UniProtKB - O43609 (SPY1_HUMAN)
Protein
Protein sprouty homolog 1
Gene
SPRY1
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).By similarity
GO - Biological processi
- animal organ development Source: GO_Central
- bud elongation involved in lung branching Source: Ensembl
- epithelial to mesenchymal transition involved in cardiac fibroblast development Source: BHF-UCL
- establishment of mitotic spindle orientation Source: Ensembl
- metanephros development Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
- negative regulation of epithelial to mesenchymal transition Source: UniProtKB
- negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
- negative regulation of fibroblast growth factor receptor signaling pathway Source: FlyBase
- negative regulation of GTPase activity Source: Ensembl
- negative regulation of lens fiber cell differentiation Source: UniProtKB
- negative regulation of MAP kinase activity Source: GO_Central
- negative regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
- negative regulation of Ras protein signal transduction Source: GO_Central
- negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
- organ induction Source: Ensembl
- ureteric bud development Source: Ensembl
Keywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
PathwayCommonsi | O43609 |
Reactomei | R-HSA-182971, EGFR downregulation |
SIGNORi | O43609 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein sprouty homolog 1Short name: Spry-1 |
Gene namesi | Name:SPRY1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11269, SPRY1 |
MIMi | 602465, gene |
neXtProti | NX_O43609 |
VEuPathDBi | HostDB:ENSG00000164056.10 |
Subcellular locationi
Other locations
Note: Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).
Cytosol
- cytosol Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: Reactome
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10252 |
OpenTargetsi | ENSG00000164056 |
PharmGKBi | PA36098 |
Miscellaneous databases
Pharosi | O43609, Tbio |
Genetic variation databases
BioMutai | SPRY1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076898 | 1 – 319 | Protein sprouty homolog 1Add BLAST | 319 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O43609 |
jPOSTi | O43609 |
MassIVEi | O43609 |
MaxQBi | O43609 |
PaxDbi | O43609 |
PeptideAtlasi | O43609 |
PRIDEi | O43609 |
ProteomicsDBi | 49078 |
PTM databases
iPTMneti | O43609 |
PhosphoSitePlusi | O43609 |
SwissPalmi | O43609 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164056, Expressed in omental fat pad and 231 other tissues |
ExpressionAtlasi | O43609, baseline and differential |
Genevisiblei | O43609, HS |
Organism-specific databases
HPAi | ENSG00000164056, Tissue enhanced (adipose) |
Interactioni
Subunit structurei
Forms heterodimers with SPRY2 (By similarity).
Interacts with TESK1 (By similarity).
Interacts with CAV1 (via C-terminus) (By similarity).
By similarityBinary interactionsi
O43609
Protein-protein interaction databases
BioGRIDi | 115546, 99 interactors |
IntActi | O43609, 86 interactors |
MINTi | O43609 |
STRINGi | 9606.ENSP00000481675 |
Miscellaneous databases
RNActi | O43609, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 183 – 295 | SPRPROSITE-ProRule annotationAdd BLAST | 113 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 181 – 310 | Cys-richAdd BLAST | 130 |
Domaini
The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
Sequence similaritiesi
Belongs to the sprouty family.Curated
Phylogenomic databases
eggNOGi | ENOG502QSDN, Eukaryota |
GeneTreei | ENSGT00950000183055 |
HOGENOMi | CLU_077696_0_0_1 |
InParanoidi | O43609 |
OMAi | PTSHLGH |
OrthoDBi | 1157681at2759 |
PhylomeDBi | O43609 |
TreeFami | TF325070 |
Family and domain databases
InterProi | View protein in InterPro IPR007875, Sprouty IPR030783, SPRY1 |
PANTHERi | PTHR12365:SF10, PTHR12365:SF10, 1 hit |
Pfami | View protein in Pfam PF05210, Sprouty, 1 hit |
PROSITEi | View protein in PROSITE PS51227, SPR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
O43609-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS
60 70 80 90 100
NEYTEGPSVV KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA
110 120 130 140 150
VLPSNARGPI LSRSTSTGSA ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS
160 170 180 190 200
ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI CEQCGKCKCG ECTAPRTLPS
210 220 230 240 250
CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS YSDNPCSCSQ
260 270 280 290 300
SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS
310
NTVYCKLESC PSRGQGKPS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RHD2 | D6RHD2_HUMAN | Protein sprouty homolog 1 | SPRY1 | 209 | Annotation score: | ||
D6REX7 | D6REX7_HUMAN | Protein sprouty homolog 1 | SPRY1 | 67 | Annotation score: | ||
D6RIE6 | D6RIE6_HUMAN | Protein sprouty homolog 1 | SPRY1 | 35 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY192146 mRNA Translation: AAP20102.1 CH471056 Genomic DNA Translation: EAX05209.1 CH471056 Genomic DNA Translation: EAX05210.1 CH471056 Genomic DNA Translation: EAX05211.1 BC063856 mRNA Translation: AAH63856.1 AY590694 mRNA Translation: AAT06102.1 AF041037 mRNA Translation: AAC39566.1 |
CCDSi | CCDS3731.1 |
RefSeqi | NP_001244967.1, NM_001258038.1 NP_001244968.1, NM_001258039.1 NP_005832.1, NM_005841.2 NP_955359.1, NM_199327.2 XP_005262743.1, XM_005262686.1 XP_016863124.1, XM_017007635.1 |
Genome annotation databases
Ensembli | ENST00000339241; ENSP00000343785; ENSG00000164056 ENST00000394339; ENSP00000377871; ENSG00000164056 ENST00000610581; ENSP00000481675; ENSG00000164056 ENST00000622283; ENSP00000480540; ENSG00000164056 ENST00000651917; ENSP00000498292; ENSG00000164056 |
GeneIDi | 10252 |
KEGGi | hsa:10252 |
UCSCi | uc003ifa.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY192146 mRNA Translation: AAP20102.1 CH471056 Genomic DNA Translation: EAX05209.1 CH471056 Genomic DNA Translation: EAX05210.1 CH471056 Genomic DNA Translation: EAX05211.1 BC063856 mRNA Translation: AAH63856.1 AY590694 mRNA Translation: AAT06102.1 AF041037 mRNA Translation: AAC39566.1 |
CCDSi | CCDS3731.1 |
RefSeqi | NP_001244967.1, NM_001258038.1 NP_001244968.1, NM_001258039.1 NP_005832.1, NM_005841.2 NP_955359.1, NM_199327.2 XP_005262743.1, XM_005262686.1 XP_016863124.1, XM_017007635.1 |
3D structure databases
SMRi | O43609 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115546, 99 interactors |
IntActi | O43609, 86 interactors |
MINTi | O43609 |
STRINGi | 9606.ENSP00000481675 |
PTM databases
iPTMneti | O43609 |
PhosphoSitePlusi | O43609 |
SwissPalmi | O43609 |
Genetic variation databases
BioMutai | SPRY1 |
Proteomic databases
EPDi | O43609 |
jPOSTi | O43609 |
MassIVEi | O43609 |
MaxQBi | O43609 |
PaxDbi | O43609 |
PeptideAtlasi | O43609 |
PRIDEi | O43609 |
ProteomicsDBi | 49078 |
Protocols and materials databases
Antibodypediai | 26880, 265 antibodies |
DNASUi | 10252 |
Genome annotation databases
Ensembli | ENST00000339241; ENSP00000343785; ENSG00000164056 ENST00000394339; ENSP00000377871; ENSG00000164056 ENST00000610581; ENSP00000481675; ENSG00000164056 ENST00000622283; ENSP00000480540; ENSG00000164056 ENST00000651917; ENSP00000498292; ENSG00000164056 |
GeneIDi | 10252 |
KEGGi | hsa:10252 |
UCSCi | uc003ifa.5, human |
Organism-specific databases
CTDi | 10252 |
DisGeNETi | 10252 |
GeneCardsi | SPRY1 |
HGNCi | HGNC:11269, SPRY1 |
HPAi | ENSG00000164056, Tissue enhanced (adipose) |
MIMi | 602465, gene |
neXtProti | NX_O43609 |
OpenTargetsi | ENSG00000164056 |
PharmGKBi | PA36098 |
VEuPathDBi | HostDB:ENSG00000164056.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSDN, Eukaryota |
GeneTreei | ENSGT00950000183055 |
HOGENOMi | CLU_077696_0_0_1 |
InParanoidi | O43609 |
OMAi | PTSHLGH |
OrthoDBi | 1157681at2759 |
PhylomeDBi | O43609 |
TreeFami | TF325070 |
Enzyme and pathway databases
PathwayCommonsi | O43609 |
Reactomei | R-HSA-182971, EGFR downregulation |
SIGNORi | O43609 |
Miscellaneous databases
BioGRID-ORCSi | 10252, 3 hits in 871 CRISPR screens |
ChiTaRSi | SPRY1, human |
GeneWikii | SPRY1 |
GenomeRNAii | 10252 |
Pharosi | O43609, Tbio |
PROi | PR:O43609 |
RNActi | O43609, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164056, Expressed in omental fat pad and 231 other tissues |
ExpressionAtlasi | O43609, baseline and differential |
Genevisiblei | O43609, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007875, Sprouty IPR030783, SPRY1 |
PANTHERi | PTHR12365:SF10, PTHR12365:SF10, 1 hit |
Pfami | View protein in Pfam PF05210, Sprouty, 1 hit |
PROSITEi | View protein in PROSITE PS51227, SPR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPY1_HUMAN | |
Accessioni | O43609Primary (citable) accession number: O43609 Secondary accession number(s): D3DNX6, Q6PNE0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | May 10, 2004 | |
Last modified: | February 10, 2021 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM