Zinc finger protein SNAI2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Human Slug is a repressor that localizes to sites of active transcription."
    Hemavathy K., Guru S.C., Harris J., Chen J.D., Ip Y.T.
    Mol. Cell. Biol. 20:5087-5095(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  • Ref.8

    "The SLUG zinc-finger protein represses E-cadherin in breast cancer."
    Hajra K.M., Chen D.Y., Fearon E.R.
    Cancer Res. 62:1613-1618(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.12

    "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes."
    Turner F.E., Broad S., Khanim F.L., Jeanes A., Talma S., Hughes S., Tselepis C., Hotchin N.A.
    J. Biol. Chem. 281:21321-21331(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  • "Slug is a direct Notch target required for initiation of cardiac cushion cellularization."
    Niessen K., Fu Y., Chang L., Hoodless P.A., McFadden D., Karsan A.
    J Cell Biol 182:315-325(2008) [PubMed] [Europe PMC] [Abstract]
• E-box binding Source: BHF-UCLInferred from direct assayⁱ
  • Ref.8

    "The SLUG zinc-finger protein represses E-cadherin in breast cancer."
    Hajra K.M., Chen D.Y., Fearon E.R.
    Cancer Res. 62:1613-1618(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• metal ion binding Source: UniProtKB-KW
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: BHF-UCLInferred from direct assayⁱ
  • Ref.8

    "The SLUG zinc-finger protein represses E-cadherin in breast cancer."
    Hajra K.M., Chen D.Y., Fearon E.R.
    Cancer Res. 62:1613-1618(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• sequence-specific DNA binding Source: BHF-UCLInferred from direct assayⁱ
  • "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein."
    Inukai T., Inoue A., Kurosawa H., Goi K., Shinjyo T., Ozawa K., Mao M., Inaba T., Look A.T.
    Mol Cell 4:343-352(1999) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Human Slug is a repressor that localizes to sites of active transcription."
    Hemavathy K., Guru S.C., Harris J., Chen J.D., Ip Y.T.
    Mol. Cell. Biol. 20:5087-5095(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• sequence-specific double-stranded DNA binding Source: ARUK-UCLInferred from direct assayⁱ
  • "Impact of cytosine methylation on DNA binding specificities of human transcription factors."
    Yin Y., Morgunova E., Jolma A., Kaasinen E., Sahu B., Khund-Sayeed S., Das P.K., Kivioja T., Dave K., Zhong F., Nitta K.R., Taipale M., Popov A., Ginno P.A., Domcke S., Yan J., Schubeler D., Vinson C., Taipale J.
    Science 356:0-0(2017) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• aortic valve morphogenesis Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT."
    Riley M.F., McBride K.L., Cole S.E.
    Biochim Biophys Acta 1812:121-129(2011) [PubMed] [Europe PMC] [Abstract]
• cell migration involved in endocardial cushion formation Source: BHF-UCL
• cellular response to epidermal growth factor stimulus Source: BHF-UCLInferred from direct assayⁱ
  • "Erk5 controls Slug expression and keratinocyte activation during wound healing."
    Arnoux V., Nassour M., L'Helgoualc'h A., Hipskind R.A., Savagner P.
    Mol Biol Cell 19:4738-4749(2008) [PubMed] [Europe PMC] [Abstract]
• desmosome disassembly Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The zinc-finger protein Slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition."
    Savagner P., Yamada K.M., Thiery J.P.
    J. Cell Biol. 137:1403-1419(1997) [PubMed] [Europe PMC] [Abstract]
• epithelial to mesenchymal transition Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin."
    Leong K.G., Niessen K., Kulic I., Raouf A., Eaves C., Pollet I., Karsan A.
    J Exp Med 204:2935-2948(2007) [PubMed] [Europe PMC] [Abstract]
  • "The zinc-finger protein Slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition."
    Savagner P., Yamada K.M., Thiery J.P.
    J. Cell Biol. 137:1403-1419(1997) [PubMed] [Europe PMC] [Abstract]
• epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
• epithelium development Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Erk5 controls Slug expression and keratinocyte activation during wound healing."
    Arnoux V., Nassour M., L'Helgoualc'h A., Hipskind R.A., Savagner P.
    Mol Biol Cell 19:4738-4749(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of anoikis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin."
    Leong K.G., Niessen K., Kulic I., Raouf A., Eaves C., Pollet I., Karsan A.
    J Exp Med 204:2935-2948(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of canonical Wnt signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer."
    Larriba M.J., Martin-Villar E., Garcia J.M., Pereira F., Pena C., de Herreros A.G., Bonilla F., Munoz A.
    Carcinogenesis 30:1459-1468(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell adhesion mediated by integrin Source: BHF-UCLInferred from direct assayⁱ
  • Ref.12

    "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes."
    Turner F.E., Broad S., Khanim F.L., Jeanes A., Talma S., Hughes S., Tselepis C., Hotchin N.A.
    J. Biol. Chem. 281:21321-21331(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• negative regulation of chondrocyte differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.13

    "Slug gene expression supports human osteoblast maturation."
    Lambertini E., Lisignoli G., Torreggiani E., Manferdini C., Gabusi E., Franceschetti T., Penolazzi L., Gambari R., Facchini A., Piva R.
    Cell. Mol. Life Sci. 66:3641-3653(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress."
    Kajita M., McClinic K.N., Wade P.A.
    Mol Cell Biol 24:7559-7566(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein."
    Inukai T., Inoue A., Kurosawa H., Goi K., Shinjyo T., Ozawa K., Mao M., Inaba T., Look A.T.
    Mol Cell 4:343-352(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress."
    Kajita M., McClinic K.N., Wade P.A.
    Mol Cell Biol 24:7559-7566(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of keratinocyte proliferation Source: BHF-UCLInferred from direct assayⁱ
  • Ref.12

    "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes."
    Turner F.E., Broad S., Khanim F.L., Jeanes A., Talma S., Hughes S., Tselepis C., Hotchin N.A.
    J. Biol. Chem. 281:21321-21331(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• negative regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "Human Slug is a repressor that localizes to sites of active transcription."
    Hemavathy K., Guru S.C., Harris J., Chen J.D., Ip Y.T.
    Mol. Cell. Biol. 20:5087-5095(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  • Ref.8

    "The SLUG zinc-finger protein represses E-cadherin in breast cancer."
    Hajra K.M., Chen D.Y., Fearon E.R.
    Cancer Res. 62:1613-1618(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • "Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells."
    Tripathi M.K., Misra S., Chaudhuri G.
    Biochem Biophys Res Commun 329:508-515(2005) [PubMed] [Europe PMC] [Abstract]
  • Ref.12

    "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes."
    Turner F.E., Broad S., Khanim F.L., Jeanes A., Talma S., Hughes S., Tselepis C., Hotchin N.A.
    J. Biol. Chem. 281:21321-21331(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• negative regulation of vitamin D biosynthetic process Source: BHF-UCLInferred from direct assayⁱ
  • "In vivo binding to and functional repression of the VDR gene promoter by SLUG in human breast cells."
    Mittal M.K., Myers J.N., Misra S., Bailey C.K., Chaudhuri G.
    Biochem Biophys Res Commun 372:30-34(2008) [PubMed] [Europe PMC] [Abstract]
  • "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer."
    Larriba M.J., Martin-Villar E., Garcia J.M., Pereira F., Pena C., de Herreros A.G., Bonilla F., Munoz A.
    Carcinogenesis 30:1459-1468(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of vitamin D receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer."
    Larriba M.J., Martin-Villar E., Garcia J.M., Pereira F., Pena C., de Herreros A.G., Bonilla F., Munoz A.
    Carcinogenesis 30:1459-1468(2009) [PubMed] [Europe PMC] [Abstract]
• neural crest cell development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.9

    "SLUG (SNAI2) deletions in patients with Waardenburg disease."
    Sanchez-Martin M., Rodriguez-Garcia A., Perez-Losada J., Sagrera A., Read A.P., Sanchez-Garcia I.
    Hum. Mol. Genet. 11:3231-3236(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INVOLVEMENT IN WS2D.
• Notch signaling involved in heart development Source: BHF-UCLTraceable author statementⁱ
  • "NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT."
    Riley M.F., McBride K.L., Cole S.E.
    Biochim Biophys Acta 1812:121-129(2011) [PubMed] [Europe PMC] [Abstract]
• Notch signaling pathway Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Slug is a direct Notch target required for initiation of cardiac cushion cellularization."
    Niessen K., Fu Y., Chang L., Hoodless P.A., McFadden D., Karsan A.
    J Cell Biol 182:315-325(2008) [PubMed] [Europe PMC] [Abstract]
• osteoblast differentiation Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts."
    Lambertini E., Franceschetti T., Torreggiani E., Penolazzi L., Pastore A., Pelucchi S., Gambari R., Piva R.
    BMC Mol Biol 11:13-13(2010) [PubMed] [Europe PMC] [Abstract]
• pigmentation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.9

    "SLUG (SNAI2) deletions in patients with Waardenburg disease."
    Sanchez-Martin M., Rodriguez-Garcia A., Perez-Losada J., Sagrera A., Read A.P., Sanchez-Garcia I.
    Hum. Mol. Genet. 11:3231-3236(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INVOLVEMENT IN WS2D.
• positive regulation of cell migration Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress."
    Kajita M., McClinic K.N., Wade P.A.
    Mol Cell Biol 24:7559-7566(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of bicellular tight junction assembly Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress."
    Kajita M., McClinic K.N., Wade P.A.
    Mol Cell Biol 24:7559-7566(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of chemokine production Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.15

    "Slug contributes to the regulation of CXCL12 expression in human osteoblasts."
    Piva R., Manferdini C., Lambertini E., Torreggiani E., Penolazzi L., Gambari R., Pastore A., Pelucchi S., Gabusi E., Piacentini A., Filardo G., Facchini A., Lisignoli G.
    Exp. Cell Res. 317:1159-1168(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• regulation of osteoblast differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.13

    "Slug gene expression supports human osteoblast maturation."
    Lambertini E., Lisignoli G., Torreggiani E., Manferdini C., Gabusi E., Franceschetti T., Penolazzi L., Gambari R., Facchini A., Piva R.
    Cell. Mol. Life Sci. 66:3641-3653(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
  • Ref.15

    "Slug contributes to the regulation of CXCL12 expression in human osteoblasts."
    Piva R., Manferdini C., Lambertini E., Torreggiani E., Penolazzi L., Gambari R., Pastore A., Pelucchi S., Gabusi E., Piacentini A., Filardo G., Facchini A., Lisignoli G.
    Exp. Cell Res. 317:1159-1168(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• regulation of transcription, DNA-templated Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sensory perception of sound Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.9

    "SLUG (SNAI2) deletions in patients with Waardenburg disease."
    Sanchez-Martin M., Rodriguez-Garcia A., Perez-Losada J., Sagrera A., Read A.P., Sanchez-Garcia I.
    Hum. Mol. Genet. 11:3231-3236(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INVOLVEMENT IN WS2D.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Mutagenesis

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLYESYSMP VIPQPEILSS 
        60         70         80         90        100
GAYSPITVWT TAAPFHAQLP NGLSPLSGYS SSLGRVSPPP PSDTSSKDHS 
       110        120        130        140        150
GSESPISDEE ERLQSKLSDP HAIEAEKFQC NLCNKTYSTF SGLAKHKQLH 
       160        170        180        190        200
CDAQSRKSFS CKYCDKEYVS LGALKMHIRT HTLPCVCKIC GKAFSRPWLL 
       210        220        230        240        250
QGHIRTHTGE KPFSCPHCNR AFADRSNLRA HLQTHSDVKK YQCKNCSKTF 
       260 
SRMSLLHKHE ESGCCVAH                                    

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 8
   Human chromosome 8: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. SIMILARITY comments
   Index of protein domains and families