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UniProtKB - O43592 (XPOT_HUMAN)

Entry version 178 (23 Feb 2022)
Sequence version 2 (30 May 2006)
Previous versions | rss
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Protein

Exportin-T

Gene

XPOT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding, tRNA-binding
Biological processTransport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O43592

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6784531, tRNA processing in the nucleus

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O43592

SIGNOR Signaling Network Open Resource

More...SIGNORi		O43592

Protein family/group databases

Transport Classification Database

More...TCDBi		1.I.1.1.3, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exportin-T
Alternative name(s):
Exportin(tRNA)
tRNA exportin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XPOT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12826, XPOT

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603180, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O43592

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000184575

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi405 – 409RKQLK → AAQLA: Abolishes binding to tRNA. Does not abolish shuttling behavior. 1 Publication5
Mutagenesisi539 – 543KVRSR → AVRSA: Does not abolish binding to tRNA. Does not abolish shuttling behavior. 1 Publication5
Mutagenesisi547 – 551LFSRF → AFSRA: Does not abolish binding to tRNA. Does not abolish shuttling behavior. 1 Publication5
Mutagenesisi548 – 552FSRFV → ASRFA: Does not abolish binding to tRNA. Does not abolish shuttling behavior. 1 Publication5
Mutagenesisi550 – 557RFVKSLNK → AFVASLNA: Abolishes binding to tRNA. Does not abolish shuttling behavior. 1 Publication8

Organism-specific databases

DisGeNET

More...DisGeNETi		11260

Open Targets

More...OpenTargetsi		ENSG00000184575

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37419

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O43592, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105803

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		XPOT

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002047161 – 962Exportin-TAdd BLAST962

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei634N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O43592

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O43592

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O43592

MaxQB - The MaxQuant DataBase

More...MaxQBi		O43592

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O43592

PeptideAtlas

More...PeptideAtlasi		O43592

PRoteomics IDEntifications database

More...PRIDEi		O43592

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49066

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O43592, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O43592

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O43592

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O43592

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000184575, Expressed in stromal cell of endometrium and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O43592, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O43592, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000184575, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins.

Interacts with Ran and tRNA in a GTP-dependent manner.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116420, 122 interactors

Protein interaction database and analysis system

More...IntActi		O43592, 53 interactors

Molecular INTeraction database

More...MINTi		O43592

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000327821

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O43592, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O43592

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 385Necessary for interaction with Ran, nuclear localization and nuclear importAdd BLAST385
Regioni443 – 962Necessary for tRNA-binding, cytoplasmic localization and nuclear exportAdd BLAST520

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2021, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007890

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004414_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O43592

Identification of Orthologs from Complete Genome Data

More...OMAi		RFSPLCW

Database of Orthologous Groups

More...OrthoDBi		142520at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O43592

TreeFam database of animal gene trees

More...TreeFami		TF314001

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR013598, Exportin-1/Importin-b-like
IPR045546, Exportin-T_C
IPR001494, Importin-beta_N
IPR040017, XPOT

The PANTHER Classification System

More...PANTHERi		PTHR15952, PTHR15952, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF19282, Exportin-T, 1 hit
PF03810, IBN_N, 1 hit
PF08389, Xpo1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00913, IBN_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O43592-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEQALLGLN PNADSDFRQR ALAYFEQLKI SPDAWQVCAE ALAQRTYSDD 
        60         70         80         90        100
HVKFFCFQVL EHQVKYKYSE LTTVQQQLIR ETLISWLQAQ MLNPQPEKTF 
       110        120        130        140        150
IRNKAAQVFA LLFVTEYLTK WPKFFFDILS VVDLNPRGVD LYLRILMAID 
       160        170        180        190        200
SELVDRDVVH TSEEARRNTL IKDTMREQCI PNLVESWYQI LQNYQFTNSE 
       210        220        230        240        250
VTCQCLEVVG AYVSWIDLSL IANDRFINML LGHMSIEVLR EEACDCLFEV 
       260        270        280        290        300
VNKGMDPVDK MKLVESLCQV LQSAGFFSID QEEDVDFLAR FSKLVNGMGQ 
       310        320        330        340        350
SLIVSWSKLI KNGDIKNAQE ALQAIETKVA LMLQLLIHED DDISSNIIGF 
       360        370        380        390        400
CYDYLHILKQ LTVLSDQQKA NVEAIMLAVM KKLTYDEEYN FENEGEDEAM 
       410        420        430        440        450
FVEYRKQLKL LLDRLAQVSP ELLLASVRRV FSSTLQNWQT TRFMEVEVAI 
       460        470        480        490        500
RLLYMLAEAL PVSHGAHFSG DVSKASALQD MMRTLVTSGV SSYQHTSVTL 
       510        520        530        540        550
EFFETVVRYE KFFTVEPQHI PCVLMAFLDH RGLRHSSAKV RSRTAYLFSR 
       560        570        580        590        600
FVKSLNKQMN PFIEDILNRI QDLLELSPPE NGHQSLLSSD DQLFIYETAG 
       610        620        630        640        650
VLIVNSEYPA ERKQALMRNL LTPLMEKFKI LLEKLMLAQD EERQASLADC 
       660        670        680        690        700
LNHAVGFASR TSKAFSNKQT VKQCGCSEVY LDCLQTFLPA LSCPLQKDIL 
       710        720        730        740        750
RSGVRTFLHR MIICLEEEVL PFIPSASEHM LKDCEAKDLQ EFIPLINQIT 
       760        770        780        790        800
AKFKIQVSPF LQQMFMPLLH AIFEVLLRPA EENDQSAALE KQMLRRSYFA 
       810        820        830        840        850
FLQTVTGSGM SEVIANQGAE NVERVLVTVI QGAVEYPDPI AQKTCFIILS 
       860        870        880        890        900
KLVELWGGKD GPVGFADFVY KHIVPACFLA PLKQTFDLAD AQTVLALSEC 
       910        920        930        940        950
AVTLKTIHLK RGPECVQYLQ QEYLPSLQVA PEIIQEFCQA LQQPDAKVFK 
       960 
NYLKVFFQRA KP
Length:962
Mass (Da):109,964
Last modified:May 30, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F407EEDEC7C2996
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDU6F8WDU6_HUMAN
Exportin-T
XPOT
201Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYW6F5GYW6_HUMAN
Exportin-T
XPOT
60Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZM3F5GZM3_HUMAN
Exportin-T
XPOT
63Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti360Q → R in AAC39793 (PubMed:9660920).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026528526A → V1 PublicationCorresponds to variant dbSNP:rs17851795Ensembl.1
Natural variantiVAR_048962716E → D. Corresponds to variant dbSNP:rs1051396Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF039022 mRNA Translation: AAC39793.1
Y16414 mRNA Translation: CAA76202.1
AC135279 Genomic DNA No translation available.
BC000950 mRNA Translation: AAH00950.1
BC020569 mRNA Translation: AAH20569.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31852.1

NCBI Reference Sequences

More...RefSeqi		NP_009166.2, NM_007235.4
XP_016874237.1, XM_017018748.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000332707; ENSP00000327821; ENSG00000184575

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11260

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11260

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000332707.10; ENSP00000327821.5; NM_007235.6; NP_009166.2

UCSC genome browser

More...UCSCi		uc001ssb.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039022 mRNA Translation: AAC39793.1
Y16414 mRNA Translation: CAA76202.1
AC135279 Genomic DNA No translation available.
BC000950 mRNA Translation: AAH00950.1
BC020569 mRNA Translation: AAH20569.1
CCDSiCCDS31852.1
RefSeqiNP_009166.2, NM_007235.4
XP_016874237.1, XM_017018748.1

3D structure databases

SMRiO43592
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116420, 122 interactors
IntActiO43592, 53 interactors
MINTiO43592
STRINGi9606.ENSP00000327821

Chemistry databases

ChEMBLiCHEMBL4105803

Protein family/group databases

TCDBi1.I.1.1.3, the nuclear pore complex (npc) family

PTM databases

GlyGeniO43592, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO43592
MetOSiteiO43592
PhosphoSitePlusiO43592

Genetic variation databases

BioMutaiXPOT

Proteomic databases

EPDiO43592
jPOSTiO43592
MassIVEiO43592
MaxQBiO43592
PaxDbiO43592
PeptideAtlasiO43592
PRIDEiO43592
ProteomicsDBi49066

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16571, 123 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		11260

Genome annotation databases

EnsembliENST00000332707; ENSP00000327821; ENSG00000184575
GeneIDi11260
KEGGihsa:11260
MANE-SelectiENST00000332707.10; ENSP00000327821.5; NM_007235.6; NP_009166.2
UCSCiuc001ssb.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11260
DisGeNETi11260

GeneCards: human genes, protein and diseases

More...GeneCardsi		XPOT
HGNCiHGNC:12826, XPOT
HPAiENSG00000184575, Low tissue specificity
MIMi603180, gene
neXtProtiNX_O43592
OpenTargetsiENSG00000184575
PharmGKBiPA37419
VEuPathDBiHostDB:ENSG00000184575

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2021, Eukaryota
GeneTreeiENSGT00390000007890
HOGENOMiCLU_004414_1_0_1
InParanoidiO43592
OMAiRFSPLCW
OrthoDBi142520at2759
PhylomeDBiO43592
TreeFamiTF314001

Enzyme and pathway databases

PathwayCommonsiO43592
ReactomeiR-HSA-6784531, tRNA processing in the nucleus
SignaLinkiO43592
SIGNORiO43592

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11260, 124 hits in 1057 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		XPOT, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		XPOT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11260
PharosiO43592, Tbio

Protein Ontology

More...PROi		PR:O43592
RNActiO43592, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000184575, Expressed in stromal cell of endometrium and 222 other tissues
ExpressionAtlasiO43592, baseline and differential
GenevisibleiO43592, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR013598, Exportin-1/Importin-b-like
IPR045546, Exportin-T_C
IPR001494, Importin-beta_N
IPR040017, XPOT
PANTHERiPTHR15952, PTHR15952, 1 hit
PfamiView protein in Pfam
PF19282, Exportin-T, 1 hit
PF03810, IBN_N, 1 hit
PF08389, Xpo1, 1 hit
SMARTiView protein in SMART
SM00913, IBN_N, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPOT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43592
Secondary accession number(s): A6NLH1
, O43784, Q8WUG2, Q9BVS7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 30, 2006
Last modified: February 23, 2022
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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