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Entry version 183 (16 Oct 2019)
Sequence version 4 (01 Sep 2009)
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Protein

Regulator of G-protein signaling 14

Gene

RGS14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor
Biological processCell cycle, Cell division

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418594 G alpha (i) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O43566

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O43566

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of G-protein signaling 14
Short name:
RGS14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGS14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9996 RGS14

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602513 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43566

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10636

Open Targets

More...
OpenTargetsi
ENSG00000169220

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34366

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O43566

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RGS14

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002042171 – 566Regulator of G-protein signaling 14Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei199PhosphoserineBy similarity1
Modified residuei203PhosphoserineBy similarity1
Modified residuei218PhosphoserineBy similarity1
Modified residuei288PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PKC. Phosphorylation is increased in presence of forskolin and may enhance the GDI activity on G(i) alpha subunit GNAI1 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O43566

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O43566

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O43566

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43566

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O43566

PeptideAtlas

More...
PeptideAtlasi
O43566

PRoteomics IDEntifications database

More...
PRIDEi
O43566

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49054 [O43566-7]
49055 [O43566-4]
49056 [O43566-5]
49057 [O43566-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43566

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O43566

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000169220 Expressed in 189 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O43566 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O43566 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046847
HPA061819

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GNAO1, GNAI2 and GNAI3 (By similarity).

Interacts with GNAI1 (PubMed:18434541, PubMed:21115486).

Interacts (via RGS and GoLoco domains) with GNAI1; the interaction occurs in the centrosomes. Interaction with GNAI1 or GNAI3 (via active GTP- or inactive GDP-bound forms) prevents association of RGS14 with centrosomes or nuclear localization (By similarity).

Interacts with RABGEF1; the interactions is GTP-dependent.

Interacts with RAP2A; the interactions is GTP-dependent and does not alter its function on G(i) alpha subunits either as GAP or as GDI (By similarity). Associates with microtubules (PubMed:15917656).

Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14.

Interacts with RIC8A (via C-terminus).

Interacts (via RBD 1 domain) with HRAS (active GTP-bound form preferentially).

Interacts (via RBD domains) with BRAF (via N-terminus); the interaction mediates the formation of a ternary complex with RAF1.

Interacts (via RBD domains) with RAF1 (via N-terminus); the interaction mediates the formation of a ternary complex with BRAF.

Interacts with KRAS (active GTP-bound form preferentially), MRAS (active GTP-bound form preferentially), NRAS (active GTP-bound form preferentially) and RRAS (active GTP-bound form preferentially).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115880, 17 interactors

Database of interacting proteins

More...
DIPi
DIP-41167N

Protein interaction database and analysis system

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IntActi
O43566, 11 interactors

Molecular INTeraction database

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MINTi
O43566

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386229

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1566
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43566

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O43566

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini67 – 184RGSPROSITE-ProRule annotationAdd BLAST118
Domaini302 – 373RBD 1PROSITE-ProRule annotationAdd BLAST72
Domaini375 – 445RBD 2PROSITE-ProRule annotationAdd BLAST71
Domaini498 – 521GoLocoPROSITE-ProRule annotationAdd BLAST24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni299 – 425Necessary for interaction with RABGEF1By similarityAdd BLAST127

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RGS domain is necessary for GTPase-activating protein (GAP) activity for G subunits and localization to the nucleus and centrosomes.By similarity
The GoLoco domain is necessary for GDP-dissociation inhibitor (GDI) activity, translocation out of the nucleus and interaction with G(i) alpha subunits GNAI1, GNAI2 and GNAI3.By similarity
The RBD domains are necessary for localization to the nucleus and centrosomes.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3589 Eukaryota
ENOG410YMJD LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161364

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049111

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O43566

KEGG Orthology (KO)

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KOi
K17706

Identification of Orthologs from Complete Genome Data

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OMAi
RQAWIGE

Database of Orthologous Groups

More...
OrthoDBi
275783at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O43566

TreeFam database of animal gene trees

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TreeFami
TF328814

Family and domain databases

Conserved Domains Database

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CDDi
cd08743 RGS_RGS14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.196.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003109 GoLoco_motif
IPR003116 RBD_dom
IPR016137 RGS
IPR030776 RGS14
IPR037881 RGS14_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR45945:SF2 PTHR45945:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02188 GoLoco, 1 hit
PF02196 RBD, 2 hits
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00390 GoLoco, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097 SSF48097, 1 hit
SSF54236 SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O43566-7) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGKPKHLGV PNGRMVLAVS DGELSSTTGP QGQGEGRGSS LSIHSLPSGP
60 70 80 90 100
SSPFPTEEQP VASWALSFER LLQDPLGLAY FTEFLKKEFS AENVTFWKAC
110 120 130 140 150
ERFQQIPASD TQQLAQEARN IYQEFLSSQA LSPVNIDRQA WLGEEVLAEP
160 170 180 190 200
RPDMFRAQQL QIFNLMKFDS YARFVKSPLY RECLLAEAEG RPLREPGSSR
210 220 230 240 250
LGSPDATRKK PKLKPGKSLP LGVEELGQLP PVEGPGGRPL RKSFRRELGG
260 270 280 290 300
TANAALRRES QGSLNSSASL DLGFLAFVSS KSESHRKSLG STEGESESRP
310 320 330 340 350
GKYCCVYLPD GTASLALARP GLTIRDMLAG ICEKRGLSLP DIKVYLVGNE
360 370 380 390 400
QALVLDQDCT VLADQEVRLE NRITFELELT ALERVVRISA KPTKRLQEAL
410 420 430 440 450
QPILEKHGLS PLEVVLHRPG EKQPLDLGKL VSSVAAQRLV LDTLPGVKIS
460 470 480 490 500
KARDKSPCRS QGCPPRTQDK ATHPPPASPS SLVKVPSSAT GKRQTCDIEG
510 520 530 540 550
LVELLNRVQS SGAHDQRGLL RKEDLVLPEF LQLPAQGPSS EETPPQTKSA
560
AQPIGGSLNS TTDSAL
Note: No experimental confirmation available.
Length:566
Mass (Da):61,447
Last modified:September 1, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i811296228B479C3D
GO
Isoform 2 (identifier: O43566-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     352-354: ALV → VGT
     355-566: Missing.

Show »
Length:201
Mass (Da):21,781
Checksum:i3CBC0E128BC8346E
GO
Isoform 3 (identifier: O43566-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     351-351: Q → QK

Show »
Length:414
Mass (Da):44,820
Checksum:i9B2548AD3346AA00
GO
Isoform 4 (identifier: O43566-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-273: Missing.
     351-351: Q → QK

Note: No experimental confirmation available.
Show »
Length:347
Mass (Da):36,922
Checksum:iFBB19202385063E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8W3H0Y8W3_HUMAN
Regulator of G-protein-signaling 14
RGS14
437Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB92614 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti407H → R in BAC85600 (PubMed:14702039).Curated1
Sequence conflicti415V → A in AAY26402 (PubMed:16819986).Curated1
Sequence conflicti502Missing in AAB92614 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0275771 – 153Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST153
Alternative sequenceiVSP_02942654 – 273Missing in isoform 4. 1 PublicationAdd BLAST220
Alternative sequenceiVSP_037959351Q → QK in isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_027578352 – 354ALV → VGT in isoform 2. 2 Publications3
Alternative sequenceiVSP_027579355 – 566Missing in isoform 2. 2 PublicationsAdd BLAST212

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY987041 mRNA Translation: AAY26402.1
AF037194 mRNA Translation: AAB92613.1
AF037195 mRNA Translation: AAB92614.1 Frameshift.
AF493936 mRNA Translation: AAM12650.1
AK123382 mRNA Translation: BAC85600.1
AC146507 Genomic DNA No translation available.
BC014094 mRNA Translation: AAH14094.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43405.1 [O43566-7]

NCBI Reference Sequences

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RefSeqi
NP_006471.2, NM_006480.4 [O43566-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000408923; ENSP00000386229; ENSG00000169220 [O43566-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10636

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10636

UCSC genome browser

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UCSCi
uc003mgf.4 human [O43566-7]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

A balanced mind - Issue 132 of October 2011

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY987041 mRNA Translation: AAY26402.1
AF037194 mRNA Translation: AAB92613.1
AF037195 mRNA Translation: AAB92614.1 Frameshift.
AF493936 mRNA Translation: AAM12650.1
AK123382 mRNA Translation: BAC85600.1
AC146507 Genomic DNA No translation available.
BC014094 mRNA Translation: AAH14094.1
CCDSiCCDS43405.1 [O43566-7]
RefSeqiNP_006471.2, NM_006480.4 [O43566-7]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JNUNMR-A56-207[»]
2OM2X-ray2.20B/D497-532[»]
2XNSX-ray3.41C/D497-517[»]
3ONWX-ray2.38C/D497-532[»]
3QI2X-ray2.80C/D497-532[»]
SMRiO43566
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115880, 17 interactors
DIPiDIP-41167N
IntActiO43566, 11 interactors
MINTiO43566
STRINGi9606.ENSP00000386229

PTM databases

iPTMnetiO43566
PhosphoSitePlusiO43566

Polymorphism and mutation databases

BioMutaiRGS14

Proteomic databases

EPDiO43566
jPOSTiO43566
MassIVEiO43566
MaxQBiO43566
PaxDbiO43566
PeptideAtlasiO43566
PRIDEiO43566
ProteomicsDBi49054 [O43566-7]
49055 [O43566-4]
49056 [O43566-5]
49057 [O43566-6]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10636

Genome annotation databases

EnsembliENST00000408923; ENSP00000386229; ENSG00000169220 [O43566-7]
GeneIDi10636
KEGGihsa:10636
UCSCiuc003mgf.4 human [O43566-7]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10636
DisGeNETi10636

GeneCards: human genes, protein and diseases

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GeneCardsi
RGS14
HGNCiHGNC:9996 RGS14
HPAiHPA046847
HPA061819
MIMi602513 gene
neXtProtiNX_O43566
OpenTargetsiENSG00000169220
PharmGKBiPA34366

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00940000161364
HOGENOMiHOG000049111
InParanoidiO43566
KOiK17706
OMAiRQAWIGE
OrthoDBi275783at2759
PhylomeDBiO43566
TreeFamiTF328814

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
SignaLinkiO43566
SIGNORiO43566

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RGS14 human
EvolutionaryTraceiO43566

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RGS14

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10636
PharosiO43566

Protein Ontology

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PROi
PR:O43566

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169220 Expressed in 189 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiO43566 baseline and differential
GenevisibleiO43566 HS

Family and domain databases

CDDicd08743 RGS_RGS14, 1 hit
Gene3Di1.10.196.10, 1 hit
InterProiView protein in InterPro
IPR003109 GoLoco_motif
IPR003116 RBD_dom
IPR016137 RGS
IPR030776 RGS14
IPR037881 RGS14_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR45945:SF2 PTHR45945:SF2, 1 hit
PfamiView protein in Pfam
PF02188 GoLoco, 1 hit
PF02196 RBD, 2 hits
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00390 GoLoco, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGS14_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43566
Secondary accession number(s): O43565
, Q506M1, Q6ZWA4, Q8TD62
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 1, 2009
Last modified: October 16, 2019
This is version 183 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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