Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Progonadoliberin-2

Gene

GNRH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

GO - Molecular functioni

  • gonadotropin hormone-releasing hormone activity Source: GO_Central
  • gonadotropin-releasing hormone receptor binding Source: GO_Central
  • hormone activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-375281 Hormone ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Progonadoliberin-2
Alternative name(s):
Progonadoliberin II
Cleaved into the following 2 chains:
Alternative name(s):
Gonadoliberin II
Gonadotropin-releasing hormone II
Short name:
GnRH II
Luliberin II
Luteinizing hormone-releasing hormone II
Short name:
LH-RH II
Alternative name(s):
GnRH-associated peptide II
Gene namesi
Name:GNRH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125787.11
HGNCiHGNC:4420 GNRH2
MIMi602352 gene
neXtProtiNX_O43555

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2797
OpenTargetsiENSG00000125787
PharmGKBiPA28799

Polymorphism and mutation databases

BioMutaiGNRH2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001245624 – 120Progonadoliberin-2Add BLAST97
PeptideiPRO_000001245724 – 33Gonadoliberin-210
PeptideiPRO_000001245837 – 120GnRH-associated peptide 2Add BLAST84

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33Glycine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiO43555
PeptideAtlasiO43555
PRIDEiO43555
ProteomicsDBi49045
49046 [O43555-2]
49047 [O43555-3]

PTM databases

iPTMnetiO43555
PhosphoSitePlusiO43555

Expressioni

Tissue specificityi

Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate.

Gene expression databases

BgeeiENSG00000125787 Expressed in 81 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_GNRH2
GenevisibleiO43555 HS

Organism-specific databases

HPAiHPA004338

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109059, 1 interactor
STRINGi9606.ENSP00000245983

Structurei

3D structure databases

ProteinModelPortaliO43555
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GnRH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4MH Eukaryota
ENOG4111DTA LUCA
GeneTreeiENSGT00390000005119
HOGENOMiHOG000112757
HOVERGENiHBG005044
InParanoidiO43555
KOiK05252
OMAiPSEAQHW
OrthoDBiEOG091G1044
PhylomeDBiO43555
TreeFamiTF353529

Family and domain databases

InterProiView protein in InterPro
IPR002012 GnRH
IPR019792 Gonadoliberin_I
PANTHERiPTHR10522 PTHR10522, 1 hit
PfamiView protein in Pfam
PF00446 GnRH, 1 hit
PROSITEiView protein in PROSITE
PS00473 GNRH, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: O43555-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP
60 70 80 90 100
PGRALDTAAG SPVQTAHGLP SDALAPLDDS MPWEGRTTAQ WSLHRKRHLA
110 120
RTLLTAAREP RPAPPSSNKV
Length:120
Mass (Da):12,918
Last modified:June 1, 1998 - v1
Checksum:iD58CDA14B6D6FB8D
GO
Isoform 2 (identifier: O43555-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-59: Missing.

Show »
Length:112
Mass (Da):12,162
Checksum:iC8F8DD070CF32CF5
GO
Isoform 3 (identifier: O43555-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-58: Missing.

Show »
Length:113
Mass (Da):12,233
Checksum:iB4638FE343839E78
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05310916A → V. Corresponds to variant dbSNP:rs6051545Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00182552 – 59Missing in isoform 2. Curated8
Alternative sequenceiVSP_00182652 – 58Missing in isoform 3. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036329 Genomic DNA Translation: AAC02980.1
AF036330 mRNA Translation: AAC02981.1
AL121905 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10559.1
BC069362 mRNA Translation: AAH69362.1
BC115399 mRNA Translation: AAI15400.1
BC115400 mRNA Translation: AAI15401.1
CCDSiCCDS13040.1 [O43555-1]
CCDS13041.1 [O43555-3]
CCDS13042.1 [O43555-2]
RefSeqiNP_001297149.1, NM_001310220.1 [O43555-1]
NP_001492.1, NM_001501.1 [O43555-1]
NP_847901.1, NM_178331.1 [O43555-3]
NP_847902.1, NM_178332.1 [O43555-2]
XP_016883312.1, XM_017027823.1 [O43555-3]
UniGeneiHs.129715

Genome annotation databases

EnsembliENST00000245983; ENSP00000245983; ENSG00000125787 [O43555-1]
ENST00000359100; ENSP00000352003; ENSG00000125787 [O43555-3]
ENST00000380346; ENSP00000369704; ENSG00000125787 [O43555-2]
ENST00000380347; ENSP00000369705; ENSG00000125787 [O43555-3]
GeneIDi2797
KEGGihsa:2797
UCSCiuc002whp.2 human [O43555-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036329 Genomic DNA Translation: AAC02980.1
AF036330 mRNA Translation: AAC02981.1
AL121905 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10559.1
BC069362 mRNA Translation: AAH69362.1
BC115399 mRNA Translation: AAI15400.1
BC115400 mRNA Translation: AAI15401.1
CCDSiCCDS13040.1 [O43555-1]
CCDS13041.1 [O43555-3]
CCDS13042.1 [O43555-2]
RefSeqiNP_001297149.1, NM_001310220.1 [O43555-1]
NP_001492.1, NM_001501.1 [O43555-1]
NP_847901.1, NM_178331.1 [O43555-3]
NP_847902.1, NM_178332.1 [O43555-2]
XP_016883312.1, XM_017027823.1 [O43555-3]
UniGeneiHs.129715

3D structure databases

ProteinModelPortaliO43555
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109059, 1 interactor
STRINGi9606.ENSP00000245983

PTM databases

iPTMnetiO43555
PhosphoSitePlusiO43555

Polymorphism and mutation databases

BioMutaiGNRH2

Proteomic databases

PaxDbiO43555
PeptideAtlasiO43555
PRIDEiO43555
ProteomicsDBi49045
49046 [O43555-2]
49047 [O43555-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245983; ENSP00000245983; ENSG00000125787 [O43555-1]
ENST00000359100; ENSP00000352003; ENSG00000125787 [O43555-3]
ENST00000380346; ENSP00000369704; ENSG00000125787 [O43555-2]
ENST00000380347; ENSP00000369705; ENSG00000125787 [O43555-3]
GeneIDi2797
KEGGihsa:2797
UCSCiuc002whp.2 human [O43555-1]

Organism-specific databases

CTDi2797
DisGeNETi2797
EuPathDBiHostDB:ENSG00000125787.11
GeneCardsiGNRH2
HGNCiHGNC:4420 GNRH2
HPAiHPA004338
MIMi602352 gene
neXtProtiNX_O43555
OpenTargetsiENSG00000125787
PharmGKBiPA28799
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4MH Eukaryota
ENOG4111DTA LUCA
GeneTreeiENSGT00390000005119
HOGENOMiHOG000112757
HOVERGENiHBG005044
InParanoidiO43555
KOiK05252
OMAiPSEAQHW
OrthoDBiEOG091G1044
PhylomeDBiO43555
TreeFamiTF353529

Enzyme and pathway databases

ReactomeiR-HSA-375281 Hormone ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events

Miscellaneous databases

GeneWikiiGNRH2
GenomeRNAii2797
PROiPR:O43555
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125787 Expressed in 81 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_GNRH2
GenevisibleiO43555 HS

Family and domain databases

InterProiView protein in InterPro
IPR002012 GnRH
IPR019792 Gonadoliberin_I
PANTHERiPTHR10522 PTHR10522, 1 hit
PfamiView protein in Pfam
PF00446 GnRH, 1 hit
PROSITEiView protein in PROSITE
PS00473 GNRH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGON2_HUMAN
AccessioniPrimary (citable) accession number: O43555
Secondary accession number(s): Q14C68
, Q14C69, Q9BYN9, Q9BYP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again