SYT7

Functionⁱ

Ca²⁺ sensor involved in Ca²⁺-dependent exocytosis of secretory and synaptic vesicles through Ca²⁺ and phospholipid binding to the C2 domain (By similarity). Ca²⁺ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca²⁺ with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca²⁺-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca²⁺-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca²⁺-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca²⁺-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca²⁺ into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca²⁺ and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca²⁺-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity).By similarity2 Publications

Cofactorⁱ

Ca²⁺By similarityNote: Binds 3 Ca²⁺ ions per C2 domain.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	166	Calcium 1By similarity	1
Metal bindingⁱ	166	Calcium 2By similarity	1
Metal bindingⁱ	172	Calcium 1By similarity	1
Metal bindingⁱ	225	Calcium 1By similarity	1
Metal bindingⁱ	225	Calcium 2By similarity	1
Metal bindingⁱ	227	Calcium 1By similarity	1
Metal bindingⁱ	227	Calcium 2By similarity	1
Metal bindingⁱ	227	Calcium 3By similarity	1
Metal bindingⁱ	230	Calcium 3By similarity	1
Metal bindingⁱ	233	Calcium 2By similarity	1
Metal bindingⁱ	233	Calcium 3By similarity	1
Metal bindingⁱ	297	Calcium 4By similarity	1
Metal bindingⁱ	297	Calcium 5By similarity	1
Metal bindingⁱ	303	Calcium 5By similarity	1
Metal bindingⁱ	357	Calcium 4By similarity	1
Metal bindingⁱ	357	Calcium 5By similarity	1
Metal bindingⁱ	359	Calcium 4By similarity	1
Metal bindingⁱ	359	Calcium 5By similarity	1
Metal bindingⁱ	359	Calcium 6By similarity	1
Metal bindingⁱ	362	Calcium 6By similarity	1
Metal bindingⁱ	365	Calcium 4By similarity	1
Metal bindingⁱ	365	Calcium 6By similarity	1

GO - Molecular functionⁱ

calcium-dependent phospholipid binding Source: UniProtKB
calcium ion binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calmodulin binding Source: UniProtKB
clathrin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
phosphatidylserine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-dependent activation of synaptic vesicle fusion Source: Ensembl
calcium ion regulated exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calcium ion-regulated exocytosis of neurotransmitter Source: UniProtKB
calcium ion regulated lysosome exocytosis Source: UniProtKB
cellular response to calcium ion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phagocytosis Source: UniProtKB
phagosome-lysosome fusion Source: UniProtKB
plasma membrane repair Source: UniProtKB
regulation of bone remodeling Source: UniProtKB
regulation of dopamine secretion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of glucagon secretion Source: UniProtKB
regulation of insulin secretion Source: UniProtKB
regulation of phagocytosis Source: UniProtKB
regulation of synaptic vesicle endocytosis Source: Ensembl
short-term synaptic potentiation Source: UniProtKB
synaptic vesicle recycling Source: UniProtKB
vesicle-mediated cholesterol transport Source: UniProtKB
vesicle-mediated transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding
Biological process	Exocytosis
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6794361 Neurexins and neuroligins

Reactomeⁱ

R-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synaptotagmin-7Curated Alternative name(s): IPCA-7 Prostate cancer-associated protein 7 Synaptotagmin VII Short name: SytVII
Gene namesⁱ	Name:SYT7Imported Synonyms:PCANAP7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000011347.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11514 SYT7
MIMⁱ	604146 gene
neXtProtⁱ	NX_O43581

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 16	VesicularSequence analysisAdd BLAST	16
Transmembraneⁱ	17 – 37	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	38 – 403	CytoplasmicSequence analysisAdd BLAST	366

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasmic vesicle, Lysosome, Membrane, Peroxisome, Synapse

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000011347
PharmGKBⁱ	PA36295

Polymorphism and mutation databases

BioMutaⁱ	SYT7

BioMutaⁱ

SYT7

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000183957	1 – 403	Synaptotagmin-7Add BLAST		403

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	52	PhosphoserineBy similarity	1
Modified residueⁱ	58	PhosphothreonineBy similarity	1
Modified residueⁱ	61	PhosphoserineBy similarity	1
Modified residueⁱ	119	PhosphoserineBy similarity	1
Modified residueⁱ	122	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Palmitoylated at its vesicular N-terminus; palmitoylation is required for localization to lysosome and phagocytosis in macrophages.By similarity

Keywords - PTMⁱ

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43581
PaxDbⁱ	O43581
PeptideAtlas More...PeptideAtlasⁱ	O43581
PRIDEⁱ	O43581
ProteomicsDBⁱ	49062

PTM databases

iPTMnetⁱ	O43581
PhosphoSitePlusⁱ	O43581

Expressionⁱ

Tissue specificityⁱ

Expressed in a variety of adult and fetal tissues.

Gene expression databases

Bgeeⁱ	ENSG00000011347 Expressed in 130 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_SYT7
ExpressionAtlasⁱ	O43581 baseline and differential
Genevisibleⁱ	O43581 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA012869

HPAⁱ

HPA012869

Interactionⁱ

Subunit structureⁱ

Homodimer. Can also form heterodimers with SYT6, SYT9 and SYT10. Interacts with calmodulin (CALM1, CALM2 or CALM3). Interacts with CD63; required for localization to lysosomes.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SIAH1	Q8IUQ4	3	EBI-10184345,EBI-747107

With

Entry

#Exp.

IntAct

Notes

SIAH1

Q8IUQ4

3

EBI-10184345,EBI-747107

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB
clathrin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114525, 4 interactors
ELMⁱ	O43581
IntActⁱ	O43581, 1 interactor
STRINGⁱ	9606.ENSP00000263846

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	138 – 145	Combined sources	8
Beta strandⁱ	147 – 149	Combined sources	3
Beta strandⁱ	152 – 161	Combined sources	10
Beta strandⁱ	166 – 169	Combined sources	4
Beta strandⁱ	173 – 181	Combined sources	9
Beta strandⁱ	184 – 188	Combined sources	5
Beta strandⁱ	202 – 206	Combined sources	5
Helixⁱ	211 – 214	Combined sources	4
Beta strandⁱ	217 – 225	Combined sources	9
Beta strandⁱ	228 – 231	Combined sources	4
Beta strandⁱ	233 – 241	Combined sources	9
Turnⁱ	242 – 244	Combined sources	3
Beta strandⁱ	251 – 255	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	O43581
SMRⁱ	O43581
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O43581

EvolutionaryTraceⁱ

O43581

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	137 – 239	C2 1PROSITE-ProRule annotationAdd BLAST		103
Domainⁱ	268 – 371	C2 2PROSITE-ProRule annotationAdd BLAST		104

Domainⁱ

The C2 domains bind Ca²⁺ and membranes. Binding to membranes involves Ca²⁺-dependent phospholipid binding. Compared to other members of the family, the C2 domains of SYT7 dock and insert into cellular membranes in response to intracellular Ca²⁺ concentrations that are lower than those required for other synaptotagmins (PubMed:22966849). The two C2 domains bind independently to planar membranes, without interdomain cooperativity (PubMed:25437758). Moreover, SYT7 C2 domains insert more deeply into membranes compared to other synaptotagmins (PubMed:26322740, PubMed:26333120).4 Publications

Sequence similaritiesⁱ

Belongs to the synaptotagmin family.Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1028 Eukaryota ENOG410XRME LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118973
HOGENOMⁱ	HOG000232126
HOVERGENⁱ	HBG005010
InParanoidⁱ	O43581
KEGG Orthology (KO) More...KOⁱ	K19907
OMAⁱ	NDNTVQQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08NG
PhylomeDBⁱ	O43581
TreeFamⁱ	TF315600

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08386 C2A_Synaptotagmin-7, 1 hit cd08405 C2B_Synaptotagmin-7, 1 hit
Gene3Dⁱ	2.60.40.150, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR037732 C2A_Synaptotagmin-7 IPR037741 C2B_Synaptotagmin-7 IPR001565 Synaptotagmin IPR015427 Synaptotagmin7
PANTHERⁱ	PTHR10024:SF206 PTHR10024:SF206, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168 C2, 2 hits
PRINTSⁱ	PR00360 C2DOMAIN PR00399 SYNAPTOTAGMN
SMARTⁱ	View protein in SMART SM00239 C2, 2 hits
PROSITEⁱ	View protein in PROSITE PS50004 C2, 2 hits

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O43581-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRSEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTEP 
       110        120        130        140        150
RSSVSDLVNS LTSEMLMLSP GSEEDEAHEG CSRENLGRIQ FSVGYNFQES 
       160        170        180        190        200
TLTVKIMKAQ ELPAKDFSGT SDPFVKIYLL PDKKHKLETK VKRKNLNPHW 
       210        220        230        240        250
NETFLFEGFP YEKVVQRILY LQVLDYDRFS RNDPIGEVSI PLNKVDLTQM 
       260        270        280        290        300
QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG 
       310        320        330        340        350
TSDPYVKVWL MYKDKRVEKK KTVTMKRNLN PIFNESFAFD IPTEKLRETT 
       360        370        380        390        400
IIITVMDKDK LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ 

LKA

Note: Major isoform.1 Publication

Length:403

Mass (Da):45,501

Last modified:September 23, 2008 - v3

Checksum:ⁱC9BFB26D298EDBE4

GO

Isoform 2 (identifier: O43581-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
71-71: I → INGTLLSGAK...HLAAGKLNLS

« Hide

        10         20         30         40         50
MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRSEKKA INGTLLSGAK VAAAAGLAVE REGRLGEKPA 
       110        120        130        140        150
PVPPPGEDAL RSGGAAPSEP GSGGKAGRGR WRTVQSHLAA GKLNLSKLPA 
       160        170        180        190        200
GGKAVNTAPV PGQTPHDESD RRTEPRSSVS DLVNSLTSEM LMLSPGSEED 
       210        220        230        240        250
EAHEGCSREN LGRIQFSVGY NFQESTLTVK IMKAQELPAK DFSGTSDPFV 
       260        270        280        290        300
KIYLLPDKKH KLETKVKRKN LNPHWNETFL FEGFPYEKVV QRILYLQVLD 
       310        320        330        340        350
YDRFSRNDPI GEVSIPLNKV DLTQMQTFWK DLKPCSDGSG SRGELLLSLC 
       360        370        380        390        400
YNPSANSIIV NIIKARNLKA MDIGGTSDPY VKVWLMYKDK RVEKKKTVTM 
       410        420        430        440        450
KRNLNPIFNE SFAFDIPTEK LRETTIIITV MDKDKLSRND VIGKIYLSWK 
       460        470 
SGPGEVKHWK DMIARPRQPV AQWHQLKA

Note: No experimental confirmation available.

Show »

Length:478

Mass (Da):52,821

Checksum:ⁱ6F6B1DD2C9AFF15F

GO

Isoform 3 (identifier: O43581-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
72-72: K → NDLDRDFWNN...QNQNAQGDKR

« Hide

        10         20         30         40         50
MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRSEKKA INDLDRDFWN NNESTVQQKW SSYPPKEFIL 
       110        120        130        140        150
NISPYAPYGD PRLSLNGTLL SGAKVAAAAG LAVEREGRLG EKPAPVPPPG 
       160        170        180        190        200
EDALRSGGAA PSEPGSGGKA GRGRWRTVQS HLAAGKLNLS NFEDSTLSTA 
       210        220        230        240        250
TTLESIPSST GEPKCQRPRT LMRQQSLQQP LSQHQRGRQP SQPTTSQSLG 
       260        270        280        290        300
QLQAHMASAP GPNPRAYGRG QARQGTSAGS KYRAAGGRSR SNPGSWDHVV 
       310        320        330        340        350
GQIRNRGLDM KSFLEGRMVV LSLVLGLSEQ DDFANIPDLQ NPGTQQNQNA 
       360        370        380        390        400
QGDKRLPAGG KAVNTAPVPG QTPHDESDRR TEPRSSVSDL VNSLTSEMLM 
       410        420        430        440        450
LSPGSEEDEA HEGCSRENLG RIQFSVGYNF QESTLTVKIM KAQELPAKDF 
       460        470        480        490        500
SGTSDPFVKI YLLPDKKHKL ETKVKRKNLN PHWNETFLFE GFPYEKVVQR 
       510        520        530        540        550
ILYLQVLDYD RFSRNDPIGE VSIPLNKVDL TQMQTFWKDL KPCSDGSGSR 
       560        570        580        590        600
GELLLSLCYN PSANSIIVNI IKARNLKAMD IGGTSDPYVK VWLMYKDKRV 
       610        620        630        640        650
EKKKTVTMKR NLNPIFNESF AFDIPTEKLR ETTIIITVMD KDKLSRNDVI 
       660        670        680 
GKIYLSWKSG PGEVKHWKDM IARPRQPVAQ WHQLKA

Show »

Length:686

Mass (Da):75,797

Checksum:ⁱ96C75AAD8D9CCBFB

GO

Isoform 4 (identifier: O43581-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
72-72: K → NDLDRDFWNN...QNQNAQGDKR

« Hide

        10         20         30         40         50
MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRSEKKA INDLDRDFWN NNESTVQQKW SSYPPKEFIL 
       110        120        130        140        150
NISPYAPYGD PRLSLNFEDS TLSTATTLES IPSSTGEPKC QRPRTLMRQQ 
       160        170        180        190        200
SLQQPLSQHQ RGRQPSQPTT SQSLGQLQAH MASAPGPNPR AYGRGQARQG 
       210        220        230        240        250
TSAGSKYRAA GGRSRSNPGS WDHVVGQIRN RGLDMKSFLE GRMVVLSLVL 
       260        270        280        290        300
GLSEQDDFAN IPDLQNPGTQ QNQNAQGDKR LPAGGKAVNT APVPGQTPHD 
       310        320        330        340        350
ESDRRTEPRS SVSDLVNSLT SEMLMLSPGS EEDEAHEGCS RENLGRIQFS 
       360        370        380        390        400
VGYNFQESTL TVKIMKAQEL PAKDFSGTSD PFVKIYLLPD KKHKLETKVK 
       410        420        430        440        450
RKNLNPHWNE TFLFEGFPYE KVVQRILYLQ VLDYDRFSRN DPIGEVSIPL 
       460        470        480        490        500
NKVDLTQMQT FWKDLKPCSD GSGSRGELLL SLCYNPSANS IIVNIIKARN 
       510        520        530        540        550
LKAMDIGGTS DPYVKVWLMY KDKRVEKKKT VTMKRNLNPI FNESFAFDIP 
       560        570        580        590        600
TEKLRETTII ITVMDKDKLS RNDVIGKIYL SWKSGPGEVK HWKDMIARPR 
       610 
QPVAQWHQLK A

Show »

Length:611

Mass (Da):68,478

Checksum:ⁱ68702B2463439DB6

GO

Isoform 5 (identifier: O43581-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
71-71: I → INDLDRDFWN...HLAAGKLNLS

« Hide

        10         20         30         40         50
MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRSEKKA INDLDRDFWN NNESTVQQKW SSYPPKEFIL 
       110        120        130        140        150
NISPYAPYGD PRLSLNGTLL SGAKVAAAAG LAVEREGRLG EKPAPVPPPG 
       160        170        180        190        200
EDALRSGGAA PSEPGSGGKA GRGRWRTVQS HLAAGKLNLS KLPAGGKAVN 
       210        220        230        240        250
TAPVPGQTPH DESDRRTEPR SSVSDLVNSL TSEMLMLSPG SEEDEAHEGC 
       260        270        280        290        300
SRENLGRIQF SVGYNFQEST LTVKIMKAQE LPAKDFSGTS DPFVKIYLLP 
       310        320        330        340        350
DKKHKLETKV KRKNLNPHWN ETFLFEGFPY EKVVQRILYL QVLDYDRFSR 
       360        370        380        390        400
NDPIGEVSIP LNKVDLTQMQ TFWKDLKPCS DGSGSRGELL LSLCYNPSAN 
       410        420        430        440        450
SIIVNIIKAR NLKAMDIGGT SDPYVKVWLM YKDKRVEKKK TVTMKRNLNP 
       460        470        480        490        500
IFNESFAFDI PTEKLRETTI IITVMDKDKL SRNDVIGKIY LSWKSGPGEV 
       510        520 
KHWKDMIARP RQPVAQWHQL KA

Show »

Length:522

Mass (Da):58,019

Checksum:ⁱDFA24AF0D17AD221

GO

Isoform 6 (identifier: O43581-6) [UniParc]FASTA Add to basket

Also known as: Synaptotagmin VIIbeta1 Publication, Syt7betaCurated

The sequence of this isoform differs from the canonical sequence as follows:
71-71: I → INDLDRDFWNNNESTVQQKWSSYPPKEFILNISPYAPYGDPRLSL

« Hide

        10         20         30         40         50
MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRSEKKA INDLDRDFWN NNESTVQQKW SSYPPKEFIL 
       110        120        130        140        150
NISPYAPYGD PRLSLKLPAG GKAVNTAPVP GQTPHDESDR RTEPRSSVSD 
       160        170        180        190        200
LVNSLTSEML MLSPGSEEDE AHEGCSRENL GRIQFSVGYN FQESTLTVKI 
       210        220        230        240        250
MKAQELPAKD FSGTSDPFVK IYLLPDKKHK LETKVKRKNL NPHWNETFLF 
       260        270        280        290        300
EGFPYEKVVQ RILYLQVLDY DRFSRNDPIG EVSIPLNKVD LTQMQTFWKD 
       310        320        330        340        350
LKPCSDGSGS RGELLLSLCY NPSANSIIVN IIKARNLKAM DIGGTSDPYV 
       360        370        380        390        400
KVWLMYKDKR VEKKKTVTMK RNLNPIFNES FAFDIPTEKL RETTIIITVM 
       410        420        430        440 
DKDKLSRNDV IGKIYLSWKS GPGEVKHWKD MIARPRQPVA QWHQLKA

Show »

Length:447

Mass (Da):50,700

Checksum:ⁱ70A51A39F51AFB7F

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H8G7	F5H8G7_HUMAN	Synaptotagmin-7 Synaptotagmin-7	SYT7	175	Annotation score:
F5GX00	F5GX00_HUMAN	Synaptotagmin-7 Synaptotagmin-7	SYT7	122	Annotation score:

Sequence cautionⁱ

The sequence AAB92667 differs from that shown. Reason: Frameshift at positions 6, 10 and 15.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	154	V → L in AAB92667 (PubMed:9615227).Curated		1
Sequence conflictⁱ	188	E → K in AAB92667 (PubMed:9615227).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052241	332	I → N1 PublicationCorresponds to variant dbSNP:rs407740Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_045991	71	I → INGTLLSGAKVAAAAGLAVE REGRLGEKPAPVPPPGEDAL RSGGAAPSEPGSGGKAGRGR WRTVQSHLAAGKLNLS in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_058231	71	I → INDLDRDFWNNNESTVQQKW SSYPPKEFILNISPYAPYGD PRLSLNGTLLSGAKVAAAAG LAVEREGRLGEKPAPVPPPG EDALRSGGAAPSEPGSGGKA GRGRWRTVQSHLAAGKLNLS in isoform 5.	1
Alternative sequenceⁱVSP_058232	71	I → INDLDRDFWNNNESTVQQKW SSYPPKEFILNISPYAPYGD PRLSL in isoform 6.	1
Alternative sequenceⁱVSP_058233	72	K → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNGTLLSGAKVAAAAGL AVEREGRLGEKPAPVPPPGE DALRSGGAAPSEPGSGGKAG RGRWRTVQSHLAAGKLNLSN FEDSTLSTATTLESIPSSTG EPKCQRPRTLMRQQSLQQPL SQHQRGRQPSQPTTSQSLGQ LQAHMASAPGPNPRAYGRGQ ARQGTSAGSKYRAAGGRSRS NPGSWDHVVGQIRNRGLDMK SFLEGRMVVLSLVLGLSEQD DFANIPDLQNPGTQQNQNAQ GDKR in isoform 3.	1
Alternative sequenceⁱVSP_058234	72	K → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNFEDSTLSTATTLESI PSSTGEPKCQRPRTLMRQQS LQQPLSQHQRGRQPSQPTTS QSLGQLQAHMASAPGPNPRA YGRGQARQGTSAGSKYRAAG GRSRSNPGSWDHVVGQIRNR GLDMKSFLEGRMVVLSLVLG LSEQDDFANIPDLQNPGTQQ NQNAQGDKR in isoform 4.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF038535 mRNA Translation: AAB92667.1 Frameshift. AP002754 Genomic DNA No translation available. AP003108 Genomic DNA No translation available. AP003559 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW73956.1 BC125170 mRNA Translation: AAI25171.1 BC125171 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31577.1 [O43581-1] CCDS58139.1 [O43581-2] CCDS73298.1 [O43581-6]
NCBI Reference Sequences More...RefSeqⁱ	NP_001238994.1, NM_001252065.1 [O43581-2] NP_001287702.1, NM_001300773.1 [O43581-6] NP_004191.2, NM_004200.3 [O43581-1] XP_005274440.1, XM_005274383.4 [O43581-3] XP_005274442.1, XM_005274385.4 [O43581-4]
UniGeneⁱ	Hs.131188 Hs.684589

Genome annotation databases

Ensemblⁱ	ENST00000263846; ENSP00000263846; ENSG00000011347 [O43581-1] ENST00000535826; ENSP00000437720; ENSG00000011347 [O43581-5] ENST00000539008; ENSP00000439694; ENSG00000011347 [O43581-3] ENST00000540677; ENSP00000444201; ENSG00000011347 [O43581-2] ENST00000542670; ENSP00000444019; ENSG00000011347 [O43581-4] ENST00000542836; ENSP00000444568; ENSG00000011347 [O43581-6]
GeneIDⁱ	9066
KEGGⁱ	hsa:9066
UCSC genome browser More...UCSCⁱ	uc001nrv.4 human [O43581-1] uc001nrx.2 human uc058cdk.1 human uc058cdl.1 human uc058cdm.1 human

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O43581	Uncharacterized protein		GORGO		403	UniRef100_O43581
Synaptotagmin-7 (Fragment)		HUMAN		175
O43581-2	Uncharacterized protein		GORGO		478	UniRef100_A0A2I2ZGU4
O43581-3	Uncharacterized protein		GORGO		686	UniRef100_G3RUH1
O43581-4	Uncharacterized protein		GORGO		611	UniRef100_A0A2I2ZXQ6
O43581-5	Uncharacterized protein		GORGO		522	UniRef100_A0A2I2ZXG4
O43581-6	Uncharacterized protein		GORGO		447	UniRef100_A0A2I2ZJ39

Protein	Similar proteins		Species	Score	Length	Source
O43581	Synaptotagmin-7	)	MOUSE		403	UniRef90_Q9R0N7
Synaptotagmin-7	)	RAT		403
Uncharacterized protein		CERAT		409
Synaptotagmin 7		COLAP		404
Synaptotagmin VII (Fragment)		MACMU		400
+79
O43581-2	Uncharacterized protein		MACMU		478	UniRef90_A0A1D5QSK3
synaptotagmin-7 isoform X2		Florida manatee		479
Uncharacterized protein		FELCA		478
Uncharacterized protein		RHIRO		478
SYT7 isoform 6		PONAB		478
+27
O43581-3	Isoform 2 of Synaptotagmin-7		RAT		687	UniRef90_Q62747-2
Synaptotagmin-7 (Fragment)		MOUSE		224
synaptotagmin-7		NEOSC		698
Synaptotagmin 7		AILME		690
Synaptotagmin 7		BOVIN		689
+53
O43581-4	Isoform 3 of Synaptotagmin-7		RAT		611	UniRef90_Q62747-3
synaptotagmin-7 isoform X5		DELLE		630
Uncharacterized protein		FELCA		612
Synaptotagmin 7		HORSE		612
Uncharacterized protein		PAPAN		611
+47
O43581-5	Isoform 5 of Synaptotagmin-7		RAT		523	UniRef90_Q62747-5
synaptotagmin-7		BALAS		550
synaptotagmin-7 isoform X8		DELLE		541
Uncharacterized protein		PROCO		522
SYT7 isoform 3		PONAB		522
+24
O43581-6	Isoform 3 of Synaptotagmin-7		MOUSE		447	UniRef90_Q9R0N7-3
Uncharacterized protein		CHICK		449
Synaptotagmin-7 beta		CASCN		447
Uncharacterized protein		PIG		447
Uncharacterized protein		PROCO		447
+43

Protein	Similar proteins		Species	Score	Length	Source
O43581	Synaptotagmin-7	)	MOUSE		403	UniRef50_Q9R0N7
Synaptotagmin-7	)	RAT		403
Uncharacterized protein		CERAT		409
Synaptotagmin 7		COLAP		404
Synaptotagmin VII (Fragment)		MACMU		400
+288
O43581-3	Isoform 2 of Synaptotagmin-7		RAT		687	UniRef50_Q62747-2
Synaptotagmin-7 (Fragment)		MOUSE		224
synaptotagmin-7		NEOSC		698
Synaptotagmin 7		AILME		690
Synaptotagmin 7		BOVIN		689
+148
O43581-4	Isoform 4 of Synaptotagmin-7		MOUSE		567	UniRef50_Q9R0N7-4
Uncharacterized protein		MACMU		577
synaptotagmin-7 isoform X4		MESAU		567
Isoform 6 of Synaptotagmin-7		RAT		567
Uncharacterized protein		PIG		567
+294
O43581-5	Isoform 5 of Synaptotagmin-7		RAT		523	UniRef50_Q62747-5
synaptotagmin-7		BALAS		550
synaptotagmin-7 isoform X8		DELLE		541
Uncharacterized protein		RHIRO		522
SYT7 isoform 3		PONAB		522
+126

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF038535 mRNA Translation: AAB92667.1 Frameshift. AP002754 Genomic DNA No translation available. AP003108 Genomic DNA No translation available. AP003559 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW73956.1 BC125170 mRNA Translation: AAI25171.1 BC125171 mRNA No translation available.
CCDSⁱ	CCDS31577.1 [O43581-1] CCDS58139.1 [O43581-2] CCDS73298.1 [O43581-6]
RefSeqⁱ	NP_001238994.1, NM_001252065.1 [O43581-2] NP_001287702.1, NM_001300773.1 [O43581-6] NP_004191.2, NM_004200.3 [O43581-1] XP_005274440.1, XM_005274383.4 [O43581-3] XP_005274442.1, XM_005274385.4 [O43581-4]
UniGeneⁱ	Hs.131188 Hs.684589

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2D8K	NMR	-	A	132-259	[»]
ProteinModelPortalⁱ	O43581
SMRⁱ	O43581
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114525, 4 interactors
ELMⁱ	O43581
IntActⁱ	O43581, 1 interactor
STRINGⁱ	9606.ENSP00000263846

PTM databases

iPTMnetⁱ	O43581
PhosphoSitePlusⁱ	O43581

Polymorphism and mutation databases

BioMutaⁱ	SYT7

BioMutaⁱ

SYT7

Proteomic databases

MaxQBⁱ	O43581
PaxDbⁱ	O43581
PeptideAtlasⁱ	O43581
PRIDEⁱ	O43581
ProteomicsDBⁱ	49062

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000263846; ENSP00000263846; ENSG00000011347 [O43581-1] ENST00000535826; ENSP00000437720; ENSG00000011347 [O43581-5] ENST00000539008; ENSP00000439694; ENSG00000011347 [O43581-3] ENST00000540677; ENSP00000444201; ENSG00000011347 [O43581-2] ENST00000542670; ENSP00000444019; ENSG00000011347 [O43581-4] ENST00000542836; ENSP00000444568; ENSG00000011347 [O43581-6]
GeneIDⁱ	9066
KEGGⁱ	hsa:9066
UCSCⁱ	uc001nrv.4 human [O43581-1] uc001nrx.2 human uc058cdk.1 human uc058cdl.1 human uc058cdm.1 human

Organism-specific databases

CTDⁱ	9066
EuPathDBⁱ	HostDB:ENSG00000011347.9
GeneCardsⁱ	SYT7
H-InvDBⁱ	HIX0009693
HGNCⁱ	HGNC:11514 SYT7
HPAⁱ	HPA012869
MIMⁱ	604146 gene
neXtProtⁱ	NX_O43581
OpenTargetsⁱ	ENSG00000011347
PharmGKBⁱ	PA36295
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1028 Eukaryota ENOG410XRME LUCA
GeneTreeⁱ	ENSGT00760000118973
HOGENOMⁱ	HOG000232126
HOVERGENⁱ	HBG005010
InParanoidⁱ	O43581
KOⁱ	K19907
OMAⁱ	NDNTVQQ
OrthoDBⁱ	EOG091G08NG
PhylomeDBⁱ	O43581
TreeFamⁱ	TF315600

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6794361 Neurexins and neuroligins

Reactomeⁱ

R-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSⁱ	SYT7 human
EvolutionaryTraceⁱ	O43581
GeneWikiⁱ	SYT7
GenomeRNAiⁱ	9066
Protein Ontology More...PROⁱ	PR:O43581
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000011347 Expressed in 130 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_SYT7
ExpressionAtlasⁱ	O43581 baseline and differential
Genevisibleⁱ	O43581 HS

Family and domain databases

CDDⁱ	cd08386 C2A_Synaptotagmin-7, 1 hit cd08405 C2B_Synaptotagmin-7, 1 hit
Gene3Dⁱ	2.60.40.150, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR037732 C2A_Synaptotagmin-7 IPR037741 C2B_Synaptotagmin-7 IPR001565 Synaptotagmin IPR015427 Synaptotagmin7
PANTHERⁱ	PTHR10024:SF206 PTHR10024:SF206, 1 hit
Pfamⁱ	View protein in Pfam PF00168 C2, 2 hits
PRINTSⁱ	PR00360 C2DOMAIN PR00399 SYNAPTOTAGMN
SMARTⁱ	View protein in SMART SM00239 C2, 2 hits
PROSITEⁱ	View protein in PROSITE PS50004 C2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYT7_HUMAN
Accessionⁱ	O43581Primary (citable) accession number: O43581 Secondary accession number(s): F5GZC2 , F5GZU9, F5H126, F5H1N2, F5H6C1, Q08AH6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
	Last sequence update:	September 23, 2008
	Last modified:	November 7, 2018
	This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43581 (SYT7_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Synaptotagmin-7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

Plasma membrane

Lysosome

Other locations

Cytosol

Extracellular region or secreted

Lysosome

Peroxisome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ