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Protein

Density-regulated protein

Gene

DENR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.3 Publications

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Density-regulated protein
Short name:
DRP
Alternative name(s):
Protein DRP1
Smooth muscle cell-associated protein 3
Short name:
SMAP-3
Gene namesi
Name:DENR
Synonyms:DRP1
ORF Names:H14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139726.10
HGNCiHGNC:2769 DENR
MIMi604550 gene
neXtProtiNX_O43583

Pathology & Biotechi

Organism-specific databases

DisGeNETi8562
OpenTargetsiENSG00000139726
PharmGKBiPA27252

Polymorphism and mutation databases

BioMutaiDENR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001306002 – 198Density-regulated proteinAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei86PhosphothreonineCombined sources1
Modified residuei189PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO43583
MaxQBiO43583
PaxDbiO43583
PeptideAtlasiO43583
PRIDEiO43583
ProteomicsDBi49063
TopDownProteomicsiO43583

PTM databases

iPTMnetiO43583
PhosphoSitePlusiO43583

Expressioni

Tissue specificityi

Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney.1 Publication

Inductioni

Up-regulated with increasing cell-density by HNRNPD. Up-regulated in ovarian and breast cancer cells by ERBB2 overexpression. Not induced by TGFB1.3 Publications

Gene expression databases

BgeeiENSG00000139726 Expressed in 230 organ(s), highest expression level in endometrium
CleanExiHS_DENR
ExpressionAtlasiO43583 baseline and differential
GenevisibleiO43583 HS

Organism-specific databases

HPAiHPA021783

Interactioni

Subunit structurei

Interacts with MCTS1.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi114131, 48 interactors
IntActiO43583, 6 interactors
MINTiO43583
STRINGi9606.ENSP00000280557

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43583
SMRiO43583
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 182SUI1PROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Belongs to the DENR family.Curated

Phylogenomic databases

eggNOGiKOG3239 Eukaryota
COG0023 LUCA
GeneTreeiENSGT00390000014349
HOGENOMiHOG000237611
HOVERGENiHBG005471
InParanoidiO43583
OMAiSGGHDCK
OrthoDBiEOG091G0R9X
PhylomeDBiO43583
TreeFamiTF105912

Family and domain databases

InterProiView protein in InterPro
IPR005873 Drp1
IPR001950 SUI1
IPR005872 SUI1_arc_bac
IPR036877 SUI1_dom_sf
PANTHERiPTHR12789 PTHR12789, 1 hit
PfamiView protein in Pfam
PF01253 SUI1, 1 hit
SUPFAMiSSF55159 SSF55159, 1 hit
TIGRFAMsiTIGR01159 DRP1, 1 hit
PROSITEiView protein in PROSITE
PS50296 SUI1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O43583-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAADISESSG ADCKGDPRNS AKLDADYPLR VLYCGVCSLP TEYCEYMPDV
60 70 80 90 100
AKCRQWLEKN FPNEFAKLTV ENSPKQEAGI SEGQGTAGEE EEKKKQKRGG
110 120 130 140 150
RGQIKQKKKT VPQKVTIAKI PRAKKKYVTR VCGLATFEID LKEAQRFFAQ
160 170 180 190
KFSCGASVTG EDEIIIQGDF TDDIIDVIQE KWPEVDDDSI EDLGEVKK
Length:198
Mass (Da):22,092
Last modified:April 27, 2001 - v2
Checksum:i023F70E0C6C0B25D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VVL1F8VVL1_HUMAN
Density-regulated protein
DENR
160Annotation score:

Sequence cautioni

The sequence AAC02985 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49 – 50DV → HE in AAF02420 (PubMed:10497265).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038554 mRNA Translation: AAC02985.2 Different initiation.
AB014731 mRNA Translation: BAB20268.1
AC026331 Genomic DNA No translation available.
AC027290 Genomic DNA No translation available.
BC007860 mRNA Translation: AAH07860.1
AF103800 mRNA Translation: AAF02420.1
CCDSiCCDS45003.1
RefSeqiNP_003668.2, NM_003677.4
UniGeneiHs.22393

Genome annotation databases

EnsembliENST00000280557; ENSP00000280557; ENSG00000139726
GeneIDi8562
KEGGihsa:8562
UCSCiuc001uda.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038554 mRNA Translation: AAC02985.2 Different initiation.
AB014731 mRNA Translation: BAB20268.1
AC026331 Genomic DNA No translation available.
AC027290 Genomic DNA No translation available.
BC007860 mRNA Translation: AAH07860.1
AF103800 mRNA Translation: AAF02420.1
CCDSiCCDS45003.1
RefSeqiNP_003668.2, NM_003677.4
UniGeneiHs.22393

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ONSX-ray2.14B24-51[»]
5VYCX-ray6.00l1/l2/l3/l4/l5/l61-198[»]
ProteinModelPortaliO43583
SMRiO43583
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114131, 48 interactors
IntActiO43583, 6 interactors
MINTiO43583
STRINGi9606.ENSP00000280557

PTM databases

iPTMnetiO43583
PhosphoSitePlusiO43583

Polymorphism and mutation databases

BioMutaiDENR

Proteomic databases

EPDiO43583
MaxQBiO43583
PaxDbiO43583
PeptideAtlasiO43583
PRIDEiO43583
ProteomicsDBi49063
TopDownProteomicsiO43583

Protocols and materials databases

DNASUi8562
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280557; ENSP00000280557; ENSG00000139726
GeneIDi8562
KEGGihsa:8562
UCSCiuc001uda.4 human

Organism-specific databases

CTDi8562
DisGeNETi8562
EuPathDBiHostDB:ENSG00000139726.10
GeneCardsiDENR
HGNCiHGNC:2769 DENR
HPAiHPA021783
MIMi604550 gene
neXtProtiNX_O43583
OpenTargetsiENSG00000139726
PharmGKBiPA27252
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3239 Eukaryota
COG0023 LUCA
GeneTreeiENSGT00390000014349
HOGENOMiHOG000237611
HOVERGENiHBG005471
InParanoidiO43583
OMAiSGGHDCK
OrthoDBiEOG091G0R9X
PhylomeDBiO43583
TreeFamiTF105912

Miscellaneous databases

ChiTaRSiDENR human
GenomeRNAii8562
PROiPR:O43583
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139726 Expressed in 230 organ(s), highest expression level in endometrium
CleanExiHS_DENR
ExpressionAtlasiO43583 baseline and differential
GenevisibleiO43583 HS

Family and domain databases

InterProiView protein in InterPro
IPR005873 Drp1
IPR001950 SUI1
IPR005872 SUI1_arc_bac
IPR036877 SUI1_dom_sf
PANTHERiPTHR12789 PTHR12789, 1 hit
PfamiView protein in Pfam
PF01253 SUI1, 1 hit
SUPFAMiSSF55159 SSF55159, 1 hit
TIGRFAMsiTIGR01159 DRP1, 1 hit
PROSITEiView protein in PROSITE
PS50296 SUI1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDENR_HUMAN
AccessioniPrimary (citable) accession number: O43583
Secondary accession number(s): Q9H3U6, Q9UKZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 27, 2001
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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