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UniProtKB - O43609 (SPY1_HUMAN)

Protein

Protein sprouty homolog 1

Gene

SPRY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-182971 EGFR downregulation

SIGNOR Signaling Network Open Resource

More...SIGNORi		O43609

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein sprouty homolog 1
Short name:
Spry-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPRY1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000164056.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:11269 SPRY1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602465 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43609

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10252

Open Targets

More...OpenTargetsi		ENSG00000164056

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36098

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPRY1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000768981 – 319Protein sprouty homolog 1Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43609

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43609

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43609

PeptideAtlas

More...PeptideAtlasi		O43609

PRoteomics IDEntifications database

More...PRIDEi		O43609

ProteomicsDB human proteome resource

More...ProteomicsDBi		49078

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43609

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43609

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O43609

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By FGF signaling.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164056 Expressed in 219 organ(s), highest expression level in omental fat pad

CleanEx database of gene expression profiles

More...CleanExi		HS_SPRY1

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43609 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43609 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB013538
HPA051369
HPA070554

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		115546, 38 interactors

Protein interaction database and analysis system

More...IntActi		O43609, 84 interactors

Molecular INTeraction database

More...MINTi		O43609

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000343785

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O43609

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43609

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini183 – 295SPRPROSITE-ProRule annotationAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi181 – 310Cys-richAdd BLAST130

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sprouty family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IJJB Eukaryota
ENOG410Z8F4 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154233

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000233079

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG003544

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43609

KEGG Orthology (KO)

More...KOi		K04704

Identification of Orthologs from Complete Genome Data

More...OMAi		NNYEHRP

Database of Orthologous Groups

More...OrthoDBi		1157681at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43609

TreeFam database of animal gene trees

More...TreeFami		TF325070

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007875 Sprouty
IPR030783 SPRY1

The PANTHER Classification System

More...PANTHERi		PTHR12365:SF10 PTHR12365:SF10, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05210 Sprouty, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51227 SPR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O43609-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS 
        60         70         80         90        100
NEYTEGPSVV KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA 
       110        120        130        140        150
VLPSNARGPI LSRSTSTGSA ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS 
       160        170        180        190        200
ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI CEQCGKCKCG ECTAPRTLPS 
       210        220        230        240        250
CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS YSDNPCSCSQ 
       260        270        280        290        300
SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS 
       310 
NTVYCKLESC PSRGQGKPS
Length:319
Mass (Da):35,122
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40E2D4D12816E057
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHD2D6RHD2_HUMAN
Protein sprouty homolog 1
SPRY1
209Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REX7D6REX7_HUMAN
Protein sprouty homolog 1
SPRY1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIE6D6RIE6_HUMAN
Protein sprouty homolog 1
SPRY1
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY192146 mRNA Translation: AAP20102.1
CH471056 Genomic DNA Translation: EAX05209.1
CH471056 Genomic DNA Translation: EAX05210.1
CH471056 Genomic DNA Translation: EAX05211.1
BC063856 mRNA Translation: AAH63856.1
AY590694 mRNA Translation: AAT06102.1
AF041037 mRNA Translation: AAC39566.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3731.1

NCBI Reference Sequences

More...RefSeqi		NP_001244967.1, NM_001258038.1
NP_001244968.1, NM_001258039.1
NP_005832.1, NM_005841.2
NP_955359.1, NM_199327.2
XP_005262743.1, XM_005262686.1
XP_016863124.1, XM_017007635.1

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.744854

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339241; ENSP00000343785; ENSG00000164056
ENST00000394339; ENSP00000377871; ENSG00000164056
ENST00000610581; ENSP00000481675; ENSG00000164056
ENST00000622283; ENSP00000480540; ENSG00000164056

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10252

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10252

UCSC genome browser

More...UCSCi		uc003ifa.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY192146 mRNA Translation: AAP20102.1
CH471056 Genomic DNA Translation: EAX05209.1
CH471056 Genomic DNA Translation: EAX05210.1
CH471056 Genomic DNA Translation: EAX05211.1
BC063856 mRNA Translation: AAH63856.1
AY590694 mRNA Translation: AAT06102.1
AF041037 mRNA Translation: AAC39566.1
CCDSiCCDS3731.1
RefSeqiNP_001244967.1, NM_001258038.1
NP_001244968.1, NM_001258039.1
NP_005832.1, NM_005841.2
NP_955359.1, NM_199327.2
XP_005262743.1, XM_005262686.1
XP_016863124.1, XM_017007635.1
UniGeneiHs.744854

3D structure databases

ProteinModelPortaliO43609
SMRiO43609
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115546, 38 interactors
IntActiO43609, 84 interactors
MINTiO43609
STRINGi9606.ENSP00000343785

PTM databases

iPTMnetiO43609
PhosphoSitePlusiO43609
SwissPalmiO43609

Polymorphism and mutation databases

BioMutaiSPRY1

Proteomic databases

EPDiO43609
MaxQBiO43609
PaxDbiO43609
PeptideAtlasiO43609
PRIDEiO43609
ProteomicsDBi49078

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		10252
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339241; ENSP00000343785; ENSG00000164056
ENST00000394339; ENSP00000377871; ENSG00000164056
ENST00000610581; ENSP00000481675; ENSG00000164056
ENST00000622283; ENSP00000480540; ENSG00000164056
GeneIDi10252
KEGGihsa:10252
UCSCiuc003ifa.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10252
DisGeNETi10252
EuPathDBiHostDB:ENSG00000164056.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPRY1
HGNCiHGNC:11269 SPRY1
HPAiCAB013538
HPA051369
HPA070554
MIMi602465 gene
neXtProtiNX_O43609
OpenTargetsiENSG00000164056
PharmGKBiPA36098

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IJJB Eukaryota
ENOG410Z8F4 LUCA
GeneTreeiENSGT00940000154233
HOGENOMiHOG000233079
HOVERGENiHBG003544
InParanoidiO43609
KOiK04704
OMAiNNYEHRP
OrthoDBi1157681at2759
PhylomeDBiO43609
TreeFamiTF325070

Enzyme and pathway databases

ReactomeiR-HSA-182971 EGFR downregulation
SIGNORiO43609

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPRY1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SPRY1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10252

Protein Ontology

More...PROi		PR:O43609

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000164056 Expressed in 219 organ(s), highest expression level in omental fat pad
CleanExiHS_SPRY1
ExpressionAtlasiO43609 baseline and differential
GenevisibleiO43609 HS

Family and domain databases

InterProiView protein in InterPro
IPR007875 Sprouty
IPR030783 SPRY1
PANTHERiPTHR12365:SF10 PTHR12365:SF10, 1 hit
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PROSITEiView protein in PROSITE
PS51227 SPR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPY1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43609
Secondary accession number(s): D3DNX6, Q6PNE0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 10, 2004
Last modified: January 16, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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