Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - O43617 (TPPC3_HUMAN)

Entry version 178 (29 Sep 2021)
Sequence version 1 (01 Jun 1998)
Previous versions | rss
Add a publicationFeedback
Protein

Trafficking protein particle complex subunit 3

Gene

TRAPPC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43617

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-204005, COPII-mediated vesicle transport
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trafficking protein particle complex subunit 3
Alternative name(s):
BET3 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAPPC31 PublicationImported
Synonyms:BET31 Publication
ORF Names:CDABP0066
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19942, TRAPPC3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610955, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43617

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000054116

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi33 – 35DYE → KVR: Impairs interaction with TRAPPC1. 1 Publication3
Mutagenesisi68C → S: Loss of palmitoylation. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		27095

Open Targets

More...OpenTargetsi		ENSG00000054116

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134972272

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43617, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB08231, Myristic acid
DB03796, Palmitic Acid
DB08342, S-palmitoyl-L-cysteine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRAPPC3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002115721 – 180Trafficking protein particle complex subunit 3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi68S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43617

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43617

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43617

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43617

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43617

PeptideAtlas

More...PeptideAtlasi		O43617

PRoteomics IDEntifications database

More...PRIDEi		O43617

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49084 [O43617-1]
918

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O43617-1 [O43617-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43617

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43617

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O43617

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000054116, Expressed in testis and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43617, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43617, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000054116, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Component of the multisubunit transport protein particle (TRAPP) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Heterodimer with TRAPPC6A. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L (PubMed:11805826, PubMed:15692564, PubMed:16262728, PubMed:19416478, PubMed:21525244). Heterodimer with TRAPPC6b. The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation (PubMed:16828797).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117997, 53 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4749, TRAPP II complex
CPX-4750, TRAPP III complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O43617

Database of interacting proteins

More...DIPi		DIP-47627N

Protein interaction database and analysis system

More...IntActi		O43617, 31 interactors

Molecular INTeraction database

More...MINTi		O43617

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000480332

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43617, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43617

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O43617

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAPP small subunits family. BET3 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3330, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003880

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_087110_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43617

Database of Orthologous Groups

More...OrthoDBi		1334804at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43617

TreeFam database of animal gene trees

More...TreeFami		TF300091

Family and domain databases

Conserved Domains Database

More...CDDi		cd14942, TRAPPC3_bet3, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016721, Bet3
IPR024096, NO_sig/Golgi_transp_ligand-bd
IPR007194, TRAPP_component

The PANTHER Classification System

More...PANTHERi		PTHR13048, PTHR13048, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04051, TRAPP, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF018293, TRAPP_I_complex_Bet3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111126, SSF111126, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43617-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRQANRGTE SKKMSSELFT LTYGALVTQL CKDYENDEDV NKQLDKMGFN 
        60         70         80         90        100
IGVRLIEDFL ARSNVGRCHD FRETADVIAK VAFKMYLGIT PSITNWSPAG 
       110        120        130        140        150
DEFSLILENN PLVDFVELPD NHSSLIYSNL LCGVLRGALE MVQMAVEAKF 
       160        170        180
VQDTLKGDGV TEIRMRFIRR IEDNLPAGEE
Length:180
Mass (Da):20,274
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5E2D92BE8A39599
GO
Isoform 2 (identifier: O43617-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Show »
Length:134
Mass (Da):15,005
Checksum:i927EE13435BDE8B9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWM0A0A087WWM0_HUMAN
Trafficking protein particle comple...
TRAPPC3
188Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYS5A0A087WYS5_HUMAN
Trafficking protein particle comple...
TRAPPC3
114Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NKE1A6NKE1_HUMAN
Trafficking protein particle comple...
TRAPPC3
118Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0470151 – 46Missing in isoform 2. CuratedAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ224335 mRNA Translation: CAA11902.1
AF041432 mRNA Translation: AAB96936.1
AY007139 mRNA Translation: AAG02000.1
AK315610 mRNA Translation: BAG37979.1
AC114484 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07385.1
CH471059 Genomic DNA Translation: EAX07386.1
CH471059 Genomic DNA Translation: EAX07387.1
BC007662 mRNA Translation: AAH07662.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS404.1 [O43617-1]
CCDS59194.1 [O43617-2]

NCBI Reference Sequences

More...RefSeqi		NP_001257823.1, NM_001270894.1
NP_001257824.1, NM_001270895.1 [O43617-2]
NP_001257825.1, NM_001270896.1 [O43617-2]
NP_001257826.1, NM_001270897.1
NP_055223.1, NM_014408.4 [O43617-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373162; ENSP00000362256; ENSG00000054116 [O43617-2]
ENST00000373163; ENSP00000362257; ENSG00000054116 [O43617-2]
ENST00000373166; ENSP00000362261; ENSG00000054116 [O43617-1]
ENST00000617904; ENSP00000480648; ENSG00000054116 [O43617-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27095

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27095

UCSC genome browser

More...UCSCi		uc001bzx.5, human [O43617-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224335 mRNA Translation: CAA11902.1
AF041432 mRNA Translation: AAB96936.1
AY007139 mRNA Translation: AAG02000.1
AK315610 mRNA Translation: BAG37979.1
AC114484 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07385.1
CH471059 Genomic DNA Translation: EAX07386.1
CH471059 Genomic DNA Translation: EAX07387.1
BC007662 mRNA Translation: AAH07662.1
CCDSiCCDS404.1 [O43617-1]
CCDS59194.1 [O43617-2]
RefSeqiNP_001257823.1, NM_001270894.1
NP_001257824.1, NM_001270895.1 [O43617-2]
NP_001257825.1, NM_001270896.1 [O43617-2]
NP_001257826.1, NM_001270897.1
NP_055223.1, NM_014408.4 [O43617-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SZ7X-ray1.55A2-180[»]
2C0JX-ray2.20A15-175[»]
2CFHX-ray2.30A/B1-180[»]
3KXCX-ray2.00A1-180[»]
SMRiO43617
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117997, 53 interactors
ComplexPortaliCPX-4749, TRAPP II complex
CPX-4750, TRAPP III complex
CORUMiO43617
DIPiDIP-47627N
IntActiO43617, 31 interactors
MINTiO43617
STRINGi9606.ENSP00000480332

Chemistry databases

DrugBankiDB08231, Myristic acid
DB03796, Palmitic Acid
DB08342, S-palmitoyl-L-cysteine

PTM databases

iPTMnetiO43617
PhosphoSitePlusiO43617
SwissPalmiO43617

Genetic variation databases

BioMutaiTRAPPC3

Proteomic databases

EPDiO43617
jPOSTiO43617
MassIVEiO43617
MaxQBiO43617
PaxDbiO43617
PeptideAtlasiO43617
PRIDEiO43617
ProteomicsDBi49084 [O43617-1]
918
TopDownProteomicsiO43617-1 [O43617-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31641, 221 antibodies

The DNASU plasmid repository

More...DNASUi		27095

Genome annotation databases

EnsembliENST00000373162; ENSP00000362256; ENSG00000054116 [O43617-2]
ENST00000373163; ENSP00000362257; ENSG00000054116 [O43617-2]
ENST00000373166; ENSP00000362261; ENSG00000054116 [O43617-1]
ENST00000617904; ENSP00000480648; ENSG00000054116 [O43617-2]
GeneIDi27095
KEGGihsa:27095
UCSCiuc001bzx.5, human [O43617-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27095
DisGeNETi27095

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRAPPC3
HGNCiHGNC:19942, TRAPPC3
HPAiENSG00000054116, Low tissue specificity
MIMi610955, gene
neXtProtiNX_O43617
OpenTargetsiENSG00000054116
PharmGKBiPA134972272
VEuPathDBiHostDB:ENSG00000054116

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3330, Eukaryota
GeneTreeiENSGT00390000003880
HOGENOMiCLU_087110_2_0_1
InParanoidiO43617
OrthoDBi1334804at2759
PhylomeDBiO43617
TreeFamiTF300091

Enzyme and pathway databases

PathwayCommonsiO43617
ReactomeiR-HSA-204005, COPII-mediated vesicle transport
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27095, 768 hits in 1020 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRAPPC3, human
EvolutionaryTraceiO43617

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TRAPPC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27095
PharosiO43617, Tbio

Protein Ontology

More...PROi		PR:O43617
RNActiO43617, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000054116, Expressed in testis and 247 other tissues
ExpressionAtlasiO43617, baseline and differential
GenevisibleiO43617, HS

Family and domain databases

CDDicd14942, TRAPPC3_bet3, 1 hit
InterProiView protein in InterPro
IPR016721, Bet3
IPR024096, NO_sig/Golgi_transp_ligand-bd
IPR007194, TRAPP_component
PANTHERiPTHR13048, PTHR13048, 1 hit
PfamiView protein in Pfam
PF04051, TRAPP, 1 hit
PIRSFiPIRSF018293, TRAPP_I_complex_Bet3, 1 hit
SUPFAMiSSF111126, SSF111126, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPPC3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43617
Secondary accession number(s): A6NDN0, B2RDN2, D3DPS2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 1998
Last modified: September 29, 2021
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again