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Protein

Bcl-2-like protein 11

Gene

BCL2L11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: GO_Central
  • protein heterodimerization activity Source: Ensembl
  • protein kinase binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-111446 Activation of BIM and translocation to mitochondria
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-193648 NRAGE signals death through JNK
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription

SIGNOR Signaling Network Open Resource

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SIGNORi
O43521

Protein family/group databases

Transport Classification Database

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TCDBi
8.A.69.1.1 the pro-apoptotic bcl-2-family protein bim (bim) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bcl-2-like protein 11
Short name:
Bcl2-L-11
Alternative name(s):
Bcl2-interacting mediator of cell death
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCL2L11
Synonyms:BIM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000153094.21

Human Gene Nomenclature Database

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HGNCi
HGNC:994 BCL2L11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603827 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43521

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi156G → A: Retains the ability to induce apoptosis. Abolishes interaction with BAX; in isoform Bim-alpha3 and isoform BimS. No effect on interaction with BCL2. 2 Publications1
Mutagenesisi156G → E: Abolishes induction of apoptosis. Abolishes interaction with BAX and BCL2; in isoform Bim-alpha3 and isoform BimS. Loses the ability to induce the conformationally active form of BAX. 2 Publications1
Mutagenesisi160N → A: Retains the ability to induce apoptosis. Abolishes interaction with BCL2; in isoform Bim-alpha3 and isoform BimS. No effect on interaction with BAX. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10018

Open Targets

More...
OpenTargetsi
ENSG00000153094

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25305

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5777

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BCL2L11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001431091 – 198Bcl-2-like protein 11Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei69Phosphoserine; by MAPK1 Publication1
Modified residuei77PhosphoserineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei94PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-69 by MAPK1/MAPK3 leads to interaction with TRIM2 and polyubiquitination, followed by proteasomal degradation (PubMed:15486195, PubMed:21478148). Deubiquitination catalyzed by USP27X stabilizes the protein (By similarity).By similarity2 Publications
Ubiquitination by TRIM2 following phosphorylation by MAPK1/MAPK3 leads to proteasomal degradation. Conversely, deubiquitination catalyzed by USP27X stabilizes the protein.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O43521

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O43521

PeptideAtlas

More...
PeptideAtlasi
O43521

PRoteomics IDEntifications database

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PRIDEi
O43521

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49009
49010 [O43521-10]
49011 [O43521-11]
49012 [O43521-12]
49013 [O43521-13]
49014 [O43521-14]
49015 [O43521-15]
49016 [O43521-16]
49017 [O43521-17]
49018 [O43521-18]
49019 [O43521-19]
49020 [O43521-2]
49021 [O43521-20]
49022 [O43521-3]
49023 [O43521-4]
49024 [O43521-5]
49025 [O43521-6]
49026 [O43521-7]
49027 [O43521-8]
49028 [O43521-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O43521

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O43521

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
O43521

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By ER stress in a DDIT3/CHOP-dependent manner.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000153094 Expressed in 190 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O43521 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43521 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026332

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms heterodimers with a number of antiapoptotic Bcl-2 proteins, including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, BHRF1, and BCL2L2/BCLW (PubMed:11997495, PubMed:27013495, PubMed:18812174). Isoform BimS and isoform Bim-alpha3 interact with BAX; this interaction may lead to BAX activation through conformational change (PubMed:11997495). Does not heterodimerize with proapoptotic proteins such as BAD, BOK or BAK. Identified in a complex containing BCL2L11, DYNLL1 and BCL2L1 isoform Bcl-X(L); BH3 integrity is required for BCL2L1-binding. Interacts with YWHAZ. When phosphorylated, interacts with TRIM2; this interaction is associated with ubiquitination and degradation (PubMed:21478148). Interacts with MCL1; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:27013495, PubMed:17389404). When phosphorylated, isoform BimEL interacts with USP27X; this interaction leads to BCL2L11 deubiquitination and stabilization (PubMed:27013495).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115335, 58 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1985 BIM:BCL-XL complex
CPX-1990 BIM:BCL-2 complex
CPX-481 MCL-1-BIM complex

Database of interacting proteins

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DIPi
DIP-29185N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
O43521

Protein interaction database and analysis system

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IntActi
O43521, 42 interactors

Molecular INTeraction database

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MINTi
O43521

STRING: functional protein association networks

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STRINGi
9606.ENSP00000376943

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O43521

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O43521

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43521

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O43521

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi148 – 162BH3Add BLAST15

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The BH3 motif is required for interaction with Bcl-2 proteins and cytotoxicity.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IZKS Eukaryota
ENOG410Y8GB LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000003178

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43521

KEGG Orthology (KO)

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KOi
K16341

Identification of Orthologs from Complete Genome Data

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OMAi
DRCPHGS

Database of Orthologous Groups

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OrthoDBi
EOG091G0XD3

Database for complete collections of gene phylogenies

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PhylomeDBi
O43521

TreeFam database of animal gene trees

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TreeFami
TF335898

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014771 Apoptosis_Bim_N
IPR017288 Bcl-2-like_11
IPR015040 Bcl-x_interacting_BH3_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08945 Bclx_interact, 1 hit
PF06773 Bim_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037827 Bcl-2-like_p11, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (20+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 20 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 20 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform BimEL (identifier: O43521-1) [UniParc]FASTAAdd to basket
Also known as: Bim(EL)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG
60 70 80 90 100
EGDSCPHGSP QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD
110 120 130 140 150
TDRSPAPMSC DKSTQTPSPP CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ
160 170 180 190
ELRRIGDEFN AYYARRVFLN NYQAAEDHPR MVILRLLRYI VRLVWRMH
Length:198
Mass (Da):22,171
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD75735E469CA6997
GO
Isoform BimL (identifier: O43521-2) [UniParc]FASTAAdd to basket
Also known as: Bim(L)

The sequence of this isoform differs from the canonical sequence as follows:
     42-101: Missing.

Show »
Length:138
Mass (Da):15,967
Checksum:i8BB4AAE06CB080FA
GO
Isoform BimS (identifier: O43521-3) [UniParc]FASTAAdd to basket
Also known as: BCL2-like 11 transcript variant 9, Bim(S)

The sequence of this isoform differs from the canonical sequence as follows:
     42-131: Missing.

Show »
Length:108
Mass (Da):12,717
Checksum:i60067208524D5BEA
GO
Isoform Bim-alpha1 (identifier: O43521-4) [UniParc]FASTAAdd to basket
Also known as: BimABCD, Bim-ABCD

The sequence of this isoform differs from the canonical sequence as follows:
     167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → LEK

Show »
Length:169
Mass (Da):18,536
Checksum:iE2E24D5697C955BA
GO
Isoform Bim-alpha2 (identifier: O43521-5) [UniParc]FASTAAdd to basket
Also known as: BimACD, Bim-ACD

The sequence of this isoform differs from the canonical sequence as follows:
     42-101: Missing.
     167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → LEK

Show »
Length:109
Mass (Da):12,332
Checksum:i4335FA21C13B49AD
GO
Isoform Bim-alpha3 (identifier: O43521-6) [UniParc]FASTAAdd to basket
Also known as: BCL2-like 11 transcript variant 10, BimAD, Bim-AD

The sequence of this isoform differs from the canonical sequence as follows:
     42-131: Missing.
     167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → LEK

Show »
Length:79
Mass (Da):9,081
Checksum:i3E03CCF2154A242C
GO
Isoform Bim-alpha4 (identifier: O43521-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-131: Missing.
     167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → LAKLLASST

Show »
Length:85
Mass (Da):9,596
Checksum:i7A6FD9AF07DA3E05
GO
Isoform Bim-alpha5 (identifier: O43521-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → MPLPPD

Show »
Length:172
Mass (Da):18,816
Checksum:iD2F7FC06EE3CE697
GO
Isoform Bim-alpha6 (identifier: O43521-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-131: Missing.
     167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → MPLPPD

Show »
Length:82
Mass (Da):9,362
Checksum:i08678A7A0FBD4215
GO
Isoform Bim-beta1 (identifier: O43521-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-135: SMR → NWD
     136-198: Missing.

Show »
Length:135
Mass (Da):14,458
Checksum:iD208F1CB6D324539
GO
Isoform Bim-beta2 (identifier: O43521-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-135: ASMR → GIFE
     136-198: Missing.

Show »
Length:135
Mass (Da):14,418
Checksum:iD3A245DECD324539
GO
Isoform Bim-beta3 (identifier: O43521-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-75: GNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFAT → VSLCHPGWSALVRSWLTATSNSQVQAVLLPQPPK

Show »
Length:198
Mass (Da):22,649
Checksum:iA8FA866EBD5CF16E
GO
Isoform Bim-beta4 (identifier: O43521-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-44: NP → IF
     45-198: Missing.

Show »
Length:44
Mass (Da):4,834
Checksum:iFA9541901CA32FD1
GO
Isoform Bim-beta5 (identifier: O43521-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-140: ASMRQAEPA → VREIEEVVV
     141-198: Missing.

Show »
Length:140
Mass (Da):15,025
Checksum:iB7590CC04A98E081
GO
Isoform Bim-beta6 (identifier: O43521-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-101: Missing.
     132-135: ASMR → GIFE
     136-198: Missing.

Show »
Length:75
Mass (Da):8,214
Checksum:i7CFE6B5A5ED671F3
GO
Isoform Bim-beta7 (identifier: O43521-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-101: Missing.
     132-140: ASMRQAEPA → VREIEEVVV
     141-198: Missing.

Show »
Length:80
Mass (Da):8,821
Checksum:i6958582B30D7BCAF
GO
Isoform Bim-gamma (identifier: O43521-17) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-101: Missing.
     132-198: ASMRQAEPAD...YIVRLVWRMH → VVILEDIGDL...TEQLNHKDFS

Show »
Length:112
Mass (Da):12,412
Checksum:i15E21254C12C239B
GO
Isoform BimABC (identifier: O43521-18) [UniParc]FASTAAdd to basket
Also known as: Bim-ABC

The sequence of this isoform differs from the canonical sequence as follows:
     42-101: Missing.
     132-166: Missing.

Show »
Length:103
Mass (Da):11,773
Checksum:iFD4F4A9292591961
GO
Isoform BimAC (identifier: O43521-19) [UniParc]FASTAAdd to basket
Also known as: Bim-AC

The sequence of this isoform differs from the canonical sequence as follows:
     132-166: Missing.

Show »
Length:163
Mass (Da):17,977
Checksum:i215890B3975C25A5
GO
Isoform BimA (identifier: O43521-20) [UniParc]FASTAAdd to basket
Also known as: Bim-A

The sequence of this isoform differs from the canonical sequence as follows:
     42-166: Missing.

Show »
Length:73
Mass (Da):8,523
Checksum:iD0CE170469B8570D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRE7A0A0A0MRE7_HUMAN
Bcl-2-like protein 11
BCL2L11
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DH20A0A0C4DH20_HUMAN
Bcl-2-like protein 11
BCL2L11
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J417C9J417_HUMAN
Bcl-2-like protein 11
BCL2L11
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZE5H7BZE5_HUMAN
Bcl-2-like protein 11
BCL2L11
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PAM9E9PAM9_HUMAN
Bcl-2-like protein 11
BCL2L11
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33P → L in BAF83066 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04286542 – 166Missing in isoform BimA. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_03560842 – 131Missing in isoform BimS, isoform Bim-alpha3, isoform Bim-alpha6 and isoform Bim-alpha4. 3 PublicationsAdd BLAST90
Alternative sequenceiVSP_00053542 – 101Missing in isoform BimABC, isoform BimL, isoform Bim-alpha2, isoform Bim-gamma, isoform Bim-beta6 and isoform Bim-beta7. 6 PublicationsAdd BLAST60
Alternative sequenceiVSP_03560942 – 75GNPEG…GPFAT → VSLCHPGWSALVRSWLTATS NSQVQAVLLPQPPK in isoform Bim-beta3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_03561043 – 44NP → IF in isoform Bim-beta4. 1 Publication2
Alternative sequenceiVSP_03561145 – 198Missing in isoform Bim-beta4. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_035612132 – 198ASMRQ…VWRMH → VVILEDIGDLSLCFGFIFTG LDLYGHHHSQDTEQLNHKDF S in isoform Bim-gamma. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_042866132 – 166Missing in isoform BimAC and isoform BimABC. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_035613132 – 140ASMRQAEPA → VREIEEVVV in isoform Bim-beta5 and isoform Bim-beta7. 1 Publication9
Alternative sequenceiVSP_035614132 – 135ASMR → GIFE in isoform Bim-beta2 and isoform Bim-beta6. 2 Publications4
Alternative sequenceiVSP_035615133 – 135SMR → NWD in isoform Bim-beta1. 1 Publication3
Alternative sequenceiVSP_035616136 – 198Missing in isoform Bim-beta1, isoform Bim-beta2 and isoform Bim-beta6. 2 PublicationsAdd BLAST63
Alternative sequenceiVSP_035617141 – 198Missing in isoform Bim-beta5 and isoform Bim-beta7. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_035620167 – 198VFLNN…VWRMH → LEK in isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3. 4 PublicationsAdd BLAST32
Alternative sequenceiVSP_035618167 – 198VFLNN…VWRMH → LAKLLASST in isoform Bim-alpha4. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_035619167 – 198VFLNN…VWRMH → MPLPPD in isoform Bim-alpha5 and isoform Bim-alpha6. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF032457 mRNA Translation: AAC39593.1
AF032458 mRNA Translation: AAC39594.1
AB071195 mRNA Translation: BAB78589.1
AB071196 mRNA Translation: BAB78590.1
AB071197 mRNA Translation: BAB78591.1
AB071198 mRNA Translation: BAB78592.1
AB071199 mRNA Translation: BAB78593.1
AB071200 mRNA Translation: BAB78594.1
AY352518 mRNA Translation: AAQ62569.1
AY305714 mRNA Translation: AAQ82546.1
AY305715 mRNA Translation: AAQ82547.1
AY423441 mRNA Translation: AAQ99148.1
AY423442 mRNA Translation: AAQ99149.1
AY423443 mRNA Translation: AAQ99150.1
AY428962 mRNA Translation: AAR06908.1
DQ849200 mRNA Translation: ABI13589.1
DQ849201 mRNA Translation: ABI13590.1
DQ849202 mRNA Translation: ABI13591.1
AK290377 mRNA Translation: BAF83066.1
AK291269 mRNA Translation: BAF83958.1
AC096670 Genomic DNA Translation: AAY14797.1
CH471237 Genomic DNA Translation: EAW50365.1
CH471237 Genomic DNA Translation: EAW50367.1
CH471237 Genomic DNA Translation: EAW50369.1
CH471237 Genomic DNA Translation: EAW50370.1
CH471237 Genomic DNA Translation: EAW50371.1
CH471237 Genomic DNA Translation: EAW50372.1
CH471237 Genomic DNA Translation: EAW50373.1
CH471237 Genomic DNA Translation: EAW50374.1
BC033694 mRNA Translation: AAH33694.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2089.1 [O43521-1]
CCDS2092.1 [O43521-17]
CCDS42731.1 [O43521-2]
CCDS56131.1 [O43521-16]
CCDS56132.1 [O43521-7]
CCDS56133.1 [O43521-9]
CCDS56134.1 [O43521-10]
CCDS56135.1 [O43521-8]
CCDS56136.1 [O43521-14]
CCDS74560.1 [O43521-4]
CCDS74561.1 [O43521-11]

NCBI Reference Sequences

More...
RefSeqi
NP_001191035.1, NM_001204106.1 [O43521-3]
NP_001191036.1, NM_001204107.1 [O43521-7]
NP_001191037.1, NM_001204108.1 [O43521-8]
NP_001191038.1, NM_001204109.1 [O43521-14]
NP_001191039.1, NM_001204110.1 [O43521-9]
NP_001191040.1, NM_001204111.1 [O43521-15]
NP_001191041.1, NM_001204112.1 [O43521-16]
NP_001191042.1, NM_001204113.1
NP_006529.1, NM_006538.4 [O43521-2]
NP_619527.1, NM_138621.4 [O43521-1]
NP_619528.1, NM_138622.3 [O43521-4]
NP_619529.1, NM_138623.3 [O43521-5]
NP_619530.1, NM_138624.3 [O43521-10]
NP_619531.1, NM_138625.3
NP_619532.1, NM_138626.3 [O43521-11]
NP_619533.1, NM_138627.3
NP_996885.1, NM_207002.3 [O43521-17]
NP_996886.1, NM_207003.2 [O43521-6]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.469658
Hs.737004

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308659; ENSP00000309226; ENSG00000153094 [O43521-2]
ENST00000337565; ENSP00000338374; ENSG00000153094 [O43521-17]
ENST00000393256; ENSP00000376943; ENSG00000153094 [O43521-1]
ENST00000405953; ENSP00000384641; ENSG00000153094 [O43521-17]
ENST00000415458; ENSP00000393781; ENSG00000153094 [O43521-16]
ENST00000431217; ENSP00000394640; ENSG00000153094 [O43521-10]
ENST00000433098; ENSP00000401662; ENSG00000153094 [O43521-5]
ENST00000436733; ENSP00000403727; ENSG00000153094 [O43521-14]
ENST00000437029; ENSP00000412892; ENSG00000153094 [O43521-8]
ENST00000439718; ENSP00000411137; ENSG00000153094 [O43521-7]
ENST00000452231; ENSP00000391292; ENSG00000153094 [O43521-9]
ENST00000610735; ENSP00000481030; ENSG00000153094 [O43521-14]
ENST00000615946; ENSP00000481423; ENSG00000153094 [O43521-7]
ENST00000619294; ENSP00000479714; ENSG00000153094 [O43521-10]
ENST00000620862; ENSP00000478133; ENSG00000153094 [O43521-5]
ENST00000621302; ENSP00000481652; ENSG00000153094 [O43521-4]
ENST00000622509; ENSP00000482175; ENSG00000153094 [O43521-8]
ENST00000622612; ENSP00000484360; ENSG00000153094 [O43521-11]
ENST00000639340; ENSP00000491154; ENSG00000153094 [O43521-16]
ENST00000640419; ENSP00000491422; ENSG00000153094 [O43521-9]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10018

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10018

UCSC genome browser

More...
UCSCi
uc002tgt.2 human [O43521-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032457 mRNA Translation: AAC39593.1
AF032458 mRNA Translation: AAC39594.1
AB071195 mRNA Translation: BAB78589.1
AB071196 mRNA Translation: BAB78590.1
AB071197 mRNA Translation: BAB78591.1
AB071198 mRNA Translation: BAB78592.1
AB071199 mRNA Translation: BAB78593.1
AB071200 mRNA Translation: BAB78594.1
AY352518 mRNA Translation: AAQ62569.1
AY305714 mRNA Translation: AAQ82546.1
AY305715 mRNA Translation: AAQ82547.1
AY423441 mRNA Translation: AAQ99148.1
AY423442 mRNA Translation: AAQ99149.1
AY423443 mRNA Translation: AAQ99150.1
AY428962 mRNA Translation: AAR06908.1
DQ849200 mRNA Translation: ABI13589.1
DQ849201 mRNA Translation: ABI13590.1
DQ849202 mRNA Translation: ABI13591.1
AK290377 mRNA Translation: BAF83066.1
AK291269 mRNA Translation: BAF83958.1
AC096670 Genomic DNA Translation: AAY14797.1
CH471237 Genomic DNA Translation: EAW50365.1
CH471237 Genomic DNA Translation: EAW50367.1
CH471237 Genomic DNA Translation: EAW50369.1
CH471237 Genomic DNA Translation: EAW50370.1
CH471237 Genomic DNA Translation: EAW50371.1
CH471237 Genomic DNA Translation: EAW50372.1
CH471237 Genomic DNA Translation: EAW50373.1
CH471237 Genomic DNA Translation: EAW50374.1
BC033694 mRNA Translation: AAH33694.1
CCDSiCCDS2089.1 [O43521-1]
CCDS2092.1 [O43521-17]
CCDS42731.1 [O43521-2]
CCDS56131.1 [O43521-16]
CCDS56132.1 [O43521-7]
CCDS56133.1 [O43521-9]
CCDS56134.1 [O43521-10]
CCDS56135.1 [O43521-8]
CCDS56136.1 [O43521-14]
CCDS74560.1 [O43521-4]
CCDS74561.1 [O43521-11]
RefSeqiNP_001191035.1, NM_001204106.1 [O43521-3]
NP_001191036.1, NM_001204107.1 [O43521-7]
NP_001191037.1, NM_001204108.1 [O43521-8]
NP_001191038.1, NM_001204109.1 [O43521-14]
NP_001191039.1, NM_001204110.1 [O43521-9]
NP_001191040.1, NM_001204111.1 [O43521-15]
NP_001191041.1, NM_001204112.1 [O43521-16]
NP_001191042.1, NM_001204113.1
NP_006529.1, NM_006538.4 [O43521-2]
NP_619527.1, NM_138621.4 [O43521-1]
NP_619528.1, NM_138622.3 [O43521-4]
NP_619529.1, NM_138623.3 [O43521-5]
NP_619530.1, NM_138624.3 [O43521-10]
NP_619531.1, NM_138625.3
NP_619532.1, NM_138626.3 [O43521-11]
NP_619533.1, NM_138627.3
NP_996885.1, NM_207002.3 [O43521-17]
NP_996886.1, NM_207003.2 [O43521-6]
UniGeneiHs.469658
Hs.737004

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F95NMR-C/D108-116[»]
2K7WNMR-B145-164[»]
2NL9X-ray1.55B141-166[»]
2V6QX-ray2.70B141-166[»]
2VM6X-ray2.20B141-165[»]
2WH6X-ray1.50B141-166[»]
2YQ6X-ray1.80B147-164[»]
2YQ7X-ray1.90B147-164[»]
3D7VX-ray2.03B141-166[»]
3FDLX-ray1.78B141-166[»]
3IO8X-ray2.30B/D141-166[»]
3IO9X-ray2.40B141-166[»]
3KJ0X-ray1.70B143-165[»]
3KJ1X-ray1.94B143-163[»]
3KJ2X-ray2.35B143-163[»]
4A1UX-ray1.54B146-163[»]
4A1WX-ray2.50P/Q/R/S146-163[»]
4B4SX-ray1.90B141-166[»]
4D2MX-ray2.10B/D141-166[»]
4QVFX-ray1.53B141-166[»]
4UF3X-ray2.70B141-166[»]
4YJ4X-ray2.10B146-165[»]
4ZIEX-ray1.80C141-166[»]
4ZIFX-ray2.40B141-160[»]
4ZIHX-ray2.50B141-160[»]
5AGWX-ray2.69C/D146-166[»]
5AGXX-ray2.24C/D146-166[»]
5C3GX-ray2.45B146-166[»]
5VWVX-ray1.90B141-165[»]
5VWWX-ray2.80C/D141-166[»]
5VWXX-ray2.49B/D142-164[»]
5VWYX-ray1.55B141-166[»]
5VWZX-ray1.62B/D141-166[»]
5VX0X-ray1.60B/D141-166[»]
5VX2X-ray1.85B/D141-166[»]
5VX3X-ray1.95B/D/F/H141-166[»]
5WOSX-ray2.45B141-166[»]
ProteinModelPortaliO43521
SMRiO43521
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115335, 58 interactors
ComplexPortaliCPX-1985 BIM:BCL-XL complex
CPX-1990 BIM:BCL-2 complex
CPX-481 MCL-1-BIM complex
DIPiDIP-29185N
ELMiO43521
IntActiO43521, 42 interactors
MINTiO43521
STRINGi9606.ENSP00000376943

Chemistry databases

BindingDBiO43521
ChEMBLiCHEMBL5777

Protein family/group databases

TCDBi8.A.69.1.1 the pro-apoptotic bcl-2-family protein bim (bim) family

PTM databases

iPTMnetiO43521
PhosphoSitePlusiO43521

Polymorphism and mutation databases

BioMutaiBCL2L11

Proteomic databases

MaxQBiO43521
PaxDbiO43521
PeptideAtlasiO43521
PRIDEiO43521
ProteomicsDBi49009
49010 [O43521-10]
49011 [O43521-11]
49012 [O43521-12]
49013 [O43521-13]
49014 [O43521-14]
49015 [O43521-15]
49016 [O43521-16]
49017 [O43521-17]
49018 [O43521-18]
49019 [O43521-19]
49020 [O43521-2]
49021 [O43521-20]
49022 [O43521-3]
49023 [O43521-4]
49024 [O43521-5]
49025 [O43521-6]
49026 [O43521-7]
49027 [O43521-8]
49028 [O43521-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10018
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308659; ENSP00000309226; ENSG00000153094 [O43521-2]
ENST00000337565; ENSP00000338374; ENSG00000153094 [O43521-17]
ENST00000393256; ENSP00000376943; ENSG00000153094 [O43521-1]
ENST00000405953; ENSP00000384641; ENSG00000153094 [O43521-17]
ENST00000415458; ENSP00000393781; ENSG00000153094 [O43521-16]
ENST00000431217; ENSP00000394640; ENSG00000153094 [O43521-10]
ENST00000433098; ENSP00000401662; ENSG00000153094 [O43521-5]
ENST00000436733; ENSP00000403727; ENSG00000153094 [O43521-14]
ENST00000437029; ENSP00000412892; ENSG00000153094 [O43521-8]
ENST00000439718; ENSP00000411137; ENSG00000153094 [O43521-7]
ENST00000452231; ENSP00000391292; ENSG00000153094 [O43521-9]
ENST00000610735; ENSP00000481030; ENSG00000153094 [O43521-14]
ENST00000615946; ENSP00000481423; ENSG00000153094 [O43521-7]
ENST00000619294; ENSP00000479714; ENSG00000153094 [O43521-10]
ENST00000620862; ENSP00000478133; ENSG00000153094 [O43521-5]
ENST00000621302; ENSP00000481652; ENSG00000153094 [O43521-4]
ENST00000622509; ENSP00000482175; ENSG00000153094 [O43521-8]
ENST00000622612; ENSP00000484360; ENSG00000153094 [O43521-11]
ENST00000639340; ENSP00000491154; ENSG00000153094 [O43521-16]
ENST00000640419; ENSP00000491422; ENSG00000153094 [O43521-9]
GeneIDi10018
KEGGihsa:10018
UCSCiuc002tgt.2 human [O43521-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10018
DisGeNETi10018
EuPathDBiHostDB:ENSG00000153094.21

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BCL2L11
HGNCiHGNC:994 BCL2L11
HPAiCAB026332
MIMi603827 gene
neXtProtiNX_O43521
OpenTargetsiENSG00000153094
PharmGKBiPA25305

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZKS Eukaryota
ENOG410Y8GB LUCA
GeneTreeiENSGT00390000003178
InParanoidiO43521
KOiK16341
OMAiDRCPHGS
OrthoDBiEOG091G0XD3
PhylomeDBiO43521
TreeFamiTF335898

Enzyme and pathway databases

ReactomeiR-HSA-111446 Activation of BIM and translocation to mitochondria
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-193648 NRAGE signals death through JNK
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription
SIGNORiO43521

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BCL2L11 human
EvolutionaryTraceiO43521

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
BCL2L11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10018
PMAP-CutDBiO43521

Protein Ontology

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PROi
PR:O43521

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000153094 Expressed in 190 organ(s), highest expression level in sperm
ExpressionAtlasiO43521 baseline and differential
GenevisibleiO43521 HS

Family and domain databases

InterProiView protein in InterPro
IPR014771 Apoptosis_Bim_N
IPR017288 Bcl-2-like_11
IPR015040 Bcl-x_interacting_BH3_dom
PfamiView protein in Pfam
PF08945 Bclx_interact, 1 hit
PF06773 Bim_N, 1 hit
PIRSFiPIRSF037827 Bcl-2-like_p11, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2L11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43521
Secondary accession number(s): A8K2W2
, O43522, Q0MSE7, Q0MSE8, Q0MSE9, Q53R28, Q6JTU6, Q6T851, Q6TE14, Q6TE15, Q6TE16, Q6V402, Q8WYL6, Q8WYL7, Q8WYL8, Q8WYL9, Q8WYM0, Q8WYM1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 1998
Last modified: December 5, 2018
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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