UniProtKB - O43524 (FOXO3_HUMAN)
Forkhead box protein O3
FOXO3
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 157 – 251 | Fork-headPROSITE-ProRule annotationAdd BLAST | 95 |
GO - Molecular functioni
- beta-catenin binding Source: ParkinsonsUK-UCL
- chromatin DNA binding Source: UniProtKB
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCL
- mitochondrial sequence-specific DNA-binding transcription factor activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB
- sequence-specific DNA binding Source: UniProtKB
- transcription factor binding Source: GO_Central
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cellular response to oxidative stress Source: UniProtKB
- cytokine-mediated signaling pathway Source: Reactome
- glucose homeostasis Source: GO_Central
- insulin receptor signaling pathway Source: GO_Central
- mitochondrial transcription Source: UniProtKB
- negative regulation of cell migration Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of apoptotic process Source: BHF-UCL
- positive regulation of autophagy Source: UniProtKB
- positive regulation of erythrocyte differentiation Source: MGI
- positive regulation of muscle atrophy Source: UniProtKB
- positive regulation of neuron apoptotic process Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of translation Source: UniProtKB
- response to starvation Source: UniProtKB
- tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Apoptosis, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-HSA-1181150 Signaling by NODAL R-HSA-198693 AKT phosphorylates targets in the nucleus R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-9614399 Regulation of localization of FOXO transcription factors R-HSA-9614657 FOXO-mediated transcription of cell death genes R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation R-HSA-9617828 FOXO-mediated transcription of cell cycle genes R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
SignaLinki | O43524 |
SIGNORi | O43524 |
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead box protein O3CuratedAlternative name(s): AF6q21 protein1 Publication Forkhead in rhabdomyosarcoma-like 11 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3821 FOXO3 |
MIMi | 602681 gene |
neXtProti | NX_O43524 |
Subcellular locationi
Nucleus
- Nucleus 9 Publications
Mitochondrion
- Mitochondrion matrix 2 Publications
- Mitochondrion outer membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Cytosol
- cytosol 8 Publications
Note: Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106). Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, PubMed:16751106). Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity). Translocates in a AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, PubMed:29445193).By similarity5 Publications
Cytosol
- cytosol Source: FlyBase
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrial outer membrane Source: UniProtKB
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2 – 148 | Missing : Loss of localization to the mitochondrion outer membrane and loss of translocation into the mitochondrion following metabolic stress. 1 PublicationAdd BLAST | 147 | |
Mutagenesisi | 2 – 30 | Missing : Loss of translocation into the mitochondrion following metabolic stress. 1 PublicationAdd BLAST | 29 | |
Mutagenesisi | 12 | S → A in normal cells, no defect in mitochondrion import following metabolic stress. In cancer cells, defective mitochondrion import following metabolic stress and abolition of ERK-mediated phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 30 | S → A: Abolishes phosphorylation. Loss of localization to the mitochondrion outer membrane and loss of translocation into the mitochondrion following metabolic stress. 1 Publication | 1 | |
Mutagenesisi | 32 | T → A: Abolishes YWHAZ-binding; when associated with A-253. Exclusively nuclear, induces transcription and promotes apoptosis; when associated with A-253 and A-315. 1 Publication | 1 | |
Mutagenesisi | 80 – 108 | Missing : Loss of translocation into the mitochondrion following metabolic stress. 1 PublicationAdd BLAST | 29 | |
Mutagenesisi | 179 | T → A: Decreased phosphorylation by AMPK and impaired ability to transactivate a reporter gene; when associated with A-399; A-413; A-555; A-588 and A-626. 1 Publication | 1 | |
Mutagenesisi | 209 | S → A: Impairs nuclear translocation upon oxidative stress. 1 Publication | 1 | |
Mutagenesisi | 242 – 271 | Missing : Loss of nuclear import. 1 PublicationAdd BLAST | 30 | |
Mutagenesisi | 242 | K → A: Slightly decreases DNA affinity. 2 Publications | 1 | |
Mutagenesisi | 242 | K → R: Reduces acetylation, increases interaction with SKP2 and inhibits FOXO3 ubiquitination and degradation; when associated with R-259; R-290 and R-569. 2 Publications | 1 | |
Mutagenesisi | 245 | K → A: Decreases DNA affinity. 1 Publication | 1 | |
Mutagenesisi | 253 | S → A: Abolishes YWHAZ-binding; when associated with A-32. Exclusively nuclear, induces transcription and promotes apoptosis; when associated with A-32 and A-315. 1 Publication | 1 | |
Mutagenesisi | 259 | K → R: Reduces acetylation, increases interaction with SKP2 and inhibits FOXO3 ubiquitination and degradation; when associated with R-242; R-290 and R-569. 1 Publication | 1 | |
Mutagenesisi | 269 | K → R: Methylation levels similar to wild-type; when associated with ARG-270. 1 Publication | 1 | |
Mutagenesisi | 270 | K → R: Methylation levels similar to wild-type; when associated with ARG-269. 1 Publication | 1 | |
Mutagenesisi | 271 | K → R: Methylation levels strongly reduced. 1 Publication | 1 | |
Mutagenesisi | 290 | K → R: Reduces acetylation, increases interaction with SKP2 and inhibits FOXO3 ubiquitination and degradation; when associated with R-242; R-259 and R-569. 1 Publication | 1 | |
Mutagenesisi | 315 | S → A: No effect on YWHAZ-binding. Promotes nuclear translocation. Exclusively nuclear, induces transcription and promotes apoptosis; when associated with A-32 and A-253. 1 Publication | 1 | |
Mutagenesisi | 399 | S → A: Decreased phosphorylation by AMPK and impaired ability to transactivate a reporter gene; when associated with A-179; A-413; A-555; A-588 and A-626. 1 Publication | 1 | |
Mutagenesisi | 413 | S → A: Decreased phosphorylation by AMPK and impaired ability to transactivate a reporter gene; when associated with A-179; A-399; A-555; A-588 and A-626. 1 Publication | 1 | |
Mutagenesisi | 555 | S → A: Decreased phosphorylation by AMPK and impaired ability to transactivate a reporter gene; when associated with A-179; A-399; A-413; A-588 and A-626. 1 Publication | 1 | |
Mutagenesisi | 569 | K → R: Reduces acetylation, increases interaction with SKP2 and inhibits FOXO3 ubiquitination and degradation; when associated with R-242; R-259 and R-290. 1 Publication | 1 | |
Mutagenesisi | 588 | S → A: Decreased phosphorylation by AMPK and impaired ability to transactivate a reporter gene; when associated with A-179; A-399; A-413; A-555 and A-626. 1 Publication | 1 | |
Mutagenesisi | 626 | S → A: Decreased phosphorylation by AMPK and impaired ability to transactivate a reporter gene; when associated with A-179; A-399; A-413; A-555 and A-588. 1 Publication | 1 | |
Mutagenesisi | 644 | S → A: Loss of phosphorylation by IKKB. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 2309 |
OpenTargetsi | ENSG00000118689 |
PharmGKBi | PA28239 |
Miscellaneous databases
Pharosi | O43524 |
Chemistry databases
ChEMBLi | CHEMBL5778 |
Polymorphism and mutation databases
BioMutai | FOXO3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000091874 | 1 – 673 | Forkhead box protein O3Add BLAST | 673 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 30 | Phosphoserine; by AMPK1 Publication | 1 | |
Modified residuei | 32 | Phosphothreonine; by PKB/AKT11 Publication | 1 | |
Modified residuei | 46 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 149 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 179 | Phosphothreonine; by AMPK1 Publication | 1 | |
Modified residuei | 209 | Phosphoserine; by STK4/MST11 Publication | 1 | |
Modified residuei | 215 | Phosphoserine; by MAPKAPK51 Publication | 1 | |
Modified residuei | 230 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 242 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 253 | Phosphoserine; by PKB/AKT1 and MAPKAPK52 Publications | 1 | |
Modified residuei | 262 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 271 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 280 | PhosphoserineCombined sources | 1 | |
Modified residuei | 284 | PhosphoserineCombined sources | 1 | |
Modified residuei | 290 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 294 | PhosphoserineBy similarity | 1 | |
Modified residuei | 299 | Phosphoserine; by CaMK2ACombined sources1 Publication | 1 | |
Modified residuei | 311 | PhosphoserineCombined sources | 1 | |
Modified residuei | 315 | Phosphoserine; by SGK12 Publications | 1 | |
Modified residuei | 399 | Phosphoserine; by AMPK1 Publication | 1 | |
Modified residuei | 413 | Phosphoserine; by AMPKCombined sources1 Publication | 1 | |
Modified residuei | 419 | N6-methyllysine1 Publication | 1 | |
Modified residuei | 421 | PhosphoserineCombined sources | 1 | |
Modified residuei | 551 | Phosphoserine; by MAPKAPK5Combined sources1 Publication | 1 | |
Modified residuei | 555 | Phosphoserine; by AMPK and MAPKAPK52 Publications | 1 | |
Modified residuei | 588 | Phosphoserine; by AMPK1 Publication | 1 | |
Modified residuei | 626 | Phosphoserine; by AMPK1 Publication | 1 | |
Modified residuei | 644 | Phosphoserine; by IKKB1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O43524 |
jPOSTi | O43524 |
MassIVEi | O43524 |
MaxQBi | O43524 |
PaxDbi | O43524 |
PeptideAtlasi | O43524 |
PRIDEi | O43524 |
ProteomicsDBi | 49029 [O43524-1] 5304 |
PTM databases
GlyConnecti | 1253 |
iPTMneti | O43524 |
PhosphoSitePlusi | O43524 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000118689 Expressed in 236 organ(s), highest expression level in trabecular bone tissue |
Genevisiblei | O43524 HS |
Organism-specific databases
HPAi | CAB004074 HPA063104 |
Interactioni
Subunit structurei
Upon metabolic stress, forms a complex composed of FOXO3, SIRT3 and mitochondrial RNA polymerase POLRMT; the complex is recruited to mtDNA in a SIRT3-dependent manner (PubMed:23283301). Also forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT (PubMed:29445193).
Interacts with SIRT2; the interaction occurs independently of SIRT2 deacetylase activity (By similarity).
Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration (PubMed:16751106). Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation (PubMed:16751106).
Interacts with PIM1 (PubMed:18593906).
Interacts with DDIT3/CHOP (PubMed:22761832).
Interacts (deacetylated form) with SKP2 (PubMed:21841822).
Interacts with CHUK and IKBKB (PubMed:15084260, PubMed:22313691).
Interacts with CAMK2A, CAMK2B and calcineurin A (By similarity). Interacts FOXO3; this interaction represses FOXO3 transactivation (PubMed:20181828).
By similarity9 PublicationsBinary interactionsi
GO - Molecular functioni
- beta-catenin binding Source: ParkinsonsUK-UCL
- protein kinase binding Source: UniProtKB
- transcription factor binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 108598, 70 interactors |
ComplexPortali | CPX-1123 FOXO3-MYC complex CPX-1147 FOXO3-YWHAZ complex |
CORUMi | O43524 |
DIPi | DIP-29723N |
IntActi | O43524, 51 interactors |
MINTi | O43524 |
STRINGi | 9606.ENSP00000385824 |
Chemistry databases
BindingDBi | O43524 |
Structurei
Secondary structure
3D structure databases
SMRi | O43524 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O43524 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 80 – 108 | Required for mitochondrial import1 PublicationAdd BLAST | 29 | |
Regioni | 300 – 673 | Mediates interaction with CHUK/IKKA and IKBKB/IKKB1 PublicationAdd BLAST | 374 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 242 – 259 | Nuclear localization signal2 PublicationsAdd BLAST | 18 |
Phylogenomic databases
eggNOGi | KOG2294 Eukaryota COG5025 LUCA |
GeneTreei | ENSGT00940000159826 |
HOGENOMi | HOG000251635 |
InParanoidi | O43524 |
KOi | K09408 |
OMAi | NSRRNIM |
OrthoDBi | 1160384at2759 |
PhylomeDBi | O43524 |
TreeFami | TF315583 |
Family and domain databases
CDDi | cd00059 FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766 Fork_head_dom IPR032067 FOXO-TAD IPR032068 FOXO_KIX-bd IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250 Forkhead, 1 hit PF16676 FOXO-TAD, 1 hit PF16675 FOXO_KIX_bdg, 1 hit |
PRINTSi | PR00053 FORKHEAD |
SMARTi | View protein in SMART SM00339 FH, 1 hit |
SUPFAMi | SSF46785 SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEAPASPAP LSPLEVELDP EFEPQSRPRS CTWPLQRPEL QASPAKPSGE
60 70 80 90 100
TAADSMIPEE EDDEDDEDGG GRAGSAMAIG GGGGSGTLGS GLLLEDSARV
110 120 130 140 150
LAPGGQDPGS GPATAAGGLS GGTQALLQPQ QPLPPPQPGA AGGSGQPRKC
160 170 180 190 200
SSRRNAWGNL SYADLITRAI ESSPDKRLTL SQIYEWMVRC VPYFKDKGDS
210 220 230 240 250
NSSAGWKNSI RHNLSLHSRF MRVQNEGTGK SSWWIINPDG GKSGKAPRRR
260 270 280 290 300
AVSMDNSNKY TKSRGRAAKK KAALQTAPES ADDSPSQLSK WPGSPTSRSS
310 320 330 340 350
DELDAWTDFR SRTNSNASTV SGRLSPIMAS TELDEVQDDD APLSPMLYSS
360 370 380 390 400
SASLSPSVSK PCTVELPRLT DMAGTMNLND GLTENLMDDL LDNITLPPSQ
410 420 430 440 450
PSPTGGLMQR SSSFPYTTKG SGLGSPTSSF NSTVFGPSSL NSLRQSPMQT
460 470 480 490 500
IQENKPATFS SMSHYGNQTL QDLLTSDSLS HSDVMMTQSD PLMSQASTAV
510 520 530 540 550
SAQNSRRNVM LRNDPMMSFA AQPNQGSLVN QNLLHHQHQT QGALGGSRAL
560 570 580 590 600
SNSVSNMGLS ESSSLGSAKH QQQSPVSQSM QTLSDSLSGS SLYSTSANLP
610 620 630 640 650
VMGHEKFPSD LDLDMFNGSL ECDMESIIRS ELMDADGLDF NFDSLISTQN
660 670
VVGLNVGNFT GAKQASSQSW VPG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 156 – 163 | AWGNLSYA → WGKPVYS in CAA04860 (PubMed:9345057).Curated | 8 | |
Sequence conflicti | 238 – 246 | PDGGKSGKA → LMGEERKT in CAA04860 (PubMed:9345057).Curated | 9 | |
Sequence conflicti | 253 | S → T in CAA04860 (PubMed:9345057).Curated | 1 | |
Sequence conflicti | 271 | Missing in CAA04860 (PubMed:9345057).Curated | 1 | |
Sequence conflicti | 292 – 330 | PGSPT…PIMAS → AWQPHVNAAVMSWMRGRTSV HAPILTPAQSVAACRPSWQV in CAA04860 (PubMed:9345057).CuratedAdd BLAST | 39 | |
Sequence conflicti | 345 – 361 | PMLYS…SVSKP → AHALQHVSQPVTFSKQA in CAA04860 (PubMed:9345057).CuratedAdd BLAST | 17 | |
Sequence conflicti | 367 | P → R in CAA04860 (PubMed:9345057).Curated | 1 | |
Sequence conflicti | 371 | D → E in CAA04860 (PubMed:9345057).Curated | 1 | |
Sequence conflicti | 382 – 383 | LT → AD in CAA04860 (PubMed:9345057).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056225 | 1 – 220 | Missing in isoform 2. 1 PublicationAdd BLAST | 220 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF032886 mRNA Translation: AAC39592.1 AK301304 mRNA Translation: BAG62858.1 AL096818 Genomic DNA No translation available. AL391646 Genomic DNA No translation available. AL365509 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48373.1 CH471051 Genomic DNA Translation: EAW48374.1 BC020227 mRNA Translation: AAH20227.1 BC021224 mRNA Translation: AAH21224.1 BC068552 mRNA Translation: AAH68552.1 AJ001589 mRNA Translation: CAA04860.1 AJ001590 Genomic DNA Translation: CAA04861.1 |
CCDSi | CCDS5068.1 [O43524-1] |
RefSeqi | NP_001446.1, NM_001455.3 [O43524-1] NP_963853.1, NM_201559.2 [O43524-1] XP_005266925.1, XM_005266868.3 [O43524-2] XP_011533930.1, XM_011535628.2 [O43524-2] XP_011533931.1, XM_011535629.2 [O43524-2] XP_016866075.1, XM_017010586.1 [O43524-2] |
Genome annotation databases
Ensembli | ENST00000343882; ENSP00000339527; ENSG00000118689 [O43524-1] ENST00000406360; ENSP00000385824; ENSG00000118689 [O43524-1] ENST00000540898; ENSP00000446316; ENSG00000118689 [O43524-2] |
GeneIDi | 2309 |
KEGGi | hsa:2309 |
UCSCi | uc003psk.3 human [O43524-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF032886 mRNA Translation: AAC39592.1 AK301304 mRNA Translation: BAG62858.1 AL096818 Genomic DNA No translation available. AL391646 Genomic DNA No translation available. AL365509 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48373.1 CH471051 Genomic DNA Translation: EAW48374.1 BC020227 mRNA Translation: AAH20227.1 BC021224 mRNA Translation: AAH21224.1 BC068552 mRNA Translation: AAH68552.1 AJ001589 mRNA Translation: CAA04860.1 AJ001590 Genomic DNA Translation: CAA04861.1 |
CCDSi | CCDS5068.1 [O43524-1] |
RefSeqi | NP_001446.1, NM_001455.3 [O43524-1] NP_963853.1, NM_201559.2 [O43524-1] XP_005266925.1, XM_005266868.3 [O43524-2] XP_011533930.1, XM_011535628.2 [O43524-2] XP_011533931.1, XM_011535629.2 [O43524-2] XP_016866075.1, XM_017010586.1 [O43524-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K86 | NMR | - | A | 151-251 | [»] | |
2LQH | NMR | - | B | 461-483 | [»] | |
2LQI | NMR | - | B | 461-483 | [»] | |
2UZK | X-ray | 2.70 | A/C | 158-253 | [»] | |
6MNL | NMR | - | A | 237-252 | [»] | |
SMRi | O43524 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 108598, 70 interactors |
ComplexPortali | CPX-1123 FOXO3-MYC complex CPX-1147 FOXO3-YWHAZ complex |
CORUMi | O43524 |
DIPi | DIP-29723N |
IntActi | O43524, 51 interactors |
MINTi | O43524 |
STRINGi | 9606.ENSP00000385824 |
Chemistry databases
BindingDBi | O43524 |
ChEMBLi | CHEMBL5778 |
PTM databases
GlyConnecti | 1253 |
iPTMneti | O43524 |
PhosphoSitePlusi | O43524 |
Polymorphism and mutation databases
BioMutai | FOXO3 |
Proteomic databases
EPDi | O43524 |
jPOSTi | O43524 |
MassIVEi | O43524 |
MaxQBi | O43524 |
PaxDbi | O43524 |
PeptideAtlasi | O43524 |
PRIDEi | O43524 |
ProteomicsDBi | 49029 [O43524-1] 5304 |
Protocols and materials databases
DNASUi | 2309 |
Genome annotation databases
Ensembli | ENST00000343882; ENSP00000339527; ENSG00000118689 [O43524-1] ENST00000406360; ENSP00000385824; ENSG00000118689 [O43524-1] ENST00000540898; ENSP00000446316; ENSG00000118689 [O43524-2] |
GeneIDi | 2309 |
KEGGi | hsa:2309 |
UCSCi | uc003psk.3 human [O43524-1] |
Organism-specific databases
CTDi | 2309 |
DisGeNETi | 2309 |
GeneCardsi | FOXO3 |
HGNCi | HGNC:3821 FOXO3 |
HPAi | CAB004074 HPA063104 |
MIMi | 602681 gene |
neXtProti | NX_O43524 |
OpenTargetsi | ENSG00000118689 |
PharmGKBi | PA28239 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2294 Eukaryota COG5025 LUCA |
GeneTreei | ENSGT00940000159826 |
HOGENOMi | HOG000251635 |
InParanoidi | O43524 |
KOi | K09408 |
OMAi | NSRRNIM |
OrthoDBi | 1160384at2759 |
PhylomeDBi | O43524 |
TreeFami | TF315583 |
Enzyme and pathway databases
Reactomei | R-HSA-1181150 Signaling by NODAL R-HSA-198693 AKT phosphorylates targets in the nucleus R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-9614399 Regulation of localization of FOXO transcription factors R-HSA-9614657 FOXO-mediated transcription of cell death genes R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation R-HSA-9617828 FOXO-mediated transcription of cell cycle genes R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
SignaLinki | O43524 |
SIGNORi | O43524 |
Miscellaneous databases
ChiTaRSi | FOXO3 human |
EvolutionaryTracei | O43524 |
GeneWikii | FOXO3 |
GenomeRNAii | 2309 |
Pharosi | O43524 |
PROi | PR:O43524 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118689 Expressed in 236 organ(s), highest expression level in trabecular bone tissue |
Genevisiblei | O43524 HS |
Family and domain databases
CDDi | cd00059 FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766 Fork_head_dom IPR032067 FOXO-TAD IPR032068 FOXO_KIX-bd IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250 Forkhead, 1 hit PF16676 FOXO-TAD, 1 hit PF16675 FOXO_KIX_bdg, 1 hit |
PRINTSi | PR00053 FORKHEAD |
SMARTi | View protein in SMART SM00339 FH, 1 hit |
SUPFAMi | SSF46785 SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FOXO3_HUMAN | |
Accessioni | O43524Primary (citable) accession number: O43524 Secondary accession number(s): B4DVZ6 Q9BZ04 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | June 1, 1998 | |
Last modified: | October 16, 2019 | |
This is version 213 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references