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Protein

Protein sprouty homolog 2

Gene

SPRY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase binding Source: BHF-UCL
  • protein serine/threonine kinase activator activity Source: UniProtKB
  • protein serine/threonine kinase inhibitor activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1295596 Spry regulation of FGF signaling
R-HSA-182971 EGFR downregulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
O43597

SIGNOR Signaling Network Open Resource

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SIGNORi
O43597

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein sprouty homolog 2
Short name:
Spry-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPRY2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000136158.10

Human Gene Nomenclature Database

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HGNCi
HGNC:11270 SPRY2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602466 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O43597

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

IgA nephropathy 3 (IGAN3)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA form of IgA nephropathy, a common primary glomerulonephritis characterized by glomerular sclerosis, interstitial fibrosis, and mesangial glomerular deposits of immunoglobulin A and immunoglobulin G visible on renal biopsies. IgA nephropathy is associated with renal insufficiency that can progress to end-stage renal disease. Proteinuria and hematuria are characteristic clinical presentations.
See also OMIM:616818
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076288119R → W in IGAN3; no effect on protein expression; negatively regulates ERK1 and ERK2 cascade. 1 PublicationCorresponds to variant dbSNP:rs869025336EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi144P → L: Inhibits cleavage by the prolyl endopeptidase FAP. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
10253

MalaCards human disease database

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MalaCardsi
SPRY2
MIMi616818 phenotype

Open Targets

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OpenTargetsi
ENSG00000136158

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36099

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPRY2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000769011 – 315Protein sprouty homolog 2Add BLAST315

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei144 – 145Cleavage; by FAP1 Publication2

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O43597

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O43597

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O43597

PeptideAtlas

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PeptideAtlasi
O43597

PRoteomics IDEntifications database

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PRIDEi
O43597

ProteomicsDB human proteome resource

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ProteomicsDBi
49069

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O43597

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O43597

SwissPalm database of S-palmitoylation events

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SwissPalmi
O43597

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By FGF signaling.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000136158 Expressed in 224 organ(s), highest expression level in cerebellum

CleanEx database of gene expression profiles

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CleanExi
HS_SPRY2

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43597 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB037205
HPA042198

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAF1 (PubMed:12717443). Part of a tripartite complex containing GAB1, METTL13 and SPRY2 (PubMed:29408807). Interacts with METTL13 (PubMed:29408807).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q5JPT63EBI-742487,EBI-10244213
AQP1P299723EBI-742487,EBI-745213
ATRIPQ8WXE13EBI-742487,EBI-747353
CATSPER1Q8NEC53EBI-742487,EBI-744545
CBLP2268117EBI-742487,EBI-518228
CHRDQ9H2X03EBI-742487,EBI-947551
CHRNGP07510-23EBI-742487,EBI-11979451
CREB5Q02930-33EBI-742487,EBI-10192698
EIF4E2O605733EBI-742487,EBI-398610
FAIMQ9NVQ43EBI-742487,EBI-10314711
FRS3O435593EBI-742487,EBI-725515
GNEQ9Y2233EBI-742487,EBI-4291090
GP9P147703EBI-742487,EBI-1754109
GRAP2O757913EBI-742487,EBI-740418
GRB2P629933EBI-742487,EBI-401755
GRNP287993EBI-742487,EBI-747754
HEXIM2Q96MH23EBI-742487,EBI-5460660
HSD3B7Q9H2F33EBI-742487,EBI-3918847
KRTAP10-11P604123EBI-742487,EBI-10217483
KRTAP10-5P603703EBI-742487,EBI-10172150
KRTAP10-8P604103EBI-742487,EBI-10171774
KRTAP10-9P604113EBI-742487,EBI-10172052
KRTAP4-11Q9BYQ63EBI-742487,EBI-10302392
KRTAP4-12Q9BQ664EBI-742487,EBI-739863
KRTAP4-7Q9BYR03EBI-742487,EBI-10302547
KRTAP5-6Q6L8G93EBI-742487,EBI-10250562
KRTAP5-9P263713EBI-742487,EBI-3958099
KRTAP9-2Q9BYQ43EBI-742487,EBI-1044640
KRTAP9-4Q9BYQ23EBI-742487,EBI-10185730
LASP1Q148473EBI-742487,EBI-742828
LCE1BQ5T7P33EBI-742487,EBI-10245913
LCE2DQ5TA823EBI-742487,EBI-10246750
LCE3CQ5T5A83EBI-742487,EBI-10245291
LCE3EQ5T5B03EBI-742487,EBI-10245456
LCE4AQ5TA783EBI-742487,EBI-10246358
LONRF1Q17RB83EBI-742487,EBI-2341787
MAPKBP1O603363EBI-742487,EBI-947402
MDFIQ997503EBI-742487,EBI-724076
MEOX2P502223EBI-742487,EBI-748397
MID2Q9UJV3-23EBI-742487,EBI-10172526
MLLT6Q6P2C63EBI-742487,EBI-5773143
NCK2O436393EBI-742487,EBI-713635
OTX1P322424EBI-742487,EBI-740446
PACSIN3Q9UKS63EBI-742487,EBI-77926
PRKAB2O437413EBI-742487,EBI-1053424
PTGER3P43115-123EBI-742487,EBI-10234038
RUNX1T1Q06455-43EBI-742487,EBI-10224192
RYDENQ9NUL53EBI-742487,EBI-10313866
SH3KBP1Q96B972EBI-742487,EBI-346595
SPRY1O436093EBI-742487,EBI-3866665
STK16O757163EBI-742487,EBI-749295
TCAF1Q9Y4C23EBI-742487,EBI-750484
TXNDC5Q86UY03EBI-742487,EBI-2825190
UBASH3AP570754EBI-742487,EBI-2105393
UBASH3BQ8TF423EBI-742487,EBI-1380492
USP20Q9Y2K63EBI-742487,EBI-2511991
ZDHHC17Q8IUH53EBI-742487,EBI-524753
ZNF417Q8TAU33EBI-742487,EBI-740727
ZNF587Q96SQ53EBI-742487,EBI-6427977

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115547, 130 interactors

Protein interaction database and analysis system

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IntActi
O43597, 82 interactors

Molecular INTeraction database

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MINTi
O43597

STRING: functional protein association networks

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STRINGi
9606.ENSP00000366306

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1315
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BUMX-ray2.00A49-61[»]
3OB1X-ray2.20A49-60[»]
5HKYX-ray1.80B36-60[»]
5HKZX-ray1.80B36-60[»]
5HL0X-ray2.20B54-60[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O43597

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43597

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O43597

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini177 – 291SPRPROSITE-ProRule annotationAdd BLAST115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi125 – 131Poly-Ser7
Compositional biasi178 – 301Cys-richAdd BLAST124

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sprouty family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHQY Eukaryota
ENOG4111S05 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154233

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG003544

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43597

KEGG Orthology (KO)

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KOi
K17383

Identification of Orthologs from Complete Genome Data

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OMAi
ECTYPRT

Database of Orthologous Groups

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OrthoDBi
1157681at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O43597

TreeFam database of animal gene trees

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TreeFami
TF325070

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007875 Sprouty
IPR030780 SPRY2

The PANTHER Classification System

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PANTHERi
PTHR12365:SF8 PTHR12365:SF8, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05210 Sprouty, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51227 SPR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O43597-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEARAQSGNG SQPLLQTPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR
60 70 80 90 100
NTNEYTEGPT VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQHSQVH
110 120 130 140 150
SSARAPLSRS ISTVSSGSRS STRTSTSSSS SEQRLLGSSF SSGPVADGII
160 170 180 190 200
RVQPKSELKP GELKPLSKED LGLHAYRCED CGKCKCKECT YPRPLPSDWI
210 220 230 240 250
CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN PCSCSQSHCC
260 270 280 290 300
TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC
310
CKVPTVPPRN FEKPT
Length:315
Mass (Da):34,688
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CC6256929D91A7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48A → V in BAG36546 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024647106P → S. Corresponds to variant dbSNP:rs504122Ensembl.1
Natural variantiVAR_076288119R → W in IGAN3; no effect on protein expression; negatively regulates ERK1 and ERK2 cascade. 1 PublicationCorresponds to variant dbSNP:rs869025336EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF039843 mRNA Translation: AAC04258.1
AL713749 mRNA Translation: CAD28524.1
AK313810 mRNA Translation: BAG36546.1
AL354668 Genomic DNA No translation available.
BC015745 mRNA Translation: AAH15745.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9463.1

NCBI Reference Sequences

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RefSeqi
NP_001305465.1, NM_001318536.1
NP_001305466.1, NM_001318537.1
NP_001305467.1, NM_001318538.1
NP_005833.1, NM_005842.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.18676

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000377102; ENSP00000366306; ENSG00000136158
ENST00000377104; ENSP00000366308; ENSG00000136158

Database of genes from NCBI RefSeq genomes

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GeneIDi
10253

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10253

UCSC genome browser

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UCSCi
uc001vli.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039843 mRNA Translation: AAC04258.1
AL713749 mRNA Translation: CAD28524.1
AK313810 mRNA Translation: BAG36546.1
AL354668 Genomic DNA No translation available.
BC015745 mRNA Translation: AAH15745.1
CCDSiCCDS9463.1
RefSeqiNP_001305465.1, NM_001318536.1
NP_001305466.1, NM_001318537.1
NP_001305467.1, NM_001318538.1
NP_005833.1, NM_005842.3
UniGeneiHs.18676

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BUMX-ray2.00A49-61[»]
3OB1X-ray2.20A49-60[»]
5HKYX-ray1.80B36-60[»]
5HKZX-ray1.80B36-60[»]
5HL0X-ray2.20B54-60[»]
ProteinModelPortaliO43597
SMRiO43597
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115547, 130 interactors
IntActiO43597, 82 interactors
MINTiO43597
STRINGi9606.ENSP00000366306

PTM databases

iPTMnetiO43597
PhosphoSitePlusiO43597
SwissPalmiO43597

Polymorphism and mutation databases

BioMutaiSPRY2

Proteomic databases

EPDiO43597
jPOSTiO43597
PaxDbiO43597
PeptideAtlasiO43597
PRIDEiO43597
ProteomicsDBi49069

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10253
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377102; ENSP00000366306; ENSG00000136158
ENST00000377104; ENSP00000366308; ENSG00000136158
GeneIDi10253
KEGGihsa:10253
UCSCiuc001vli.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10253
DisGeNETi10253
EuPathDBiHostDB:ENSG00000136158.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPRY2
HGNCiHGNC:11270 SPRY2
HPAiCAB037205
HPA042198
MalaCardsiSPRY2
MIMi602466 gene
616818 phenotype
neXtProtiNX_O43597
OpenTargetsiENSG00000136158
PharmGKBiPA36099

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHQY Eukaryota
ENOG4111S05 LUCA
GeneTreeiENSGT00940000154233
HOVERGENiHBG003544
InParanoidiO43597
KOiK17383
OMAiECTYPRT
OrthoDBi1157681at2759
PhylomeDBiO43597
TreeFamiTF325070

Enzyme and pathway databases

ReactomeiR-HSA-1295596 Spry regulation of FGF signaling
R-HSA-182971 EGFR downregulation
SignaLinkiO43597
SIGNORiO43597

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPRY2 human
EvolutionaryTraceiO43597

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SPRY2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10253

Protein Ontology

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PROi
PR:O43597

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136158 Expressed in 224 organ(s), highest expression level in cerebellum
CleanExiHS_SPRY2
GenevisibleiO43597 HS

Family and domain databases

InterProiView protein in InterPro
IPR007875 Sprouty
IPR030780 SPRY2
PANTHERiPTHR12365:SF8 PTHR12365:SF8, 1 hit
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PROSITEiView protein in PROSITE
PS51227 SPR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPY2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43597
Secondary accession number(s): B2R9J9, Q5T6Z7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 1998
Last modified: January 16, 2019
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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