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Protein

Fibroblast growth factor receptor substrate 3

Gene

FRS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.1 Publication

GO - Molecular functioni

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: MGI
  • MAPK cascade Source: Reactome
  • signal transduction Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
SignaLinkiO43559
SIGNORiO43559

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor substrate 3
Short name:
FGFR substrate 3
Alternative name(s):
FGFR-signaling adaptor SNT2
Suc1-associated neurotrophic factor target 2
Short name:
SNT-2
Gene namesi
Name:FRS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137218.10
HGNCiHGNC:16970 FRS3
MIMi607744 gene
neXtProtiNX_O43559

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10817
OpenTargetsiENSG00000137218
PharmGKBiPA134961503

Polymorphism and mutation databases

BioMutaiFRS3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00000873462 – 492Fibroblast growth factor receptor substrate 3Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Post-translational modificationi

Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.By similarity2 Publications

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiO43559
PaxDbiO43559
PeptideAtlasiO43559
PRIDEiO43559
ProteomicsDBi49051

PTM databases

iPTMnetiO43559
PhosphoSitePlusiO43559

Expressioni

Gene expression databases

BgeeiENSG00000137218 Expressed in 145 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_FRS3
ExpressionAtlasiO43559 baseline and differential
GenevisibleiO43559 HS

Organism-specific databases

HPAiHPA030162
HPA030174

Interactioni

Subunit structurei

Binds NTRK1 (By similarity). Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116030, 29 interactors
IntActiO43559, 108 interactors
MINTiO43559
STRINGi9606.ENSP00000259748

Structurei

Secondary structure

1492
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO43559
SMRiO43559
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43559

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 115IRS-type PTBPROSITE-ProRule annotationAdd BLAST103

Phylogenomic databases

eggNOGiKOG4047 Eukaryota
ENOG410XS2S LUCA
GeneTreeiENSGT00510000046707
HOGENOMiHOG000290694
HOVERGENiHBG062705
InParanoidiO43559
OMAiPPVWESH
OrthoDBiEOG091G06AV
PhylomeDBiO43559
TreeFamiTF324994

Family and domain databases

CDDicd01202 PTB_FRS2, 1 hit
InterProiView protein in InterPro
IPR038742 FRS2_PTB
IPR002404 IRS_PTB
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O43559-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSCCSCLNR DSVPDNHPTK FKVTNVDDEG VELGSGVMEL TQSELVLHLH
60 70 80 90 100
RREAVRWPYL CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CSRAEEIFNL
110 120 130 140 150
LQDLMQCNSI NVMEEPVIIT RNSHPAELDL PRAPQPPNAL GYTVSSFSNG
160 170 180 190 200
CPGEGPRFSA PRRLSTSSLR HPSLGEESTH ALIAPDEQSH TYVNTPASED
210 220 230 240 250
DHRRGRHCLQ PLPEGQAPFL PQARGPDQRD PQVFLQPGQV KFVLGPTPAR
260 270 280 290 300
RHMVKCQGLC PSLHDPPHHN NNNEAPSECP AQPKCTYENV TGGLWRGAGW
310 320 330 340 350
RLSPEEPGWN GLAHRRAALL HYENLPPLPP VWESQAQQLG GEAGDDGDSR
360 370 380 390 400
DGLTPSSNGF PDGEEDETPL QKPTSTRAAI RSHGSFPVPL TRRRGSPRVF
410 420 430 440 450
NFDFRRPGPE PPRQLNYIQV ELKGWGGDRP KGPQNPSSPQ APMPTTHPAR
460 470 480 490
SSDSYAVIDL KKTVAMSNLQ RALPRDDGTA RKTRHNSTDL PL
Length:492
Mass (Da):54,462
Last modified:January 23, 2007 - v3
Checksum:iF06BFC662B531765
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSM8A0A0A0MSM8_HUMAN
Fibroblast growth factor receptor s...
FRS3
147Annotation score:
A6PVU0A6PVU0_HUMAN
Fibroblast growth factor receptor s...
FRS3
36Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033855221P → L. Corresponds to variant dbSNP:rs3747747Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036718 mRNA Translation: AAB92555.1
CR457026 mRNA Translation: CAG33307.1
AL365205 Genomic DNA No translation available.
BC010611 mRNA Translation: AAH10611.1
CCDSiCCDS4860.1
RefSeqiNP_006644.1, NM_006653.4
XP_011512556.1, XM_011514254.2
XP_011512557.1, XM_011514255.2
UniGeneiHs.194208

Genome annotation databases

EnsembliENST00000259748; ENSP00000259748; ENSG00000137218
ENST00000373018; ENSP00000362109; ENSG00000137218
GeneIDi10817
KEGGihsa:10817
UCSCiuc003orc.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036718 mRNA Translation: AAB92555.1
CR457026 mRNA Translation: CAG33307.1
AL365205 Genomic DNA No translation available.
BC010611 mRNA Translation: AAH10611.1
CCDSiCCDS4860.1
RefSeqiNP_006644.1, NM_006653.4
XP_011512556.1, XM_011514254.2
XP_011512557.1, XM_011514255.2
UniGeneiHs.194208

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KUPNMR-A8-146[»]
2KUQNMR-A8-120[»]
2YS5NMR-A8-146[»]
2YT2NMR-A8-120[»]
ProteinModelPortaliO43559
SMRiO43559
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116030, 29 interactors
IntActiO43559, 108 interactors
MINTiO43559
STRINGi9606.ENSP00000259748

PTM databases

iPTMnetiO43559
PhosphoSitePlusiO43559

Polymorphism and mutation databases

BioMutaiFRS3

Proteomic databases

MaxQBiO43559
PaxDbiO43559
PeptideAtlasiO43559
PRIDEiO43559
ProteomicsDBi49051

Protocols and materials databases

DNASUi10817
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259748; ENSP00000259748; ENSG00000137218
ENST00000373018; ENSP00000362109; ENSG00000137218
GeneIDi10817
KEGGihsa:10817
UCSCiuc003orc.3 human

Organism-specific databases

CTDi10817
DisGeNETi10817
EuPathDBiHostDB:ENSG00000137218.10
GeneCardsiFRS3
HGNCiHGNC:16970 FRS3
HPAiHPA030162
HPA030174
MIMi607744 gene
neXtProtiNX_O43559
OpenTargetsiENSG00000137218
PharmGKBiPA134961503
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4047 Eukaryota
ENOG410XS2S LUCA
GeneTreeiENSGT00510000046707
HOGENOMiHOG000290694
HOVERGENiHBG062705
InParanoidiO43559
OMAiPPVWESH
OrthoDBiEOG091G06AV
PhylomeDBiO43559
TreeFamiTF324994

Enzyme and pathway databases

ReactomeiR-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
SignaLinkiO43559
SIGNORiO43559

Miscellaneous databases

ChiTaRSiFRS3 human
EvolutionaryTraceiO43559
GeneWikiiFRS3
GenomeRNAii10817
PROiPR:O43559
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137218 Expressed in 145 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_FRS3
ExpressionAtlasiO43559 baseline and differential
GenevisibleiO43559 HS

Family and domain databases

CDDicd01202 PTB_FRS2, 1 hit
InterProiView protein in InterPro
IPR038742 FRS2_PTB
IPR002404 IRS_PTB
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRS3_HUMAN
AccessioniPrimary (citable) accession number: O43559
Secondary accession number(s): Q5T3D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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