
ENOG410XRPF LUCA
GeneTreeiENSGT00940000157728
HOGENOMiHOG000290684
HOVERGENiHBG000719
InParanoidiO43639
KOiK19862
OMAiHSMDELV
OrthoDBi1097449at2759
PhylomeDBiO43639
TreeFamiTF351631

Enzyme and pathway databases

ReactomeiR-HSA-186763 Downstream signal transduction
R-HSA-373753 Nephrin family interactions
R-HSA-3928664 Ephrin signaling
R-HSA-428540 Activation of RAC1
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-8985801 Regulation of cortical dendrite branching
SignaLinkiO43639
SIGNORiO43639

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NCK2 human
EvolutionaryTraceiO43639

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NCK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8440

Protein Ontology

More...
PROi
PR:O43639

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000071051 Expressed in 223 organ(s), highest expression level in hair follicle
ExpressionAtlasiO43639 baseline and differential
GenevisibleiO43639 HS

Family and domain databases

CDDicd10409 SH2_Nck2, 1 hit
cd11899 SH3_Nck2_1, 1 hit
cd11902 SH3_Nck2_2, 1 hit
cd11903 SH3_Nck2_3, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR017304 NCK
IPR035883 Nck2_SH2
IPR035559 Nck2_SH3_1
IPR035560 Nck2_SH3_2
IPR035561 Nck2_SH3_3
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits
PF14604 SH3_9, 1 hit
PIRSFiPIRSF037874 Cytoplasmic_NCK, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 3 hits
SUPFAMiSSF50044 SSF50044, 3 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCK2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43639
Secondary accession number(s): D3DVK1, Q9BWN9, Q9UIC3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2002
Last modified: February 13, 2019
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again