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Entry version 134 (13 Feb 2019)
Sequence version 2 (21 Feb 2001)
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Protein

Protein sprouty homolog 3

Gene

SPRY3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein sprouty homolog 3
Short name:
Spry-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPRY3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168939.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11271 SPRY3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300531 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43610

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10251

Open Targets

More...
OpenTargetsi
ENSG00000168939

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36100

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPRY3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000769041 – 288Protein sprouty homolog 3Add BLAST288

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43610

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43610

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43610

PeptideAtlas

More...
PeptideAtlasi
O43610

PRoteomics IDEntifications database

More...
PRIDEi
O43610

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49079

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43610

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43610

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed; particularly in the fetal tissues.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By FGF signaling.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168939 Expressed in 95 organ(s), highest expression level in cerebellar hemisphere

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43610 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB013505

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115545, 1 interactor

Protein interaction database and analysis system

More...
IntActi
O43610, 27 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302978

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O43610

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini154 – 260SPRPROSITE-ProRule annotationAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi147 – 270Cys-richAdd BLAST124

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sprouty family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKW1 Eukaryota
ENOG4111S05 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154300

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233079

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003544

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43610

KEGG Orthology (KO)

More...
KOi
K17384

Identification of Orthologs from Complete Genome Data

More...
OMAi
RANNDYV

Database of Orthologous Groups

More...
OrthoDBi
1157681at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43610

TreeFam database of animal gene trees

More...
TreeFami
TF325070

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007875 Sprouty
IPR030786 SPRY3

The PANTHER Classification System

More...
PANTHERi
PTHR12365:SF9 PTHR12365:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05210 Sprouty, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51227 SPR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O43610-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAAVTDDFQ QILPIEQLRS THASNDYVER PPAPCKQALS SPSLIVQTHK
60 70 80 90 100
SDWSLATMPT SLPRSLSQCH QLQPLPQHLS QSSIASSMSH STTASDQRLL
110 120 130 140 150
ASITPSPSGQ SIIRTQPGAG VHPKADGALK GEAEQSAGHP SEHLFICEEC
160 170 180 190 200
GRCKCVPCTA ARPLPSCWLC NQRCLCSAES LLDYGTCLCC VKGLFYHCST
210 220 230 240 250
DDEDNCADEP CSCGPSSCFV RWAAMSLISL FLPCLCCYLP TRGCLHLCQQ
260 270 280
GYDSLRRPGC RCKRHTNTVC RKISSGSAPF PKAQEKSV
Length:288
Mass (Da):31,222
Last modified:February 21, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62C59F5E897D99B8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC39567 differs from that shown. Reason: Frameshift at position 96.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti93T → P in AAC39567 (PubMed:9458049).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034519161A → T. Corresponds to variant dbSNP:rs35474915Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ271735 Genomic DNA Translation: CAB96768.1
AK289543 mRNA Translation: BAF82232.1
CH471247 Genomic DNA Translation: EAW55876.1
BC069609 mRNA Translation: AAH69609.1
BC074972 mRNA Translation: AAH74972.1
BC074973 mRNA Translation: AAH74973.1
AF041038 mRNA Translation: AAC39567.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14769.4

NCBI Reference Sequences

More...
RefSeqi
NP_001291919.1, NM_001304990.1
NP_005831.1, NM_005840.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.381912

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302805; ENSP00000302978; ENSG00000168939

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10251

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10251

UCSC genome browser

More...
UCSCi
uc004fnq.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271735 Genomic DNA Translation: CAB96768.1
AK289543 mRNA Translation: BAF82232.1
CH471247 Genomic DNA Translation: EAW55876.1
BC069609 mRNA Translation: AAH69609.1
BC074972 mRNA Translation: AAH74972.1
BC074973 mRNA Translation: AAH74973.1
AF041038 mRNA Translation: AAC39567.1 Frameshift.
CCDSiCCDS14769.4
RefSeqiNP_001291919.1, NM_001304990.1
NP_005831.1, NM_005840.2
UniGeneiHs.381912

3D structure databases

ProteinModelPortaliO43610
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115545, 1 interactor
IntActiO43610, 27 interactors
STRINGi9606.ENSP00000302978

PTM databases

iPTMnetiO43610
PhosphoSitePlusiO43610

Polymorphism and mutation databases

BioMutaiSPRY3

Proteomic databases

jPOSTiO43610
MaxQBiO43610
PaxDbiO43610
PeptideAtlasiO43610
PRIDEiO43610
ProteomicsDBi49079

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10251
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302805; ENSP00000302978; ENSG00000168939
GeneIDi10251
KEGGihsa:10251
UCSCiuc004fnq.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10251
DisGeNETi10251
EuPathDBiHostDB:ENSG00000168939.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPRY3
HGNCiHGNC:11271 SPRY3
HPAiCAB013505
MIMi300531 gene
neXtProtiNX_O43610
OpenTargetsiENSG00000168939
PharmGKBiPA36100

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKW1 Eukaryota
ENOG4111S05 LUCA
GeneTreeiENSGT00940000154300
HOGENOMiHOG000233079
HOVERGENiHBG003544
InParanoidiO43610
KOiK17384
OMAiRANNDYV
OrthoDBi1157681at2759
PhylomeDBiO43610
TreeFamiTF325070

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SPRY3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10251

Protein Ontology

More...
PROi
PR:O43610

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168939 Expressed in 95 organ(s), highest expression level in cerebellar hemisphere
GenevisibleiO43610 HS

Family and domain databases

InterProiView protein in InterPro
IPR007875 Sprouty
IPR030786 SPRY3
PANTHERiPTHR12365:SF9 PTHR12365:SF9, 1 hit
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PROSITEiView protein in PROSITE
PS51227 SPR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPY3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43610
Secondary accession number(s): A8K0H8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: February 13, 2019
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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