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Protein

Galanin receptor type 2

Gene

GALR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).6 Publications

GO - Molecular functioni

  • galanin receptor activity Source: UniProtKB
  • G protein-coupled peptide receptor activity Source: GO_Central
  • neuropeptide binding Source: Ensembl
  • peptide hormone binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiO43603

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 2
Short name:
GAL2-R
Short name:
GALR-2
Gene namesi
Name:GALR2
Synonyms:GALNR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000182687.3
HGNCiHGNC:4133 GALR2
MIMi603691 gene
neXtProtiNX_O43603

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 60CytoplasmicSequence analysisAdd BLAST11
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 99ExtracellularSequence analysisAdd BLAST18
Transmembranei100 – 121Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini122 – 141CytoplasmicSequence analysisAdd BLAST20
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 187ExtracellularSequence analysisAdd BLAST25
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 237CytoplasmicSequence analysisAdd BLAST29
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 260ExtracellularSequence analysis2
Transmembranei261 – 281Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini282 – 387CytoplasmicSequence analysisAdd BLAST106

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8811
OpenTargetsiENSG00000182687
PharmGKBiPA28546

Chemistry databases

ChEMBLiCHEMBL3176
GuidetoPHARMACOLOGYi244

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694661 – 387Galanin receptor type 2Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO43603
PeptideAtlasiO43603
PRIDEiO43603
ProteomicsDBi49077

PTM databases

iPTMnetiO43603
PhosphoSitePlusiO43603

Expressioni

Tissue specificityi

Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.

Gene expression databases

BgeeiENSG00000182687 Expressed in 43 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExiHS_GALR2
GenevisibleiO43603 HS

Organism-specific databases

HPAiHPA044513

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GALP224662EBI-6624855,EBI-6624800

Protein-protein interaction databases

IntActiO43603, 2 interactors
STRINGi9606.ENSP00000329684

Chemistry databases

BindingDBiO43603

Structurei

3D structure databases

ProteinModelPortaliO43603
SMRiO43603
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150908
HOGENOMiHOG000230487
HOVERGENiHBG101447
InParanoidiO43603
KOiK04231
OMAiFRKICAG
OrthoDBiEOG091G0ZDG
PhylomeDBiO43603
TreeFamiTF315737

Family and domain databases

InterProiView protein in InterPro
IPR003907 GAL2_rcpt
IPR000405 Galanin_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01419 GALANIN2R
PR00663 GALANINR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O43603-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVSGCPGAG NASQAGGGGG WHPEAVIVPL LFALIFLVGT VGNTLVLAVL
60 70 80 90 100
LRGGQAVSTT NLFILNLGVA DLCFILCCVP FQATIYTLDG WVFGSLLCKA
110 120 130 140 150
VHFLIFLTMH ASSFTLAAVS LDRYLAIRYP LHSRELRTPR NALAAIGLIW
160 170 180 190 200
GLSLLFSGPY LSYYRQSQLA NLTVCHPAWS APRRRAMDIC TFVFSYLLPV
210 220 230 240 250
LVLGLTYART LRYLWRAVDP VAAGSGARRA KRKVTRMILI VAALFCLCWM
260 270 280 290 300
PHHALILCVW FGQFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR
310 320 330 340 350
KGFRTICAGL LGRAPGRASG RVCAAARGTH SGSVLERESS DLLHMSEAAG
360 370 380
ALRPCPGASQ PCILEPCPGP SWQGPKAGDS ILTVDVA
Length:387
Mass (Da):41,700
Last modified:June 1, 1998 - v1
Checksum:iC2D2FCB93E53C47E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040630 mRNA Translation: AAC39634.1
AF080586 mRNA Translation: AAD08671.1
AF058762 Genomic DNA Translation: AAC18118.1
AF042782 Genomic DNA Translation: AAC36587.1
EF577401 mRNA Translation: ABQ52421.1
CH471099 Genomic DNA Translation: EAW89364.1
BC069130 mRNA Translation: AAH69130.1
BC074914 mRNA Translation: AAH74914.1
BC074915 mRNA Translation: AAH74915.1
BC109051 mRNA Translation: AAI09052.1
BC109052 mRNA Translation: AAI09053.1
CCDSiCCDS11739.1
PIRiJC5949
RefSeqiNP_003848.1, NM_003857.3
UniGeneiHs.666366

Genome annotation databases

EnsembliENST00000329003; ENSP00000329684; ENSG00000182687
GeneIDi8811
KEGGihsa:8811
UCSCiuc002jqm.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040630 mRNA Translation: AAC39634.1
AF080586 mRNA Translation: AAD08671.1
AF058762 Genomic DNA Translation: AAC18118.1
AF042782 Genomic DNA Translation: AAC36587.1
EF577401 mRNA Translation: ABQ52421.1
CH471099 Genomic DNA Translation: EAW89364.1
BC069130 mRNA Translation: AAH69130.1
BC074914 mRNA Translation: AAH74914.1
BC074915 mRNA Translation: AAH74915.1
BC109051 mRNA Translation: AAI09052.1
BC109052 mRNA Translation: AAI09053.1
CCDSiCCDS11739.1
PIRiJC5949
RefSeqiNP_003848.1, NM_003857.3
UniGeneiHs.666366

3D structure databases

ProteinModelPortaliO43603
SMRiO43603
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO43603, 2 interactors
STRINGi9606.ENSP00000329684

Chemistry databases

BindingDBiO43603
ChEMBLiCHEMBL3176
GuidetoPHARMACOLOGYi244

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO43603
PhosphoSitePlusiO43603

Proteomic databases

PaxDbiO43603
PeptideAtlasiO43603
PRIDEiO43603
ProteomicsDBi49077

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329003; ENSP00000329684; ENSG00000182687
GeneIDi8811
KEGGihsa:8811
UCSCiuc002jqm.3 human

Organism-specific databases

CTDi8811
DisGeNETi8811
EuPathDBiHostDB:ENSG00000182687.3
GeneCardsiGALR2
HGNCiHGNC:4133 GALR2
HPAiHPA044513
MIMi603691 gene
neXtProtiNX_O43603
OpenTargetsiENSG00000182687
PharmGKBiPA28546
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150908
HOGENOMiHOG000230487
HOVERGENiHBG101447
InParanoidiO43603
KOiK04231
OMAiFRKICAG
OrthoDBiEOG091G0ZDG
PhylomeDBiO43603
TreeFamiTF315737

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiO43603

Miscellaneous databases

GeneWikiiGalanin_receptor_2
GenomeRNAii8811
PROiPR:O43603
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182687 Expressed in 43 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExiHS_GALR2
GenevisibleiO43603 HS

Family and domain databases

InterProiView protein in InterPro
IPR003907 GAL2_rcpt
IPR000405 Galanin_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01419 GALANIN2R
PR00663 GALANINR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGALR2_HUMAN
AccessioniPrimary (citable) accession number: O43603
Secondary accession number(s): A5JUU4, Q32MN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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