SNAI2

Functionⁱ

Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.By similarity6 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	128 – 150	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	159 – 181	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	185 – 207	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	213 – 235	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	241 – 264	C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: BHF-UCL
Inferred from direct assayⁱ
- 11912130
E-box binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 11912130
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: BHF-UCL
Inferred from direct assayⁱ
RNA polymerase II regulatory region sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 11912130
sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 10518215
- 10866665
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aortic valve morphogenesis
Source: BHF-UCL
Traceable author statementⁱ
- 20951801
cartilage morphogenesis Source: Ensembl
cell migration involved in endocardial cushion formation Source: BHF-UCL
cellular response to epidermal growth factor stimulus
Source: BHF-UCL
Inferred from direct assayⁱ
- 18716062
cellular response to ionizing radiation Source: Ensembl
desmosome disassembly
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 9182671
epithelial to mesenchymal transition
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17984306
- 9182671
epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
epithelium development
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 18716062
negative regulation of anoikis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17984306
negative regulation of canonical Wnt signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 19502595
negative regulation of cell adhesion involved in substrate-bound cell migration Source: Ensembl
negative regulation of cell adhesion mediated by integrin
Source: BHF-UCL
Inferred by curatorⁱ
- 16707493
negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
negative regulation of chondrocyte differentiation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19756381
negative regulation of DNA damage response, signal transduction by p53 class mediator
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15314165
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 10518215
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15314165
negative regulation of keratinocyte proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 16707493
negative regulation of stem cell proliferation Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 10866665
- 11912130
negative regulation of vitamin D biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 18485278
- 19502595
negative regulation of vitamin D receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 19502595
neural crest cell development
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12444107
Notch signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18663143
osteoblast differentiation
Source: UniProtKB
Inferred from expression patternⁱ
- 20128911
pigmentation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12444107
positive regulation of cell migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15314165
positive regulation of fat cell differentiation Source: Ensembl
positive regulation of histone acetylation Source: Ensembl
regulation of bicellular tight junction assembly
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15314165
regulation of branching involved in salivary gland morphogenesis Source: Ensembl
regulation of chemokine production
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21182836
regulation of osteoblast differentiation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19756381
- 21182836
regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
roof of mouth development Source: Ensembl
sensory perception of sound
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12444107
white fat cell differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORⁱ	O43623

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein SNAI2 Alternative name(s): Neural crest transcription factor Slug Protein snail homolog 2
Gene namesⁱ	Name:SNAI2 Synonyms:SLUG, SLUGH
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000019549.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11094 SNAI2
MIMⁱ	602150 gene
neXtProtⁱ	NX_O43623

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Waardenburg syndrome 2D (WS2D)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionWS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.

Piebald trait (PBT)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAutosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	87	S → A: Increases protein stability. Does not affect repressor activity on E-cadherin/CDH1 promoter. 1 Publication	1
Mutagenesisⁱ	92	S → A: Increases protein stability, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-96. 1 Publication	1
Mutagenesisⁱ	96	S → A: Increases protein stability, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-92. 1 Publication	1
Mutagenesisⁱ	100	S → A: Increases protein stability and half-life, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-104. 1 Publication	1
Mutagenesisⁱ	104	S → A: Increases protein stability and half-life, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-100. 1 Publication	1
Mutagenesisⁱ	166	K → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-175. 1 Publication	1
Mutagenesisⁱ	175	K → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-166. 1 Publication	1
Mutagenesisⁱ	192	K → E: Abolishes binding to KPNA2 and impairs binding to KPNB1, IPO7 and TMPO1; when associated with E-196. 1 Publication	1
Mutagenesisⁱ	196	R → E: Abolishes binding to KPNA2 and impairs binding to KPNB1, IPO7 and TMPO1; when associated with E-192. 1 Publication	1
Mutagenesisⁱ	225	R → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-229. 1 Publication	1
Mutagenesisⁱ	229	R → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-225. 1 Publication	1

Keywords - Diseaseⁱ

Deafness, Waardenburg syndrome

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6591
MalaCards human disease database More...MalaCardsⁱ	SNAI2
MIMⁱ	172800 phenotype 608890 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000019549
Orphanetⁱ	2884 Piebaldism 895 Waardenburg syndrome type 2
PharmGKBⁱ	PA35945

Polymorphism and mutation databases

BioMutaⁱ	SNAI2

BioMutaⁱ

SNAI2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047032	1 – 268	Zinc finger protein SNAI2Add BLAST		268

Post-translational modificationⁱ

GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.1 Publication

Proteomic databases

EPDⁱ	O43623
PaxDbⁱ	O43623
PeptideAtlas More...PeptideAtlasⁱ	O43623
PRIDEⁱ	O43623
ProteomicsDBⁱ	49085

PTM databases

iPTMnetⁱ	O43623
PhosphoSitePlusⁱ	O43623

Expressionⁱ

Tissue specificityⁱ

Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).4 Publications

Gene expression databases

Bgeeⁱ	ENSG00000019549 Expressed in 205 organ(s), highest expression level in tibia
CleanExⁱ	HS_SNAI2
ExpressionAtlasⁱ	O43623 baseline and differential
Genevisibleⁱ	O43623 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB011671

HPAⁱ

CAB011671

Interactionⁱ

Subunit structureⁱ

Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains) (By similarity). Interacts (via zinc fingers) with KPNA2, KPNB1, and TNPO1. May interact (via zinc fingers) with IPO7.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CSNK2A1	P68400	4	EBI-9876238,EBI-347804
SAT1	P21673	3	EBI-9876238,EBI-711613
TRIM23	P36406	3	EBI-9876238,EBI-740098

Protein-protein interaction databases

BioGridⁱ	112476, 24 interactors
IntActⁱ	O43623, 5 interactors
STRINGⁱ	9606.ENSP00000020945

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43623
SMRⁱ	O43623
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 20	SNAG domainBy similarityAdd BLAST		20

Domainⁱ

Repression activity depends on the C-terminal DNA-binding zinc fingers and on the N-terminal repression domain.

Sequence similaritiesⁱ

Belongs to the snail C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	128 – 150	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	159 – 181	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	185 – 207	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	213 – 235	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	241 – 264	C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2462 Eukaryota ENOG41106JS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011027
HOGENOMⁱ	HOG000261665
HOVERGENⁱ	HBG007477
InParanoidⁱ	O43623
KEGG Orthology (KO) More...KOⁱ	K05706
OMAⁱ	YSPITMW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q0V
PhylomeDBⁱ	O43623
TreeFamⁱ	TF315515

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 5 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O43623-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLYESYSMP VIPQPEILSS 
        60         70         80         90        100
GAYSPITVWT TAAPFHAQLP NGLSPLSGYS SSLGRVSPPP PSDTSSKDHS 
       110        120        130        140        150
GSESPISDEE ERLQSKLSDP HAIEAEKFQC NLCNKTYSTF SGLAKHKQLH 
       160        170        180        190        200
CDAQSRKSFS CKYCDKEYVS LGALKMHIRT HTLPCVCKIC GKAFSRPWLL 
       210        220        230        240        250
QGHIRTHTGE KPFSCPHCNR AFADRSNLRA HLQTHSDVKK YQCKNCSKTF 
       260 
SRMSLLHKHE ESGCCVAH

Length:268

Mass (Da):29,986

Last modified:June 1, 1998 - v1

Checksum:ⁱ63F068C8E6B275D4

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1X7SC17	A0A1X7SC17_HUMAN		Zinc finger protein SNAI2 Zinc finger protein SNAI2	SNAI2	89	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	126	E → K in BAD97088 (Ref. 5) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_069163	31	P → T. Corresponds to variant dbSNP:rs11544360Ensembl.	1
Natural variantⁱVAR_009873	119	D → E in a patient with neural tube defects. 1 PublicationCorresponds to variant dbSNP:rs748917911Ensembl.	1
Natural variantⁱVAR_069164	234	T → I. Corresponds to variant dbSNP:rs13280993Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF042001 Genomic DNA Translation: AAC34288.1 AF084243 Genomic DNA Translation: AAD55240.1 AK312661 mRNA Translation: BAG35543.1 AK223368 mRNA Translation: BAD97088.1 CH471068 Genomic DNA Translation: EAW86700.1 BC014890 mRNA Translation: AAH14890.1 BC015895 mRNA Translation: AAH15895.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6146.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003059.1, NM_003068.4
UniGeneⁱ	Hs.360174

Genome annotation databases

Ensemblⁱ	ENST00000020945; ENSP00000020945; ENSG00000019549 ENST00000642303; ENSP00000494171; ENSG00000019549
GeneIDⁱ	6591
KEGGⁱ	hsa:6591
UCSC genome browser More...UCSCⁱ	uc003xqp.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43623	Protein snail-like protein 2		MACMU		268	UniRef100_O43623
Snail family transcriptional repressor 2		CALJA		268
SNAI2 isoform 1		PANTR		268
Protein snail-like protein 2		MACFA		268
SNAI2 isoform 1		PONAB		268
+15

Protein	Similar proteins		Species	Score	Length	Source
O43623	Zinc finger protein SNAI2		MOUSE		269	UniRef90_O43623
Zinc finger protein SNAI2		RAT		268
Zinc finger protein SNAI2		BOVIN		268
Protein snail-like protein 2		MACMU		268
Snail family transcriptional repressor 2		CALJA		268
+165

Protein	Similar proteins		Species	Score	Length	Source
O43623	Zinc finger protein SNAI2		MOUSE		269	UniRef50_O43623
Zinc finger protein SNAI2		RAT		268
Zinc finger protein SNAI2		BOVIN		268
Zinc finger protein SNAI2		XENLA		266
Protein snail-like protein 2		MACMU		268
+248

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF042001 Genomic DNA Translation: AAC34288.1 AF084243 Genomic DNA Translation: AAD55240.1 AK312661 mRNA Translation: BAG35543.1 AK223368 mRNA Translation: BAD97088.1 CH471068 Genomic DNA Translation: EAW86700.1 BC014890 mRNA Translation: AAH14890.1 BC015895 mRNA Translation: AAH15895.1
CCDSⁱ	CCDS6146.1
RefSeqⁱ	NP_003059.1, NM_003068.4
UniGeneⁱ	Hs.360174

3D structure databases

ProteinModelPortalⁱ	O43623
SMRⁱ	O43623
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112476, 24 interactors
IntActⁱ	O43623, 5 interactors
STRINGⁱ	9606.ENSP00000020945

PTM databases

iPTMnetⁱ	O43623
PhosphoSitePlusⁱ	O43623

Polymorphism and mutation databases

BioMutaⁱ	SNAI2

BioMutaⁱ

SNAI2

Proteomic databases

EPDⁱ	O43623
PaxDbⁱ	O43623
PeptideAtlasⁱ	O43623
PRIDEⁱ	O43623
ProteomicsDBⁱ	49085

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6591
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000020945; ENSP00000020945; ENSG00000019549 ENST00000642303; ENSP00000494171; ENSG00000019549
GeneIDⁱ	6591
KEGGⁱ	hsa:6591
UCSCⁱ	uc003xqp.5 human

Organism-specific databases

CTDⁱ	6591
DisGeNETⁱ	6591
EuPathDBⁱ	HostDB:ENSG00000019549.8
GeneCardsⁱ	SNAI2
H-InvDBⁱ	HIX0007497
HGNCⁱ	HGNC:11094 SNAI2
HPAⁱ	CAB011671
MalaCardsⁱ	SNAI2
MIMⁱ	172800 phenotype 602150 gene 608890 phenotype
neXtProtⁱ	NX_O43623
OpenTargetsⁱ	ENSG00000019549
Orphanetⁱ	2884 Piebaldism 895 Waardenburg syndrome type 2
PharmGKBⁱ	PA35945
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2462 Eukaryota ENOG41106JS LUCA
GeneTreeⁱ	ENSGT00390000011027
HOGENOMⁱ	HOG000261665
HOVERGENⁱ	HBG007477
InParanoidⁱ	O43623
KOⁱ	K05706
OMAⁱ	YSPITMW
OrthoDBⁱ	EOG091G0Q0V
PhylomeDBⁱ	O43623
TreeFamⁱ	TF315515

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORⁱ	O43623

Miscellaneous databases

GeneWikiⁱ	SNAI2
GenomeRNAiⁱ	6591
Protein Ontology More...PROⁱ	PR:O43623
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000019549 Expressed in 205 organ(s), highest expression level in tibia
CleanExⁱ	HS_SNAI2
ExpressionAtlasⁱ	O43623 baseline and differential
Genevisibleⁱ	O43623 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 5 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNAI2_HUMAN
Accessionⁱ	O43623Primary (citable) accession number: O43623 Secondary accession number(s): B2R6P6, Q53FC1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	June 1, 1998
	Last modified:	November 7, 2018
	This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

UniProtKB

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Help

UniRef

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Supporting data

UniProtKB - O43623 (SNAI2_HUMAN)

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Zinc finger protein SNAI2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ