UniProtKB - O43521 (B2L11_HUMAN)
Bcl-2-like protein 11
BCL2L11
Functioni
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
4 PublicationsGO - Molecular functioni
- microtubule binding Source: Ensembl
- protein kinase binding Source: Ensembl
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- apoptotic process Source: UniProtKB
- apoptotic process involved in embryonic digit morphogenesis Source: Ensembl
- B cell homeostasis Source: Ensembl
- brain development Source: Ensembl
- cell-matrix adhesion Source: Ensembl
- cellular response to amyloid-beta Source: Ensembl
- cellular response to estradiol stimulus Source: Ensembl
- cellular response to glucocorticoid stimulus Source: ARUK-UCL
- developmental pigmentation Source: Ensembl
- ear development Source: Ensembl
- extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
- intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
- in utero embryonic development Source: Ensembl
- kidney development Source: Ensembl
- male gonad development Source: Ensembl
- mammary gland development Source: Ensembl
- meiosis I Source: GO_Central
- myeloid cell homeostasis Source: Ensembl
- odontogenesis of dentin-containing tooth Source: Ensembl
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of autophagy in response to ER overload Source: Ensembl
- positive regulation of cell cycle Source: Ensembl
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
- positive regulation of fibroblast apoptotic process Source: UniProtKB
- positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
- positive regulation of IRE1-mediated unfolded protein response Source: ParkinsonsUK-UCL
- positive regulation of mitochondrial membrane permeability involved in apoptotic process Source: Ensembl
- positive regulation of neuron apoptotic process Source: Ensembl
- positive regulation of protein-containing complex assembly Source: BHF-UCL
- positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
- post-embryonic animal organ morphogenesis Source: Ensembl
- regulation of apoptotic process Source: ComplexPortal
- regulation of developmental pigmentation Source: Ensembl
- regulation of organ growth Source: Ensembl
- response to endoplasmic reticulum stress Source: UniProtKB
- spermatogenesis Source: Ensembl
- spleen development Source: Ensembl
- T cell homeostasis Source: Ensembl
- thymocyte apoptotic process Source: Ensembl
- thymus development Source: Ensembl
- tube formation Source: Ensembl
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | O43521 |
Reactomei | R-HSA-111446, Activation of BIM and translocation to mitochondria R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-193648, NRAGE signals death through JNK R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8952158, RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-9607240, FLT3 Signaling R-HSA-9614657, FOXO-mediated transcription of cell death genes |
SignaLinki | O43521 |
SIGNORi | O43521 |
Protein family/group databases
TCDBi | 8.A.69.1.1, the pro-apoptotic bcl-2-family protein bim (bim) family |
Names & Taxonomyi
Protein namesi | Recommended name: Bcl-2-like protein 11Short name: Bcl2-L-11 Alternative name(s): Bcl2-interacting mediator of cell death |
Gene namesi | Name:BCL2L11 Synonyms:BIM |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:994, BCL2L11 |
MIMi | 603827, gene |
neXtProti | NX_O43521 |
VEuPathDBi | HostDB:ENSG00000153094 |
Subcellular locationi
Other locations
- Endomembrane system By similarity; Peripheral membrane protein By similarity
Note: Associated with intracytoplasmic membranes.By similarity
Mitochondrion
Note: Translocates from microtubules to mitochondria on loss of cell adherence.
Mitochondrion
Mitochondrion
Mitochondrion
Cytosol
- cytosol Source: UniProtKB
Mitochondrion
- mitochondrial outer membrane Source: Reactome
- mitochondrion Source: GO_Central
Other locations
- Bcl-2 family protein complex Source: ComplexPortal
- BIM-BCL-2 complex Source: UniProtKB
- BIM-BCL-xl complex Source: UniProtKB
- endomembrane system Source: UniProtKB-SubCell
- extrinsic component of membrane Source: Ensembl
Keywords - Cellular componenti
Membrane, MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 156 | G → A: Retains the ability to induce apoptosis. Abolishes interaction with BAX; in isoform Bim-alpha3 and isoform BimS. No effect on interaction with BCL2. 2 Publications | 1 | |
Mutagenesisi | 156 | G → E: Abolishes induction of apoptosis. Abolishes interaction with BAX and BCL2; in isoform Bim-alpha3 and isoform BimS. Loses the ability to induce the conformationally active form of BAX. 2 Publications | 1 | |
Mutagenesisi | 160 | N → A: Retains the ability to induce apoptosis. Abolishes interaction with BCL2; in isoform Bim-alpha3 and isoform BimS. No effect on interaction with BAX. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 10018 |
OpenTargetsi | ENSG00000153094 |
PharmGKBi | PA25305 |
Miscellaneous databases
Pharosi | O43521, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5777 |
Genetic variation databases
BioMutai | BCL2L11 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143109 | 1 – 198 | Bcl-2-like protein 11Add BLAST | 198 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 69 | Phosphoserine; by MAPK1 Publication | 1 | |
Modified residuei | 77 | PhosphoserineBy similarity | 1 | |
Modified residuei | 87 | PhosphoserineBy similarity | 1 | |
Modified residuei | 94 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O43521 |
MassIVEi | O43521 |
MaxQBi | O43521 |
PaxDbi | O43521 |
PeptideAtlasi | O43521 |
PRIDEi | O43521 |
ProteomicsDBi | 49009 [O43521-1] 49010 [O43521-10] 49011 [O43521-11] 49012 [O43521-12] 49013 [O43521-13] 49014 [O43521-14] 49015 [O43521-15] 49016 [O43521-16] 49017 [O43521-17] 49018 [O43521-18] 49019 [O43521-19] 49020 [O43521-2] 49021 [O43521-20] 49022 [O43521-3] 49023 [O43521-4] 49024 [O43521-5] 49025 [O43521-6] 49026 [O43521-7] 49027 [O43521-8] 49028 [O43521-9] |
PTM databases
iPTMneti | O43521 |
PhosphoSitePlusi | O43521 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000153094, Expressed in sperm and 204 other tissues |
ExpressionAtlasi | O43521, baseline and differential |
Genevisiblei | O43521, HS |
Organism-specific databases
HPAi | ENSG00000153094, Low tissue specificity |
Interactioni
Subunit structurei
Forms heterodimers with a number of antiapoptotic Bcl-2 proteins, including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, BHRF1, and BCL2L2/BCLW (PubMed:11997495, PubMed:27013495, PubMed:18812174). Does not heterodimerize with proapoptotic proteins such as BAD, BOK or BAK.
Identified in a complex containing BCL2L11, DYNLL1 and BCL2L1 isoform Bcl-X(L); BH3 integrity is required for BCL2L1-binding.
Interacts with YWHAZ. When phosphorylated, interacts with TRIM2; this interaction is associated with ubiquitination and degradation (PubMed:21478148).
Interacts with MCL1; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:27013495, PubMed:17389404).
Interacts with GIMAP5 (PubMed:16509771).
Interacts with BCL2L10/BCL-B (PubMed:23235460, PubMed:23563182, PubMed:22498477).
9 PublicationsInteracts (when phosphorylated) with USP27X; the interaction leads to BCL2L11 deubiquitination and stabilization (PubMed:27013495).
Interacts with humanin; the interaction prevents BIM-induced apoptosis.
1 PublicationInteracts with BAX; the interaction may lead to BAX activation through conformational change.
1 PublicationBinary interactionsi
O43521
Isoform BimEL [O43521-1]
With | #Exp. | IntAct |
---|---|---|
BCL2 [P10415] | 3 | EBI-526416,EBI-77694 |
BCL2L1 - isoform Bcl-X(L) [Q07817-1] | 2 | EBI-526416,EBI-287195 |
BCL2L10 [Q9HD36] | 2 | EBI-526416,EBI-2126349 |
Isoform BimL [O43521-2]
With | #Exp. | IntAct |
---|---|---|
BCL2 [P10415] | 4 | EBI-526420,EBI-77694 |
MIF [P14174] | 5 | EBI-526420,EBI-372712 |
GO - Molecular functioni
- microtubule binding Source: Ensembl
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 115335, 69 interactors |
ComplexPortali | CPX-1985, BIM:BCL-XL complex CPX-1990, BIM:BCL-2 complex CPX-481, MCL-1-BIM complex |
DIPi | DIP-29185N |
ELMi | O43521 |
IntActi | O43521, 56 interactors |
MINTi | O43521 |
STRINGi | 9606.ENSP00000376943 |
Chemistry databases
BindingDBi | O43521 |
Miscellaneous databases
RNActi | O43521, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | O43521 |
SMRi | O43521 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O43521 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 72 | DisorderedSequence analysisAdd BLAST | 72 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 148 – 162 | BH3Add BLAST | 15 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502S0DF, Eukaryota |
GeneTreei | ENSGT00390000003178 |
HOGENOMi | CLU_171932_0_0_1 |
InParanoidi | O43521 |
OMAi | EIWIARE |
OrthoDBi | 1460067at2759 |
PhylomeDBi | O43521 |
TreeFami | TF335898 |
Family and domain databases
InterProi | View protein in InterPro IPR014771, Apoptosis_Bim_N IPR017288, Bcl-2-like_11 IPR015040, Bcl-x_interacting_BH3_dom |
Pfami | View protein in Pfam PF08945, Bclx_interact, 1 hit PF06773, Bim_N, 1 hit |
PIRSFi | PIRSF037827, Bcl-2-like_p11, 1 hit |
s (20+)i Sequence
Sequence statusi: Complete.
This entry describes 20 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 20 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG
60 70 80 90 100
EGDSCPHGSP QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD
110 120 130 140 150
TDRSPAPMSC DKSTQTPSPP CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ
160 170 180 190
ELRRIGDEFN AYYARRVFLN NYQAAEDHPR MVILRLLRYI VRLVWRMH
The sequence of this isoform differs from the canonical sequence as follows:
42-101: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
42-131: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → LEK
The sequence of this isoform differs from the canonical sequence as follows:
42-101: Missing.
167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → LEK
The sequence of this isoform differs from the canonical sequence as follows:
42-131: Missing.
167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → LEK
The sequence of this isoform differs from the canonical sequence as follows:
42-131: Missing.
167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → LAKLLASST
The sequence of this isoform differs from the canonical sequence as follows:
167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → MPLPPD
The sequence of this isoform differs from the canonical sequence as follows:
42-131: Missing.
167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → MPLPPD
The sequence of this isoform differs from the canonical sequence as follows:
133-135: SMR → NWD
136-198: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
132-135: ASMR → GIFE
136-198: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
42-75: GNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFAT → VSLCHPGWSALVRSWLTATSNSQVQAVLLPQPPK
The sequence of this isoform differs from the canonical sequence as follows:
43-44: NP → IF
45-198: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
132-140: ASMRQAEPA → VREIEEVVV
141-198: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
42-101: Missing.
132-135: ASMR → GIFE
136-198: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
42-101: Missing.
132-140: ASMRQAEPA → VREIEEVVV
141-198: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
42-101: Missing.
132-198: ASMRQAEPAD...YIVRLVWRMH → VVILEDIGDL...TEQLNHKDFS
The sequence of this isoform differs from the canonical sequence as follows:
42-101: Missing.
132-166: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
132-166: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
42-166: Missing.
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MRE7 | A0A0A0MRE7_HUMAN | Bcl-2-like protein 11 | BCL2L11 | 98 | Annotation score: | ||
C9J417 | C9J417_HUMAN | Bcl-2-like protein 11 | BCL2L11 | 122 | Annotation score: | ||
H7BZE5 | H7BZE5_HUMAN | Bcl-2-like protein 11 | BCL2L11 | 96 | Annotation score: | ||
A0A0C4DH20 | A0A0C4DH20_HUMAN | Bcl-2-like protein 11 | BCL2L11 | 75 | Annotation score: | ||
E9PAM9 | E9PAM9_HUMAN | Bcl-2-like protein 11 | BCL2L11 | 71 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 33 | P → L in BAF83066 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042865 | 42 – 166 | Missing in isoform BimA. 1 PublicationAdd BLAST | 125 | |
Alternative sequenceiVSP_035608 | 42 – 131 | Missing in isoform BimS, isoform Bim-alpha3, isoform Bim-alpha6 and isoform Bim-alpha4. 3 PublicationsAdd BLAST | 90 | |
Alternative sequenceiVSP_000535 | 42 – 101 | Missing in isoform BimABC, isoform BimL, isoform Bim-alpha2, isoform Bim-gamma, isoform Bim-beta6 and isoform Bim-beta7. 6 PublicationsAdd BLAST | 60 | |
Alternative sequenceiVSP_035609 | 42 – 75 | GNPEG…GPFAT → VSLCHPGWSALVRSWLTATS NSQVQAVLLPQPPK in isoform Bim-beta3. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_035610 | 43 – 44 | NP → IF in isoform Bim-beta4. 1 Publication | 2 | |
Alternative sequenceiVSP_035611 | 45 – 198 | Missing in isoform Bim-beta4. 1 PublicationAdd BLAST | 154 | |
Alternative sequenceiVSP_035612 | 132 – 198 | ASMRQ…VWRMH → VVILEDIGDLSLCFGFIFTG LDLYGHHHSQDTEQLNHKDF S in isoform Bim-gamma. 1 PublicationAdd BLAST | 67 | |
Alternative sequenceiVSP_042866 | 132 – 166 | Missing in isoform BimAC and isoform BimABC. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_035613 | 132 – 140 | ASMRQAEPA → VREIEEVVV in isoform Bim-beta5 and isoform Bim-beta7. 1 Publication | 9 | |
Alternative sequenceiVSP_035614 | 132 – 135 | ASMR → GIFE in isoform Bim-beta2 and isoform Bim-beta6. 2 Publications | 4 | |
Alternative sequenceiVSP_035615 | 133 – 135 | SMR → NWD in isoform Bim-beta1. 1 Publication | 3 | |
Alternative sequenceiVSP_035616 | 136 – 198 | Missing in isoform Bim-beta1, isoform Bim-beta2 and isoform Bim-beta6. 2 PublicationsAdd BLAST | 63 | |
Alternative sequenceiVSP_035617 | 141 – 198 | Missing in isoform Bim-beta5 and isoform Bim-beta7. 1 PublicationAdd BLAST | 58 | |
Alternative sequenceiVSP_035620 | 167 – 198 | VFLNN…VWRMH → LEK in isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3. 4 PublicationsAdd BLAST | 32 | |
Alternative sequenceiVSP_035618 | 167 – 198 | VFLNN…VWRMH → LAKLLASST in isoform Bim-alpha4. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_035619 | 167 – 198 | VFLNN…VWRMH → MPLPPD in isoform Bim-alpha5 and isoform Bim-alpha6. 1 PublicationAdd BLAST | 32 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1F95 | NMR | - | C/D | 108-116 | [»] | |
2K7W | NMR | - | B | 145-164 | [»] | |
2NL9 | X-ray | 1.55 | B | 141-166 | [»] | |
2V6Q | X-ray | 2.70 | B | 141-166 | [»] | |
2VM6 | X-ray | 2.20 | B | 141-165 | [»] | |
2WH6 | X-ray | 1.50 | B | 141-166 | [»] | |
2YQ6 | X-ray | 1.80 | B | 147-164 | [»] | |
2YQ7 | X-ray | 1.90 | B | 147-164 | [»] | |
3D7V | X-ray | 2.03 | B | 141-166 | [»] | |
3FDL | X-ray | 1.78 | B | 141-166 | [»] | |
3IO8 | X-ray | 2.30 | B/D | 141-166 | [»] | |
3IO9 | X-ray | 2.40 | B | 141-166 | [»] | |
3KJ0 | X-ray | 1.70 | B | 143-165 | [»] | |
3KJ1 | X-ray | 1.94 | B | 143-163 | [»] | |
3KJ2 | X-ray | 2.35 | B | 143-163 | [»] | |
4A1U | X-ray | 1.54 | B | 146-163 | [»] | |
4A1W | X-ray | 2.50 | P/Q/R/S | 146-163 | [»] | |
4B4S | X-ray | 1.90 | B | 141-166 | [»] | |
4D2M | X-ray | 2.10 | B/D | 141-166 | [»] | |
4QVF | X-ray | 1.53 | B | 141-166 | [»] | |
4UF3 | X-ray | 2.70 | B | 141-166 | [»] | |
4YJ4 | X-ray | 2.10 | B | 146-165 | [»] | |
4ZIE | X-ray | 1.80 | C | 141-166 | [»] | |
4ZIF | X-ray | 2.40 | B | 141-160 | [»] | |
4ZIH | X-ray | 2.50 | B | 141-160 | [»] | |
5AGW | X-ray | 2.69 | C/D | 146-166 | [»] | |
5AGX | X-ray | 2.24 | C/D | 146-166 | [»] | |
5C3G | X-ray | 2.45 | B | 146-166 | [»] | |
5VWV | X-ray | 1.90 | B | 141-165 | [»] | |
5VWW | X-ray | 2.80 | C/D | 141-166 | [»] | |
5VWX | X-ray | 2.49 | B/D | 142-164 | [»] | |
5VWY | X-ray | 1.55 | B | 141-166 | [»] | |
5VWZ | X-ray | 1.62 | B/D | 141-166 | [»] | |
5VX0 | X-ray | 1.60 | B/D | 141-166 | [»] | |
5VX2 | X-ray | 1.85 | B/D | 141-166 | [»] | |
5VX3 | X-ray | 1.95 | B/D/F/H | 141-166 | [»] | |
5WOS | X-ray | 2.45 | B | 141-166 | [»] | |
6QFI | X-ray | 2.40 | B | 141-166 | [»] | |
6RJP | X-ray | 2.57 | C/D | 147-163 | [»] | |
6TQQ | X-ray | 3.00 | B | 141-166 | [»] | |
6UA3 | X-ray | 1.55 | B | 146-166 | [»] | |
6UAB | X-ray | 2.10 | B | 146-166 | [»] | |
6VBX | X-ray | 1.95 | B | 148-159 | [»] | |
6X8O | X-ray | 1.31 | A/B/C/D | 141-166 | [»] | |
AlphaFoldDBi | O43521 | |||||
SMRi | O43521 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115335, 69 interactors |
ComplexPortali | CPX-1985, BIM:BCL-XL complex CPX-1990, BIM:BCL-2 complex CPX-481, MCL-1-BIM complex |
DIPi | DIP-29185N |
ELMi | O43521 |
IntActi | O43521, 56 interactors |
MINTi | O43521 |
STRINGi | 9606.ENSP00000376943 |
Chemistry databases
BindingDBi | O43521 |
ChEMBLi | CHEMBL5777 |
Protein family/group databases
TCDBi | 8.A.69.1.1, the pro-apoptotic bcl-2-family protein bim (bim) family |
PTM databases
iPTMneti | O43521 |
PhosphoSitePlusi | O43521 |
Genetic variation databases
BioMutai | BCL2L11 |
Proteomic databases
EPDi | O43521 |
MassIVEi | O43521 |
MaxQBi | O43521 |
PaxDbi | O43521 |
PeptideAtlasi | O43521 |
PRIDEi | O43521 |
ProteomicsDBi | 49009 [O43521-1] 49010 [O43521-10] 49011 [O43521-11] 49012 [O43521-12] 49013 [O43521-13] 49014 [O43521-14] 49015 [O43521-15] 49016 [O43521-16] 49017 [O43521-17] 49018 [O43521-18] 49019 [O43521-19] 49020 [O43521-2] 49021 [O43521-20] 49022 [O43521-3] 49023 [O43521-4] 49024 [O43521-5] 49025 [O43521-6] 49026 [O43521-7] 49027 [O43521-8] 49028 [O43521-9] |
Protocols and materials databases
Antibodypediai | 3621, 1278 antibodies from 44 providers |
DNASUi | 10018 |
Genome annotation databases
Organism-specific databases
CTDi | 10018 |
DisGeNETi | 10018 |
GeneCardsi | BCL2L11 |
HGNCi | HGNC:994, BCL2L11 |
HPAi | ENSG00000153094, Low tissue specificity |
MIMi | 603827, gene |
neXtProti | NX_O43521 |
OpenTargetsi | ENSG00000153094 |
PharmGKBi | PA25305 |
VEuPathDBi | HostDB:ENSG00000153094 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S0DF, Eukaryota |
GeneTreei | ENSGT00390000003178 |
HOGENOMi | CLU_171932_0_0_1 |
InParanoidi | O43521 |
OMAi | EIWIARE |
OrthoDBi | 1460067at2759 |
PhylomeDBi | O43521 |
TreeFami | TF335898 |
Enzyme and pathway databases
PathwayCommonsi | O43521 |
Reactomei | R-HSA-111446, Activation of BIM and translocation to mitochondria R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-193648, NRAGE signals death through JNK R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8952158, RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-9607240, FLT3 Signaling R-HSA-9614657, FOXO-mediated transcription of cell death genes |
SignaLinki | O43521 |
SIGNORi | O43521 |
Miscellaneous databases
BioGRID-ORCSi | 10018, 21 hits in 1086 CRISPR screens |
ChiTaRSi | BCL2L11, human |
EvolutionaryTracei | O43521 |
GeneWikii | BCL2L11 |
GenomeRNAii | 10018 |
Pharosi | O43521, Tchem |
PROi | PR:O43521 |
RNActi | O43521, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153094, Expressed in sperm and 204 other tissues |
ExpressionAtlasi | O43521, baseline and differential |
Genevisiblei | O43521, HS |
Family and domain databases
InterProi | View protein in InterPro IPR014771, Apoptosis_Bim_N IPR017288, Bcl-2-like_11 IPR015040, Bcl-x_interacting_BH3_dom |
Pfami | View protein in Pfam PF08945, Bclx_interact, 1 hit PF06773, Bim_N, 1 hit |
PIRSFi | PIRSF037827, Bcl-2-like_p11, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B2L11_HUMAN | |
Accessioni | O43521Primary (citable) accession number: O43521 Secondary accession number(s): A8K2W2 Q8WYM1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | June 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 201 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families