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Protein

DNA repair protein XRCC2

Gene

XRCC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • centrosome cycle Source: UniProtKB
  • DNA repair Source: BHF-UCL
  • double-strand break repair via homologous recombination Source: UniProtKB
  • in utero embryonic development Source: Ensembl
  • meiotic cell cycle Source: ProtInc
  • mitotic cell cycle Source: UniProtKB
  • multicellular organism growth Source: Ensembl
  • negative regulation of neuron apoptotic process Source: Ensembl
  • positive regulation of neurogenesis Source: Ensembl
  • regulation of fibroblast apoptotic process Source: Ensembl
  • response to gamma radiation Source: Ensembl
  • response to X-ray Source: Ensembl
  • somitogenesis Source: Ensembl
  • strand invasion Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein XRCC2
Alternative name(s):
X-ray repair cross-complementing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XRCC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000196584.2

Human Gene Nomenclature Database

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HGNCi
HGNC:12829 XRCC2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600375 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O43543

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Fanconi anemia, complementation group U (FANCU)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
See also OMIM:617247

Keywords - Diseasei

Fanconi anemia

Organism-specific databases

DisGeNET

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DisGeNETi
7516

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
XRCC2

MalaCards human disease database

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MalaCardsi
XRCC2
MIMi617247 phenotype

Open Targets

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OpenTargetsi
ENSG00000196584

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
84 Fanconi anemia
227535 Hereditary breast cancer
399805 Male infertility with azoospermia or oligozoospermia due to single gene mutation

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37421

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
XRCC2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001229481 – 280DNA repair protein XRCC2Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O43543

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O43543

MaxQB - The MaxQuant DataBase

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MaxQBi
O43543

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O43543

PeptideAtlas

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PeptideAtlasi
O43543

PRoteomics IDEntifications database

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PRIDEi
O43543

ProteomicsDB human proteome resource

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ProteomicsDBi
49042

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O43543

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O43543

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196584 Expressed in 223 organ(s), highest expression level in buccal mucosa cell

CleanEx database of gene expression profiles

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CleanExi
HS_XRCC2

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43543 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA065153

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAD51D. Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA.6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113350, 17 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O43543

Database of interacting proteins

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DIPi
DIP-24242N

Protein interaction database and analysis system

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IntActi
O43543, 11 interactors

Molecular INTeraction database

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MINTi
O43543

STRING: functional protein association networks

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STRINGi
9606.ENSP00000352271

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O43543

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43543

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2859 Eukaryota
ENOG4112B2N LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000020445

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000004802

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG079347

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43543

KEGG Orthology (KO)

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KOi
K10879

Identification of Orthologs from Complete Genome Data

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OMAi
TTQSIMQ

Database of Orthologous Groups

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OrthoDBi
1522846at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O43543

TreeFam database of animal gene trees

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TreeFami
TF101202

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013632 DNA_recomb/repair_Rad51_C
IPR027417 P-loop_NTPase
IPR020588 RecA_ATP-bd
IPR030547 XRCC2

The PANTHER Classification System

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PANTHERi
PTHR22942:SF44 PTHR22942:SF44, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08423 Rad51, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50162 RECA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O43543-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCSAFHRAES GTELLARLEG RSSLKEIEPN LFADEDSPVH GDILEFHGPE
60 70 80 90 100
GTGKTEMLYH LTARCILPKS EGGLEVEVLF IDTDYHFDML RLVTILEHRL
110 120 130 140 150
SQSSEEIIKY CLGRFFLVYC SSSTHLLLTL YSLESMFCSH PSLCLLILDS
160 170 180 190 200
LSAFYWIDRV NGGESVNLQE STLRKCSQCL EKLVNDYRLV LFATTQTIMQ
210 220 230 240 250
KASSSSEEPS HASRRLCDVD IDYRPYLCKA WQQLVKHRMF FSKQDDSQSS
260 270 280
NQFSLVSRCL KSNSLKKHFF IIGESGVEFC
Length:280
Mass (Da):31,956
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5656277E74C06074
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02040316A → S Polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs4987090Ensembl.1
Natural variantiVAR_07716747H → R Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs587780126EnsemblClinVar.1
Natural variantiVAR_07716861L → I Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs569810249EnsemblClinVar.1
Natural variantiVAR_07716975E → Q Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs1327414828Ensembl.1
Natural variantiVAR_07717091R → W Rare variant; found in breast cancer; unknown pathological significance; moderately decreased function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs730882043EnsemblClinVar.1
Natural variantiVAR_07717195I → V Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 3 PublicationsCorresponds to variant dbSNP:rs140214637EnsemblClinVar.1
Natural variantiVAR_077172118V → A Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs185815454Ensembl.1
Natural variantiVAR_077173120C → Y Rare variant; found in breast cancer; unknown pathological significance; moderately decreased function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs1432878196Ensembl.1
Natural variantiVAR_077174133L → P Rare variant; found in breast cancer; unknown pathological significance; moderately decreased function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs765276614Ensembl.1
Natural variantiVAR_077175164E → Q Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs1215678098Ensembl.1
Natural variantiVAR_077176170E → A Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs778143946EnsemblClinVar.1
Natural variantiVAR_077177188R → C Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs139219364EnsemblClinVar.1
Natural variantiVAR_020404188R → H Polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs3218536EnsemblClinVar.1
Natural variantiVAR_077178194T → M Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs775565256EnsemblClinVar.1
Natural variantiVAR_077179199M → L Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_077180207E → G Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs61762969EnsemblClinVar.1
Natural variantiVAR_077181220D → V Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs765021741EnsemblClinVar.1
Natural variantiVAR_029294221I → T1 PublicationCorresponds to variant dbSNP:rs3218537EnsemblClinVar.1
Natural variantiVAR_077182231W → C Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs1267462913Ensembl.1
Natural variantiVAR_077183238R → S Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs534746330EnsemblClinVar.1
Natural variantiVAR_077184248Q → E Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs190900560EnsemblClinVar.1
Natural variantiVAR_077185258R → C Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 PublicationsCorresponds to variant dbSNP:rs759300252Ensembl.1
Natural variantiVAR_077186270F → V Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 3 PublicationsCorresponds to variant dbSNP:rs145085742EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF035587 mRNA Translation: AAC05369.1
AC003109 Genomic DNA Translation: AAC05802.1
Y08837 mRNA Translation: CAA70065.1
Y17033 Genomic DNA Translation: CAA76597.1
AF520762 Genomic DNA Translation: AAM55241.1
AK313607 mRNA Translation: BAG36372.1
CH471173 Genomic DNA Translation: EAW53968.1
BC042137 mRNA Translation: AAH42137.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5933.1

NCBI Reference Sequences

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RefSeqi
NP_005422.1, NM_005431.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.647093

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000359321; ENSP00000352271; ENSG00000196584

Database of genes from NCBI RefSeq genomes

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GeneIDi
7516

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7516

UCSC genome browser

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UCSCi
uc003wld.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035587 mRNA Translation: AAC05369.1
AC003109 Genomic DNA Translation: AAC05802.1
Y08837 mRNA Translation: CAA70065.1
Y17033 Genomic DNA Translation: CAA76597.1
AF520762 Genomic DNA Translation: AAM55241.1
AK313607 mRNA Translation: BAG36372.1
CH471173 Genomic DNA Translation: EAW53968.1
BC042137 mRNA Translation: AAH42137.1
CCDSiCCDS5933.1
RefSeqiNP_005422.1, NM_005431.1
UniGeneiHs.647093

3D structure databases

ProteinModelPortaliO43543
SMRiO43543
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113350, 17 interactors
CORUMiO43543
DIPiDIP-24242N
IntActiO43543, 11 interactors
MINTiO43543
STRINGi9606.ENSP00000352271

PTM databases

iPTMnetiO43543
PhosphoSitePlusiO43543

Polymorphism and mutation databases

BioMutaiXRCC2

Proteomic databases

EPDiO43543
jPOSTiO43543
MaxQBiO43543
PaxDbiO43543
PeptideAtlasiO43543
PRIDEiO43543
ProteomicsDBi49042

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7516
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359321; ENSP00000352271; ENSG00000196584
GeneIDi7516
KEGGihsa:7516
UCSCiuc003wld.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7516
DisGeNETi7516
EuPathDBiHostDB:ENSG00000196584.2

GeneCards: human genes, protein and diseases

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GeneCardsi
XRCC2
GeneReviewsiXRCC2
HGNCiHGNC:12829 XRCC2
HPAiHPA065153
MalaCardsiXRCC2
MIMi600375 gene
617247 phenotype
neXtProtiNX_O43543
OpenTargetsiENSG00000196584
Orphaneti84 Fanconi anemia
227535 Hereditary breast cancer
399805 Male infertility with azoospermia or oligozoospermia due to single gene mutation
PharmGKBiPA37421

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2859 Eukaryota
ENOG4112B2N LUCA
GeneTreeiENSGT00390000020445
HOGENOMiHOG000004802
HOVERGENiHBG079347
InParanoidiO43543
KOiK10879
OMAiTTQSIMQ
OrthoDBi1522846at2759
PhylomeDBiO43543
TreeFamiTF101202

Enzyme and pathway databases

ReactomeiR-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
XRCC2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
XRCC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7516

Protein Ontology

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PROi
PR:O43543

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000196584 Expressed in 223 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_XRCC2
GenevisibleiO43543 HS

Family and domain databases

InterProiView protein in InterPro
IPR013632 DNA_recomb/repair_Rad51_C
IPR027417 P-loop_NTPase
IPR020588 RecA_ATP-bd
IPR030547 XRCC2
PANTHERiPTHR22942:SF44 PTHR22942:SF44, 1 hit
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXRCC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43543
Secondary accession number(s): B2R925
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: June 1, 1998
Last modified: January 16, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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