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Protein

Trafficking protein particle complex subunit 3

Gene

TRAPPC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 3
Alternative name(s):
BET3 homolog
Gene namesi
Name:TRAPPC3
Synonyms:BET3
ORF Names:CDABP0066
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000054116.11
HGNCiHGNC:19942 TRAPPC3
MIMi610955 gene
neXtProtiNX_O43617

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi68C → S: Loss of palmitoylation. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000054116
PharmGKBiPA134972272

Chemistry databases

DrugBankiDB08231 MYRISTIC ACID
DB03796 Palmitic Acid
DB08342 S-PALMITOYL-L-CYSTEINE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115721 – 180Trafficking protein particle complex subunit 3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi68S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiO43617
MaxQBiO43617
PaxDbiO43617
PeptideAtlasiO43617
PRIDEiO43617
ProteomicsDBi49084
TopDownProteomicsiO43617-1 [O43617-1]

PTM databases

iPTMnetiO43617
PhosphoSitePlusiO43617
SwissPalmiO43617

Expressioni

Gene expression databases

BgeeiENSG00000054116 Expressed in 234 organ(s), highest expression level in testis
CleanExiHS_TRAPPC3
ExpressionAtlasiO43617 baseline and differential
GenevisibleiO43617 HS

Organism-specific databases

HPAiHPA028408

Interactioni

Subunit structurei

Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Heterodimer with TRAPPC6A. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L.5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117997, 42 interactors
CORUMiO43617
DIPiDIP-47627N
IntActiO43617, 25 interactors
MINTiO43617
STRINGi9606.ENSP00000362261

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43617
SMRiO43617
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43617

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3330 Eukaryota
ENOG410Z1VV LUCA
GeneTreeiENSGT00390000003880
HOGENOMiHOG000186184
HOVERGENiHBG055045
InParanoidiO43617
KOiK20302
PhylomeDBiO43617
TreeFamiTF300091

Family and domain databases

CDDicd14942 TRAPPC3_bet3, 1 hit
InterProiView protein in InterPro
IPR016721 Bet3
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR007194 TRAPP_component
PANTHERiPTHR13048 PTHR13048, 1 hit
PfamiView protein in Pfam
PF04051 TRAPP, 1 hit
PIRSFiPIRSF018293 TRAPP_I_complex_Bet3, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: O43617-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRQANRGTE SKKMSSELFT LTYGALVTQL CKDYENDEDV NKQLDKMGFN
60 70 80 90 100
IGVRLIEDFL ARSNVGRCHD FRETADVIAK VAFKMYLGIT PSITNWSPAG
110 120 130 140 150
DEFSLILENN PLVDFVELPD NHSSLIYSNL LCGVLRGALE MVQMAVEAKF
160 170 180
VQDTLKGDGV TEIRMRFIRR IEDNLPAGEE
Length:180
Mass (Da):20,274
Last modified:June 1, 1998 - v1
Checksum:iB5E2D92BE8A39599
GO
Isoform 2 (identifier: O43617-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: Gene prediction based on EST data.
Show »
Length:134
Mass (Da):15,005
Checksum:i927EE13435BDE8B9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWM0A0A087WWM0_HUMAN
Trafficking protein particle comple...
TRAPPC3
188Annotation score:
A0A087WYS5A0A087WYS5_HUMAN
Trafficking protein particle comple...
TRAPPC3
114Annotation score:
A6NKE1A6NKE1_HUMAN
Trafficking protein particle comple...
TRAPPC3
118Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0470151 – 46Missing in isoform 2. CuratedAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224335 mRNA Translation: CAA11902.1
AF041432 mRNA Translation: AAB96936.1
AY007139 mRNA Translation: AAG02000.1
AK315610 mRNA Translation: BAG37979.1
AC114484 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07385.1
CH471059 Genomic DNA Translation: EAX07386.1
CH471059 Genomic DNA Translation: EAX07387.1
BC007662 mRNA Translation: AAH07662.1
CCDSiCCDS404.1 [O43617-1]
CCDS59194.1 [O43617-2]
RefSeqiNP_001257823.1, NM_001270894.1
NP_001257824.1, NM_001270895.1 [O43617-2]
NP_001257825.1, NM_001270896.1 [O43617-2]
NP_001257826.1, NM_001270897.1
NP_055223.1, NM_014408.4 [O43617-1]
UniGeneiHs.523131

Genome annotation databases

EnsembliENST00000373162; ENSP00000362256; ENSG00000054116 [O43617-2]
ENST00000373163; ENSP00000362257; ENSG00000054116 [O43617-2]
ENST00000373166; ENSP00000362261; ENSG00000054116 [O43617-1]
ENST00000617904; ENSP00000480648; ENSG00000054116 [O43617-2]
GeneIDi27095
KEGGihsa:27095
UCSCiuc001bzx.5 human [O43617-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224335 mRNA Translation: CAA11902.1
AF041432 mRNA Translation: AAB96936.1
AY007139 mRNA Translation: AAG02000.1
AK315610 mRNA Translation: BAG37979.1
AC114484 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07385.1
CH471059 Genomic DNA Translation: EAX07386.1
CH471059 Genomic DNA Translation: EAX07387.1
BC007662 mRNA Translation: AAH07662.1
CCDSiCCDS404.1 [O43617-1]
CCDS59194.1 [O43617-2]
RefSeqiNP_001257823.1, NM_001270894.1
NP_001257824.1, NM_001270895.1 [O43617-2]
NP_001257825.1, NM_001270896.1 [O43617-2]
NP_001257826.1, NM_001270897.1
NP_055223.1, NM_014408.4 [O43617-1]
UniGeneiHs.523131

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SZ7X-ray1.55A2-180[»]
2C0JX-ray2.20A15-175[»]
2CFHX-ray2.30A/B1-180[»]
3KXCX-ray2.00A1-180[»]
ProteinModelPortaliO43617
SMRiO43617
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117997, 42 interactors
CORUMiO43617
DIPiDIP-47627N
IntActiO43617, 25 interactors
MINTiO43617
STRINGi9606.ENSP00000362261

Chemistry databases

DrugBankiDB08231 MYRISTIC ACID
DB03796 Palmitic Acid
DB08342 S-PALMITOYL-L-CYSTEINE

PTM databases

iPTMnetiO43617
PhosphoSitePlusiO43617
SwissPalmiO43617

Proteomic databases

EPDiO43617
MaxQBiO43617
PaxDbiO43617
PeptideAtlasiO43617
PRIDEiO43617
ProteomicsDBi49084
TopDownProteomicsiO43617-1 [O43617-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373162; ENSP00000362256; ENSG00000054116 [O43617-2]
ENST00000373163; ENSP00000362257; ENSG00000054116 [O43617-2]
ENST00000373166; ENSP00000362261; ENSG00000054116 [O43617-1]
ENST00000617904; ENSP00000480648; ENSG00000054116 [O43617-2]
GeneIDi27095
KEGGihsa:27095
UCSCiuc001bzx.5 human [O43617-1]

Organism-specific databases

CTDi27095
EuPathDBiHostDB:ENSG00000054116.11
GeneCardsiTRAPPC3
HGNCiHGNC:19942 TRAPPC3
HPAiHPA028408
MIMi610955 gene
neXtProtiNX_O43617
OpenTargetsiENSG00000054116
PharmGKBiPA134972272
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3330 Eukaryota
ENOG410Z1VV LUCA
GeneTreeiENSGT00390000003880
HOGENOMiHOG000186184
HOVERGENiHBG055045
InParanoidiO43617
KOiK20302
PhylomeDBiO43617
TreeFamiTF300091

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiTRAPPC3 human
EvolutionaryTraceiO43617
GeneWikiiTRAPPC3
GenomeRNAii27095
PROiPR:O43617
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000054116 Expressed in 234 organ(s), highest expression level in testis
CleanExiHS_TRAPPC3
ExpressionAtlasiO43617 baseline and differential
GenevisibleiO43617 HS

Family and domain databases

CDDicd14942 TRAPPC3_bet3, 1 hit
InterProiView protein in InterPro
IPR016721 Bet3
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR007194 TRAPP_component
PANTHERiPTHR13048 PTHR13048, 1 hit
PfamiView protein in Pfam
PF04051 TRAPP, 1 hit
PIRSFiPIRSF018293 TRAPP_I_complex_Bet3, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPPC3_HUMAN
AccessioniPrimary (citable) accession number: O43617
Secondary accession number(s): A6NDN0, B2RDN2, D3DPS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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