UniProtKB - O43581 (SYT7_HUMAN)
Protein
Synaptotagmin-7
Gene
SYT7
Organism
Homo sapiens (Human)
Status
Functioni
Ca2+ sensor involved in Ca2+-dependent exocytosis of secretory and synaptic vesicles through Ca2+ and phospholipid binding to the C2 domain (By similarity). Ca2+ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca2+ with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca2+-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca2+-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca2+-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca2+-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca2+ into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca2+ and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca2+-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity).By similarity2 Publications
Cofactori
Ca2+PROSITE-ProRule annotationNote: Binds 3 Ca2+ ions per C2 domain.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 166 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 166 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 172 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 225 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 225 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 227 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 227 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 227 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 230 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 233 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 233 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 297 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 297 | Calcium 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 303 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 357 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 357 | Calcium 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 359 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 359 | Calcium 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 359 | Calcium 6PROSITE-ProRule annotation | 1 | |
Metal bindingi | 362 | Calcium 6PROSITE-ProRule annotation | 1 | |
Metal bindingi | 365 | Calcium 4By similarity | 1 | |
Metal bindingi | 365 | Calcium 6PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: UniProtKB
- calcium ion binding Source: GO_Central
- calmodulin binding Source: UniProtKB
- clathrin binding Source: GO_Central
- phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
- phosphatidylserine binding Source: GO_Central
- SNARE binding Source: GO_Central
- syntaxin binding Source: Ensembl
GO - Biological processi
- calcium-dependent activation of synaptic vesicle fusion Source: Ensembl
- calcium-ion regulated exocytosis Source: GO_Central
- calcium ion-regulated exocytosis of neurotransmitter Source: UniProtKB
- calcium ion regulated lysosome exocytosis Source: UniProtKB
- cellular response to calcium ion Source: GO_Central
- phagocytosis Source: UniProtKB
- phagosome-lysosome fusion Source: UniProtKB
- plasma membrane repair Source: UniProtKB
- positive regulation of calcium ion-dependent exocytosis Source: Ensembl
- regulation of bone remodeling Source: UniProtKB
- regulation of calcium ion-dependent exocytosis Source: GO_Central
- regulation of dopamine secretion Source: GO_Central
- regulation of glucagon secretion Source: UniProtKB
- regulation of insulin secretion Source: UniProtKB
- regulation of phagocytosis Source: UniProtKB
- regulation of synaptic vesicle endocytosis Source: Ensembl
- short-term synaptic potentiation Source: UniProtKB
- synaptic vesicle recycling Source: UniProtKB
- vesicle-mediated cholesterol transport Source: UniProtKB
- vesicle-mediated transport Source: GO_Central
Keywordsi
Molecular function | Calmodulin-binding |
Biological process | Exocytosis |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | O43581 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptotagmin-7CuratedAlternative name(s): IPCA-7 Prostate cancer-associated protein 7 Synaptotagmin VII Short name: SytVII |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11514, SYT7 |
MIMi | 604146, gene |
neXtProti | NX_O43581 |
VEuPathDBi | HostDB:ENSG00000011347.9 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass membrane protein Sequence analysis
- presynaptic cell membrane By similarity; Single-pass membrane protein Sequence analysis
Peroxisome
- Peroxisome membrane By similarity; Single-pass membrane protein Sequence analysis
Lysosome
- Lysosome membrane By similarity; Single-pass membrane protein Sequence analysis
Other locations
- synaptic vesicle membrane By similarity; Single-pass membrane protein Sequence analysis
- phagosome membrane By similarity; Single-pass membrane protein Sequence analysis
- secretory vesicle membrane By similarity; Single-pass membrane protein Sequence analysis
Note: Localization to lysosomes is dependent on N-terminal palmitoylation and interaction with CD63.By similarity
Cytosol
- cytosol Source: GOC
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
- lysosome Source: UniProtKB
Peroxisome
- peroxisomal membrane Source: UniProtKB-SubCell
- peroxisome Source: UniProtKB
Plasma Membrane
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: GO_Central
Other locations
- axon terminus Source: Ensembl
- dendrite Source: Ensembl
- dense core granule Source: Ensembl
- early phagosome Source: UniProtKB
- exocytic vesicle Source: GO_Central
- GABA-ergic synapse Source: Ensembl
- glutamatergic synapse Source: Ensembl
- hippocampal mossy fiber to CA3 synapse Source: Ensembl
- neuronal cell body Source: Ensembl
- phagocytic vesicle membrane Source: UniProtKB-SubCell
- synaptic vesicle Source: UniProtKB
- synaptic vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | VesicularSequence analysisAdd BLAST | 16 | |
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 38 – 403 | CytoplasmicSequence analysisAdd BLAST | 366 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Lysosome, Membrane, Peroxisome, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 9066 |
OpenTargetsi | ENSG00000011347 |
PharmGKBi | PA36295 |
Miscellaneous databases
Pharosi | O43581, Tbio |
Genetic variation databases
BioMutai | SYT7 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183957 | 1 – 403 | Synaptotagmin-7Add BLAST | 403 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 52 | PhosphoserineBy similarity | 1 | |
Modified residuei | 58 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 61 | PhosphoserineBy similarity | 1 | |
Modified residuei | 119 | PhosphoserineBy similarity | 1 | |
Modified residuei | 122 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Palmitoylated at its vesicular N-terminus; palmitoylation is required for localization to lysosome and phagocytosis in macrophages.By similarity
Keywords - PTMi
Lipoprotein, Palmitate, PhosphoproteinProteomic databases
jPOSTi | O43581 |
MassIVEi | O43581 |
MaxQBi | O43581 |
PaxDbi | O43581 |
PeptideAtlasi | O43581 |
PRIDEi | O43581 |
ProteomicsDBi | 24992 25136 25521 25708 27141 49062 [O43581-1] |
PTM databases
iPTMneti | O43581 |
PhosphoSitePlusi | O43581 |
Expressioni
Tissue specificityi
Expressed in a variety of adult and fetal tissues.
Gene expression databases
Bgeei | ENSG00000011347, Expressed in islet of Langerhans and 147 other tissues |
ExpressionAtlasi | O43581, baseline and differential |
Genevisiblei | O43581, HS |
Organism-specific databases
HPAi | ENSG00000011347, Tissue enhanced (brain, prostate, salivary gland) |
Interactioni
Subunit structurei
Homodimer. Can also form heterodimers with SYT6, SYT9 and SYT10.
Interacts with calmodulin (CALM1, CALM2 or CALM3).
Interacts with CD63; required for localization to lysosomes.
Interacts with APP (By similarity).
By similarityBinary interactionsi
O43581
With | #Exp. | IntAct |
---|---|---|
SIAH1 [Q8IUQ4] | 3 | EBI-10184345,EBI-747107 |
GO - Molecular functioni
- calmodulin binding Source: UniProtKB
- clathrin binding Source: GO_Central
- SNARE binding Source: GO_Central
- syntaxin binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 114525, 10 interactors |
CORUMi | O43581 |
ELMi | O43581 |
IntActi | O43581, 4 interactors |
STRINGi | 9606.ENSP00000444201 |
Miscellaneous databases
RNActi | O43581, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O43581 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O43581 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 135 – 255 | C2 1PROSITE-ProRule annotationAdd BLAST | 121 | |
Domaini | 266 – 399 | C2 2PROSITE-ProRule annotationAdd BLAST | 134 |
Domaini
The C2 domains bind Ca2+ and membranes. Binding to membranes involves Ca2+-dependent phospholipid binding. Compared to other members of the family, the C2 domains of SYT7 dock and insert into cellular membranes in response to intracellular Ca2+ concentrations that are lower than those required for other synaptotagmins (PubMed:22966849). The two C2 domains bind independently to planar membranes, without interdomain cooperativity (PubMed:25437758). Moreover, SYT7 C2 domains insert more deeply into membranes compared to other synaptotagmins (PubMed:26322740, PubMed:26333120).4 Publications
Sequence similaritiesi
Belongs to the synaptotagmin family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000157180 |
HOGENOMi | CLU_023008_7_2_1 |
InParanoidi | O43581 |
OMAi | WCQRRLG |
OrthoDBi | 925064at2759 |
PhylomeDBi | O43581 |
TreeFami | TF315600 |
Family and domain databases
CDDi | cd08386, C2A_Synaptotagmin-7, 1 hit cd08405, C2B_Synaptotagmin-7, 1 hit |
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR037732, C2A_Synaptotagmin-7 IPR037741, C2B_Synaptotagmin-7 IPR001565, Synaptotagmin IPR015427, Synaptotagmin7 |
PANTHERi | PTHR10024:SF358, PTHR10024:SF358, 2 hits |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O43581-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK
60 70 80 90 100
NSLETVGTPD SGRGRSEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTEP
110 120 130 140 150
RSSVSDLVNS LTSEMLMLSP GSEEDEAHEG CSRENLGRIQ FSVGYNFQES
160 170 180 190 200
TLTVKIMKAQ ELPAKDFSGT SDPFVKIYLL PDKKHKLETK VKRKNLNPHW
210 220 230 240 250
NETFLFEGFP YEKVVQRILY LQVLDYDRFS RNDPIGEVSI PLNKVDLTQM
260 270 280 290 300
QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG
310 320 330 340 350
TSDPYVKVWL MYKDKRVEKK KTVTMKRNLN PIFNESFAFD IPTEKLRETT
360 370 380 390 400
IIITVMDKDK LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ
LKA
Note: Major isoform.1 Publication
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H8G7 | F5H8G7_HUMAN | Synaptotagmin-7 | SYT7 | 175 | Annotation score: | ||
F5GX00 | F5GX00_HUMAN | Synaptotagmin-7 | SYT7 | 122 | Annotation score: |
Sequence cautioni
The sequence AAB92667 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 154 | V → L in AAB92667 (PubMed:9615227).Curated | 1 | |
Sequence conflicti | 188 | E → K in AAB92667 (PubMed:9615227).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052241 | 332 | I → N1 PublicationCorresponds to variant dbSNP:rs407740Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045991 | 71 | I → INGTLLSGAKVAAAAGLAVE REGRLGEKPAPVPPPGEDAL RSGGAAPSEPGSGGKAGRGR WRTVQSHLAAGKLNLS in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_058231 | 71 | I → INDLDRDFWNNNESTVQQKW SSYPPKEFILNISPYAPYGD PRLSLNGTLLSGAKVAAAAG LAVEREGRLGEKPAPVPPPG EDALRSGGAAPSEPGSGGKA GRGRWRTVQSHLAAGKLNLS in isoform 5. | 1 | |
Alternative sequenceiVSP_058232 | 71 | I → INDLDRDFWNNNESTVQQKW SSYPPKEFILNISPYAPYGD PRLSL in isoform 6. | 1 | |
Alternative sequenceiVSP_058233 | 72 | K → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNGTLLSGAKVAAAAGL AVEREGRLGEKPAPVPPPGE DALRSGGAAPSEPGSGGKAG RGRWRTVQSHLAAGKLNLSN FEDSTLSTATTLESIPSSTG EPKCQRPRTLMRQQSLQQPL SQHQRGRQPSQPTTSQSLGQ LQAHMASAPGPNPRAYGRGQ ARQGTSAGSKYRAAGGRSRS NPGSWDHVVGQIRNRGLDMK SFLEGRMVVLSLVLGLSEQD DFANIPDLQNPGTQQNQNAQ GDKR in isoform 3. | 1 | |
Alternative sequenceiVSP_058234 | 72 | K → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNFEDSTLSTATTLESI PSSTGEPKCQRPRTLMRQQS LQQPLSQHQRGRQPSQPTTS QSLGQLQAHMASAPGPNPRA YGRGQARQGTSAGSKYRAAG GRSRSNPGSWDHVVGQIRNR GLDMKSFLEGRMVVLSLVLG LSEQDDFANIPDLQNPGTQQ NQNAQGDKR in isoform 4. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038535 mRNA Translation: AAB92667.1 Frameshift. AP002754 Genomic DNA No translation available. AP003108 Genomic DNA No translation available. AP003559 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW73956.1 BC125170 mRNA Translation: AAI25171.1 BC125171 mRNA No translation available. |
CCDSi | CCDS31577.1 [O43581-1] CCDS58139.1 [O43581-2] CCDS73298.1 [O43581-6] |
RefSeqi | NP_001238994.1, NM_001252065.1 [O43581-2] NP_001287702.1, NM_001300773.1 [O43581-6] NP_004191.2, NM_004200.3 [O43581-1] XP_005274440.1, XM_005274383.4 XP_005274442.1, XM_005274385.4 [O43581-4] |
Genome annotation databases
Ensembli | ENST00000263846; ENSP00000263846; ENSG00000011347 [O43581-1] ENST00000535826; ENSP00000437720; ENSG00000011347 [O43581-5] ENST00000539008; ENSP00000439694; ENSG00000011347 [O43581-3] ENST00000540677; ENSP00000444201; ENSG00000011347 [O43581-2] ENST00000542670; ENSP00000444019; ENSG00000011347 [O43581-4] ENST00000542836; ENSP00000444568; ENSG00000011347 [O43581-6] |
GeneIDi | 9066 |
KEGGi | hsa:9066 |
UCSCi | uc001nrv.4, human [O43581-1] uc001nrx.2, human uc058cdk.1, human uc058cdl.1, human uc058cdm.1, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038535 mRNA Translation: AAB92667.1 Frameshift. AP002754 Genomic DNA No translation available. AP003108 Genomic DNA No translation available. AP003559 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW73956.1 BC125170 mRNA Translation: AAI25171.1 BC125171 mRNA No translation available. |
CCDSi | CCDS31577.1 [O43581-1] CCDS58139.1 [O43581-2] CCDS73298.1 [O43581-6] |
RefSeqi | NP_001238994.1, NM_001252065.1 [O43581-2] NP_001287702.1, NM_001300773.1 [O43581-6] NP_004191.2, NM_004200.3 [O43581-1] XP_005274440.1, XM_005274383.4 XP_005274442.1, XM_005274385.4 [O43581-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2D8K | NMR | - | A | 132-259 | [»] | |
SMRi | O43581 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114525, 10 interactors |
CORUMi | O43581 |
ELMi | O43581 |
IntActi | O43581, 4 interactors |
STRINGi | 9606.ENSP00000444201 |
PTM databases
iPTMneti | O43581 |
PhosphoSitePlusi | O43581 |
Genetic variation databases
BioMutai | SYT7 |
Proteomic databases
jPOSTi | O43581 |
MassIVEi | O43581 |
MaxQBi | O43581 |
PaxDbi | O43581 |
PeptideAtlasi | O43581 |
PRIDEi | O43581 |
ProteomicsDBi | 24992 25136 25521 25708 27141 49062 [O43581-1] |
Protocols and materials databases
Antibodypediai | 2220, 248 antibodies |
Genome annotation databases
Ensembli | ENST00000263846; ENSP00000263846; ENSG00000011347 [O43581-1] ENST00000535826; ENSP00000437720; ENSG00000011347 [O43581-5] ENST00000539008; ENSP00000439694; ENSG00000011347 [O43581-3] ENST00000540677; ENSP00000444201; ENSG00000011347 [O43581-2] ENST00000542670; ENSP00000444019; ENSG00000011347 [O43581-4] ENST00000542836; ENSP00000444568; ENSG00000011347 [O43581-6] |
GeneIDi | 9066 |
KEGGi | hsa:9066 |
UCSCi | uc001nrv.4, human [O43581-1] uc001nrx.2, human uc058cdk.1, human uc058cdl.1, human uc058cdm.1, human |
Organism-specific databases
CTDi | 9066 |
DisGeNETi | 9066 |
GeneCardsi | SYT7 |
HGNCi | HGNC:11514, SYT7 |
HPAi | ENSG00000011347, Tissue enhanced (brain, prostate, salivary gland) |
MIMi | 604146, gene |
neXtProti | NX_O43581 |
OpenTargetsi | ENSG00000011347 |
PharmGKBi | PA36295 |
VEuPathDBi | HostDB:ENSG00000011347.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000157180 |
HOGENOMi | CLU_023008_7_2_1 |
InParanoidi | O43581 |
OMAi | WCQRRLG |
OrthoDBi | 925064at2759 |
PhylomeDBi | O43581 |
TreeFami | TF315600 |
Enzyme and pathway databases
PathwayCommonsi | O43581 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
Miscellaneous databases
BioGRID-ORCSi | 9066, 6 hits in 873 CRISPR screens |
ChiTaRSi | SYT7, human |
EvolutionaryTracei | O43581 |
GeneWikii | SYT7 |
GenomeRNAii | 9066 |
Pharosi | O43581, Tbio |
PROi | PR:O43581 |
RNActi | O43581, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000011347, Expressed in islet of Langerhans and 147 other tissues |
ExpressionAtlasi | O43581, baseline and differential |
Genevisiblei | O43581, HS |
Family and domain databases
CDDi | cd08386, C2A_Synaptotagmin-7, 1 hit cd08405, C2B_Synaptotagmin-7, 1 hit |
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR037732, C2A_Synaptotagmin-7 IPR037741, C2B_Synaptotagmin-7 IPR001565, Synaptotagmin IPR015427, Synaptotagmin7 |
PANTHERi | PTHR10024:SF358, PTHR10024:SF358, 2 hits |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYT7_HUMAN | |
Accessioni | O43581Primary (citable) accession number: O43581 Secondary accession number(s): F5GZC2 Q08AH6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 10, 2021 | |
This is version 183 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families