TRAPPC3

Protein namesⁱ	Recommended name: Trafficking protein particle complex subunit 3 Alternative name(s): BET3 homolog
Gene namesⁱ	Name:TRAPPC3 Synonyms:BET3 ORF Names:CDABP0066
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000054116.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19942 TRAPPC3
MIMⁱ	610955 gene
neXtProtⁱ	NX_O43617

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	68	C → S: Loss of palmitoylation. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000054116
PharmGKBⁱ	PA134972272

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB08231 MYRISTIC ACID DB03796 Palmitic Acid DB08342 S-PALMITOYL-L-CYSTEINE

DrugBankⁱ

DB08231 MYRISTIC ACID
DB03796 Palmitic Acid
DB08342 S-PALMITOYL-L-CYSTEINE

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000211572	1 – 180	Trafficking protein particle complex subunit 3Add BLAST		180

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	68	S-palmitoyl cysteine1 Publication		1

Keywords - PTMⁱ

Lipoprotein, Palmitate

Proteomic databases

EPDⁱ	O43617
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43617
PaxDbⁱ	O43617
PeptideAtlas More...PeptideAtlasⁱ	O43617
PRIDEⁱ	O43617
ProteomicsDBⁱ	49084
TopDownProteomicsⁱ	O43617-1 [O43617-1]

PTM databases

iPTMnetⁱ	O43617
PhosphoSitePlusⁱ	O43617
SwissPalmⁱ	O43617

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000054116 Expressed in 234 organ(s), highest expression level in testis
CleanExⁱ	HS_TRAPPC3
ExpressionAtlasⁱ	O43617 baseline and differential
Genevisibleⁱ	O43617 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028408

HPAⁱ

HPA028408

Interactionⁱ

Subunit structureⁱ

Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Heterodimer with TRAPPC6A. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
PLEKHF2	Q9H8W4	3	EBI-743566,EBI-742388
TRAPPC1	Q9Y5R8	4	EBI-743566,EBI-6160554
TRAPPC13	A5PLN9	2	EBI-743566,EBI-2857298
TRAPPC2	P0DI81-3	8	EBI-743566,EBI-11961968
TRAPPC2L	Q9UL33	6	EBI-743566,EBI-747601
TRAPPC2L	Q9UL33-2	4	EBI-743566,EBI-11119202
TRAPPC5	Q8IUR0	4	EBI-743566,EBI-3246160
TRAPPC6A	O75865	7	EBI-743566,EBI-743573
TRAPPC6A	O75865-2	7	EBI-743566,EBI-8451480
TRAPPC6B	Q86SZ2	3	EBI-743566,EBI-6160531
TRAPPC8	Q9Y2L5	2	EBI-743566,EBI-2820056

GO - Molecular functionⁱ

Rab guanyl-nucleotide exchange factor activity Source: Reactome

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117997, 42 interactors
CORUMⁱ	O43617
Database of interacting proteins More...DIPⁱ	DIP-47627N
IntActⁱ	O43617, 25 interactors
Molecular INTeraction database More...MINTⁱ	O43617
STRINGⁱ	9606.ENSP00000362261

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	17 – 34	Combined sources	18
Helixⁱ	37 – 62	Combined sources	26
Helixⁱ	71 – 80	Combined sources	10
Helixⁱ	82 – 87	Combined sources	6
Beta strandⁱ	92 – 94	Combined sources	3
Beta strandⁱ	102 – 109	Combined sources	8
Helixⁱ	120 – 122	Combined sources	3
Turnⁱ	127 – 129	Combined sources	3
Helixⁱ	130 – 140	Combined sources	11
Turnⁱ	141 – 143	Combined sources	3
Beta strandⁱ	144 – 152	Combined sources	9
Helixⁱ	154 – 156	Combined sources	3
Beta strandⁱ	159 – 170	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	O43617
SMRⁱ	O43617
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O43617

EvolutionaryTraceⁱ

O43617

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TRAPP small subunits family. BET3 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG3330 Eukaryota ENOG410Z1VV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003880
HOGENOMⁱ	HOG000186184
HOVERGENⁱ	HBG055045
InParanoidⁱ	O43617
KEGG Orthology (KO) More...KOⁱ	K20302
PhylomeDBⁱ	O43617
TreeFamⁱ	TF300091

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14942 TRAPPC3_bet3, 1 hit
InterProⁱ	View protein in InterPro IPR016721 Bet3 IPR024096 NO_sig/Golgi_transp_ligand-bd IPR007194 TRAPP_component
PANTHERⁱ	PTHR13048 PTHR13048, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04051 TRAPP, 1 hit
PIRSFⁱ	PIRSF018293 TRAPP_I_complex_Bet3, 1 hit
SUPFAMⁱ	SSF111126 SSF111126, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: O43617-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRQANRGTE SKKMSSELFT LTYGALVTQL CKDYENDEDV NKQLDKMGFN 
        60         70         80         90        100
IGVRLIEDFL ARSNVGRCHD FRETADVIAK VAFKMYLGIT PSITNWSPAG 
       110        120        130        140        150
DEFSLILENN PLVDFVELPD NHSSLIYSNL LCGVLRGALE MVQMAVEAKF 
       160        170        180
VQDTLKGDGV TEIRMRFIRR IEDNLPAGEE

Length:180

Mass (Da):20,274

Last modified:June 1, 1998 - v1

Checksum:ⁱB5E2D92BE8A39599

GO

Isoform 2 (identifier: O43617-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-46: Missing.

« Hide

        10         20         30         40         50
MGFNIGVRLI EDFLARSNVG RCHDFRETAD VIAKVAFKMY LGITPSITNW 
        60         70         80         90        100
SPAGDEFSLI LENNPLVDFV ELPDNHSSLI YSNLLCGVLR GALEMVQMAV 
       110        120        130 
EAKFVQDTLK GDGVTEIRMR FIRRIEDNLP AGEE

Note: Gene prediction based on EST data.

Show »

Length:134

Mass (Da):15,005

Checksum:ⁱ927EE13435BDE8B9

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
A0A087WWM0	A0A087WWM0_HUMAN	Trafficking protein particle comple... Trafficking protein particle complex subunit	TRAPPC3	188	Annotation score:
A0A087WYS5	A0A087WYS5_HUMAN	Trafficking protein particle comple... Trafficking protein particle complex subunit 3	TRAPPC3	114	Annotation score:
A6NKE1	A6NKE1_HUMAN	Trafficking protein particle comple... Trafficking protein particle complex subunit 3	TRAPPC3	118	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047015	1 – 46	Missing in isoform 2. CuratedAdd BLAST		46

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ224335 mRNA Translation: CAA11902.1 AF041432 mRNA Translation: AAB96936.1 AY007139 mRNA Translation: AAG02000.1 AK315610 mRNA Translation: BAG37979.1 AC114484 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07385.1 CH471059 Genomic DNA Translation: EAX07386.1 CH471059 Genomic DNA Translation: EAX07387.1 BC007662 mRNA Translation: AAH07662.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS404.1 [O43617-1] CCDS59194.1 [O43617-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001257823.1, NM_001270894.1 NP_001257824.1, NM_001270895.1 [O43617-2] NP_001257825.1, NM_001270896.1 [O43617-2] NP_001257826.1, NM_001270897.1 NP_055223.1, NM_014408.4 [O43617-1]
UniGeneⁱ	Hs.523131

Genome annotation databases

Ensemblⁱ	ENST00000373162; ENSP00000362256; ENSG00000054116 [O43617-2] ENST00000373163; ENSP00000362257; ENSG00000054116 [O43617-2] ENST00000373166; ENSP00000362261; ENSG00000054116 [O43617-1] ENST00000617904; ENSP00000480648; ENSG00000054116 [O43617-2]
GeneIDⁱ	27095
KEGGⁱ	hsa:27095
UCSC genome browser More...UCSCⁱ	uc001bzx.5 human [O43617-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43617	Trafficking protein particle complex subunit		PANTR		180	UniRef100_O43617
Trafficking protein particle complex subunit		MACMU		180
Trafficking protein particle complex subunit		MACFA		180
Trafficking protein particle complex subunit		PONAB		180
Trafficking protein particle complex subunit		COLAP		180
+9
O43617-2	TRAPPC3 isoform 2		PANTR		134	UniRef100_A0A2J8LYA1
TRAPPC3 isoform 1		PONAB		134
UPI00004C2C67		HUMAN		200

Protein	Similar proteins		Species	Score	Length	Source
O43617	Trafficking protein particle complex subunit 3	)	MOUSE		180	UniRef90_O43617
Trafficking protein particle complex subunit 3		RAT		180
Trafficking protein particle complex subunit		PANTR		180
Trafficking protein particle complex subunit		MACMU		180
Trafficking protein particle complex subunit		MACFA		180
+60

Protein	Similar proteins		Species	Score	Length	Source
O43617	Trafficking protein particle complex subunit 3	)	MOUSE		180	UniRef50_O43617
Trafficking protein particle complex subunit 3		RAT		180
Trafficking protein particle complex subunit 3-like protein		HUMAN		181
Trafficking protein particle complex subunit 3		CHICK		180
Trafficking protein particle complex subunit		PANTR		180
+338

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ224335 mRNA Translation: CAA11902.1 AF041432 mRNA Translation: AAB96936.1 AY007139 mRNA Translation: AAG02000.1 AK315610 mRNA Translation: BAG37979.1 AC114484 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07385.1 CH471059 Genomic DNA Translation: EAX07386.1 CH471059 Genomic DNA Translation: EAX07387.1 BC007662 mRNA Translation: AAH07662.1
CCDSⁱ	CCDS404.1 [O43617-1] CCDS59194.1 [O43617-2]
RefSeqⁱ	NP_001257823.1, NM_001270894.1 NP_001257824.1, NM_001270895.1 [O43617-2] NP_001257825.1, NM_001270896.1 [O43617-2] NP_001257826.1, NM_001270897.1 NP_055223.1, NM_014408.4 [O43617-1]
UniGeneⁱ	Hs.523131

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1SZ7	X-ray	1.55	A	2-180	[»]
	2C0J	X-ray	2.20	A	15-175	[»]
	2CFH	X-ray	2.30	A/B	1-180	[»]
	3KXC	X-ray	2.00	A	1-180	[»]
ProteinModelPortalⁱ	O43617
SMRⁱ	O43617
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117997, 42 interactors
CORUMⁱ	O43617
DIPⁱ	DIP-47627N
IntActⁱ	O43617, 25 interactors
MINTⁱ	O43617
STRINGⁱ	9606.ENSP00000362261

Chemistry databases

DrugBankⁱ	DB08231 MYRISTIC ACID DB03796 Palmitic Acid DB08342 S-PALMITOYL-L-CYSTEINE

DrugBankⁱ

DB08231 MYRISTIC ACID
DB03796 Palmitic Acid
DB08342 S-PALMITOYL-L-CYSTEINE

PTM databases

iPTMnetⁱ	O43617
PhosphoSitePlusⁱ	O43617
SwissPalmⁱ	O43617

Proteomic databases

EPDⁱ	O43617
MaxQBⁱ	O43617
PaxDbⁱ	O43617
PeptideAtlasⁱ	O43617
PRIDEⁱ	O43617
ProteomicsDBⁱ	49084
TopDownProteomicsⁱ	O43617-1 [O43617-1]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000373162; ENSP00000362256; ENSG00000054116 [O43617-2] ENST00000373163; ENSP00000362257; ENSG00000054116 [O43617-2] ENST00000373166; ENSP00000362261; ENSG00000054116 [O43617-1] ENST00000617904; ENSP00000480648; ENSG00000054116 [O43617-2]
GeneIDⁱ	27095
KEGGⁱ	hsa:27095
UCSCⁱ	uc001bzx.5 human [O43617-1]

Organism-specific databases

CTDⁱ	27095
EuPathDBⁱ	HostDB:ENSG00000054116.11
GeneCardsⁱ	TRAPPC3
HGNCⁱ	HGNC:19942 TRAPPC3
HPAⁱ	HPA028408
MIMⁱ	610955 gene
neXtProtⁱ	NX_O43617
OpenTargetsⁱ	ENSG00000054116
PharmGKBⁱ	PA134972272
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3330 Eukaryota ENOG410Z1VV LUCA
GeneTreeⁱ	ENSGT00390000003880
HOGENOMⁱ	HOG000186184
HOVERGENⁱ	HBG055045
InParanoidⁱ	O43617
KOⁱ	K20302
PhylomeDBⁱ	O43617
TreeFamⁱ	TF300091

Enzyme and pathway databases

Reactomeⁱ	R-HSA-204005 COPII-mediated vesicle transport R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSⁱ	TRAPPC3 human
EvolutionaryTraceⁱ	O43617
GeneWikiⁱ	TRAPPC3
GenomeRNAiⁱ	27095
Protein Ontology More...PROⁱ	PR:O43617
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000054116 Expressed in 234 organ(s), highest expression level in testis
CleanExⁱ	HS_TRAPPC3
ExpressionAtlasⁱ	O43617 baseline and differential
Genevisibleⁱ	O43617 HS

Family and domain databases

CDDⁱ	cd14942 TRAPPC3_bet3, 1 hit
InterProⁱ	View protein in InterPro IPR016721 Bet3 IPR024096 NO_sig/Golgi_transp_ligand-bd IPR007194 TRAPP_component
PANTHERⁱ	PTHR13048 PTHR13048, 1 hit
Pfamⁱ	View protein in Pfam PF04051 TRAPP, 1 hit
PIRSFⁱ	PIRSF018293 TRAPP_I_complex_Bet3, 1 hit
SUPFAMⁱ	SSF111126 SSF111126, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TPPC3_HUMAN
Accessionⁱ	O43617Primary (citable) accession number: O43617 Secondary accession number(s): A6NDN0, B2RDN2, D3DPS2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
	Last sequence update:	June 1, 1998
	Last modified:	September 12, 2018
	This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43617 (TPPC3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Trafficking protein particle complex subunit 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Golgi apparatus

Cytosol

Endoplasmic reticulum

Golgi apparatus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ