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Entry version 201 (12 Aug 2020)
Sequence version 2 (10 May 2002)
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Protein

Cytoplasmic protein NCK2

Gene

NCK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranslation regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
O43639

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-186763, Downstream signal transduction
R-HSA-373753, Nephrin family interactions
R-HSA-3928664, Ephrin signaling
R-HSA-428540, Activation of RAC1
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-8985801, Regulation of cortical dendrite branching

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
O43639

SIGNOR Signaling Network Open Resource

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SIGNORi
O43639

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
O43639, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic protein NCK2
Alternative name(s):
Growth factor receptor-bound protein 4
NCK adaptor protein 2
Short name:
Nck-2
SH2/SH3 adaptor protein NCK-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCK2
Synonyms:GRB4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000071051.13

Human Gene Nomenclature Database

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HGNCi
HGNC:7665, NCK2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604930, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O43639

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi148W → K: Abolishes interaction with DOCK1. 1 Publication1
Mutagenesisi234W → K: Abolishes interaction with DOCK1. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
8440

Open Targets

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OpenTargetsi
ENSG00000071051

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31467

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
O43639, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NCK2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000967672 – 380Cytoplasmic protein NCK2Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei92PhosphothreonineCombined sources1
Modified residuei94PhosphoserineBy similarity1
Modified residuei110PhosphotyrosineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O43639

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O43639

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O43639

MaxQB - The MaxQuant DataBase

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MaxQBi
O43639

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O43639

PeptideAtlas

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PeptideAtlasi
O43639

PRoteomics IDEntifications database

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PRIDEi
O43639

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
49088

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O43639

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O43639

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000071051, Expressed in cortical plate and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O43639, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43639, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000071051, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DOCK1, LIMS1 and TGFB1I1.

Part of a complex containing PPP1R15B, PP1 and NCK2.

Interacts with FASLG (By similarity).

Interacts with AXL.

Interacts with PAK1, PKN2 and SOS1.

Interacts (via SH2 domain) with EGFR.

Interacts (via SH2 domain) with DDR1.

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O43639
With#Exp.IntAct
ABI2 [Q9NYB9]6EBI-713635,EBI-743598
ABI2 - isoform 2 [Q9NYB9-2]10EBI-713635,EBI-11096309
ABI3 [Q9P2A4]6EBI-713635,EBI-742038
ANKRD55 [Q3KP44]3EBI-713635,EBI-14493093
ANKS1B - isoform 3 [Q7Z6G8-3]3EBI-713635,EBI-17714371
ARHGAP32 [A7KAX9]3EBI-713635,EBI-308663
BCAR1 [P56945]3EBI-713635,EBI-702093
BCL11A - isoform 2 [Q9H165-2]6EBI-713635,EBI-10183342
BTG1 [P62324]3EBI-713635,EBI-742279
C4orf17 [Q53FE4]3EBI-713635,EBI-715110
CBARP - isoform 2 [Q8N350-4]3EBI-713635,EBI-19051169
CBLB [Q13191]8EBI-713635,EBI-744027
CCDC120 [Q96HB5]3EBI-713635,EBI-744556
CD3E [P07766]4EBI-713635,EBI-1211297
CHN1 [P15882]16EBI-713635,EBI-718947
CHN2 [P52757]6EBI-713635,EBI-714925
CIB1 [Q99828]3EBI-713635,EBI-372594
CIPC [Q9C0C6]3EBI-713635,EBI-5654244
CLEC17A [Q6ZS10]3EBI-713635,EBI-11977093
CPSF6 - isoform 2 [Q16630-2]3EBI-713635,EBI-11088043
CPSF7 [Q8N684]4EBI-713635,EBI-746909
CPSF7 - isoform 3 [Q8N684-3]3EBI-713635,EBI-11523759
CUEDC1 [Q9NWM3]3EBI-713635,EBI-5838167
DDR1 [Q08345]3EBI-713635,EBI-711879
DEFB124 [Q8NES8]3EBI-713635,EBI-12843376
DISC1 - isoform 2 [Q9NRI5-2]3EBI-713635,EBI-11988027
DLGAP4 - isoform 2 [Q9Y2H0-1]6EBI-713635,EBI-12000556
DRAP1 [Q14919]3EBI-713635,EBI-712941
DTX3 [Q8N9I9]5EBI-713635,EBI-2340258
DVL1 [Q86TH3]3EBI-713635,EBI-10185025
EFHC2 [Q5JST6]3EBI-713635,EBI-2349927
EFNB2 [P52799]7EBI-713635,EBI-7532268
EIF3H [O15372]6EBI-713635,EBI-709735
EIF3S3 [Q6IB98]3EBI-713635,EBI-10184995
ERBB2 [P04626]2EBI-713635,EBI-641062
ERBB3 [P21860]2EBI-713635,EBI-720706
FAM124A [Q86V42]3EBI-713635,EBI-744506
FAM22F [B7ZLH0]3EBI-713635,EBI-10220102
FAM47A [A0A0C4DGW7]3EBI-713635,EBI-12011070
FAM53C [Q9NYF3]8EBI-713635,EBI-1644252
FAM83A [Q86UY5]3EBI-713635,EBI-1384254
FASLG [P48023]4EBI-713635,EBI-495538
FBXL19 - isoform 2 [Q6PCT2-2]3EBI-713635,EBI-11959077
FCRL2 [Q96LA5]3EBI-713635,EBI-10185081
FOSB [P53539]3EBI-713635,EBI-2806743
FYB1 [O15117]3EBI-713635,EBI-1753267
GAB1 [Q13480]5EBI-713635,EBI-517684
GAREM1 [Q9H706]3EBI-713635,EBI-3440103
GGN [Q86UU5]3EBI-713635,EBI-10259069
HOMEZ - isoform 2 [Q8IX15-3]3EBI-713635,EBI-10172004
HOXA1 [P49639]3EBI-713635,EBI-740785
HOXC4 [P09017]3EBI-713635,EBI-3923226
HOXC4 [Q86TF7]3EBI-713635,EBI-10185009
HOXD8 [P13378]3EBI-713635,EBI-7098661
HSF2BP [O75031]3EBI-713635,EBI-7116203
INCA1 [Q0VD86]3EBI-713635,EBI-6509505
INTS2 [Q9H0H0]3EBI-713635,EBI-8471507
KCTD17 [Q8N5Z5]3EBI-713635,EBI-743960
KIAA0408 [Q6ZU52]7EBI-713635,EBI-739493
KIT [P10721]2EBI-713635,EBI-1379503
KLHL24 [Q6TFL4]3EBI-713635,EBI-2510117
KLHL35 [Q6PF15]3EBI-713635,EBI-9477654
KPRP [Q5T749]3EBI-713635,EBI-10981970
LCP2 [Q13094]10EBI-713635,EBI-346946
LIMS1 [P48059]2EBI-713635,EBI-306928
LNX1 [Q8TBB1]3EBI-713635,EBI-739832
LRRIQ3 [A6PVS8]6EBI-713635,EBI-10184751
LZTS2 [Q9BRK4]6EBI-713635,EBI-741037
MAGEA6 [P43360]6EBI-713635,EBI-1045155
MBD6 [Q96DN6]3EBI-713635,EBI-719591
MEOX2 [P50222]3EBI-713635,EBI-748397
MEOX2 [Q6FHY5]3EBI-713635,EBI-16439278
MET [P08581]2EBI-713635,EBI-1039152
MIA3 [Q5JRA6]3EBI-713635,EBI-2291868
MNT [Q99583]3EBI-713635,EBI-7959025
MYPOP [Q86VE0]3EBI-713635,EBI-2858213
NCKIPSD - isoform 3 [Q9NZQ3-3]3EBI-713635,EBI-10963850
NELFA [Q9H3P2]3EBI-713635,EBI-5461341
NET1 [Q7Z628]3EBI-713635,EBI-2511306
NFKBID [Q8NI38]3EBI-713635,EBI-10271199
NHSL2 [Q5HYW2]6EBI-713635,EBI-2859639
NPAS2 [Q99743]6EBI-713635,EBI-3932727
NR5A1 [Q13285]3EBI-713635,EBI-874629
ONECUT3 [O60422]3EBI-713635,EBI-17431136
PAK1 [Q13153]10EBI-713635,EBI-1307
PAK2 [Q13177]8EBI-713635,EBI-1045887
PBX4 [Q9BYU1]3EBI-713635,EBI-10302990
PHETA1 - isoform 4 [Q8N4B1-4]3EBI-713635,EBI-14131832
PIK3AP1 - isoform 3 [Q6ZUJ8-3]7EBI-713635,EBI-11981743
PRDM6 [Q9NQX0]3EBI-713635,EBI-11320284
PRR16 [Q569H4]3EBI-713635,EBI-5564642
PRR20C [P86479]3EBI-713635,EBI-10172814
PRR20D [P86480]3EBI-713635,EBI-12754095
PSMD10 [O75832]2EBI-713635,EBI-752185
RASSF7 [Q02833]5EBI-713635,EBI-929013
RBBP8NL [Q8NC74]3EBI-713635,EBI-11322432
RBM26 [Q5T8P6]3EBI-713635,EBI-3232077
REEP4 [Q9H6H4]3EBI-713635,EBI-7545592
REL [Q04864]3EBI-713635,EBI-307352
REL - isoform 2 [Q04864-2]3EBI-713635,EBI-10829018
RHOU [Q7L0Q8]6EBI-713635,EBI-1638043
RHOV [Q96L33]4EBI-713635,EBI-8538631
RTN4 [Q9NQC3]2EBI-713635,EBI-715945
SCML2 [Q9UQR0]3EBI-713635,EBI-2513111
SCX [Q7RTU7]3EBI-713635,EBI-17492262
SF1 - isoform 4 [Q15637-4]3EBI-713635,EBI-12223157
SF3A2 [Q15428]3EBI-713635,EBI-2462271
SF3B4 [Q15427]7EBI-713635,EBI-348469
SHD [Q96IW2]3EBI-713635,EBI-4402781
SNW1 [Q13573]3EBI-713635,EBI-632715
SOCS7 [O14512]3EBI-713635,EBI-1539606
SORBS2 [O94875]3EBI-713635,EBI-311323
SPATA2L [Q8IUW3]3EBI-713635,EBI-2510414
SPATC1L - isoform 2 [Q9H0A9-2]5EBI-713635,EBI-11995806
SPRY2 [O43597]3EBI-713635,EBI-742487
SRMS [Q9H3Y6]3EBI-713635,EBI-8541270
SSH3 [Q8TE77]3EBI-713635,EBI-8743776
SYNGAP1 [Q96PV0]3EBI-713635,EBI-2682386
TCF4 [P15884]3EBI-713635,EBI-533224
TCP10L [Q8TDR4]3EBI-713635,EBI-3923210
TMEM121 [Q9BTD3]3EBI-713635,EBI-12155101
TNR [A1L306]3EBI-713635,EBI-10182881
TRIM27 [P14373]6EBI-713635,EBI-719493
TRIM41 [Q8WV44]8EBI-713635,EBI-725997
TRIP6 [Q15654]8EBI-713635,EBI-742327
TXK [P42681]3EBI-713635,EBI-7877438
UBC [P0CG48]2EBI-713635,EBI-3390054
USP32 - isoform 2 [Q8NFA0-2]5EBI-713635,EBI-12220239
VARS2 [Q5ST30]3EBI-713635,EBI-2116622
VARS2 - isoform 4 [Q5ST30-4]3EBI-713635,EBI-10244997
VPS37B [Q9H9H4]6EBI-713635,EBI-4400866
WAS [P42768]3EBI-713635,EBI-346375
WASF1 [Q92558]4EBI-713635,EBI-1548747
WASL [O00401]7EBI-713635,EBI-957615
WIPF1 - isoform 4 [O43516-4]3EBI-713635,EBI-12052927
ZBTB12 [Q9Y330]3EBI-713635,EBI-12377219
ZBTB42 [B2RXF5]3EBI-713635,EBI-12287587
ZBTB7B [O15156]3EBI-713635,EBI-740434
ZBTB7B - isoform 2 [O15156-2]3EBI-713635,EBI-11522250
ZC2HC1A [Q96GY0]3EBI-713635,EBI-5458880
ZC2HC1B [Q5TFG8]3EBI-713635,EBI-12275374
ZNF341 [Q9BYN7]3EBI-713635,EBI-9089622
ZNF526 [Q8TF50]3EBI-713635,EBI-11035148
ZNF688 [P0C7X2]3EBI-713635,EBI-4395732

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114020, 142 interactors

Protein interaction database and analysis system

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IntActi
O43639, 200 interactors

Molecular INTeraction database

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MINTi
O43639

STRING: functional protein association networks

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STRINGi
9606.ENSP00000233154

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O43639, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43639

Database of comparative protein structure models

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ModBasei
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Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
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Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O43639

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 61SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini111 – 170SH3 2PROSITE-ProRule annotationAdd BLAST60
Domaini195 – 257SH3 3PROSITE-ProRule annotationAdd BLAST63
Domaini285 – 380SH2PROSITE-ProRule annotationAdd BLAST96

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4226, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000157728

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_025160_0_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43639

KEGG Orthology (KO)

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KOi
K19862

Identification of Orthologs from Complete Genome Data

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OMAi
KNWWKVV

Database of Orthologous Groups

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OrthoDBi
1097449at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O43639

TreeFam database of animal gene trees

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TreeFami
TF351631

Family and domain databases

Conserved Domains Database

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CDDi
cd10409, SH2_Nck2, 1 hit
cd11899, SH3_Nck2_1, 1 hit
cd11902, SH3_Nck2_2, 1 hit
cd11903, SH3_Nck2_3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017304, NCK
IPR035883, Nck2_SH2
IPR035559, Nck2_SH3_1
IPR035560, Nck2_SH3_2
IPR035561, Nck2_SH3_3
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

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Pfami
View protein in Pfam
PF00017, SH2, 1 hit
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF037874, Cytoplasmic_NCK, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00401, SH2DOMAIN
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50044, SSF50044, 3 hits
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50001, SH2, 1 hit
PS50002, SH3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O43639-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY
60 70 80 90 100
VPSNYVERKN SLKKGSLVKN LKDTLGLGKT RRKTSARDAS PTPSTDAEYP
110 120 130 140 150
ANGSGADRIY DLNIPAFVKF AYVAEREDEL SLVKGSRVTV MEKCSDGWWR
160 170 180 190 200
GSYNGQIGWF PSNYVLEEVD EAAAESPSFL SLRKGASLSN GQGSRVLHVV
210 220 230 240 250
QTLYPFSSVT EEELNFEKGE TMEVIEKPEN DPEWWKCKNA RGQVGLVPKN
260 270 280 290 300
YVVVLSDGPA LHPAHAPQIS YTGPSSSGRF AGREWYYGNV TRHQAECALN
310 320 330 340 350
ERGVEGDFLI RDSESSPSDF SVSLKASGKN KHFKVQLVDN VYCIGQRRFH
360 370 380
TMDELVEHYK KAPIFTSEHG EKLYLVRALQ
Length:380
Mass (Da):42,915
Last modified:May 10, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A211085E46F4452
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EPF5E7EPF5_HUMAN
Cytoplasmic protein NCK2
NCK2
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PEE2E9PEE2_HUMAN
Cytoplasmic protein NCK2
NCK2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERP6E7ERP6_HUMAN
Cytoplasmic protein NCK2
NCK2
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25K → KV in AAC04831 (PubMed:9737977).Curated1
Sequence conflicti100P → A in AAC80284 (PubMed:9843575).Curated1
Sequence conflicti296E → Q in AAC04831 (PubMed:9737977).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF043119 mRNA Translation: AAC04831.1
AF047487 mRNA Translation: AAC80284.1
CH471127 Genomic DNA Translation: EAX01753.1
CH471127 Genomic DNA Translation: EAX01754.1
BC000103 mRNA Translation: AAH00103.1
BC007195 mRNA Translation: AAH07195.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33266.1

NCBI Reference Sequences

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RefSeqi
NP_001004720.1, NM_001004720.2
NP_003572.2, NM_003581.4
XP_006712860.1, XM_006712797.3
XP_011510293.1, XM_011511991.2
XP_016860592.1, XM_017005103.1
XP_016860593.1, XM_017005104.1
XP_016860594.1, XM_017005105.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000233154; ENSP00000233154; ENSG00000071051
ENST00000393349; ENSP00000377018; ENSG00000071051

Database of genes from NCBI RefSeq genomes

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GeneIDi
8440

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8440

UCSC genome browser

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UCSCi
uc002tdg.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043119 mRNA Translation: AAC04831.1
AF047487 mRNA Translation: AAC80284.1
CH471127 Genomic DNA Translation: EAX01753.1
CH471127 Genomic DNA Translation: EAX01754.1
BC000103 mRNA Translation: AAH00103.1
BC007195 mRNA Translation: AAH07195.1
CCDSiCCDS33266.1
RefSeqiNP_001004720.1, NM_001004720.2
NP_003572.2, NM_003581.4
XP_006712860.1, XM_006712797.3
XP_011510293.1, XM_011511991.2
XP_016860592.1, XM_017005103.1
XP_016860593.1, XM_017005104.1
XP_016860594.1, XM_017005105.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U5SNMR-A192-262[»]
1WX6NMR-A188-265[»]
1Z3KNMR-A283-380[»]
2B86NMR-A1-59[»]
2CIAX-ray1.45A284-380[»]
2FRWNMR-A114-170[»]
2FRYNMR-A198-256[»]
2JXBNMR-A1-59[»]
4E6RX-ray2.20A/B114-170[»]
SMRiO43639
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114020, 142 interactors
IntActiO43639, 200 interactors
MINTiO43639
STRINGi9606.ENSP00000233154

Protein family/group databases

MoonDBiO43639, Predicted

PTM databases

iPTMnetiO43639
PhosphoSitePlusiO43639

Polymorphism and mutation databases

BioMutaiNCK2

Proteomic databases

EPDiO43639
jPOSTiO43639
MassIVEiO43639
MaxQBiO43639
PaxDbiO43639
PeptideAtlasiO43639
PRIDEiO43639
ProteomicsDBi49088

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
O43639, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

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Antibodypediai
4240, 328 antibodies

Genome annotation databases

EnsembliENST00000233154; ENSP00000233154; ENSG00000071051
ENST00000393349; ENSP00000377018; ENSG00000071051
GeneIDi8440
KEGGihsa:8440
UCSCiuc002tdg.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8440
DisGeNETi8440
EuPathDBiHostDB:ENSG00000071051.13

GeneCards: human genes, protein and diseases

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GeneCardsi
NCK2
HGNCiHGNC:7665, NCK2
HPAiENSG00000071051, Low tissue specificity
MIMi604930, gene
neXtProtiNX_O43639
OpenTargetsiENSG00000071051
PharmGKBiPA31467

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4226, Eukaryota
GeneTreeiENSGT00940000157728
HOGENOMiCLU_025160_0_1_1
InParanoidiO43639
KOiK19862
OMAiKNWWKVV
OrthoDBi1097449at2759
PhylomeDBiO43639
TreeFamiTF351631

Enzyme and pathway databases

PathwayCommonsiO43639
ReactomeiR-HSA-186763, Downstream signal transduction
R-HSA-373753, Nephrin family interactions
R-HSA-3928664, Ephrin signaling
R-HSA-428540, Activation of RAC1
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-8985801, Regulation of cortical dendrite branching
SignaLinkiO43639
SIGNORiO43639

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
8440, 2 hits in 868 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NCK2, human
EvolutionaryTraceiO43639

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NCK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8440
PharosiO43639, Tbio

Protein Ontology

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PROi
PR:O43639
RNActiO43639, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000071051, Expressed in cortical plate and 239 other tissues
ExpressionAtlasiO43639, baseline and differential
GenevisibleiO43639, HS

Family and domain databases

CDDicd10409, SH2_Nck2, 1 hit
cd11899, SH3_Nck2_1, 1 hit
cd11902, SH3_Nck2_2, 1 hit
cd11903, SH3_Nck2_3, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR017304, NCK
IPR035883, Nck2_SH2
IPR035559, Nck2_SH3_1
IPR035560, Nck2_SH3_2
IPR035561, Nck2_SH3_3
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00017, SH2, 1 hit
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit
PIRSFiPIRSF037874, Cytoplasmic_NCK, 1 hit
PRINTSiPR00401, SH2DOMAIN
PR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 3 hits
SUPFAMiSSF50044, SSF50044, 3 hits
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001, SH2, 1 hit
PS50002, SH3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCK2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43639
Secondary accession number(s): D3DVK1, Q9BWN9, Q9UIC3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2002
Last modified: August 12, 2020
This is version 201 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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