Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein sprouty homolog 3

Gene

SPRY3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sprouty homolog 3
Short name:
Spry-3
Gene namesi
Name:SPRY3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000168939.11
HGNCiHGNC:11271 SPRY3
MIMi300531 gene
neXtProtiNX_O43610

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10251
OpenTargetsiENSG00000168939
PharmGKBiPA36100

Polymorphism and mutation databases

BioMutaiSPRY3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769041 – 288Protein sprouty homolog 3Add BLAST288

Proteomic databases

MaxQBiO43610
PaxDbiO43610
PeptideAtlasiO43610
PRIDEiO43610
ProteomicsDBi49079

PTM databases

iPTMnetiO43610
PhosphoSitePlusiO43610

Expressioni

Tissue specificityi

Widely expressed; particularly in the fetal tissues.

Inductioni

By FGF signaling.

Gene expression databases

BgeeiENSG00000168939 Expressed in 95 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_SPRY3
GenevisibleiO43610 HS

Organism-specific databases

HPAiCAB013505

Interactioni

Protein-protein interaction databases

BioGridi115545, 1 interactor
IntActiO43610, 27 interactors
STRINGi9606.ENSP00000302978

Structurei

3D structure databases

ProteinModelPortaliO43610
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 260SPRPROSITE-ProRule annotationAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi147 – 270Cys-richAdd BLAST124

Domaini

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

Sequence similaritiesi

Belongs to the sprouty family.Curated

Phylogenomic databases

eggNOGiENOG410IKW1 Eukaryota
ENOG4111S05 LUCA
GeneTreeiENSGT00390000003535
HOGENOMiHOG000233079
HOVERGENiHBG003544
InParanoidiO43610
KOiK17384
OMAiRANNDYV
OrthoDBiEOG091G0DOQ
PhylomeDBiO43610
TreeFamiTF325070

Family and domain databases

InterProiView protein in InterPro
IPR007875 Sprouty
IPR030786 SPRY3
PANTHERiPTHR12365:SF9 PTHR12365:SF9, 1 hit
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PROSITEiView protein in PROSITE
PS51227 SPR, 1 hit

Sequencei

Sequence statusi: Complete.

O43610-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAAVTDDFQ QILPIEQLRS THASNDYVER PPAPCKQALS SPSLIVQTHK
60 70 80 90 100
SDWSLATMPT SLPRSLSQCH QLQPLPQHLS QSSIASSMSH STTASDQRLL
110 120 130 140 150
ASITPSPSGQ SIIRTQPGAG VHPKADGALK GEAEQSAGHP SEHLFICEEC
160 170 180 190 200
GRCKCVPCTA ARPLPSCWLC NQRCLCSAES LLDYGTCLCC VKGLFYHCST
210 220 230 240 250
DDEDNCADEP CSCGPSSCFV RWAAMSLISL FLPCLCCYLP TRGCLHLCQQ
260 270 280
GYDSLRRPGC RCKRHTNTVC RKISSGSAPF PKAQEKSV
Length:288
Mass (Da):31,222
Last modified:February 21, 2001 - v2
Checksum:i62C59F5E897D99B8
GO

Sequence cautioni

The sequence AAC39567 differs from that shown. Reason: Frameshift at position 96.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93T → P in AAC39567 (PubMed:9458049).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034519161A → T. Corresponds to variant dbSNP:rs35474915Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271735 Genomic DNA Translation: CAB96768.1
AK289543 mRNA Translation: BAF82232.1
CH471247 Genomic DNA Translation: EAW55876.1
BC069609 mRNA Translation: AAH69609.1
BC074972 mRNA Translation: AAH74972.1
BC074973 mRNA Translation: AAH74973.1
AF041038 mRNA Translation: AAC39567.1 Frameshift.
CCDSiCCDS14769.4
RefSeqiNP_001291919.1, NM_001304990.1
NP_005831.1, NM_005840.2
UniGeneiHs.381912

Genome annotation databases

EnsembliENST00000302805; ENSP00000302978; ENSG00000168939
GeneIDi10251
KEGGihsa:10251
UCSCiuc004fnq.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271735 Genomic DNA Translation: CAB96768.1
AK289543 mRNA Translation: BAF82232.1
CH471247 Genomic DNA Translation: EAW55876.1
BC069609 mRNA Translation: AAH69609.1
BC074972 mRNA Translation: AAH74972.1
BC074973 mRNA Translation: AAH74973.1
AF041038 mRNA Translation: AAC39567.1 Frameshift.
CCDSiCCDS14769.4
RefSeqiNP_001291919.1, NM_001304990.1
NP_005831.1, NM_005840.2
UniGeneiHs.381912

3D structure databases

ProteinModelPortaliO43610
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115545, 1 interactor
IntActiO43610, 27 interactors
STRINGi9606.ENSP00000302978

PTM databases

iPTMnetiO43610
PhosphoSitePlusiO43610

Polymorphism and mutation databases

BioMutaiSPRY3

Proteomic databases

MaxQBiO43610
PaxDbiO43610
PeptideAtlasiO43610
PRIDEiO43610
ProteomicsDBi49079

Protocols and materials databases

DNASUi10251
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302805; ENSP00000302978; ENSG00000168939
GeneIDi10251
KEGGihsa:10251
UCSCiuc004fnq.2 human

Organism-specific databases

CTDi10251
DisGeNETi10251
EuPathDBiHostDB:ENSG00000168939.11
GeneCardsiSPRY3
HGNCiHGNC:11271 SPRY3
HPAiCAB013505
MIMi300531 gene
neXtProtiNX_O43610
OpenTargetsiENSG00000168939
PharmGKBiPA36100
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKW1 Eukaryota
ENOG4111S05 LUCA
GeneTreeiENSGT00390000003535
HOGENOMiHOG000233079
HOVERGENiHBG003544
InParanoidiO43610
KOiK17384
OMAiRANNDYV
OrthoDBiEOG091G0DOQ
PhylomeDBiO43610
TreeFamiTF325070

Miscellaneous databases

GeneWikiiSPRY3
GenomeRNAii10251
PROiPR:O43610
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168939 Expressed in 95 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_SPRY3
GenevisibleiO43610 HS

Family and domain databases

InterProiView protein in InterPro
IPR007875 Sprouty
IPR030786 SPRY3
PANTHERiPTHR12365:SF9 PTHR12365:SF9, 1 hit
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PROSITEiView protein in PROSITE
PS51227 SPR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPY3_HUMAN
AccessioniPrimary (citable) accession number: O43610
Secondary accession number(s): A8K0H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again