UniProtKB - O43617 (TPPC3_HUMAN)
Trafficking protein particle complex subunit 3
TRAPPC3
Functioni
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- intra-Golgi vesicle-mediated transport Source: GO_Central
Keywordsi
Biological process | ER-Golgi transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | O43617 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
SignaLinki | O43617 |
Names & Taxonomyi
Protein namesi | Recommended name: Trafficking protein particle complex subunit 3Alternative name(s): BET3 homolog |
Gene namesi | ORF Names:CDABP0066 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19942, TRAPPC3 |
MIMi | 610955, gene |
neXtProti | NX_O43617 |
VEuPathDBi | HostDB:ENSG00000054116 |
Subcellular locationi
Golgi apparatus
- cis-Golgi network By similarity
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Golgi apparatus
- cis-Golgi network membrane Source: GO_Central
- Golgi apparatus Source: HPA
- Golgi membrane Source: Ensembl
Other locations
- TRAPP complex Source: UniProtKB
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 33 – 35 | DYE → KVR: Impairs interaction with TRAPPC1. 1 Publication | 3 | |
Mutagenesisi | 68 | C → S: Loss of palmitoylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 27095 |
OpenTargetsi | ENSG00000054116 |
PharmGKBi | PA134972272 |
Miscellaneous databases
Pharosi | O43617, Tbio |
Chemistry databases
DrugBanki | DB08231, Myristic acid DB03796, Palmitic Acid DB08342, S-palmitoyl-L-cysteine |
Genetic variation databases
BioMutai | TRAPPC3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211572 | 1 – 180 | Trafficking protein particle complex subunit 3Add BLAST | 180 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 68 | S-palmitoyl cysteine1 Publication | 1 |
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
EPDi | O43617 |
jPOSTi | O43617 |
MassIVEi | O43617 |
MaxQBi | O43617 |
PaxDbi | O43617 |
PeptideAtlasi | O43617 |
PRIDEi | O43617 |
ProteomicsDBi | 49084 [O43617-1] 918 |
TopDownProteomicsi | O43617-1 [O43617-1] |
PTM databases
iPTMneti | O43617 |
PhosphoSitePlusi | O43617 |
SwissPalmi | O43617 |
Expressioni
Gene expression databases
Bgeei | ENSG00000054116, Expressed in testis and 247 other tissues |
ExpressionAtlasi | O43617, baseline and differential |
Genevisiblei | O43617, HS |
Organism-specific databases
HPAi | ENSG00000054116, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
Component of the multisubunit transport protein particle (TRAPP) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Heterodimer with TRAPPC6A. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L (PubMed:11805826, PubMed:15692564, PubMed:16262728, PubMed:19416478, PubMed:21525244). Heterodimer with TRAPPC6b. The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation (PubMed:16828797).
6 PublicationsBinary interactionsi
O43617
Protein-protein interaction databases
BioGRIDi | 117997, 55 interactors |
ComplexPortali | CPX-4749, TRAPP II complex, TRAPPC2 variant CPX-4750, TRAPP III complex, TRAPPC2 variant CPX-6902, TRAPP II complex, TRAPPC2B variant CPX-6903, TRAPP III complex, TRAPPC2B variant |
CORUMi | O43617 |
DIPi | DIP-47627N |
IntActi | O43617, 31 interactors |
MINTi | O43617 |
STRINGi | 9606.ENSP00000480332 |
Miscellaneous databases
RNActi | O43617, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O43617 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O43617 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3330, Eukaryota |
GeneTreei | ENSGT00390000003880 |
HOGENOMi | CLU_087110_2_0_1 |
InParanoidi | O43617 |
OrthoDBi | 1334804at2759 |
PhylomeDBi | O43617 |
TreeFami | TF300091 |
Family and domain databases
CDDi | cd14942, TRAPPC3_bet3, 1 hit |
InterProi | View protein in InterPro IPR016721, Bet3 IPR024096, NO_sig/Golgi_transp_ligand-bd IPR007194, TRAPP_component |
PANTHERi | PTHR13048, PTHR13048, 1 hit |
Pfami | View protein in Pfam PF04051, TRAPP, 1 hit |
PIRSFi | PIRSF018293, TRAPP_I_complex_Bet3, 1 hit |
SUPFAMi | SSF111126, SSF111126, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRQANRGTE SKKMSSELFT LTYGALVTQL CKDYENDEDV NKQLDKMGFN
60 70 80 90 100
IGVRLIEDFL ARSNVGRCHD FRETADVIAK VAFKMYLGIT PSITNWSPAG
110 120 130 140 150
DEFSLILENN PLVDFVELPD NHSSLIYSNL LCGVLRGALE MVQMAVEAKF
160 170 180
VQDTLKGDGV TEIRMRFIRR IEDNLPAGEE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WWM0 | A0A087WWM0_HUMAN | Trafficking protein particle comple... | TRAPPC3 | 188 | Annotation score: | ||
A0A087WYS5 | A0A087WYS5_HUMAN | Trafficking protein particle comple... | TRAPPC3 | 114 | Annotation score: | ||
A6NKE1 | A6NKE1_HUMAN | Trafficking protein particle comple... | TRAPPC3 | 118 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047015 | 1 – 46 | Missing in isoform 2. CuratedAdd BLAST | 46 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ224335 mRNA Translation: CAA11902.1 AF041432 mRNA Translation: AAB96936.1 AY007139 mRNA Translation: AAG02000.1 AK315610 mRNA Translation: BAG37979.1 AC114484 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07385.1 CH471059 Genomic DNA Translation: EAX07386.1 CH471059 Genomic DNA Translation: EAX07387.1 BC007662 mRNA Translation: AAH07662.1 |
CCDSi | CCDS404.1 [O43617-1] CCDS59194.1 [O43617-2] |
RefSeqi | NP_001257823.1, NM_001270894.1 NP_001257824.1, NM_001270895.1 [O43617-2] NP_001257825.1, NM_001270896.1 [O43617-2] NP_001257826.1, NM_001270897.1 NP_055223.1, NM_014408.4 [O43617-1] |
Genome annotation databases
Ensembli | ENST00000373162; ENSP00000362256; ENSG00000054116 [O43617-2] ENST00000373163; ENSP00000362257; ENSG00000054116 [O43617-2] ENST00000373166; ENSP00000362261; ENSG00000054116 ENST00000617904; ENSP00000480648; ENSG00000054116 [O43617-2] |
GeneIDi | 27095 |
KEGGi | hsa:27095 |
MANE-Selecti | ENST00000373166.8; ENSP00000362261.3; NM_014408.5; NP_055223.1 |
UCSCi | uc001bzx.5, human [O43617-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ224335 mRNA Translation: CAA11902.1 AF041432 mRNA Translation: AAB96936.1 AY007139 mRNA Translation: AAG02000.1 AK315610 mRNA Translation: BAG37979.1 AC114484 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07385.1 CH471059 Genomic DNA Translation: EAX07386.1 CH471059 Genomic DNA Translation: EAX07387.1 BC007662 mRNA Translation: AAH07662.1 |
CCDSi | CCDS404.1 [O43617-1] CCDS59194.1 [O43617-2] |
RefSeqi | NP_001257823.1, NM_001270894.1 NP_001257824.1, NM_001270895.1 [O43617-2] NP_001257825.1, NM_001270896.1 [O43617-2] NP_001257826.1, NM_001270897.1 NP_055223.1, NM_014408.4 [O43617-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1SZ7 | X-ray | 1.55 | A | 2-180 | [»] | |
2C0J | X-ray | 2.20 | A | 15-175 | [»] | |
2CFH | X-ray | 2.30 | A/B | 1-180 | [»] | |
3KXC | X-ray | 2.00 | A | 1-180 | [»] | |
SMRi | O43617 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117997, 55 interactors |
ComplexPortali | CPX-4749, TRAPP II complex, TRAPPC2 variant CPX-4750, TRAPP III complex, TRAPPC2 variant CPX-6902, TRAPP II complex, TRAPPC2B variant CPX-6903, TRAPP III complex, TRAPPC2B variant |
CORUMi | O43617 |
DIPi | DIP-47627N |
IntActi | O43617, 31 interactors |
MINTi | O43617 |
STRINGi | 9606.ENSP00000480332 |
Chemistry databases
DrugBanki | DB08231, Myristic acid DB03796, Palmitic Acid DB08342, S-palmitoyl-L-cysteine |
PTM databases
iPTMneti | O43617 |
PhosphoSitePlusi | O43617 |
SwissPalmi | O43617 |
Genetic variation databases
BioMutai | TRAPPC3 |
Proteomic databases
EPDi | O43617 |
jPOSTi | O43617 |
MassIVEi | O43617 |
MaxQBi | O43617 |
PaxDbi | O43617 |
PeptideAtlasi | O43617 |
PRIDEi | O43617 |
ProteomicsDBi | 49084 [O43617-1] 918 |
TopDownProteomicsi | O43617-1 [O43617-1] |
Protocols and materials databases
Antibodypediai | 31641, 222 antibodies from 28 providers |
DNASUi | 27095 |
Genome annotation databases
Ensembli | ENST00000373162; ENSP00000362256; ENSG00000054116 [O43617-2] ENST00000373163; ENSP00000362257; ENSG00000054116 [O43617-2] ENST00000373166; ENSP00000362261; ENSG00000054116 ENST00000617904; ENSP00000480648; ENSG00000054116 [O43617-2] |
GeneIDi | 27095 |
KEGGi | hsa:27095 |
MANE-Selecti | ENST00000373166.8; ENSP00000362261.3; NM_014408.5; NP_055223.1 |
UCSCi | uc001bzx.5, human [O43617-1] |
Organism-specific databases
CTDi | 27095 |
DisGeNETi | 27095 |
GeneCardsi | TRAPPC3 |
HGNCi | HGNC:19942, TRAPPC3 |
HPAi | ENSG00000054116, Low tissue specificity |
MIMi | 610955, gene |
neXtProti | NX_O43617 |
OpenTargetsi | ENSG00000054116 |
PharmGKBi | PA134972272 |
VEuPathDBi | HostDB:ENSG00000054116 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3330, Eukaryota |
GeneTreei | ENSGT00390000003880 |
HOGENOMi | CLU_087110_2_0_1 |
InParanoidi | O43617 |
OrthoDBi | 1334804at2759 |
PhylomeDBi | O43617 |
TreeFami | TF300091 |
Enzyme and pathway databases
PathwayCommonsi | O43617 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
SignaLinki | O43617 |
Miscellaneous databases
BioGRID-ORCSi | 27095, 768 hits in 1048 CRISPR screens |
ChiTaRSi | TRAPPC3, human |
EvolutionaryTracei | O43617 |
GeneWikii | TRAPPC3 |
GenomeRNAii | 27095 |
Pharosi | O43617, Tbio |
PROi | PR:O43617 |
RNActi | O43617, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000054116, Expressed in testis and 247 other tissues |
ExpressionAtlasi | O43617, baseline and differential |
Genevisiblei | O43617, HS |
Family and domain databases
CDDi | cd14942, TRAPPC3_bet3, 1 hit |
InterProi | View protein in InterPro IPR016721, Bet3 IPR024096, NO_sig/Golgi_transp_ligand-bd IPR007194, TRAPP_component |
PANTHERi | PTHR13048, PTHR13048, 1 hit |
Pfami | View protein in Pfam PF04051, TRAPP, 1 hit |
PIRSFi | PIRSF018293, TRAPP_I_complex_Bet3, 1 hit |
SUPFAMi | SSF111126, SSF111126, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TPPC3_HUMAN | |
Accessioni | O43617Primary (citable) accession number: O43617 Secondary accession number(s): A6NDN0, B2RDN2, D3DPS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | June 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families