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Protein

Protein sprouty homolog 1

Gene

SPRY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

ReactomeiR-HSA-182971 EGFR downregulation
SIGNORiO43609

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sprouty homolog 1
Short name:
Spry-1
Gene namesi
Name:SPRY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164056.10
HGNCiHGNC:11269 SPRY1
MIMi602465 gene
neXtProtiNX_O43609

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10252
OpenTargetsiENSG00000164056
PharmGKBiPA36098

Polymorphism and mutation databases

BioMutaiSPRY1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000768981 – 319Protein sprouty homolog 1Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO43609
MaxQBiO43609
PaxDbiO43609
PeptideAtlasiO43609
PRIDEiO43609
ProteomicsDBi49078

PTM databases

iPTMnetiO43609
PhosphoSitePlusiO43609
SwissPalmiO43609

Expressioni

Inductioni

By FGF signaling.

Gene expression databases

BgeeiENSG00000164056 Expressed in 219 organ(s), highest expression level in omental fat pad
CleanExiHS_SPRY1
ExpressionAtlasiO43609 baseline and differential
GenevisibleiO43609 HS

Organism-specific databases

HPAiCAB013538
HPA051369
HPA070554

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi115546, 38 interactors
IntActiO43609, 84 interactors
MINTiO43609
STRINGi9606.ENSP00000343785

Structurei

3D structure databases

ProteinModelPortaliO43609
SMRiO43609
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 295SPRPROSITE-ProRule annotationAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 310Cys-richAdd BLAST130

Domaini

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

Sequence similaritiesi

Belongs to the sprouty family.Curated

Phylogenomic databases

eggNOGiENOG410IJJB Eukaryota
ENOG410Z8F4 LUCA
GeneTreeiENSGT00390000003535
HOGENOMiHOG000233079
HOVERGENiHBG003544
InParanoidiO43609
KOiK04704
OMAiNNYEHRP
OrthoDBiEOG091G0DOQ
PhylomeDBiO43609
TreeFamiTF325070

Family and domain databases

InterProiView protein in InterPro
IPR007875 Sprouty
IPR030783 SPRY1
PANTHERiPTHR12365:SF10 PTHR12365:SF10, 1 hit
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PROSITEiView protein in PROSITE
PS51227 SPR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O43609-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS
60 70 80 90 100
NEYTEGPSVV KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA
110 120 130 140 150
VLPSNARGPI LSRSTSTGSA ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS
160 170 180 190 200
ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI CEQCGKCKCG ECTAPRTLPS
210 220 230 240 250
CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS YSDNPCSCSQ
260 270 280 290 300
SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS
310
NTVYCKLESC PSRGQGKPS
Length:319
Mass (Da):35,122
Last modified:May 10, 2004 - v2
Checksum:i40E2D4D12816E057
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHD2D6RHD2_HUMAN
Protein sprouty homolog 1
SPRY1
209Annotation score:
D6REX7D6REX7_HUMAN
Protein sprouty homolog 1
SPRY1
67Annotation score:
D6RIE6D6RIE6_HUMAN
Protein sprouty homolog 1
SPRY1
35Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY192146 mRNA Translation: AAP20102.1
CH471056 Genomic DNA Translation: EAX05209.1
CH471056 Genomic DNA Translation: EAX05210.1
CH471056 Genomic DNA Translation: EAX05211.1
BC063856 mRNA Translation: AAH63856.1
AY590694 mRNA Translation: AAT06102.1
AF041037 mRNA Translation: AAC39566.1
CCDSiCCDS3731.1
RefSeqiNP_001244967.1, NM_001258038.1
NP_001244968.1, NM_001258039.1
NP_005832.1, NM_005841.2
NP_955359.1, NM_199327.2
XP_005262743.1, XM_005262686.1
XP_016863124.1, XM_017007635.1
UniGeneiHs.744854

Genome annotation databases

EnsembliENST00000339241; ENSP00000343785; ENSG00000164056
ENST00000394339; ENSP00000377871; ENSG00000164056
ENST00000610581; ENSP00000481675; ENSG00000164056
ENST00000622283; ENSP00000480540; ENSG00000164056
GeneIDi10252
KEGGihsa:10252
UCSCiuc003ifa.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY192146 mRNA Translation: AAP20102.1
CH471056 Genomic DNA Translation: EAX05209.1
CH471056 Genomic DNA Translation: EAX05210.1
CH471056 Genomic DNA Translation: EAX05211.1
BC063856 mRNA Translation: AAH63856.1
AY590694 mRNA Translation: AAT06102.1
AF041037 mRNA Translation: AAC39566.1
CCDSiCCDS3731.1
RefSeqiNP_001244967.1, NM_001258038.1
NP_001244968.1, NM_001258039.1
NP_005832.1, NM_005841.2
NP_955359.1, NM_199327.2
XP_005262743.1, XM_005262686.1
XP_016863124.1, XM_017007635.1
UniGeneiHs.744854

3D structure databases

ProteinModelPortaliO43609
SMRiO43609
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115546, 38 interactors
IntActiO43609, 84 interactors
MINTiO43609
STRINGi9606.ENSP00000343785

PTM databases

iPTMnetiO43609
PhosphoSitePlusiO43609
SwissPalmiO43609

Polymorphism and mutation databases

BioMutaiSPRY1

Proteomic databases

EPDiO43609
MaxQBiO43609
PaxDbiO43609
PeptideAtlasiO43609
PRIDEiO43609
ProteomicsDBi49078

Protocols and materials databases

DNASUi10252
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339241; ENSP00000343785; ENSG00000164056
ENST00000394339; ENSP00000377871; ENSG00000164056
ENST00000610581; ENSP00000481675; ENSG00000164056
ENST00000622283; ENSP00000480540; ENSG00000164056
GeneIDi10252
KEGGihsa:10252
UCSCiuc003ifa.5 human

Organism-specific databases

CTDi10252
DisGeNETi10252
EuPathDBiHostDB:ENSG00000164056.10
GeneCardsiSPRY1
HGNCiHGNC:11269 SPRY1
HPAiCAB013538
HPA051369
HPA070554
MIMi602465 gene
neXtProtiNX_O43609
OpenTargetsiENSG00000164056
PharmGKBiPA36098
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJJB Eukaryota
ENOG410Z8F4 LUCA
GeneTreeiENSGT00390000003535
HOGENOMiHOG000233079
HOVERGENiHBG003544
InParanoidiO43609
KOiK04704
OMAiNNYEHRP
OrthoDBiEOG091G0DOQ
PhylomeDBiO43609
TreeFamiTF325070

Enzyme and pathway databases

ReactomeiR-HSA-182971 EGFR downregulation
SIGNORiO43609

Miscellaneous databases

ChiTaRSiSPRY1 human
GeneWikiiSPRY1
GenomeRNAii10252
PROiPR:O43609
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164056 Expressed in 219 organ(s), highest expression level in omental fat pad
CleanExiHS_SPRY1
ExpressionAtlasiO43609 baseline and differential
GenevisibleiO43609 HS

Family and domain databases

InterProiView protein in InterPro
IPR007875 Sprouty
IPR030783 SPRY1
PANTHERiPTHR12365:SF10 PTHR12365:SF10, 1 hit
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PROSITEiView protein in PROSITE
PS51227 SPR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPY1_HUMAN
AccessioniPrimary (citable) accession number: O43609
Secondary accession number(s): D3DNX6, Q6PNE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 10, 2004
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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