UniProtKB - O43592 (XPOT_HUMAN)

BLAST

>sp|O43592|XPOT_HUMAN Exportin-T OS=Homo sapiens OX=9606 GN=XPOT PE=1 SV=2
MDEQALLGLNPNADSDFRQRALAYFEQLKISPDAWQVCAEALAQRTYSDDHVKFFCFQVL
EHQVKYKYSELTTVQQQLIRETLISWLQAQMLNPQPEKTFIRNKAAQVFALLFVTEYLTK
WPKFFFDILSVVDLNPRGVDLYLRILMAIDSELVDRDVVHTSEEARRNTLIKDTMREQCI
PNLVESWYQILQNYQFTNSEVTCQCLEVVGAYVSWIDLSLIANDRFINMLLGHMSIEVLR
EEACDCLFEVVNKGMDPVDKMKLVESLCQVLQSAGFFSIDQEEDVDFLARFSKLVNGMGQ
SLIVSWSKLIKNGDIKNAQEALQAIETKVALMLQLLIHEDDDISSNIIGFCYDYLHILKQ
LTVLSDQQKANVEAIMLAVMKKLTYDEEYNFENEGEDEAMFVEYRKQLKLLLDRLAQVSP
ELLLASVRRVFSSTLQNWQTTRFMEVEVAIRLLYMLAEALPVSHGAHFSGDVSKASALQD
MMRTLVTSGVSSYQHTSVTLEFFETVVRYEKFFTVEPQHIPCVLMAFLDHRGLRHSSAKV
RSRTAYLFSRFVKSLNKQMNPFIEDILNRIQDLLELSPPENGHQSLLSSDDQLFIYETAG
VLIVNSEYPAERKQALMRNLLTPLMEKFKILLEKLMLAQDEERQASLADCLNHAVGFASR
TSKAFSNKQTVKQCGCSEVYLDCLQTFLPALSCPLQKDILRSGVRTFLHRMIICLEEEVL
PFIPSASEHMLKDCEAKDLQEFIPLINQITAKFKIQVSPFLQQMFMPLLHAIFEVLLRPA
EENDQSAALEKQMLRRSYFAFLQTVTGSGMSEVIANQGAENVERVLVTVIQGAVEYPDPI
AQKTCFIILSKLVELWGGKDGPVGFADFVYKHIVPACFLAPLKQTFDLADAQTVLALSEC
AVTLKTIHLKRGPECVQYLQQEYLPSLQVAPEIIQEFCQALQQPDAKVFKNYLKVFFQRA
KP

Align
Format
Add to basket Added to basket
History
Entry version 157 (10 Oct 2018)
Sequence version 2 (30 May 2006)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Exportin-T

Gene

XPOT

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.3 Publications

GO - Molecular functionⁱ

Ran GTPase binding Source: GO_Central
tRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9660920

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

tRNA export from nucleus
Source: UniProtKB
Inferred from direct assayⁱ
- 9660920
tRNA re-export from nucleus Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding, tRNA-binding
Biological process	Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6784531 tRNA processing in the nucleus

Reactomeⁱ

R-HSA-6784531 tRNA processing in the nucleus

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Exportin-T Alternative name(s): Exportin(tRNA) tRNA exportin
Gene namesⁱ	Name:XPOT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000184575.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12826 XPOT
MIMⁱ	603180 gene
neXtProtⁱ	NX_O43592

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	405 – 409	RKQLK → AAQLA: Abolishes binding to tRNA. Does not abolish shuttling behavior. 1 Publication	5
Mutagenesisⁱ	539 – 543	KVRSR → AVRSA: Does not abolish binding to tRNA. Does not abolish shuttling behavior. 1 Publication	5
Mutagenesisⁱ	547 – 551	LFSRF → AFSRA: Does not abolish binding to tRNA. Does not abolish shuttling behavior. 1 Publication	5
Mutagenesisⁱ	548 – 552	FSRFV → ASRFA: Does not abolish binding to tRNA. Does not abolish shuttling behavior. 1 Publication	5
Mutagenesisⁱ	550 – 557	RFVKSLNK → AFVASLNA: Abolishes binding to tRNA. Does not abolish shuttling behavior. 1 Publication	8

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11260
Open Targets More...OpenTargetsⁱ	ENSG00000184575
PharmGKBⁱ	PA37419

Polymorphism and mutation databases

BioMutaⁱ	XPOT

BioMutaⁱ

XPOT

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204716	1 – 962	Exportin-TAdd BLAST		962

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1
Modified residueⁱ	634	N6-acetyllysineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	O43592
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43592
PaxDbⁱ	O43592
PeptideAtlas More...PeptideAtlasⁱ	O43592
PRIDEⁱ	O43592
ProteomicsDBⁱ	49066

PTM databases

iPTMnetⁱ	O43592
PhosphoSitePlusⁱ	O43592

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000184575 Expressed in 203 organ(s), highest expression level in endothelial cell
CleanExⁱ	HS_XPOT
ExpressionAtlasⁱ	O43592 baseline and differential
Genevisibleⁱ	O43592 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048067 HPA057602

HPAⁱ

HPA048067
HPA057602

Interactionⁱ

Subunit structureⁱ

Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins. Interacts with Ran and tRNA in a GTP-dependent manner.3 Publications

GO - Molecular functionⁱ

Ran GTPase binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116420, 50 interactors
IntActⁱ	O43592, 30 interactors
Molecular INTeraction database More...MINTⁱ	O43592
STRINGⁱ	9606.ENSP00000327821

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43592
SMRⁱ	O43592
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 385	Necessary for interaction with Ran, nuclear localization and nuclear importAdd BLAST		385
Regionⁱ	443 – 962	Necessary for tRNA-binding, cytoplasmic localization and nuclear exportAdd BLAST		520

Sequence similaritiesⁱ

Belongs to the exportin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2021 Eukaryota ENOG410XZDZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007890
HOGENOMⁱ	HOG000007104
HOVERGENⁱ	HBG094163
InParanoidⁱ	O43592
KEGG Orthology (KO) More...KOⁱ	K14288
OMAⁱ	WVSWIDI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04A1
PhylomeDBⁱ	O43592
TreeFamⁱ	TF314001

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR013598 Exportin-1/Importin-b-like IPR001494 Importin-beta_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03810 IBN_N, 1 hit PF08389 Xpo1, 1 hit
SMARTⁱ	View protein in SMART SM00913 IBN_N, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

O43592-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDEQALLGLN PNADSDFRQR ALAYFEQLKI SPDAWQVCAE ALAQRTYSDD 
        60         70         80         90        100
HVKFFCFQVL EHQVKYKYSE LTTVQQQLIR ETLISWLQAQ MLNPQPEKTF 
       110        120        130        140        150
IRNKAAQVFA LLFVTEYLTK WPKFFFDILS VVDLNPRGVD LYLRILMAID 
       160        170        180        190        200
SELVDRDVVH TSEEARRNTL IKDTMREQCI PNLVESWYQI LQNYQFTNSE 
       210        220        230        240        250
VTCQCLEVVG AYVSWIDLSL IANDRFINML LGHMSIEVLR EEACDCLFEV 
       260        270        280        290        300
VNKGMDPVDK MKLVESLCQV LQSAGFFSID QEEDVDFLAR FSKLVNGMGQ 
       310        320        330        340        350
SLIVSWSKLI KNGDIKNAQE ALQAIETKVA LMLQLLIHED DDISSNIIGF 
       360        370        380        390        400
CYDYLHILKQ LTVLSDQQKA NVEAIMLAVM KKLTYDEEYN FENEGEDEAM 
       410        420        430        440        450
FVEYRKQLKL LLDRLAQVSP ELLLASVRRV FSSTLQNWQT TRFMEVEVAI 
       460        470        480        490        500
RLLYMLAEAL PVSHGAHFSG DVSKASALQD MMRTLVTSGV SSYQHTSVTL 
       510        520        530        540        550
EFFETVVRYE KFFTVEPQHI PCVLMAFLDH RGLRHSSAKV RSRTAYLFSR 
       560        570        580        590        600
FVKSLNKQMN PFIEDILNRI QDLLELSPPE NGHQSLLSSD DQLFIYETAG 
       610        620        630        640        650
VLIVNSEYPA ERKQALMRNL LTPLMEKFKI LLEKLMLAQD EERQASLADC 
       660        670        680        690        700
LNHAVGFASR TSKAFSNKQT VKQCGCSEVY LDCLQTFLPA LSCPLQKDIL 
       710        720        730        740        750
RSGVRTFLHR MIICLEEEVL PFIPSASEHM LKDCEAKDLQ EFIPLINQIT 
       760        770        780        790        800
AKFKIQVSPF LQQMFMPLLH AIFEVLLRPA EENDQSAALE KQMLRRSYFA 
       810        820        830        840        850
FLQTVTGSGM SEVIANQGAE NVERVLVTVI QGAVEYPDPI AQKTCFIILS 
       860        870        880        890        900
KLVELWGGKD GPVGFADFVY KHIVPACFLA PLKQTFDLAD AQTVLALSEC 
       910        920        930        940        950
AVTLKTIHLK RGPECVQYLQ QEYLPSLQVA PEIIQEFCQA LQQPDAKVFK 
       960 
NYLKVFFQRA KP

Length:962

Mass (Da):109,964

Last modified:May 30, 2006 - v2

Checksum:ⁱ2F407EEDEC7C2996

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8WDU6	F8WDU6_HUMAN	Exportin-T Exportin-T	XPOT	201	Annotation score:
F5GYW6	F5GYW6_HUMAN	Exportin-T Exportin-T	XPOT	60	Annotation score:
F5GZM3	F5GZM3_HUMAN	Exportin-T Exportin-T	XPOT	63	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	360	Q → R in AAC39793 (PubMed:9660920).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_026528	526	A → V1 PublicationCorresponds to variant dbSNP:rs17851795Ensembl.		1
Natural variantⁱVAR_048962	716	E → D. Corresponds to variant dbSNP:rs1051396Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF039022 mRNA Translation: AAC39793.1 Y16414 mRNA Translation: CAA76202.1 AC135279 Genomic DNA No translation available. BC000950 mRNA Translation: AAH00950.1 BC020569 mRNA Translation: AAH20569.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31852.1
NCBI Reference Sequences More...RefSeqⁱ	NP_009166.2, NM_007235.4 XP_016874237.1, XM_017018748.1
UniGeneⁱ	Hs.592579 Hs.734564 Hs.85951

Genome annotation databases

Ensemblⁱ	ENST00000332707; ENSP00000327821; ENSG00000184575
GeneIDⁱ	11260
KEGGⁱ	hsa:11260
UCSC genome browser More...UCSCⁱ	uc001ssb.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43592	Exportin for tRNA		PANTR		962	UniRef100_O43592
Uncharacterized protein		PANPA		962
Exportin for tRNA		GORGO		962
Exportin-T (Fragment)		HUMAN		201
XPOT isoform 5 (Fragment)		PANTR		202

Protein	Similar proteins		Species	Score	Length	Source
O43592	Exportin-T		MOUSE		963	UniRef90_O43592
Exportin-T		PONAB		962
Exportin for tRNA		PANTR		962
Uncharacterized protein		PANPA		962
Exportin for tRNA		GORGO		962
+285

Protein	Similar proteins		Species	Score	Length	Source
O43592	Exportin-T		MOUSE		963	UniRef50_O43592
Exportin-T		PONAB		962
Exportin for tRNA		PANTR		962
Uncharacterized protein		PANPA		962
Exportin for tRNA		GORGO		962
+353

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF039022 mRNA Translation: AAC39793.1 Y16414 mRNA Translation: CAA76202.1 AC135279 Genomic DNA No translation available. BC000950 mRNA Translation: AAH00950.1 BC020569 mRNA Translation: AAH20569.1
CCDSⁱ	CCDS31852.1
RefSeqⁱ	NP_009166.2, NM_007235.4 XP_016874237.1, XM_017018748.1
UniGeneⁱ	Hs.592579 Hs.734564 Hs.85951

3D structure databases

ProteinModelPortalⁱ	O43592
SMRⁱ	O43592
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116420, 50 interactors
IntActⁱ	O43592, 30 interactors
MINTⁱ	O43592
STRINGⁱ	9606.ENSP00000327821

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetⁱ	O43592
PhosphoSitePlusⁱ	O43592

Polymorphism and mutation databases

BioMutaⁱ	XPOT

BioMutaⁱ

XPOT

Proteomic databases

EPDⁱ	O43592
MaxQBⁱ	O43592
PaxDbⁱ	O43592
PeptideAtlasⁱ	O43592
PRIDEⁱ	O43592
ProteomicsDBⁱ	49066

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000332707; ENSP00000327821; ENSG00000184575
GeneIDⁱ	11260
KEGGⁱ	hsa:11260
UCSCⁱ	uc001ssb.4 human

Organism-specific databases

CTDⁱ	11260
DisGeNETⁱ	11260
EuPathDBⁱ	HostDB:ENSG00000184575.11
GeneCardsⁱ	XPOT
HGNCⁱ	HGNC:12826 XPOT
HPAⁱ	HPA048067 HPA057602
MIMⁱ	603180 gene
neXtProtⁱ	NX_O43592
OpenTargetsⁱ	ENSG00000184575
PharmGKBⁱ	PA37419
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2021 Eukaryota ENOG410XZDZ LUCA
GeneTreeⁱ	ENSGT00390000007890
HOGENOMⁱ	HOG000007104
HOVERGENⁱ	HBG094163
InParanoidⁱ	O43592
KOⁱ	K14288
OMAⁱ	WVSWIDI
OrthoDBⁱ	EOG091G04A1
PhylomeDBⁱ	O43592
TreeFamⁱ	TF314001

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6784531 tRNA processing in the nucleus

Reactomeⁱ

R-HSA-6784531 tRNA processing in the nucleus

Miscellaneous databases

ChiTaRSⁱ	XPOT human
GeneWikiⁱ	XPOT
GenomeRNAiⁱ	11260
Protein Ontology More...PROⁱ	PR:O43592
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000184575 Expressed in 203 organ(s), highest expression level in endothelial cell
CleanExⁱ	HS_XPOT
ExpressionAtlasⁱ	O43592 baseline and differential
Genevisibleⁱ	O43592 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR013598 Exportin-1/Importin-b-like IPR001494 Importin-beta_N
Pfamⁱ	View protein in Pfam PF03810 IBN_N, 1 hit PF08389 Xpo1, 1 hit
SMARTⁱ	View protein in SMART SM00913 IBN_N, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	XPOT_HUMAN
Accessionⁱ	O43592Primary (citable) accession number: O43592 Secondary accession number(s): A6NLH1 , O43784, Q8WUG2, Q9BVS7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
	Last sequence update:	May 30, 2006
	Last modified:	October 10, 2018
	This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43592 (XPOT_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Exportin-T

XPOT

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ